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MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

PRACTICAL PATHOLOGY 2: AMYLOIDOSIS AND BONE TUMOURS

1. Jars

Organ: Piece of skull bone Description: The bone shows in one area small, sessile, hard bony projection with a smooth ivory-like surface. Diagnosis: Osteoma

ACE 2013/14

MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

Organ: Part of vertebrae column. Description: The dorsal part of one vertebrae shows a mass which is: Solitary Well circumscribed Non-encapsulated Colour-brown Cut surface- honey comb appearance

Diagnosis: Cavernous hemangioma of a vertebrae.

ACE 2013/14

MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

ACE 2013/14

MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

Organ: Upper hand of humerus Description: The upper hand of the humerus shows a bulky tumour mass arising at metaphyseal region. The mass destroyed the bone cortex and extended to soft tissue producing a fusiform mass giving a mutton leg appearance. On section, the mass is: o Fleshy o Grayish white in colour o Focal brownish area of haemorrhage o Yellowish area of necrosis The epiphyseal cartilage is intact. New bone formation is noted in subperiosteal area. Diagnosis: Osteosarcoma

ACE 2013/14

MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

Organ: Lower end of femur. Description: The epiphyseal end of the femur is expended by a tumour mass and with marked thinning of the cortical bone. Cut surface of the mass shows: o Brownish area of necrosis o Focal cystic area of degeneration. The remnants soft bone is seen. No new bone formation. Diagnosis: Osteoclastoma (Giant cell tumour of bone)

ACE 2013/14

MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

ACE 2013/14

MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

Organ: liver Description: A slice from an enlarged liver shows. Surface- smooth Border- sharp Consistency- firm Cut surface o Colour dark brown o Semitranslucent o Appearance waxy

Description: Amyloidosis of the liver

ACE 2013/14

MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

Organ: Slice of the brain Description: The brain is swollen with flatten gyri The meninges are o Opaque, lusterless o Covered by purulent exudative material particularly abundant in the sulci. Diagnosis: Acute suppurative meningitis.

ACE 2013/14

MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

1. HISTOPATHOLOGY

ACE 2013/14

MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

Osteochondroma: Tumour tissue shows: A cap of benign looking hyaline cartilage. Underlying core of bone trabeculae enclosing mostly fatty marrow elements.

ACE 2013/14

MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

Amyloidosis, Liver Section in the liver showing. The liver architecture is preserved Eosinophilic structureless homogenous amyloid material is deposited extracellularly in space of Disse ( the space between the hepatocyte and sinusoidal epithelial cells. The compressed hepatocytes are atrophied.

ACE 2013/14

MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

Osteoclastoma (Giant Cell tumour of bone) Tissue tumour formed of: Numerous evenly distributed osteoclast like tumour cell showing numerous centrally clustered nuclei within abundant cytoplasm. interverning round to spindle shaped mononuclear cells.

ACE 2013/14

MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

Chondroma Sections revealed lobulated tumour tissue formed of irregularly scattered benign looking chondrocytes of different sizes and shapes in groups embedded within abundant faint blue condroid matrix.

ACE 2013/14