SIGMA-ALDRICH

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Material Safety Data Sheet

Version 4.2 Revision Date 01/12/2011 Print Date 11/21/2011

1. PRODUCT AND COMPANY IDENTIFICATION Product name Product Number Brand Product Use Supplier : : : : :

4-Hydroxy-4-methyl-2-pentanone
31450 Fluka For laboratory research purposes. Sigma-Aldrich Canada, Ltd 2149 Winston Park Drive OAKVILLE ON L6H 6J8 CANADA +1 9058299500 +1 9058299292 1-800-424-9300 Manufacturer : Sigma-Aldrich Corporation 3050 Spruce St. St. Louis, Missouri 63103 USA

Telephone Fax Emergency Phone # (For both supplier and manufacturer) Preparation Information

: : :

Sigma-Aldrich Corporation Product Safety - Americas Region 1-800-521-8956

2. HAZARDS IDENTIFICATION Emergency Overview Target Organs Blood, Liver, Kidney WHMIS Classification B3 Combustible Liquid D2B GHS Classification Flammable liquids (Category 3) Acute toxicity, Oral (Category 5) Acute toxicity, Inhalation (Category 3) Serious eye damage (Category 1) GHS Label elements, including precautionary statements Pictogram Signal word Hazard statement(s) H226 H303 H318 H331 Danger Flammable liquid and vapour. May be harmful if swallowed. Causes serious eye damage. Toxic if inhaled. Combustible Liquid Moderate eye irritant

Precautionary statement(s) P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P280 Wear protective gloves/ eye protection/ face protection. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P311 Call a POISON CENTER or doctor/ physician.
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HMIS Classification Health hazard: Chronic Health Hazard: Flammability: Physical hazards: Potential Health Effects Inhalation Skin Eyes Ingestion

2 * 2 0

May be harmful if inhaled. Causes respiratory tract irritation. May be harmful if absorbed through skin. Causes skin irritation. Causes eye irritation. May be harmful if swallowed.

3. COMPOSITION/INFORMATION ON INGREDIENTS Synonyms Formula Molecular Weight CAS-No. : : : Diacetone alcohol C6H12O2 116.16 g/mol Index-No. 603-016-00-1 Concentration -

EC-No.

4-Hydroxy-4-methylpentan-2-one 123-42-2 204-626-7

4. FIRST AID MEASURES General advice Consult a physician. Show this safety data sheet to the doctor in attendance.Move out of dangerous area. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. 5. FIRE-FIGHTING MEASURES Conditions of flammability Flammable in the presence of a source of ignition when the temperature is above the flash point. Keep away from heat/sparks/open flame/hot surface. No smoking. Suitable extinguishing media For small (incipient) fires, use media such as "alcohol" foam, dry chemical, or carbon dioxide. For large fires, apply water from as far as possible. Use very large quantities (flooding) of water applied as a mist or spray; solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Special protective equipment for fire-fighters Wear self contained breathing apparatus for fire fighting if necessary. Hazardous combustion products Hazardous decomposition products formed under fire conditions. - Carbon oxides Explosion data - sensitivity to mechanical impact no data available Explosion data - sensitivity to static discharge no data available

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Further information Use water spray to cool unopened containers. 6. ACCIDENTAL RELEASE MEASURES Personal precautions Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13). 7. HANDLING AND STORAGE Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge. Conditions for safe storage Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Store under inert gas. 8. EXPOSURE CONTROLS/PERSONAL PROTECTION Components with workplace control parameters

Components 4-Hydroxy-4methylpentan-2one

CAS-No. 123-42-2

Value TWA

Control parameters 50 ppm 238 mg/m3 50 ppm 238 mg/m3 50 ppm 238 mg/m3 50 ppm 50 ppm 240 mg/m3 75 ppm 360 mg/m3 50 ppm 238 mg/m3

Basis USA. ACGIH Threshold Limit Values (TLV)

TWA TWA TWA TWAE V STEV TWA Personal protective equipment

Canada. Alberta, Occupational Health and Safety Code (table 2: OEL) Canada. Alberta, Occupational Health and Safety Code (table 2: OEL) Canada. British Columbia OEL Canada. Ontario OELs

