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Malathion (cas 121-75-5) MSDS

1. 1.1 IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING Product identifiers
Product name Product Number Brand Index-No. CAS-No. : : : : : :

malathion
36143 Fluka 015-041-00-X 121-75-5 Laboratory chemicals, Manufacture of substances

1.2 2. 2.1

Relevant identified uses of the substance or mixture and uses advised against
Identified uses

HAZARDS IDENTIFICATION Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]
Acute toxicity, Oral (Category 4) Skin sensitization (Category 1) Acute aquatic toxicity (Category 1) Chronic aquatic toxicity (Category 1)

Classification according to EU Directives 67/548/EEC or 1999/45/EC

Harmful if swallowed. May cause sensitization by skin contact. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.

2.2

Label elements Labelling according Regulation (EC) No 1272/2008 [CLP]

Pictogram Signal word Hazard statement(s) H302 H317 H410 Precautionary statement(s) P273 P280 P501 Supplemental Hazard Statements Hazard symbol(s) R-phrase(s) R22 R43 R50/53 S-phrase(s) S24 S37 S46 S60 S61 Warning Harmful if swallowed. May cause an allergic skin reaction. Very toxic to aquatic life with long lasting effects. Avoid release to the environment. Wear protective gloves. Dispose of contents/ container to an approved waste disposal plant. none

According to European Directive 67/548/EEC as amended.

Harmful if swallowed. May cause sensitization by skin contact. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Avoid contact with skin. Wear suitable gloves. If swallowed, seek medical advice immediately and show this container or label. This material and its container must be disposed of as hazardous waste. Avoid release to the environment. Refer to special instructions/ Safety data sheets.

2.3 3.

Other hazards - none COMPOSITION/INFORMATION ON INGREDIENTS

3.1

Substances
Formula Molecular Weight Component : : C10H19O6PS2 330,36 g/mol Concentration 121-75-5 204-497-7 015-041-00-X -

Malathion
CAS-No. EC-No. Index-No.

4. 4.1

FIRST AID MEASURES Description of first aid measures General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Flush eyes with water as a precaution.

If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2

Most important symptoms and effects, both acute and delayed

To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

4.3

Indication of any immediate medical attention and special treatment needed

no data available

5. 5.1

FIREFIGHTING MEASURES Extinguishing media Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 5.3 5.4 6. 6.1 6.2

Special hazards arising from the substance or mixture Carbon oxides, Sulphur oxides, Oxides of phosphorus Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.

Further information
no data available

ACCIDENTAL RELEASE MEASURES Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation.

Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3

Methods and materials for containment and cleaning up

Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.

6.4 7. 7.1 7.2

Reference to other sections

For disposal see section 13.

HANDLING AND STORAGE Precautions for safe handling

Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Recommended storage temperature: 2 - 8 C

7.3

Specific end uses

no data available

8. 8.1 8.2

EXPOSURE CONTROLS/PERSONAL PROTECTION Control parameters Components with workplace control parameters Exposure controls Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment Eye/face protection

Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

9. 9.1

PHYSICAL AND CHEMICAL PROPERTIES Information on basic physical and chemical properties
a) Appearance b) c) d) e) Odour Odour Threshold pH Melting point/freezing point f) Initial boiling point and boiling range g) Flash point h) Evaporation rate i) j) Form: liquid Colour: colourless no data available no data available no data available no data available 156 - 157 C at 1,00 hPa no data available no data available

Flammability (solid, gas) no data available Upper/lower no data available flammability or explosive limits no data available no data available 1,230 g/cm3 slightly soluble log Pow: 5,0 no data available no data available no data available no data available no data available

k) Vapour pressure l) Vapour density m) Relative density n) Water solubility o) Partition coefficient: noctanol/water p) Autoignition temperature q) Decomposition temperature r) Viscosity s) Explosive properties t) Oxidizing properties

9.2

Other safety information

no data available

10. STABILITY AND REACTIVITY 10.1 Reactivity

no data available

10.2 Chemical stability

no data available

10.3 Possibility of hazardous reactions

no data available

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Strong oxidizing agents, Corrodes metal

10.6 Hazardous decomposition products

Other decomposition products - no data available

11. TOXICOLOGICAL INFORMATION 11.1 Information on toxicological effects Acute toxicity

LDLO Oral - Human - female - 246 mg/kg Remarks: Vascular:BP lowering not charactertized in autonomic section. Lungs, Thorax, or Respiration:Chronic pulmonary edema. Prolonged skin contact may cause skin irritation and/or dermatitis. LDLO Oral - Human - male - 471 mg/kg Remarks: Behavioral:Coma. Vascular:BP lowering not charactertized in autonomic section. Lungs, Thorax, or Respiration:Dyspnea. LD50 Oral - rat - 1.000 - 1.350 mg/kg LD50 Oral - Bird (wild) - 400 mg/kg Inhalation: no data available LD50 Dermal - rabbit - 8.790 mg/kg

