Introduction
Because Autologous Stem Cells from bone marrow are easily accessible from both healthy donors and pa-
1
tients and can be expanded on a therapeutic scale, they have attracted attention for cell-based therapy .
Although the mechanisms are not yet completely understood, some small clinical trials with Spinal Cord
Injury patients have demonstrated a positive effect on their use and proved that the use of Autologous Stem
2-4
Cells is safe .
Methods
On a larger scale XCell-Center treated chronic Spinal Cord Injury Patients with Autologous Stem Cells using
the Lumbar Puncture procedure 200 ml of Bone Marrow was extracted out of the Iliaca crest and was con-
centrated for transplantation using gradient centrifugation (mean number of given cells was 6.000.000).
After treatment the patients were evaluated using a Post Treatment Survey. The results of surveys of 85 pa-
tients treated with autologous stem cell transplantation were evaluated and are presented in this poster.
The picture on the right shows the distribu- 1. Severity of the Spinal Cord Injury
100%
50%
The side effects reported by the patients 2. Level of Spinal Cord Injury lesion
were caused by the Lumbar Puncture tre- Quadra
Plegic
High cervical lesions (c1-c4) 43
atment and not by the stem cells. The 36
20
Low cervical lesion (c5-c7)
Nearly 60% of the treated patients expe- SCI - Class of Spinal Cord Injury
Complete and incomplete spinal cord lesions (85)
rienced improvements. There was nearly
100%
ported in 40% of all patients. Less weak- Deterioration No Change Improvement Spinal Cord Injuries
ons was also reported by more than 10% Table: Improvements type of Spinal Cord Injury
of the patients. The results show no appa- (complete or incomplete lesion / N=85)
70%
40%
10% Yes
XCell-Center showed one of the lowest in- 0%
28,6% 9,5% 28,6% 38,1% 28,6 % 52,4% 33,3% 23,8% 4,8%
ills
n
ity
b
bs
tio
tio
tio
Lim
sk
ic
im
tiv
ba
nc
nc
st
5
or
ac
sL
(3,7%) .
un
in
pa
fu
fu
ot
es
Pa
io
rf
le
S
at
el
al
kn
de
c
ss
ss
xu
us
ns
e
ea
Le
Le
ad
Bo
Fin
Se
M
Se
W
Bl
n
References
a tio
ur
D
1. Dezawa M. Systematic neuronal and muscle induction systems in bone marrow stromal cells: the potential for tissue reconstruction in neurodegenerative
and muscle degenerative diseases. Medical molecular morphology. Mar 2008;41(1):14-19.
2. Deda H, Inci MC, Kurekci AE, Kayihan K, Ozgun E, Ustunsoy GE, Kocabay S. Treatment of chronic spinal cord injured patients with autologous bone
marrow-derived hematopoietic stem cell transplantation: 1-year follow-up. Cytotherapy. 2008;10(6):565-574.
3. Bakshi A, Barshinger AL, Swanger SA, Madhavani V, Shumsky JS, Neuhuber B, Fischer I. Lumbar puncture delivery of bone marrow stromal cells in spinal
cord contusion: a novel method for minimally invasive cell transplantation. Journal of neurotrauma. Jan 2006;23(1):55-65.
4. Mackay-Sim A, Feron F, Cochrane J, Bassingthwaighte L, Bayliss C, Davies W, Fronek P, Gray C, Kerr G, Licina P, Nowitzke A, Perry C, Silburn PA, Urquhart
S, Geraghty T. Autologous olfactory ensheathing cell transplantation in human paraplegia: a 3-year clinical trial. Brain. Sep 2008;131(Pt 9):2376-2386.
5. Frank RL. Lumbar puncture and post-dural puncture headaches: implications for the emergency physician. The Journal of emergency medicine. Aug
2008;35(2):149-157.