Canada. Ontario OELs Canada. Quebec OELs

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Hand protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
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Eye protection Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin and body protection Complete suit protecting against chemicals, Flame retardant antistatic protective clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Hygiene measures Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product. Specific engineering controls Use mechanical exhaust or laboratory fumehood to avoid exposure. 9. PHYSICAL AND CHEMICAL PROPERTIES Appearance Form Colour Safety data pH Melting/freezing point Boiling point Flash point Ignition temperature Autoignition temperature Lower explosion limit Upper explosion limit Vapour pressure Density Water solubility Partition coefficient: n-octanol/water Relative vapour density Odour Odour Threshold Evaporation rate no data available no data available 166 C (331 F) - lit. 58 C (136 F) - closed cup no data available no data available 1.8 %(V) 6.9 %(V) no data available 0.931 g/mL at 25 C (77 F) no data available no data available 4.01 - (Air = 1.0) no data available no data available no data available clear, liquid light yellow

10. STABILITY AND REACTIVITY Chemical stability Stable under recommended storage conditions. Possibility of hazardous reactions no data available Conditions to avoid Heat, flames and sparks. Materials to avoid Oxidizing agents, Strong bases
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Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides Other decomposition products - no data available 11. TOXICOLOGICAL INFORMATION Acute toxicity Oral LD50 LD50 Oral - rat - 2,520 mg/kg Remarks: Behavioral:Tremor. Behavioral:Convulsions or effect on seizure threshold. Liver:Other changes. Inhalation LC50 LC50 Inhalation - rat - 4 h - 1500 ppm Dermal LD50 LD50 Dermal - rabbit - 13,500 mg/kg Other information on acute toxicity no data available Skin corrosion/irritation Serious eye damage/eye irritation Eyes - rabbit - Severe eye irritation - 24 h Respiratory or skin sensitization no data available Germ cell mutagenicity no data available Carcinogenicity IARC: ACGIH: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by ACGIH.

Reproductive toxicity

no data available Teratogenicity no data available

Specific target organ toxicity - single exposure (Globally Harmonized System) no data available Specific target organ toxicity - repeated exposure (Globally Harmonized System) no data available Aspiration hazard no data available Potential health effects Inhalation Ingestion Skin Eyes May be harmful if inhaled. Causes respiratory tract irritation. May be harmful if swallowed. May be harmful if absorbed through skin. Causes skin irritation. Causes eye irritation.

Signs and Symptoms of Exposure

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Central nervous system depression, Symptoms and signs include headache, dizziness, fatigue, muscular weakness, drowsiness and in extreme cases, loss of consciousness., Blood disorders, Dermatitis, Blurred vision, Effects due to ingestion may include:, To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Synergistic effects no data available Additional Information RTECS: SA9100000 12. ECOLOGICAL INFORMATION Toxicity Toxicity to fish Toxicity to daphnia and other aquatic invertebrates. LC50 - Lepomis macrochirus (Bluegill) - 420 mg/l - 96 h EC50 - Daphnia magna (Water flea) - 9,000 mg/l - 24 h

Persistence and degradability no data available Bioaccumulative potential no data available Mobility in soil no data available PBT and vPvB assessment no data available Other adverse effects no data available 13. DISPOSAL CONSIDERATIONS Product Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging Dispose of as unused product. 14. TRANSPORT INFORMATION DOT (US) UN-Number: 1148 Class: 3 Proper shipping name: Diacetone alcohol Marine pollutant: No Poison Inhalation Hazard: No Packing group: III

IMDG UN-Number: 1148 Class: 3 Packing group: III Proper shipping name: DIACETONE ALCOHOL Marine pollutant: No IATA UN-Number: 1148 Class: 3 Proper shipping name: Diacetone alcohol 15. REGULATORY INFORMATION DSL Status All components of this product are on the Canadian DSL list.
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EMS-No: F-E, S-D

Packing group: III

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WHMIS Classification B3 Combustible Liquid D2B

Combustible Liquid Moderate eye irritant

This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all the information required by the Controlled Products Regulations. 16. OTHER INFORMATION Further information Copyright 2011 Sigma-Aldrich Co. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Co., shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale.

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