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PY TEST SERIES-X
Duration: 2.00 hours Max Marks: 100

1. 2. 3. 4. 5. 6. 7.

This question paper contains 40 objective type questions. Q. 1 to 40 carry 2 marks each. Q. 41and 50 are common data based question, each carry two marks. In case of wrong answer 0.5 marks will be deducted. Using HP pencil, darken the appropriate double under each digit of your registration number and the letters corresponding to your paper code. Calculator is allowed in the examination hall. charts, graph sheets or tables are NOT allowed in the examination hall Rough work can be done on the question paper itself. Additionally blank pages are given at the end of the question paper for work.

CENTRE - LIC BUILDING, 3rd FLOOR, CIVIL LINES, SAGAR (M.P.) Sunil mokati

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PY TEST SERIES-X
1. 2. Which of the following is an example of Competitive enzyme inhibition mode of drug action (a) Physostigmine- Cholinesterase (b) Theophylline- Phosphodiesterase (c) Acetazolamine- Carbonic anhydrase (d) Aspirin- Cyclooxygenase Functional group requirement in drug molecule for its inactivation through glucuronide conjugation is (a) Amino & hydrazine moiety (b) Carboxyl & hydroxyl moiety (c) Phenolic moiety (d) Quinone & epoxide moiety The bioassay of acetyl choline is done on (a) Rat (b) Mice (c) Frog (d) Rabbit Carvone is main chemical constituent of (a) Spearmint (b) Caraway (c) Dill (d) All Which of the following statement is uncorrect about drug-protein interaction (a) Drugprotein binding tends to lower (b) Drugprotein binding engance duration volume of distribution of drug action (c) Drug-protein binding facilitates (d) Drug-protein binding is necessary for sustained drug effects drug storage Cellular hypersensitivity reactions are mediated through the production of (a) IgG antibody (b) IgG & IgM antibodies (c) Immune complex (d) T- lymphocytes Which of the following is not the diagnostic test for hepatitis (a) ELISA (b) RIA (c) Western blot test (d) Australian antigen test The fruit of fennel, come in the category of (a) Cremmocarps (b) Glabrous (c) Orhtospermous (d) All Movement of drugs from its site of administration to the body tissue refers to (a) Absorption (b) Distribution (c) Metabolism (d) Excretion Requirement of higher dose of pharmacologically related drugs to produce disered response is called as (a) Cross tolerance (b) Drug resistance (c) Intolerance (d) Cumulation On addition of a drop of ferric chloride solution to a drop of volatile oil, a pale green color is produced, then the oil is (a) Cinnamomum zeylenicum (b) Cinnamomum cassia (c) Cinnamomum burmanii (d) Allium sativum Which of the following is anti inflammatory trirerpens (a) Galangin (b) Allicin (c) Sorghumol (d) Myristicin Which of the following statement is correct on drug absorption (a) Acidic drug highly absorbed at lower pH (b) Acidic drug highly absorbed at high pH (c) Acidic drug highly absorbed at neutral (d) Acidic drug absorption in pH pH independent manner 2

3. 4. 5.

6. 7. 8. 9. 10.

11.

12. 13.

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18.

19 20. 21.

22. \ 23. 24. 25.

26. 27.

Generation of photoallergic reactions take place on which of the following drug therapy (a) Penicillins (b) Sulfonamides (c) Tetracyclins (d) Cephalosporins Mitsuda test is used for the diagnosis of (a) Leprosy (b) Cholera (c) Typhoid (d) Tuberculosis The method which is used for extraction of citrus oils is (a) Hydro-distillation (b) Ecuelle (c) Enfleurage (d) None Which of the following statement is correct about enzymetic mode of drug action (a) Inhibition of enzyme is common mode of drug action (b) Km and Vmax is increase and reduced respectively in nonequilibrium type inhibition (c) Km and Vmax is increase and unchanged respectively in equilibrium type inhibition (d) All Which of the following statement is/are correct about volatile oil (a) They are also called ethereal oil (b) Most of them are optically inactive (c) They have very low refractive indices (d) All are the only drug which is effective in type- II, III & IV hypersensitive reactions (a) Glucocorticoids (b) Antihistaminics (c) Adrenaline (d) ACE inhibitors Capacity of drug to cause foetal abnormalities on administration to pregnant women is known as (a) Carcinogenicity (b) Mutagenicity (c) Teratogenicity (d) Iatrogenicity During autoclaving process, the product is kept at a temperature of 126-129 at a pressure of 20 lb/Sq.inch. Then minimum holding time will be a) 3 min. (b) 10 min. (c) 15min. (d) 30 min. Guggul is found as adulterated with resins of various commiphora species like (a) C. mukul (b) C. weightii (c) C. roxburgii (d) All Body surface area (BSA) for dose determination of an individual can be calculated (a) Youngs formula (b) Dillings formula (c) Dubois formula (d) All Compound having affinity but submaximal intrinsic activity to activate receptor is clled (a) Agonist (b) Partial agonist (c) Antagonist (d) Inverse agonist Tetraterpenoids are C40 compounds of terpenoid groups and biosynthetically prepared by (a) Tail-to-head condensation of geranyl (b) Head-to-tail condensation of geranyl geraniol geraniol (c) Tail-to-tail condensation of geranyl (d) Head to head condensation of geranyl geraniol geraniol As per I.P. 2007, the biological indicator for dry heat sterilization precess should be (a) Bacillus stearothermophilus (b) Clostridium sporogenus (c) Bacillus subtilis (d) Bacillus pumilis G- protein coupled receptors mediated effector pathway which generate drug response in relatively shorter time period is (a) Phospholipase C-IP3 :DAG pathway 3

