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placement. Surg Neurol. 49(2):127-34, 1998 2- Jackson CC, Chwals WJ, Frim DM: A single-incision laparoscopic technique for retrieval and replacement of disconnected ventriculoperitoneal shunt tubing found in the peritoneum.Pediatr Neurosurg. 36(4):175-7, 2002 3- Kirshtein B, Benifla M, Roy-Shapira A, Merkin V, Melamed I, Cohen Z, Cohen A: Laparoscopically guided distal ventriculoperitoneal shunt placement. Surg Laparosc Endosc Percutan T ech. 14(5):276-8, 2004 4- Bani A, Hassler WE: Laparoscopy-guided insertion of peritoneal catheters in ventriculoperitoneal shunt procedures: analysis of 39 children. Pediatr Neurosurg. 42(3):156-8, 2006 5- Yu S, Bensard DD, Partrick DA, Petty JK, Karrer FM, Hendrickson RJ: Laparoscopic guidance or revision of ventriculoperitoneal shunts in children.JSLS. 10(1):122-5, 2006 6- Johnson BW, Pimpalwar A: Laparoscopic-assisted placement of ventriculo-peritoneal shunt tips in children with multiple previous open abdominal ventriculo-peritoneal shunt surgeries. Eur J Pediatr Surg. 19(2):79-82, 2009 7- Martin K, Baird R, Farmer JP, et al: T he use of laparoscopy in ventriculoperitoneal shunt revisions. J Pediatr Surg. 46(11): 2146-2150, 2011
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reconstruction. Techniques used to revascularize the kidney included thoracoabdominal to infrarenal aortic bypass with renal artery reimplantation, splenorenal bypass, gastroduodenal to renal bypass, aortorenal bypass and autotransplantation.
References: 1- Panayiotopoulos YP, Tyrrell MR, Koffman G, Reidy JF, Haycock GB, Taylor PR: Mid-aortic syndrome presenting in childhood. Br J Surg. 83(2):235-40, 1996 2- Tummolo A, Marks SD, Stadermann M, Roebuck DJ, McLaren CA, Hamilton G, Dillon MJ, Tullus K: Mid-aortic syndrome: long-term outcome of 36 children. Pediatr Nephrol. 24(11):2225-32, 2009 3- Lin YJ, Hwang B, Lee PC, Yang LY, Meng CC: Mid-aortic syndrome: a case report and review of the literature. Int J Cardiol. 123(3):348-52, 2008 4- Chocrn de Benzaquen S, Munoz Lopez M, Madrid Aris AD, Castellote Alonso A, Enriquez G, Nieto Rey JL: [Midaortic syndrome: case studies from a paediatric nephrology department]. An Pediatr (Barc). 75(1):33-9, 2011 5- Bleacher J, Turner ME, Quivers E, Schwartz MZ: Renal autotransplantation for renovascular hypertension caused by midaortic syndrome. J Pediatr Surg. 32(2):248-50, 1997 6- Sethna CB, Kaplan BS, Cahill AM, Velazquez OC, Meyers KE: Idiopathic mid-aortic syndrome in children. Pediatr Nephrol. 23(7):1135-42, 2008
ALTE
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An apparent life-threatening event (ALTE) is defined as an episode that is frightening to the caretaker and is characterized by some combination of apnea (which can be central or occasionally obstructive), color change (usually cyanotic or pallid but occasionally erythematous or plethoric), marked change in muscle tone (usually limpness), choking or gagging. Although the natural history of ALTE is most often benign, there is a risk for subsequent morbidity and mortality. The most common causes of ALTE are gastroesophageal reflux, seizure activity and lower respiratory tract infections, specially respiratory syncytial virus infection. Other causes include otolaryngology conditions, inborn errors in metabolism and cardiac diseases. The incidence of sudden infant death syndrome is reported to be higher after ALTE episodes. Tow mechanisms explain why reflux can result in ALTE: chemoreflex in the larynx prompted by acid fluid and stimulation of the distal esophagus by the gastric content. Children with ALTE and gastroesophageal reflux, other cardiac, respiratory and neurological causes appropriately excluded should be considered candidates for fundoplication since medical management carries a high risk of recurrent ALTE. After fundoplication the incidence of ALTE is significantly reduced.
