Contrast enhancement occurs primarily because of a relative increase in blood volume or blood flow and/or from an abnormal increase in permeability due to an absence of the blood-brain-barrier (BBB). Ring enhancing lesions represent a special subset of contrast enhancing abnormalities. CONTRAST ENHANCEMENT Vascularity Permeability
The popular mnemonic for ring-enhancing lesions is: M - Metastasis, MS A - Abscess (also cerebritis) G - Glioblastoma, Granuloma I -Infarct (esp. Basal ganglia) C - Contusion (rare) A - AIDS (Toxo, etc.) L - Lymphoma (in aids) D - Demyelination (active) R - Resolving hematoma, Radiation change (necrosis) The primary characteristic of ring-enhancing lesions is that the center is composed of avascular tissue (dead or dying neoplastic tissue), old blood, infected and necrotic brain (abscess and cerebritis), tumor secreted fluid, or normal tissue adjacent to bands or rings of abnormal tissue. Therefore one or more of the following is usually present: Necrotic (dead) tissue (neoplasm, radiation necrosis, old infarction) Hemorrhage (blood old or new) Cyst fluid (craniopharyngioma, pilocytic astrocytoma, hemangioblastoma, etc.) Pus (abscess) Normal tissue (reparative phase of demyelination)
Demyelinating Disease
One of the more complex causes of a ring-enhancing lesion is demyelinating disease. The most common and therefore classic example is multiple sclerosis (MS). The underlying lesion in MS is a perivascular inflammatory process associated with destruction and removal of pre-existing normal myelin. During the active phase of inflammation, there is a transient disruption of the blood-brain-barrier. However, since this occurs in the white matter, which is relatively sparsely vascularized (compared to gray matter) the extravasation of contrast is relatively limited and usually not accompanied by perilesional edema. Usually, for a self-limited period of 4-8 weeks, there is limited contrast enhancement in a ring pattern. The ring enhancing area is the advancing zone of inflammation; the center is a region of demyelination with reinstatement of the integrity of the BBB; and on the outside, normal brain not yet affected the process. Because the process is perivascular, one of the characteristic lesions of MS (that usually doesn't enhance) is the perivenular inflammation around the small veins that run perpendicular to the lateral margin of the lateral ventricles - these are the "Dawson fingers" of demyelination.
CONTRAST ENHANCEMENT Abscess 2 - 4 wks. for ORGANIZED WALL 2 LAYERS MESENCHYMAL (capillaries, fibroblasts, collagen) ASTROGLIAL (reactive astrocytes) WALL facing GM is well formed 3-7 mm WALL FACING WM IS THINNER/WEAKER Daughter Abscess Ventricular Spill ("pyocephalus")
CONTRAST ENHANCEMENT Ring Lesion Features For Neoplasm NECROTIC NEOPLASM: thick and irregular wall shaggy inner margin (usually) may "fill in" heterogeneously on delayed images these are usually aggressive and malignant tumors CYSTIC NEOPLASM: thin wall +/- MURAL NODULE PART OF WALL MAY NOT ENHANCE smooth inner margin uniform fluid enhancement or FLUID LEVEL these are often benign and/or low-grade tumors
Ring enhancement in an infarct is very rare. However, when an infarct involves the deep gray matter - like the basal ganglia the shape of the enhancing gray matter will create a ring lesion. CONTRAST ENHANCEMENT Hematoma EARLY: Hyperdense, round/oval Homogeneous mass of RBC's Proportional mass effect for volume Edema "Halo", not spreading LATER: Iso-/Hypodense, smaller Reactive capillaries form outside Uniform rim of enhancement May see "vasogenic" edema
CONTRAST ENHANCEMENT Post-Operative RESIDUAL TUMOR (left behind) RECURRENT TUMOR (grew back) INFECTION NORMAL POSTOPERATIVE CHANGE (surgical trauma, healing) RADIATION Tx.?
References
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