38 Tequillo, Hazel Joy M.

2FPh PROBLEMS ILLUSTRATION DEFINITION This occurs when the coating fills in the lettering or logo on the tablet and is typically caused by improper application of the solution, poor design of the tablet embossing, high coating viscosity, high percentage of solids in the solution, or improper atomization pressure. REMEDY

Logo Bridging

Increasing the plasticizer content or changing the plasticizer can decrease the incidence of bridging.

Twinning

This is the term for two tablets that stick together, and its a common problem with capsule shaped tablets.

Assuming you dont wish to change the tablet shape, you can solve this problem by balancing the pan speed and spray rate. Try reducing the spray rate or increasing the pan speed. In some cases, it is necessary to modify the design of the tooling by vary slightly

38 Tequillo, Hazel Joy M. 2FPh changing the radius. The change is almost impossible to see, but it prevents the twinning problem. Intagliation filled with either particles of dried polymer or solidified foam, due to bubble or foam Add alcohol or formation use spray because of air nozzle capable spraying of of finer polymer atomization. solution and over drying of spray or excessive foaming of coating solution. This can be the result of soft or friable tablets (and the pan turning too fast), an overwetted tablet surface, inadequate drying, or lack of tablet surface length. The defect whereby pits occur in the Modifying the drying (inlet air)

Logo Infilling

Core Erosion

Pitting

38 Tequillo, Hazel Joy M. 2FPh surface of a temperature tablet core such that the without any temperature visible of the tablet disruption of core is greater the film than the coating melting point because the of the batch temperature of of the the tablet core additives is greater than used. the melting point of the materials used in the tablet formulation. It is a defect of film coating whereby volcanic-like craters appears exposing the Use efficient tablet surface and optimum because the drying coating conditions and solution increase penetrates the viscosity of surface of the coating tablet, often at solution to the crown decrease where the spray surface is application more porous, rate. causing localized disintegration of the core and disruption of the coating. Coating Decrease becomes dull plasticizer immediately or concentrations after a prolong and increase

Cratering

Blooming

38 Tequillo, Hazel Joy M. 2FPh storage. Film becomes detached from a substrate forming a blister due to love molecular weight plasticizers included in the coating formulation. It is a defect best described as whitish specks or haziness in the film due to precipitated polymer exacerbated by the use of high coating temperature at or above the thermal gelation temperature of the polymers. When coated tablets require further drying in ovens, too rapid evaporation of the solvent from the core and the effect of high temperature on the strength, elasticity, and adhesion of molecular weight of plasticizer.

Blushing

Decrease drying air temperature and avoid use of sorbitol with Hydroxy Propyl Cellulose, Hydroxy Propyl Methyl Cellulose, Methyl Cellulose, and Cellulose Ethers.

Blistering

Milder drying conditions are warranted in this case.

38 Tequillo, Hazel Joy M. 2FPh the film may result in blistering. Using keying in tooling, i.e. inset a key alongside of the punch, so that it fits the punch and prevents punch rotation.

Double Impression

Free rotation of either upper punch or lower punch during ejection of a tablet.