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GRAPE SEED EXTRACT (GRAPE) INTERACTIONS Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts

s with GRAPE
Some medications are changed and broken down by the liver. Grape juice might increase how quickly the liver breaks down some medications. Taking grape along with some medications that are changed by the liver can decrease the effectiveness of some medications. Before taking grape talk to your healthcare provider if you take any medications that are changed by the liver. Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.

Phenacetin interacts with GRAPE

The body breaks down phenacetin to get rid of it. Drinking grape juice might increase how quickly the body breaks down phenacetin. Taking phenacetin along with grape juice might decrease the effectiveness of phenacetin.

Warfarin (Coumadin) interacts with GRAPE

Warfarin (Coumadin) is used to slow blood clotting. Grape seed might also slow blood clotting. Taking grape seed along with warfarin (Coumadin) might increase the chances of bruising and bleeding. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.

Conditions and illness related to grape seed extract ConConditions & Treatments Related to Grape Seed Extract (GRAPEditions & Treatments Related to Varicose veins Treatments High blood pressure Treatments Allergic rhinitis (hayfever) Treatments Allergies Treatments Allergy Treatments Cardiovascular disease Treatments Chronic venous insufficiency Treatments Hayfever Treatments Hypertension Treatments Isolated systolic hypertension Treatments Night vision Treatments Ocular stress Treatments Stress Treatments Venous insufficiency Treatments

GRAPE
Other Names: Activin, Black Grape Raisins, Calzin, Draksha, Enocianina, European Wine Grape, Extrait de Feuille de Raisin, Extrait de Feuille de Vigne Rouge, Extrait de Peau de Raisin, Extrait de Pepins de Raisin, Feuille de Raisin, Feuille de Vigne Rouge, Feuille de Vigne Rouge AS 195, Flame Grape, Flame Raisins, Flame Seedless, Folia Vitis Viniferae, Grape Fruit, Grape Fruit Skin, Grape Juice, Grape Leaf, Grape Leaf Extract, Grape Seed, Grape Seed Extract, Grape Seed Oil, Grape Skin, Grape Skin Extract, Grapes, Grapeseed, Huile de Ppins de Raisin, Kali Draksha, Leucoanthocyanin, Muscat, Muskat, Oligomres Procyanidoliques, Oligomeric Proanthocyanidins, Oligomeric Procyanidins, OPC, OPCs, PCO, PCOs, Peau de Raisin, Ppin de Raisin, Petite Sirah, Proanthocyanidines Oligomriques, Proanthodyn, Proanthodyne, Procyanidines Oligomriques, Procyanidolic Oligomers, Purple Grape, Raisin, Raisin Blanc, Raisin de Table, Raisin de Vigne, Raisins, Raisins Noirs, Red Globe, Red Grape, Red Malaga, Red Vine Leaf AS 195, Red Vine Leaf Extract, Sultanas, Table Grapes, Thompson Seedless, Uva, Vitis vinifera, White Grape, Wine Grape, Wine Grapes.

GRAPE SEED EXTRACT (GRAPE) OVERVIEW INFORMATION


Grapes are the fruit of a vine (Vitis vinifera). The whole fruit, skin, leaves and seed of the grape plant are used as medicine. Grape seeds are by-products of the manufacturing of wine. Be careful not to confuse grape with grapefruit, and other similar sounding medicines. Grape is used for preventing diseases of the heart and blood vessels, varicose veins, hemorrhoids, hardening of the arteries (atherosclerosis), high blood pressure, swelling after injury or surgery, heart attack, and stroke.

Some people also use grape as a mild laxative for constipation. You have probably heard of grape fasts as part of detoxification. Grape seed is used for diabetes complications such as nerve and eye problems, improving wound healing, preventing tooth decay, preventing cancer, an eye disease called age-related macular degeneration (AMD), poor night vision, liver disorders, and hay fever. Dried grapes, raisins, or sultanas (white raisins) are used for cough. Grape leaf is used for attention deficit-hyperactivity disorder (ADHD), chronic fatigue syndrome (CFS), diarrhea, heavy menstrual bleeding, uterine bleeding, and canker sores. Grape leaf is used as a food, particularly in Greek cooking. How does it work? Grape contains flavonoids, which can have antioxidant effects, lower the levels of low density lipoproteins (LDLs, or bad cholesterol), relax blood vessels, and reduce the risk of coronary heart disease. The antioxidants in grape might help to prevent heart disease and have other potentially beneficial effects. Red grape varieties provide more antioxidants than white or blush grape varieties. Grape leaf might reduce inflammation and have astringent effects. In other words, grape leaf seems to be able to draw tissue together, which could help stop bleeding and diarrhea. These properties appear to be greatest in the red leaves.

