Code: 9A23601

1
COMPUTATIONAL MOLECULAR BIOLOGY
(Biotechnology)

B.Tech III Year II Semester (R09) Regular & Supplementary Examinations, April/May 2013

Time: 3 hours Answer any FIVE questions All questions carry equal marks
***** 1 (a) (b) (a) (b)

Max Marks: 70

What is dynamic programming? Discuss in detail its principles with an example. Describe any two biological problems that can be solved by using dynamic programming. Discuss in detail the significance of DNA sequence. Explain homology based gene prediction. What are microarrays? Discuss in detail the process of microarray technology with an example. Discuss the different methods available for structure determination of proteins.

4 5 (a) (b) (a) (b)

Write about protein homology modeling. Discuss the protein design emphasis on structural bioinformatics. Discuss the rooted phylogenetic tree. Discuss the weighted parsimony method for construction of phylogenetic trees. What are dendrograms? Discuss the distance based methods for construction of phylogenetic trees. Discuss in detail how computational tools aid in drug discovery.

*****

Code: 9A23601

2
COMPUTATIONAL MOLECULAR BIOLOGY
(Biotechnology)

B.Tech III Year II Semester (R09) Regular & Supplementary Examinations, April/May 2013

Time: 3 hours Answer any FIVE questions All questions carry equal marks
***** 1 2 (a) (b) 3 4 5 6 (a) (b) 7 8 (a) (b)

Max Marks: 70

Define transcription. How transcription is used for global expression analysis? Discuss in detail how computational molecular biology differs with basic molecular biology. Differentiate functional genomics and comparative genomics. Discuss in detail the structural properties of proteins leading to stability. What is microarray? Explain its procedure in detail with example. What is single nucleotide polymorphism? How is it helpful in analyzing genetic disorders? structure predication of protein. Protein threading. Discuss in detail the rational drug design. What is dendrograms? Write about its significance. Write about dendrograms and its interpretation.

*****

Code: 9A23601

3
COMPUTATIONAL MOLECULAR BIOLOGY
(Biotechnology)

B.Tech III Year II Semester (R09) Regular & Supplementary Examinations, April/May 2013

Time: 3 hours Answer any FIVE questions All questions carry equal marks
***** 1 2 (a) (b)

Max Marks: 70

Discuss the various involved in the graphical representation of biochemical systems. Applications of SNP. EST approach. Discuss in detail the steps involved in microarray analysis. Discuss in detail the various tools to predict the secondary structure of proteins. (a) (b) Write about protein homology modeling. Discuss the protein design emphasis on structural bioinformatics. What are dendrograms? Discuss in detail the different types od dendrograms. Discuss in detail the basic concepts in evolution to its molecular level. Discuss in detail the different phases of drug discovery cycle to its formulation.

3 4 5

6 7 8

*****

Code: 9A23601

4
COMPUTATIONAL MOLECULAR BIOLOGY
(Biotechnology)

B.Tech III Year II Semester (R09) Regular & Supplementary Examinations, April/May 2013

Time: 3 hours Answer any FIVE questions All questions carry equal marks
***** 1 (a) (b) 2 (a) (b) Add notes on: S-system equations. Steady state analysis with an example. Discuss in detail the significance of DNA sequence. Explain homology based gene prediction. Discuss in detail the steps involved in microarray analysis. (a) (b) Write about protein homology modeling. Discuss the protein design emphasis on structural bioinformatics. Discuss in detail the structural properties of proteins leading to stability. (a) (b) (a) (b)

Max Marks: 70

3 4

5 6

Discuss the rooted phylogenetic tree. Discuss the weighted parsimony method for construction of phylogenetic trees. What is dendrograms? Write about its significance. Write about dendrograms and its interpretation. Discuss in detail the rational drug design.

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