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Sep. 2, 2008 Researchers in Canada report
discovery of unusual proteins in a small group of
Kenyan sex workers that appear to be associated
with resistance to infection with HIV, the virus that
causes AIDS.
The discovery could lead to the
improved design of vaccines and
drugs to fight the deadly virus, which
infects an estimated 40 million
people worldwide, the scientists say
in a new report.
In the new study, Adam Burgener
and colleagues note that 140 of more
than 2000 sex workers studied in
Nairobi, Kenya, appear resistant to
HIV infection. Although evidence
suggests that certain biological
factors in their vaginal fluid may play
a role in resistance, the exact identity
of these substances was unclear.
The scientists used a high-tech
analytical method to compare
differences among proteins in
vaginal fluids from HIV-resistant
women and those infected with the
virus or susceptible to it.
HIV-resistant women had proteins
significantly different from other
women. Vaginal fluids of the
HIV-resistant women had higher
levels of proteins with anti-viral and
anti-inflammatory actions.
These proteins could be used as the
basis for new medications to prevent
infection, the scientists suggest.
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The above story is reprinted from materials provided by
American Chemical Society.
Note: Materials may be edited for content and length. For
further information, please contact the source cited above.
Journal Reference:
Burgener et al. Identification of Differentially Expressed
Proteins in the Cervical Mucosa of HIV-1-Resistant Sex
Workers. Journal of Proteome Research, 2008; 0 (0): 0
DOI: 10.1021/pr800406r
1.
Need to cite this story in your essay, paper, or report? Use
one of the following formats:
American Chemical Society (2008, September
2). Vaginal Proteins In HIV-resistant Prostitutes
Suggest New Prevention Measures.
ScienceDaily. Retrieved December 18, 2012,
from http://www.sciencedaily.com/releases
/2008/09/080901205622.htm
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Disclaimer: This article is not intended to provide medical
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