GRAPE SEED EXTRACT (GRAPE) USES & EFFECTIVENESS


Possibly Effective for:

Circulation problems, such as poor blood flow in the legs (chronic venous insufficiency) that can cause the legs to swell. Taking grape seed extract seems to reduce symptoms such as tired or heavy legs, tension, and tingling and pain. Decreasing eye stress from glare.

Possibly Ineffective for:

Hay fever and seasonal nasal allergies.

Insufficient Evidence for:

Preventing heart disease. There is some evidence drinking grape juice or red wine might help to prevent heart disease. High blood pressure. Early research suggests that grape seed does not have a significant effect on blood pressure in people with high blood pressure. Poor night vision. Preliminary research suggests grape seed extract containing chemicals called proanthocyanidins might improve night vision. Treating varicose veins. Hemorrhoids. Constipation. Cough. Attention deficit-hyperactivity disorder (ADHD). Chronic fatigue syndrome (CFS). Diarrhea. Heavy menstrual periods. Age-related macular degeneration (AMD). Canker sores. Liver damage. High cholesterol levels. Other conditions.

More evidence is needed to rate the effectiveness of grape for these uses.

GRAPE SEED EXTRACT (GRAPE) SIDE EFFECTS & SAFETY


Grape is LIKELY SAFE for most people. Eating large quantities of grapes, dried grapes, raisins, or sultanas might cause diarrhea. Some people have allergic reactions to grapes and grape products. Some other potential side effects include stomach upset, indigestion, nausea, vomiting, cough, dry mouth, sore throat, infections, headache, and muscular problems. Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of grape in medicinal amounts (supplements or amounts that are higher than normal food amounts) during pregnancy and breastfeeding. Stay on the safe side and avoid use GRAPE SEED EXTRACT (GRAPE) INTERACTIONS Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with GRAPE
Some medications are changed and broken down by the liver. Grape juice might increase how quickly the liver breaks down some medications. Taking grape along with some medications that are changed by the liver can decrease the effectiveness of some medications. Before taking grape talk to your healthcare provider if you take any medications that are changed by the liver. Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.

Phenacetin interacts with GRAPE

The body breaks down phenacetin to get rid of it. Drinking grape juice might increase how quickly the body breaks down phenacetin. Taking phenacetin along with grape juice might decrease the effectiveness of phenacetin.

Warfarin (Coumadin) interacts with GRAPE

Warfarin (Coumadin) is used to slow blood clotting. Grape seed might also slow blood clotting. Taking grape seed along with warfarin (Coumadin) might increase the chances of bruising and bleeding. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed. The following doses have been studied in scientific research: BY MOUTH: For poor blood flow in the legs (chronic venous insufficiency):

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Standardized red vine grape extract AS 195 (Antistax, Boehringer Ingelheim 360 mg or 720 mg once daily. Grape seed extract as tablets or capsules dosed at 75-300 mg daily for three weeks followed by a maintenance dose of 40-80 mg daily. Grape seed extract proanthocyanidin doses of 150-300 mg per day. Proanthocyanidin is one of the active ingredients in grape. For reducing eye stress due to glare: Grape seed extract proanthocyanidin doses of 200-300 mg per day.

Description
Name of the plant: vitis vinifera L Part of the plant used: seed Description: The plant is a 30 cm high climbing vine with heavily-branched roots, a woody trunk, orbicular leaves, and globular fruit with pear-shaped seeds. It is indigenous to southern Europe and western Asia; however, it is now cultivated in temperate regions around the world. The medicinal parts of the plant include the leaves, fruit, and juice. Chemical definition: Proanthocyanidins Specification: Assay By UV) proanthocyanidins 95% Appearance: Brown-Red fine powder with Characteristic odor.