CORNELIU STANCIU

Frederick, MD, 21703, USA 765-409-6365

Seeking a position as

cstanciu01@gmail.com

RESEARCH SCIENTIST-CHEMISTRY
Chemistry Pharmaceuticals Senior Scientist-Chemistry with a PhD in Chemistry, University of California-Davis. Uniquely positioned to improve lab performance through the utilization of high throughput experimentation (HTE) techniques. Noted for setting up and managing the HTE Catalysis Center at the University of Pennsylvania. Technically savvy and a quick study in new technologies, systems and tools that enhance productivity. Skilled in organic and inorganic synthesis, organometallic chemistry, polymers and catalysis, as well as in medicinal chemistry. Experience with process development and quality control of chemicals in pharmaceuticals. Lab management, project management and safety regulations expertise. Hands-on experience with toxic (inorganic and organic) compounds, flammable liquids and solids, metal powders and mildly explosive substances. Proficient with HPLC, GC, MPLC, UPLC-MS and SFC instruments (Waters, Agilent). Adept in NMR (both Varian and Bruker instruments), IR, UV-VIS. Familiar with the Biotage and Teledyne-ISCO flash chromatography instruments. Titration methods. CORE COMPETENCIES Organic synthesis Reaction Automation High Throughput Experimentation (HTE) Techniques Drug Discovery Homogenous Catalysis Single-Site Olefin Polymerization Reactions Quality Control Project Management Organometallic Compounds Medicinal Chemistry Intensive Air & Moisture Free Synthesis SAR Based Ligand Design Lab Automation Lab Management Instrument Troubleshooting Titration Methods Data Interpretation

PROFESSIONAL EXPERIENCE Intrexon Corporation, Germantown, MD

2011 2013

Senior Scientist, Chemistry Facilitate synthesis of new ligand molecules for treatment of some forms of melanoma. Play a contributing role in the synthesis of new ligands utilized in gene switches with applications in human therapeutics as well as in agrochemical industry. Perform organic syntheses on a project-by-project basis employing classical organic chemistry techniques (protection/deprotection, coupling reactions, and borylations). Play a pivotal role in two larger scale syntheses performed by the cGMP specifications. Routinely utilize Waters and Agilent LC-MS instruments for reaction monitoring or quality control. Additionally utilize ISCO Teledyne MPLC instruments for flash chromatography purification. Synthesized and registered in the CDB more than 350 final compounds, a few of which made it to advanced testing (CYP inhibition, hERG) while more than 1500 reactions were performed in only one year. Employed a parallel synthesis approach to increase efficiency and reduce delivery time on projects.

ACADEMIC & INDUSTRIAL POSTDOCTORAL EXPERIENCE

University of Pennsylvania Philadelphia, PA

2009 2011

NSF-GOALI Postdoctoral Researcher-Department of Chemistry Under the direction of Prof. Gary A. Molander (UPenn) and Dr. Spencer D. Dreher (MRL) served in a joint appointment between the Department of Chemistry, University of Pennsylvania, Philadelphia, PA, USA and Merck Research Laboratories, Rahway, NJ, USA. Facilitated reaction development and automation of cross-coupling reactions of relevance to medicinal chemistry and pharmaceutical industry. Conducted research on site at the Merck Research Laboratories (MRL) of Merck and Co. Inc. in Rahway, New Jersey, USA.

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University of Pennsylvania (continued)

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Gained invaluable experience in the optimization of Suzuki-Miyaura, Heck, Miyaura borylation, phase-transfer catalysis (PTC), as well s in decarboxylative coupling and benzylic coupling reactions utilizing high throughput experimentation (HTE) techniques. Pioneered the use of HTE techniques in the lab. Established and managed the HTE Catalysis Center at UPenn. http://www.chem.upenn.edu/chem/facilities/upenn_merck_htel.php. Personally trained and certified PhD students and postdocs. Evaluated and procured HPLC, GC, MPLC and UPLC-MS instruments (Waters, Agilent). Staffed the department.

Technische Universitt Kaiserslautern, KL, Germany 2008 2009

Alexander von Humboldt Postdoctoral Fellow, Chemistry Department-Organic Chemistry Division Worked in close collaboration with Mentor, Prof. Dr. Lukas J. Gooen. Performed work on Carboxylic Acids as Substrates for Carbon-Carbon Coupling Reactions through Homogeneous Catalysis; worked on new synthesis of very sterically crowded meta-terphenyl ligands.

Purdue University, Indiana, USA

2005 2008

Postdoctoral Associate, Department of Chemistry Assisted Professor Mahdi M.Abu-Omar. Worked in close collaboration with a team from Chemical Engineering Department tasked with running catalytic single-site olefin polymerization reactions. Synthesized new catalysts and new ligands for homogeneous olefin polymerization reactions, particularly for 1-hexene Developed skills as a team leader and team player. o Directly supervised two PhD students. o Liaised with Chemical Engineering to ensure efficient transfer of information and implement necessary adjustments to the project. 2000 2005

UC Davis, Davis, CA

Graduate Assistant Assisted Prof. Philip P. Power. Developed skills in conducting intensive air and moisture free syntheses of organic and organometallic compounds. Improved the synthesis of the bulkiest phenols and derivatives. Synthesized and characterized new types of main group and transition metal compounds.

EDUCATION
Ph.D., Chemistry, University of California-Davis, December 2005 Research Adviser: Prof. Philip P. Power Inorganic Chemistry

AWARDS AND AFFILIATIONS

Alexander von Humboldt Postdoctoral Fellowship (August 2008-July 2009) American Chemical Society- Member SiLA-Standardization in Lab Automation consortium-Member

PUBLICATIONS & CONFERENCE PRESENTATIONS

Authored 16 publications and 12 conference presentations.