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Tooth development consists of three stages: bud stage, cap stage and bell stage.

Bud stage is early signs of development of teeth occurred at week 6 embryos. Cells in the basal layer of the oral epithelium (stomodeum) seem to proliferate more rapidly than adjacent cells. This thickening occurs at the site would be called the dental lamina. This inward thickening occurs in each jaw and forms a ribbon or a sheet of ectoderm cells to form following the arch is going to dental arch. Enamel-organ is not growing at the same time. After bud stage, proliferation goes on to form the buds do not stay round cells at the edge of the area growing faster toward the bottom so it looks like a hat. The cells in the outer covering and the cube-shaped convex portion called the outer enamel epithelium (OEE). Coating on the inside of the cell called the inner enamel epithelium (IEE). Intercellular fluid contained between enamel epithelium and outer enamel multiply that separates the cells in the area and connected each others like nets called stellate reticulum like foam rubber which is then useful as buffer and protector of the enamel-forming cells. Under the organ growing proliferation of mesenchymal tissue below also solidified into dental papilla which will be forming organs dentin and dental pulp will. The changes in the papilla coincided with changes in the enamel organ. This stage is called the cap stage. The subsequent development of the enamel organ shape will continue to change, the papilla will urge the edges of the enamel organ down and cause enamel organ shape looks like a bell so this stage is called bell stage. At this stage, the relationship with the dental lamina oral disconnected. Parts of the enamel organ banks continue to migrate into the enamel organ so that the shape looks like a bell. Enamel epithelial cells differentiate into the cells of a long shaft with a diameter of 40 microns and 4-5 microns is called ameloblast. Among the enamel layer in the stellate reticulum appeared several layers of cells called the stratum intemedium. The cells in the outer enamel epithelium form a low or flattened cube. While the dental lamina continues to thrives in the seeds forming permanent teeth. Enamel epithelium prior to the forming enamel, mesenchymal cells in the dental papilla edge differentiated to be odontoblast. Basal membrane separating the enamel organ with dental papilla called preformative membrane. Fibers in the dental sac structured so that it looks like a circular arrangement of the capsule. With the development of roots, these fibers will differentiate into the fibers of the periodontium. At the bell stage further as the boundary between the epithelium in the odontoblas is going relationship with the enamel dentine called dentino enamel Junction. The tip of the enamel organ will later form the epithelial root sheath of Hertwig. If an interruption occurs when the bell stage, the ameloblast cells that should be inactive after

calcium and hydroxyapatite apposision since enamel formation become active again and continue to proliferate and form ameloblastoma (solid or multicystic / unycystic). Ameloblast like cells will be found in the capsule along with ameloblastoma of outer enamel epithelial epithelium. In the lumen of existing solid or multicystic ameloblastoma contains stellate reticulum cells. Multicystic ameloblastoma may occur because there ameloblast cells in the tumor capsule that out then degenerates to form a new cyst lining. Swelling caused by the excessive proliferation of cells due to the growth factor. Growth factor affects DNA synthesis and mitosis of the cell. However, in this state is still in a state of normal cells, either in the form, structure, composition and function.

The nature of a benign tumor is not any pain. We feel the sensation of pain when there is pain signal received by the pain receptors. In this case, he felt no pain sensation because the cells making up the tumor is benign under normal circumstances. It means that the process of cell growth was similar to normal cells with slow growth process. The absence of pain is also influenced by the adaptation by the surrounding tissue. The thickness of the tissues around to offset the pressure of the expansive tumor. Thickening of the tissue surrounding the tumor will inhibit tissue to push around because the surface surrounding tissue that has thickened. Sudiono janti,2008. Pemeriksaan Patologi untuk Diagnosis Neoplasma Mulut. EGC: Jakarta Ameloblastoma also can be caused by the development of Dentigerous cyst. Dentigerous cysts are the most common noninflammatory odontogenic cysts. They develop within the normal dental follicle surrounding an unerupted tooth and are a result of fluid accumulation between the follicular epithelium and the enamel; thus, at radiography, an unerupted tooth with its crown centered in a lucent mass is suggestive of a dentigerous cyst. The roots of the tooth typically are seen outside the lucent lesion, and the cortical bone is preserved; however, large lesions may cause osseous expansion. Epithelial disposition and proliferation that will continually cause thickening of nodules in the cyst wall. The neoplasmic epithelial proliferation forming parenchyma parts contain ameloblast "like" cells. So the histopathology section of parenchyma ameloblastoma look ameloblast "like" cells called reticulum stellate. Ceylan, Z., Barton F., Simion I., Leon Barnes. 2010. Ameloblastoma and Dentigerous Cyst Associated with Impacted Mandibular Third Molar Tooth. University of Pittsburgh Medical Center, 200 Lothrop St, Pittsburgh PA 15213. Radiographic. No. 30. pp:14151420