References: 1- National Institutes of Health Consensus Development Conference on Infantile Apnea and Home Monitoring. Pediatrics 79:292- 299, 1987 2- McGovern MC, Smith MB: Causes of apparent life threatening events in infants: a systematic review. Arch Dis Child. 89(11):1043-8, 2004 3- Dewolfe CC: Apparent life-threatening event: a review. Pediatr Clin North Am. 52(4):1127-46, 2005 4- Esani N, Hodgman JE, Ehsani N, Hoppenbrouwers T: Apparent life-threatening events and sudden infant death syndrome: comparison of risk factors. J Pediatr. 152(3):365-70, 2008 5- Valusek PA, St Peter SD, Tsao K, et al. The use of fundoplication for prevention of apparent life-threatening events. J Pediatr Surg 42:1022-1024, 2007 6- Tirosh E, Ariov-Antebi N, Cohen A: Autonomic function, gastroesophageal reflux in apparent life threatening event. Clin Auton Res. 20(3):161-6, 2010
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1- Knechtle SJ, Filston HC: Anomalous biliary ducts associated with duodenal atresia. J Pediatr Surg. 25(12):1266-9, 1990 2- Panuel M, Bourliere-Najean B, Delarue A, Viard L, Faure F, Devred P: [Duodenal atresia with bifid termination of the common bile duct]. Arch Fr Pediatr. 49(4):365-7, 1992 3- Ando H, Kaneko K, Ito F, Seo T, Harada T, Watanabe Y: Embryogenesis of pancreaticobiliary maljunction inferred from development of duodenal atresia. J Hepatobiliary Pancreat Surg. 6(1):50-4, 1999 4- Tashjian DB, Moriarty KP: Duodenal atresia with an anomalous common bile duct masquerading as a midgut volvulus. J Pediatr Surg. 36(6):956-7, 2001 5- Mali V, Wagener S, Sharif K, Millar AJ: Foregut atresias and bile duct anomalies: rare, infrequent or common? Pediatr Surg Int. 23(9):889-95, 2007 6- Komuro H, Ono K, Hoshino N, Urita Y, Gotoh C, Fujishiro J, Shinkai T, Ikebukuro K: Bile duct duplication as a cause of distal bowel gas in neonatal duodenal obstruction. J Pediatr Surg. 46(12):2301-4, 2011
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experimental animals for timed deployment of an expanding device for bowel Lengthening. The restored jejunal segment had an increase in crypt depth and no difference in villus height compared with normal jejunum. Sucrase activity in the restored segment was not different from that in normal jejunum. Using these methods the small bowel can be lengthened three to fourfold times its original length. Mechanical lengthening may be a useful technique to increase intestinal length in patients with short bowel syndrome.
References: 1- Shekherdimian S, Scott A, Chan A, Dunn JC: Intestinal lengthening in rats after massive small intestinal resection. Surgery. 146(2):291-5, 2009 2- Park J, Puapong DP, Wu BM, Atkinson JB, Dunn JC: Enterogenesis by mechanical lengthening: morphology and function of the lengthened small intestine. J Pediatr Surg. 39(12):1823-7, 2004 3- Chang PC, Mendoza J, Park J, Lam MM, Wu B, Atkinson JB, Dunn JC: Sustainability of mechanically lengthened bowel in rats. J Pediatr Surg. 41(12):2019-22, 2006 4- Stark R, Zupekan T, Bondada S, Dunn JC: Restoration of mechanically lengthened jejunum into intestinal continuity in rats. J Pediatr Surg. 46(12):2321-6, 2011 5- Stark R, Panduranga M, Carman G, Dunn JC: Development of an endoluminal intestinal lengthening capsule. J Pediatr Surg. 47(1):136-41, 2012
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6- Han SS, Kim YH, Lee SH, Kim GJ, Kim HJ, Kim JW, Park NH, Song YS, Kang SB: Underuse of ovarian transposition in reproductive-aged cancer patients treated by primary or adjuvant pelvic irradiation. J Obstet Gynaecol Res. 37(7):825-9, 2011 7- Morris SN, Ryley D: Fertility preservation: nonsurgical and surgical options. Semin Reprod Med. 29(2):147-54, 2011
Adrenal Cysts
Adrenal cysts are rare, usually found incidentally during autopsy series. Adrenal cysts are usually asymptomatic; mostly an occasional discovery during ultrasound or CT done for other reason. Acute abdominal or flank pain may be presented in some cases. From the histological point of view adrenal cysts are vascular or endothelial, hemorrhagic or pseudocyst and epithelial-lined or "true" adrenal cysts. Less than 10% of adrenal cysts are malignant. The most common types are epithelial and pseudocysts. Intra-cystic hemorrhage spontaneously or post-traumatic may be present. Due to the asymptomatic nature of the cyst they can attain large sizes usually in the range of 10 cm when diagnosed. Preoperative CT-guided aspiration for cytology and biopsy are useful technique to establish a diagnosis. Resection of the cyst should be performed for cysts larger than 3 cm, symptomatic, suspicion of malignancy, hormonally active or rapidly enlarging. Either laparoscopic or open are standard methods to remove the cyst along with the adrenal gland associated. Laparoscopic adrenalectomy or cyst unroofing is a safe and effective treatment for benign adrenal cysts with the advantages of a shorter hospital stay, less blood loss and enhanced cosmesis.
References: 1- El-Hefnawy AS, El Garba M, Osman Y, Eraky I, El Mekresh M, Ibrahim el-H: Surgical management of adrenal cysts: single-institution experience. BJU Int. 104(6):847-50, 2009 2- Poiana C, Carsote M, Chirita C, Terzea D, Paun S, Beuran M: Giant adrenal cyst: case study. J Med Life. 3(3):308-13, 2010 3- Guazzoni G, Montorsi F, Rigatti P, Lanzi R, Pontiroli AE, Silvestre P, Breda G: Laparoscopic unroofing of adrenal cysts. Eur Urol. 31(4):499-502, 1997 4- Pradeep PV, Mishra AK, Aggarwal V, Bhargav PR, Gupta SK, Agarwal A: Adrenal cysts: an institutional experience. World J Surg. 30(10):1817-20, 2006 5- Lal TG, Kaulback KR, Bombonati A, Palazzo JP, Jeffrey RB, Weigel RJ: Surgical management of adrenal cysts. Am Surg. 69(9):812-4, 2003 6- Castillo OA, Litvak JP, Kerkebe M, Urena RD: Laparoscopic management of symptomatic and large adrenal cysts. J Urol. 173(3):915-7, 2005
Measuring IAP
The abdominal compartment syndrome (ACS) is a clinical syndrome caused by persistency elevated intraabdominal pressure (IAP) leading to decreased venous return and cardiac output, increase intracranial pressure, impaired ventilation, and kidney and bowel end-organ damage. The most common etiologies of ACS in children are isolated head trauma, abdominal trauma, surgery for abdominal wall defect, bowel ischemia/necrosis and meningococcemia. The most accurate method for measurement of IAP is directly via an intraperitoneal catheter. Due to invasiveness, the indirect method of measuring IAP using the intravesical method has prevailed as the gold standard. The bladder technique requires that the bladder be infused with a certain amount of saline, to ensure that there is a conductive fluid column between the bladder and the transducer. The method uses a Foley catheter inserted into the bladder while the bladder is filled with saline. The closest correlation with intraabdominal pressure occurs when a volume of 1 ml/kg of weight is utilized in children. The higher the bladder filling volume, the higher the overestimation of IAP. Optimal patient position for IAP measurement is supine, taken at end-expiration with the transducer calibrated to the level of the mid-axillary line. Infusion of saline at room temperature
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causes higher bladder pressure due to contraction of the detrusor bladder muscle. Mean IAP in critically ill children is 7 +/- 3 mm Hg. Above 12 mm Hg IAP is elevated.
References: 1- Chiumello D, Tallarini F, Chierichetti M, Polli F, Li Bassi G, Motta G, Azzari S, Carsenzola C, Gattinoni L: The effect of different volumes and temperatures of saline on the bladder pressure measurement in critically ill patients. Crit Care. 11(4):R82, 2007 2- Gudmundsson FF, Viste A, Gislason H, Svanes K: Comparison of different methods for measuring intra-abdominal pressure. Intensive Care Med. 28(4):509-14, 2002 3- Zengerink I, McBeth PB, Zygun DA, Ranson K, Ball CG, Laupland KB, Widder S, Kirkpatrick AW: Validation and experience with a simple continuous intra-abdominal pressure measurement technique in a multidisciplinary medical/surgical critical care unit. J Trauma. 64(5):1159-64, 2008 4- Balogh Z, Jones F, D'Amours S, Parr M, Sugrue M: Continuous intra-abdominal pressure measurement technique. Am J Surg. 188(6):679-84, 2004 5- Suominen PK, Pakarinen MP, Rautiainen P, Mattila I, Sairanen H: Comparison of direct and intravesical measurement of intraabdominal pressure in children. J Pediatr Surg. 41(8):1381-5, 2006 6- Ejike JC, Bahjri K, Mathur M: What is the normal intra-abdominal pressure in critically ill children and how should we measure it? Crit Care Med. 36(7):2157-62, 2008 7- Davis PJ, Koottayi S, Taylor A, Butt WW: Comparison of indirect methods of measuring intra-abdominal pressure in children. Intensive Care Med. 31(3):471-5, 2005
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pediatric patients: pathophysiology, classification, and treatment. J Infus Nurs. 34(4):242-9, 2011
Cloacogenic Polyps
Inflammatory cloacogenic polyps are very rarely found in the pediatric age. They arise from the transitional zone of the anal canal, but can extend proximally toward the sigmoid colon. Characterized histologically by marked hyperplasia of the muscularis mucosa with extension of smooth muscle and fibrous stroma into the lamina propria. The typical presentation of the patient is difficulty with defecation and passage of mucous and blood per rectum. The polyps can prolapse; this is due to the malfunction of the internal anal sphincter; and the smooth muscle that covers the rectum. During endoscopy they can appear polypoid with flat base. The polyps vary in size from 3-4 cm in diameter, and have a sessile appearance. Inflammatory cloacogenic polyp is related to
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solitary rectal ulcer syndrome and is most likely due to prolapse of the anorectal transition zone. Cloacogenic polyps are not a neoplasm arising from a preexistent normal transitional epithelium but a nonspecific regenerative process. Management consists of endoscopic removal of the polyps. Those unable to be removed endoscopically or endorectal will need sigmoidectomy with low anterior resection.
References: 1- Ciriza de Los Rios C, Tomas Moro E, Garcia Duran F, et al: [Inflammatory cloacogenic polyps: a rare cause of rectal bleeding]. Gastroenterol Hepatol. 30(8):461-4, 2007 2- Calva-Rodriguez R, Gonzalez-Palafox MA, Rivera-Dominguez ME, et al: [Inflammatory cloacogenic polyp]. Rev Gastroenterol Mex. 72(4):371-5, 2007 3- Washington K, Rourk MH Jr, McDonagh D, Oldham KT: Inflammatory cloacogenic polyp in a child: part of the spectrum of solitary rectal ulcer syndrome. Pediatr Pathol. 13(4):409-14, 1993 4- Bass J, Soucy P, Walton M, Nizalik E: Inflammatory cloacogenic polyps in children. J Pediatr Surg. 30(4):585-8, 1995 5- Poon KK, Mills S, Booth IW, Murphy MS: Inflammatory cloacogenic polyp: an unrecognized cause of hematochezia and tenesmus in childhood. J Pediatr. 130(2):327-9, 1997 6- Siafakas C, Vottler TP, Andersen JM: Rectal prolapse in pediatrics. Clin Pediatr (Phila). 38(2):63-72, 1999
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biology influences the prognosis of nephroblastoma patients with primary pulmonary metastases: results from SIOP 9301/GPOH and SIOP 2001/GPOH.Ann Surg. 254(1):155-62, 2011 7- Letourneau PA, Xiao L, Harting MT, Lally KP, Cox CS Jr, Andrassy RJ, Hayes-Jordan AA: Location of pulmonary metastasis in pediatric osteosarcoma is predictive of outcome. J Pediatr Surg. 46(7):1333-7, 2011
Magnet Ingestion
Most foreign body ingestion in infant and children passes through the gastrointestinal tract without causing significant sequelae. Surgical intervention is generally required if an object becomes lodged in the gastrointestinal tract or if the material has a harmful effect such as the corrosive effect of batteries. With rare-earth magnets present in many small toys, the situation can be very different. A single magnet ingestion is innocuous and is expected to pass through the GI tract. Unfortunately, a misdiagnosis and misconception that a solitary magnet has been ingested when in fact they are two or more joined together may lead to a delay in diagnosis and subsequent severe and possibly preventable complications. The ingestion of multiple magnets can cause bowel obstruction, volvulus, perforation or internal bowel fistula formation owning to pressure necrosis from magnet attraction. Pressure necrosis and fistula formation can be a gradual process resulting in minimal physical examination findings. In many of the toys the magnets are embedded in plastic parts that are easily detachable. If in the stomach, the magnet should be removed endoscopically. If the history, clinical findings and imaging are suggestive of multiple magnetic ingestion early intervention using laparoscopy or open surgery is indicated to prevent serious life-threatening complications. It is imperative health authorities give more information to parents and physicians about the potential risk of small magnetic toys in children.
References: 1- Hernandez Anselmi E, Gutierrez San Roman C, Barrios Fontoba JE, et al: Intestinal perforation caused by magnetic toys. J Pediatr Surg. 42(3):E13-6, 2007 2- Alzahem AM, Soundappan SS, Jefferies H, Cass DT: Ingested magnets and gastrointestinal complications. J Paediatr Child Health. 43(6):497-8, 2007 3- Butterworth J, Feltis B: Toy magnet ingestion in children: revising the algorithm. J Pediatr Surg. 42(12):e3-5, 2007 4- Dutta S, Barzin A: Multiple magnet ingestion as a source of severe gastrointestinal complications requiring surgical intervention. Arch Pediatr Adolesc Med. 162(2):123-5, 2008 5- Naji H, Isacson D, Svensson JF, Wester T: Bowel injuries caused by ingestion of multiple magnets in children: a growing hazard. Pediatr Surg Int. 28(4):367-7, 2012 6-Salimi A, Kooraki S, Esfahani SA, Mehdizadeh M: Multiple magnet ingestion: Is there a role for early surgical intervention? Ann Saudi Med. 32(1):93-6, 2012
HIPEC
Hyperthermic intraperitoneal chemotherapy (HIPEC) is an alternative of management based on the fact that hyperthermia and chemotherapy have synergistic cytotoxicity for microscopic carcinomatous disease. In adults it has been applied successfully for extensive peritoneal disease associated with such tumors as mesothelioma, appendiceal, colonic, gastric and ovarian carcinoma. During closed-technique HIPEC the skin is temporarily closed and chemotherapy is delivered at supranormal temperatures. Drugs known to have synergy with hyperthermia include mitomycin C, doxorubicin and cisplatin. HIPEC has been found to be safe and improve median survival in children with dermoplastic small round cell tumor after complete surgical excision. Adult and pediatric patient undergoing HIPEC are a highly selected group who does not have uncontrolled disease outside the abdominal cavity. HIPEC and cytoreductive surgery is not recommended for palliative purposes. Other rare instances where HIPEC has been used effectively in children
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include peritoneal metastasis from melanoma, signet cell colonic carcinoma and Wilms's tumor. Indications for HIPEC include resectability to no visible disease, active disease limited to the abdomen, no liver metastasis, normal liver and kidney function and disease partially responsive to neoadjuvant chemotherapy.
References: 1- Reingruber B, Boettcher MI, Klein P, Hohenberger W, Pelz JO: Hyperthermic intraperitoneal chemoperfusion is an option for treatment of peritoneal carcinomatosis in children. J Pediatr Surg. 42(9):E17-21, 2007 2- Hayes-Jordan A, Green H, Fitzgerald N, Xiao L, Anderson P: Novel treatment for desmoplastic small round cell tumor: hyperthermic intraperitoneal perfusion. J Pediatr Surg. 45(5):1000-6, 2010 3- Msika S, Gruden E, Sarnacki S, Orbach D, Philippe-Chomette P, Castel B, Sabata JM, Flamant Y, Kianmanesh R: Cytoreductive surgery associated to hyperthermic intraperitoneal chemoperfusion for desmoplastic round small cell tumor with peritoneal carcinomatosis in young patients. J Pediatr Surg. 45(8):1617-21, 2010 4- Owusu-Agyemang P, Arunkumar R, Green H, Hurst D, Landoski K, Hayes-Jordan A: Anesthetic Management and Renal Function in Pediatric Patients Undergoing Cytoreductive Surgery with Continuous Hyperthermic Intraperitoneal Chemotherapy (HIPEC) with Cisplatin. Ann Surg Oncol. 2012 Mar 27. 5- Hayes-Jordan A, Green H, Ludwig J, Anderson P: Toxicity of hyperthermic intraperitoneal chemotherapy (HIPEC) in pediatric patients with sarcomatosis/carcinomatosis: Early experience and phase 1 results. Pediatr Blood Cancer. 2012 Apr 10. doi: 10.1002/pbc.24160.
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