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Caracteriza-se por espessamento da membrana basal da cpsula de Bowman. Foto da esquerda. Foto da direita demonstra deposio de imunocoplexos, pela tcnica de imunofluorescncia

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Caracteriza-se por espessamento da membrana basal da cpsula de Bowman. Foto da esquerda. Foto da direita demonstra deposio de imunocoplexos, pela tcnica de imunofluorescncia

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Aumento da celularidade do tufo glomerular. Foto da esquerda: HE, tufo muito celular. Foto da direita: colorao de prata demonstra que no ocorreu espessamento da membrana da cpsula de Bowman

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Wound healing (fracture healing) in bone involves organization of hemorrhage, periosteal deposition of woven bone, formation of fibro- and hyaline cartilage, endochondral ossification and remodeling of bone. This process in the bone is a long process depending on the fractured bone.

 necessrio a remoo de TODAS os restos de tecido morto, em especial fragmentos sseos

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All of the key steps in wound healing also occur in bone with the generation of granulation tissue. All of the key steps in wound healing also occur in bone with the generation of granulation tissue.

All of the key steps in wound healing also occur in bone with the generation of granulation tissue.

The "scar" formed is bony and requires remodeling (osteoclastic and blastic activity).

Wound healing (fracture healing) in bone involves organization of hemorrhage, periosteal deposition of woven bone, formation of fibro- and hyaline cartilage, endochondral ossification and remodeling of bone. This process in the bone is a long process depending on the fractured bone.

In this region of a recent fracture, callus is seen forming at the broken ends of bony trabeculae that extend to the center from the left and top

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This is Snoopy. Snoopy was initially presented with a small swelling of unknown origin on his back. Over several days, a larger area of skin on his back and neck began to die. (Pictures unavailable) Snoopy was given anesthesia and the dead skin tissue was surgically debrided leaving infected and exposed subcutaneous tissue. Snoopy was placed on IV fluids to prevent dehydration (a large amount of fluid can be lost with such extensive skin loss), pain medications, and antibiotics. Red arrow-hard, dead patch of skin Yellow arrow-infected tissue (pus)

Additional areas of skin and subcutaneous tissue were removed as they continued to die. Snoopy was sedated, bathed, and bandaged daily as the infection resolved Healthy granulation tissue is very red and bleeds easily (red arrows). It is necessary for the skin to regenerate. Once a good layer of granulation tissue is present, new skin will grow from the edges of the wound and fill in towards the center. This process is very rapid.

After 1 1/2-2 weeks of hopitalization, Snoopy was discharged. He continued to return every 2-3 days for bandage changes as his skin regenerated. Red arrows-additional, healthy granulation tissue Green arrows-new skin regenerating from the wound edges

In wounds like this, the majority of the new skin will have the capacity to grow hair. As expected, Snoopy grew some new hair.

This is Snoopy today. Only a small scar remains. He has recovered fully and is doing very well. The cause of Snoopy's extensive skin loss is still unknown. Special thanks to Snoopy's family for allowing us to share this case.

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Wound healing (fracture healing) in bone involves organization of hemorrhage, periosteal deposition of woven bone, formation of fibro- and hyaline cartilage, endochondral ossification and remodeling of bone. This process in the bone is a long process depending on the fractured bone.

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Step 1. Cell Body Respose This starts with the decentralization of the nucleus

Step 2 Metabolic Reaction Increased number of ribosomes around the nucleus. Step 3 Immune Ressponse Macrophages start attacking the Schwann cells of the distal segment

Step 5 Enzymatic Action The axon of the distal segment is broken down by enzymes and the products of the of this action is carried by retrograde transport to the soma

Step 6 Rapid Cell Division The Shwann cell at the end of the proximal segment starts a rapid mitotic division in attempt to locate the target tissue for the severed neuron

Step 7 Formation of Growth Path The chain of the Schwann cells that reaches the target tissue will serve as a path for the growth of the axon

Step 8 Axon Growth and death of the Extra Schwann cells the remainder of the axon in the proximal tubule starts growing in the tube prepared by the Schwann cells. In the mean time, the Schwann cell s who did not make it to the target cells will start dying phagocytes will take care of heir remains.

Step 9 Death of Sprouts The re-innervation of the target tissue by the regenerating neuron leads to an automatic death of the sprouts of the adjacent neurons

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