CNS OVERVIEW
Daripada Abu Hurairah r.a, daripada Nabi SAW bersabda maksudnya: Sesiapa yang melepaskan sesuatu kesusahan seorang mukmin dari kesusahan-kesusahan dunia Allah akan melepaskan darinya satu kesusahan dari kesusahan hari Akhirat dan sesiapa melapangkan seorang yang berada di dalam kesempitan Allah akan melapangkan untuknya di dunia dan di akhirat dan sesiapa yang menutup keburukan saudaranya maka Allah akan menutup keburukannya di dunia dan akhirat dan Allah pasti menolong hamba-Nya selagi mana hambanya menolong saudaranya. Dan sesiapa mengikuti satu jalan untuk mencari ilmu Allah akan memudahkan untuknya jalan ke syurga. Tidak berkumpul satu kaum di dalam rumah dari rumah-rumah Allah dan saling belajar dan mengajar antara satu sama lain melainkan turunlah ketenangan atas mereka, rahmat meliputi mereka, para malaikat mengerumuni mereka dan Allah akan menyebut (nama-nama) mereka di sisi-Nya. Dan sesiapa yang kurang amalannya maka nasab (keturunannya) tidak akan dapat menyempurnakannya. (Muslim) by:
*toxicity of benzodiazepine is treated with Flumazenil Barbiturates Sub-Groups Subclass / T Long acting 10-12 hrs Intermediate active 6-8 hrs Short acting 3-4 hrs Ultrashort acting 15 mins Drugs Phenobarbital & mephobarbital Butabarbital, talbutal, amobarbital Pentobarbital & sarcobarbital Thiopental sodium & methohexital sodium
Other sedative
Buspirone, paraldehyde, chloral hydrate, meprobomate & glutethimide Drugs with other major use but with sedative action : antihistamines -adrenergic blockers (pass BBB) clonidine antidepressants
ANTIEPILEPTIC DRUGS
CLASSIFICATION
DRUGS
Block Na Channels
Phenytoin Carbamazepine Oxcarbazepine, lamotrigine & topiramate Valproic acid, benzodiazepine Phenobarbitone & primidone topiramate Ethosuximide, trimethadione Felbamate
ANALGESIC DRUGS
GROUPS Narcotic Analgesic (Opiod) CLASSIFICATIONS 1. Phenanthrene alkaloids opium 2. Semisynthetic morphine derivatives 3. Synthetic morphine substitute 4. Mixed agonist antagonist narcotics analgesic 1. Sialicylic derivatives 2. Aniline derivatives 3. Indole derivatives 4. Phenyl acetic acids 5. Proprionic acids 6. Fenamic acids 7. Oxicams 8. Pyrazolones 9. Others DRUGS Morphine & codeine Diacetyl morphine, dihydromorphine, oxymorphine, oxycodone & dihydrocodeinone Meperidine, fentanyl, methadone & dextropropoxyphene Pentazocine, nalbuphine, buprenorphine & butorphanol Aspirin. sodium salicylate, diflunisal Paracetamol Indomethacin & sulindac Diclofenac, ketorolac & etodolac Ibuprofen, naproxen & ketoprofen Mefenamic acid & flufenamic acid Prioxicam & tenoxicam Phenylbutazone & azapropazone Nabumetone
DRUGS OF THERAPIES
DISEASES Rheumatic Fever DRUGS
Salicylate (avoid this drug in rheumatic carditis or cardiac failure) Prenisolone (in rheumatic carditis) Penicilin (Procaine peniciline) Prophylaxis chemoprophylaxis streptococcal infection Penicilin : Benzathine penicilin G or oral penicilin V If sensitive to penicilin : use erythromycin or sulphonamide Acute
Rheumatoid Arthritis
1 Line Drugs nd 2 Line drugs Disease modifying Antirheumatoid Drugs (DMARDs) 3 Line Drugs
rd
st
NSAIDs Methotrexate (chemotherapy) Gold salts (gold Na thiomalate) Penicillamine Hydroxychloroquine Sulphasalazine Immunosuppressive drugs ( Azathioprine & Cyclophosphamide) : indicated in patient with disabling rheumatoid arthritis or systemic manifestation who are refractory to or intolerant to DMARD theraphy Corticosteroids
Gout Prophylaxis Acute Colchicine (Drug of choice) NSAIDs (when colchicine failed) Steroidal anti inflammatory drugs in refractory cases : ACTH, Prednisolone inhibit uric acid synthesis : allopurinol increase UA secretion (uricosuric agents) : Aspirin, Probencid, Sulphinpyrazone & benzbromarone
