Title of the PhD proposal: Circadian and circatidal rhythm modelling, estimation and control of oysters Keywords: Biomathematics;

Nonlinear dynamical systems; Identification Author of the proposal: Denis Efimov, Rosane Ushirobira, Damien Tran Mission: Circadian rhythm is responsible for activity/passivity of living organisms on Ea rth. It is formed by certain hormones whose concentrations oscillate during the day, predefining the activity patterns. Disorders of circadian rhythm are respon sible for many diseases and health inconveniences. For example, the jet lag prob lem corresponds to phase resetting of the circadian rhythm oscillation with resp ect to the current exogenous light influence after a long distance flight. Despi te of the fact that circadian models are well developed for some organisms (like Drosophila or Neurospora, for instance), in general there is no common approach for their design. Especially this is true for marine animals, since their activ ity is also strongly influenced by tides. Job offer description + bibliographical references: The objective of this PhD is the development of mathematical models for circadia n and circatidal rhythm behavior of oysters using real measurements of their act ivity. This activity is evaluated based on measured opening angle of the shell v alves. Next, real-time estimation algorithms have to be synthesized. A final obj ective of the project is to design a control algorithm for phase resetting of ci rcadian rhythm, this solution is partly related with the jet lag avoidance/treat ment for humans: 1. Tran D., Nadau A., Durrieu G., Ciret P., Parisot J.P., Massabuau J.C. Field c hronobiology of a molluscan bivalve: how the moon and sun cycles interact to dri ve oyster activity rhythms. Chronobiol Int., 28 (4), 2011, pp. 307?317. 2. Efimov D. Phase resetting control based on direct phase response curve. Journ al of Mathematical Biology, 63 (5), 2011, pp. 855?879. 3. Ushirobira R., Perruquetti W., Mboup M., Fliess M. Algebraic parameter estima tion of a biased sinusoidal waveform signal from noisy data. Proc. SysId 2012, B ruxelles, 2012, pp. 167?172. Skills and profile: A Master in applied mathematics or control science. Knowledg e of model approximation/estimation techniques is appreciated. About Inria and the job : Inria, with its academic, institutional and industrial partners, is commited to major research and innovation projects in the field of computational sciences. T he institute disseminates across France thanks to its eight research centres. The Inria Lille - Nord Europe research centre, inaugurated in 2008, employs 357 people, including 250 scientists, in its seventeen research teams. Recognised fo r its significant contribution to the social and economic development of the Nor d - Pas-de-Calais region, the Inria Lille - Nord Europe research centre promotes a policy of close cooperation with major businesses and small enterprises. By e ncouraging synergies between researchers and industrial partners, Inria contribu tes to the transfer of skills and expertise in computational technologies and pr ovides access to top-level European and international research in order to suppo rt innovation and businesses, particularly in the region of Lille.

Whether designing innovative software for business or logistics, modelling livin g cells or fusion plasma, or developing medical simulators or interfaces to faci litate human-computer interaction, our research opens up new possibilities that can revolutionise common practice and contribute to a better understanding of th e natural phenomena which surround us. The team Non-A (https://team.inria.fr/non-a/) is developing an estimation theory , built around differential algebra and operational calculation on the one hand, and high gain algorithms (such as sliding mode, etc.) on the other hand. Both a pproaches allow for estimating in finite-time the derivatives of noisy signals, which opens a lot of prospects in control and signal processing. It has resulted in relatively simple, rapid algorithms. Unlike traditional methods, the majorit y of which pertain to asymptotic statistics, the Non-A estimators are ''non-asym ptotic''. These estimators found their applications in electrical engineering, r obotics, aerospace and bioscience