Sunil mokati

28. 29.

30.

31. 32. 33. 34.

35 36. 37. 38. 39. 40.

(b) Adenyl cyclase-c AMP pathway (c) Ion channel regulation pathway (d) Enzyme activation pathway Gallotannic acid is present in (a) Tulsi (b) Acorus (c) Clove (d) Taxus Receptor occupation theory postulates that (a) Drug and its receptor stand in lock and (b) Intensity of response is proportional to key relationship receptorfraction bind with drug (c) Drug exert all or none action on each (d) All receptor Ferulic acid on treatment with hydrolic acid is converted into A, which loose water to form B. the compound B is (a) Umbellic acid (b) Feraldehyde (c) Umbellicferone (d) Fenchone The microbiological source of vit. B2 is (a) Pseudomonas dentrificans (b) Clostridium butilicum (c) Panicillium griseofulvin (d) Aspergillus Most selective requirement of parenterally administered dosage forms is (a) Should be non irritative (b) Should be non pyrogenic (c) Shoule be sterile (d) Should be biocompatible Movement of the drug or alteration of the drug by the body is refers to (a) Pharmacodynamics (b) Pharmacokinetics (c) Pharmacotherapeutics (d) Pharmacotoxicity Etoposide is (a) 4-demethylepipodophylotoxin ethyledene (b) 2-3-di-benzylepipodophylotoxin glucoside ethyledene glucoside (c) Teranhydronapthalene derivative (d) 2-4-biepiandroepipodophylotoxin ethyledene glucoside Which of the following is a live vaccine (a) Cholera (b) Rubella (c) Plague (d) Typhus Select the drug which is not include in Orphan drugs category (a) Liothyronine (b) Sodium nitrite (c) Protamine sulphate (d) None Drug dose which modifies measerable physiological parameters and can be accurately adjusted is (a) Standard dose (b) Regulated dose (c) Target level dose (d) Titrated dose Paraquetry cells is present in (a) Cardamom (b) Caraway (c) Coriander (d) Dill Korarima cardamom is distinguished from the genuine drug on the basis of (a) Size (b) Color (c) Rugae (d) All Entrapement of weak electrolyte within cells in pH dependent manner is called (a) Ionization (b) Ion trapping (c) Immobilization (d) Encapsulation DATA FOR 41-42 A volatile is a very valuable anthelmintic, specifically for round-worm (ascaris). It is also used 4

Sunil mokati

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43. 44.

45. 46.

47.

48.

49. 50.

to expel hook-worms and dwarf tape-worms. The drug is (a) American wormseed oil (b) Dinkum oil (c) lemon grass oil (d) Oil of turpentine The above oil contains chiefly (a) Citral (b) Ascaridole (c) Cineol (d) Pinene LINKED QUESTION Which of the following antibody is called as P-H antibody (a) Ig D (b) Ig M (c) Ig A (d) Ig E The function of the above antibody is (a) Protection against early infection (b) Protection to mucous membrane (c) Cause allergies and drug sensitivity (d) Control antigen stimulation of B cells reaction LINKED QUESTION Acrolein is an active metabolite of (a) Cyclophosphamide (b) Primidine (c) Sulfasalazine (d) Losartan Prominent side effct produced by acrolein during above drug therapy is (a) Alopecia and cystitis (b) Platelets damage (c) Cardiac arrhythmia (d) Bone marrow dipression LINKED QUESTION Inhibition of pharmacological response of drug when two drugs act by different mechanism on different receptors is refers to (a) Physical antagonism (b) Chemical antagonism (c) Functional antagonism (d) Receptor mediated antagonism An example of above type antagonism is (a) Tannins + Alkaloids (b) Histamine + Adrenaline (c) Charcoal + Alkaloids (d) Ach + Atropine DATA FOR 49-50 A plant shows glandular trichome and diacytic stomata. The leaf of the same plant have sharply dentate margin and pungent taste follwed by colling sensation. The plant should be (a) Trychyspermum ammi (b) Anethum graveolens (c) Menthe piperita (d) Foeniculum vulgare The above plant is used as (a) Antispasmodic (b) Smooth muscle relaxant (c) Anthelmintic (d) Emmenagogue

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