DRUGS Phenothiazine aliphatic derivatives : chlorpromazine piperazine derivatives : fluphenazine piperidine derivatives : thioridazine Butyrophenones : haloperidol, droperidol Thioxanthines : flupenthixol, clopenthiol Sulpiride, pimozide, clozapine, risperidone & olanzapine
Atypical Neuroleptics
2.ANTIPARKINSONIAN DRUGS
DRUGS Atropine & hyoscine Trihexyphenidyl (artane) Benztropine (Cogentin) Procyclidine (kemadrin) Biberiden (akineton) Ethopropazine Diphenydramine Orphenadrine (disipal) Levodopa (L-dopa) Amantadine
3. Phenothiazine with anticholinergic properties 4. Drugs with both anticholinergic & antihistaminic properties 1. Replete neuronal dopamine 2. Increase release dopamine from the stores and inhibit reuptake
Activity
MAOBi : sellegline (deprenyl) COMTi : tolcapone & entacapone Ergot : bromocriptine, perglide & luseride Non ergot : pramipexole & ropinirole
Electroconvulsive theraphy (ECT) is very effective & act more rapid than antidepressants
LESSON ON : ANESTHETICS
PREANESTHETIC MEDICATION
CLASSIFICATION Sedative hypnotics & Antianxiety Opioid analgesic Anticholinergic Drugs reduce acidity and volume of gastric contents Antiemitics & anthistaminics Anesthetic adjuvants Diazepam
DRUGS
Vasopressor drugs Preanesthetic medication Controlled hypotension : trimetaphan in neuro and plastic surgery Hypothermic : chlorpromazine in cardiosurgery
GENERAL ANESTHETICS
CLASSIFICATION Inhalation
DRUGS Volatile liquids : Halogenated anesthetic : halothane, enflurane, isoflurane, methoxyflurance, desflurance, sevoflurane chloroform & trichloroethylene Ether : diethyl ether & divineyl ether Gases : Nitrous oxide & cyclopropane Ultrashort acting barbiturates : Na thiopentone & methohexitoe Benzodiazepines (diazepam, midazolam) Ketamine (dissociative anesthesia) Etomidate Propofol Opioid analgesic : morphine, fentanyl & fentanyl congeners Neuroleptalanalgesia
Intravenous
Basal anesthesia
Balanced anesthesia
Definition : light anesthesia not deep enough to permit surgical operation not used as sole agents for surgical anesthesia d/t : I. hard to adjust depth & duration of anesthesia II. cant remove excess once they reached the blood III. depend on state of health of metabolizing and excreting organs e.g : diazepam, thiopentone, paraldehyde Definition : combination different drugs to take each drugs beneficial effects while minimizing each agents adverse effects These drugs include : I. pre anesthetic agents II. induction anesthesia : IV --> more rapid induction III. maintenance anesthesia : using inhalation anesthesia IV. NM relaxants : facilitate intubation & relaxation of muscles
LOCAL ANESTHETICS
CLASSIFICATION According to solubility & therapeutic application Soluble LA suitable for injection
DRUGS Procaine, dibucaine, lidocaine & tetracaine all produce surface anesthesia except procaine Particularly on eye
Esters
Amides
Cocaine HCL, phenacaine HCL Benzocaine Use as surface anesthetics as powders & ointments for wound and ulcers Ester of benzoic acid : cocaine Ester of P-aminobenzoic acid : procaine, benzocaine & tetracaine Lidocaine (xylocaine, ligocaine) prilocaine, mepivacaine (carbocaine) & dibucaine
Indirect Dual
Strychnine
DRUGS ABUSE
opioids barbiturates & other sedatives hypnotics including alcohol CNS stimulants : caffeine, cocaine & aphetamine hallucinogen : lysergic acid diethylamide (LSD) & phencyclidine (PCP, angle dust) marijuana (cannabis) inhalants : ether, chloroform, industrial solvents like gasoline, pint thinner, glueshoe polish and organics nitrites