Skin corrosion/irritation
no data available

Serious eye damage/eye irritation

Eyes - rabbit - No eye irritation

Respiratory or skin sensitization

May cause allergic skin reaction. no data available

Germ cell mutagenicity

Genotoxicity in vitro - Human - leukocyte Cytogenetic analysis Genotoxicity in vitro - Human - lymphocyte Cytogenetic analysis Genotoxicity in vitro - Human - lymphocyte DNA inhibition Genotoxicity in vitro - Human - fibroblast Other mutation test systems Genotoxicity in vitro - Human - leukocyte Sister chromatid exchange Genotoxicity in vitro - Human - fibroblast Sister chromatid exchange Genotoxicity in vitro - Hamster - ovary Cytogenetic analysis Genotoxicity in vitro - Hamster - Lungs Cytogenetic analysis Genotoxicity in vitro - Hamster - Lungs Sister chromatid exchange Genotoxicity in vitro - Hamster - ovary Sister chromatid exchange Genotoxicity in vitro - Human - lymphocyte Unscheduled DNA synthesis Genotoxicity in vitro - Human - lymphocyte Micronucleus test

Genotoxicity in vivo - mouse - Oral Cytogenetic analysis Genotoxicity in vivo - mouse - Skin Cytogenetic analysis Genotoxicity in vivo - mouse - Intraperitoneal Cytogenetic analysis Genotoxicity in vivo - Hamster - Intraperitoneal Cytogenetic analysis

Carcinogenicity
IARC: 3 - Group 3: Not classifiable as to its carcinogenicity to humans (Malathion)

Reproductive toxicity
Reproductive toxicity - rat - Oral Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total number of implants). Reproductive toxicity - rat - Oral Effects on Newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4). Effects on Newborn: Growth statistics (e.g., reduced weight gain). Effects on Newborn: Other postnatal measures or effects. Reproductive toxicity - rat - Unreported Paternal Effects: Spermatogenesis (including genetic material, sperm morphology,motility, and count). Paternal Effects: Testes, epididymis, sperm duct. Developmental Toxicity - rat - Oral Specific Developmental Abnormalities: Urogenital system. Developmental Toxicity - rabbit - Oral Effects on Embryo or Fetus: Other effects to embryo.

Specific target organ toxicity - single exposure

no data available

Specific target organ toxicity - repeated exposure

no data available

Aspiration hazard
no data available

Potential health effects Inhalation May be harmful if inhaled. May cause respiratory tract irritation. Ingestion Harmful if swallowed. Skin May be harmful if absorbed through skin. May cause skin irritation. Eyes May cause eye irritation. Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

Additional Information
RTECS: WM8400000

12. ECOLOGICAL INFORMATION 12.1 Toxicity Toxicity to fish mortality LOEC - Lepomis macrochirus - 0,079 mg/l - 7,0 d
mortality NOEC - Ptychocheilus lucius - 1,68 mg/l - 32 h LC50 - Lepomis macrochirus (Bluegill) - 0,046 mg/l - 96,0 h Toxicity to daphnia and other aquatic invertebrates Toxicity to algae no data available EC50 - Daphnia magna (Water flea) - 0,002 mg/l - 48 h

EC50 - Pseudokirchneriella subcapitata (green algae) - 4,06 mg/l - 72 h

12.2 Persistence and degradability 12.3 Bioaccumulative potential

Bioaccumulation Oryzias latipes - 168 h -12,8 g/l Bioconcentration factor (BCF): 12 Remarks: Can accumulate in aquatic organisms.

12.4 Mobility in soil

no data available

12.5 Results of PBT and vPvB assessment

no data available

12.6 Other adverse effects

Very toxic to aquatic life with long lasting effects.

13. DISPOSAL CONSIDERATIONS 13.1 Waste treatment methods Product

Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging
Dispose of as unused product.

14. TRANSPORT INFORMATION 14.1 UN number

ADR/RID: 3082 IMDG: 3082 IATA: 3082

14.2 UN proper shipping name

ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S. (Malathion) IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S. (Malathion) IATA: Environmentally hazardous substance, liquid, n.o.s. (Malathion)

14.3 Transport hazard class(es)

ADR/RID: 9 IMDG: 9 IMDG: III IMDG Marine pollutant: yes IATA: 9 IATA: III IATA: yes

14.4 Packaging group

ADR/RID: III

14.5 Environmental hazards

ADR/RID: yes

14.6 Special precautions for user

no data available

15.

REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available

15.2 Chemical Safety Assessment

no data available

16.

OTHER INFORMATION Further information

The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information this document is based on the resent state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. guidechem shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale.