Table. Odds ratio of hypoglycemia for patients receiving varying interventions.

40 mg/dl
50 mg/dl
(2.2 mmol/L)
(2.8 mmol/L)
PR (%)
OR (95% CI)
PR (%)
OR (95% CI)

60 mg/dl
(3.3 mmol/L)
OR (95% CI)
OR (95% CI)

Patient cohort
No VP or MV
VP

6/670 (0.9%)
8/138 (5.8%)

VP, no MV

1/9 (11.1%)

MV

13/220 (5.9%)

MV, no VP

6/91 (6.6%)

VP and MV

7/129 (5.4%)

VP or MV

14/229 (6.1%)

Inc BG, VP or MV

12/181 (6.6%)

Referent
6.81
(2.32, 19.96) b
13.83
(1.49, 128.50) a
6.95
(2.61, 18.52) b
7.81
(2.46, 24.77) a
6.35
(2.10, 19.22) a
7.21
(2.74, 18.98) b
7.86
(2.91, 21.24) b

24/670 (3.6%)
12/138 (8.7%)
1/9 (11.1%)
24/220 (10.9%)
13/91 (14.3%)
11/129 (8.5%)
25/229 (10.9%)
23/181 (12.7%)

Referent
2.60
(1.27, 5.35) a
3.36
(0.40, 27.99)
3.30
(1.83, 5.93) b
4.49
(2.20, 9.17) b
2.51
(1.20, 5.26) a
3.30
(1.84, 5.90) b
3.92
(2.16, 7.12) b

32/670 (4.8%)
15/138 (10.9%)
1/9 (11.1%)
34/220 (15.5%)
20/91 (22.0%)
14/129 (10.9%)
35/229 (15.3%)
32/181 (17.7%)

Referent
2.43
(1.29, 4.62) a
2.49
(0.30, 20.54)
3.64
(2.19, 6.07) b
5.62
(3.05, 10.34) b
2.43
(1.26, 4.69) a
3.60
(2.17, 5.96) b
4.28
(2.54, 7.21) b

All patient admissions

No VP or MV
VP
VP, no MV

6/745 (0.8%)
11/186 (5.9%)
1/14 (7.1%)

MV

28/291 (9.6%)

MV, no VP

18/119 (15.1%)

Referent
7.74
(2.82, 21.21) b
9.47
(1.06, 84.39) a
13.11
(5.37, 32.02) b
21.95

22/745 (3.0%)
16/186 (8.6%)
1/14 (7.1%)
49/291 (16.8%)
27/119 (22.7%)

Referent
3.09
(1.59, 6.02) b
2.53
(0.32, 20.19)
6.65
(3.94, 11.23) b
9.64

34/745 (4.6%)
21/186 (11.3%)
3/14 (21.4%)
69/291 (23.7%)
47/119 (39.5%)

Referent
2.66
(1.51, 4.71) b
5.70
(1.52, 21.40) a
6.50
(4.20, 10.07) b
13.65

VP and MV

10/172 (5.8%)

VP or MV

29/305 (9.5%)

Inc BG, VP or MV

27/246 (11.0%)

(8.51, 56.59) b
7.60
(2.72, 21.21) b
12.94
(5.32, 31.51) b
15.18
(6.19, 37.25) b

15/172 (8.7%)
50/305 (16.4%)
48/246 (19.5%)

(5.28, 17.63) b
3.14
(1.59, 6.19) a
6.44
(3.83, 10.85) b
7.97
(4.70, 13.52) b

18/172 (10.5%)
72/305 (23.6%)
68/246 (27.6%)

(8.25, 22.58) b
2.44
(1.35, 4.44) a
6.46
(4.19, 9.97) b
7.99
(5.13, 12.44) b

Patients with length of stay less than one day

Referent
2.94
(0.57, 15.02)
1/5 (20%)
1/5 (20%)
15.42
1/5 (20%)
VP, no MV
(1.49, 159.26) a
1/44 (2.3%)
1/44 (2.3%)
2/44 (4.5%)
2.94
MV
(0.57, 15.02)
0/36 (0%)
0/36 (0%)
1/36 (2.8%)
1.76
MV, no VP
(0.21, 15.05)
1/8 (12.5%)
17.76
1/8 (12.5%)
8.81
1/8 (12.5%)
8.81
VP and MV
(1.64, 192.60) a
(0.93, 83.18)
(0.93, 83.18)
3/49 (6.1%)
8.11
3/49 (6.1%)
4.02
4/49 (8.2%)
5.48
VP or MV
(1.59, 41.36) a
(0.97, 16.63)
(1.49, 20.16) a
2/34 (5.9%)
3.85
3/34 (8.8%)
5.97
2/34 (5.9%)
7.77
Inc BG, VP or MV
(0.75, 19.88)
(1.42, 25.03) a
(1.25, 48.21) a
PR-prevalence rate; OR-odds ratio; CI-confidence interval; VP-vasopressor support; MV-mechanical ventilation; inc BG-increased
blood glucose defined as blood glucose > 150 mg/dl (8.3 mmol/L). aP<.05; bP<.01.
No VP or MV
VP

3/376 (0.8%)
2/13 (15.4%)

Referent
22.61
(3.43, 149.19) a
31.08
(2.63, 366.88) a
2.89
(0.29, 28.41)
uncalculable

6/376 (1.6%)
2/13 (15.4%)

Referent
11.21
(2.03, 61.93) a
15.42
(1.49, 159.26) a
1.43
(0.17, 12.19)
uncalculable

6/376 (1.6%)
2/13 (15.4%)

Figure

50%
40%
30%

abb
bbb

bbb

20%

aaa

baa

bbb

10%
0%
all patients

no VP or
MV

VP

VP, no MV

MV

MV, no VP VP and MV VP or MV inc BG, VP

or MV

50%
40%

bbb

30%

bbb

bbb

bbb

aba
20%

baa

bbb
10%
0%
all
ll patients
ti t

no VP or
MV

VP

VP, no MV
VP

MV

MV,
MV no VP VP andd MV VP or MV inc
i BG,
BG VP
or MV

50%
40%
30%

aaa

aaa

20%

abb

aba

aba

10%
0%
all patients

no VP or
MV

VP

VP, no MV

<40 mg/dl (2.2 mmol/L)

MV

MV, no VP VP and MV VP or MV inc BG, VP

or MV

<50 mg/dl (2.8 mmol/L)

<60 mg/dl (3.3 mmol/L)

Figure. Prevalence of hypoglycemia in the (A) patient cohort, (B) all patient admissions and (C)
admissions with length of stay of less than one day. Values are expressed as proportion with
standard deviation as error bars. Brackets indicate comparison groups. VP-vasopressor support;
MV-mechanical ventilation; inc BG-increased blood glucose defined as blood glucose > 150
mg/dl (8.3 mmol/L). aP<.05; bP<.01.