``

PY TEST SERIES-II
Duration: 2.00 hours Max Marks: 120

1. 2. 3. 4. 5. 6. 7.

This question paper contains 50 objective type questions. Q. 1 to 50 carry 2 marks each. Q. 51and 60 are common data based question, each carry two marks. In case of wrong answer 0.5 marks will be deducted. Using HP pencil, darken the appropriate double under each digit of your registration number and the letters corresponding to your paper code. Calculator is allowed in the examination hall. charts, graph sheets or tables are NOT allowed in the examination hall Rough work can be done on the question paper itself. Additionally blank pages are given at the end of the question paper for work.

CENTRE - LIC BUILDING, 3rd FLOOR, CIVIL LINES, SAGAR (M.P.) Sunil mokati

Mob.: 9753030576, 9907039445, 9981779766, 9039459437

PY TEST SERIES-II
1. 2. 3. N-acetyl muramic acid is cellular receptor for (a) Herpes virus (b) Retro virus (c) Influenza virus (d) Chicken pox virus Capsule No 0 has the capacity of (a) 0.15 ml (b) 0.75 ml (c) 1.5 ml (d) 7.5 ml An antimetabolite drug- flucytocine which is used as anti fungal drug whose mechanism of action is (a) inhibitor of sqaline epoxide (b) inhibitor of thymidylate synthesis (c) inhibitor of uridylate synthesis (d) it is combine with ergosterole and fom a micropore A antiviral drug which is mutagenic, carcinogenic and teratogenic in animals is (a) Idoxuridine (b) Famciclovir (c) Ganciclovir (d) Amntadine The commonly used derivatizing agents for alkaloids is (a) Ninhydrin (b) Bromocresol green (c) Mercuric nitrate (d) 2,4 dinitrophenyl hydrazine The techniques employed to upgrading the microbial purity of the water supply used in oral liquids is/are (a) Reverse osmosis (b) Membrane filtration (c) Ultraviolet sterilization (d) All The stationary phases used in partition chromatography is (a) Cellulose (b) ODS silica gel (c) Ion exchange resins (d) Dextran gel Stationary phase used in paper chromatography is especially prepared from (a) 95-99% cellulose (b) 99% cellulose (c) 95-99% cellulose (d) 99% cellulose Alcohol cause hot flushing and a disulfiram like reaction in patients receiving (a) Hydroxurea (b) Procarbazine (c) Cisplatin (d) Vincristine Tailing and carge on the solute particles are controlled in paper chromatography (a) NH3 and HCl (b) NH4OH and HCl (c) NH3 and CH3COOH (d) NH4OH and CH3COOH Berkefield and chamber land filter are (a) Bacteria proof (b) Made up of porcelain (c) Made up of diatomaceous earth (d) All of the above Adsorbent layer in HPTLC gives up to about (a) 50,000 theoritical plate (b) 5,000 theoritical plate (c) 500 theoritical plate (d) 50 theoritical plate Adverse effect of ketoconazle include the following EXCEPT (a) Gynecomastria (b) Oligozoospermia (c) Kidney damage (d) Menstrual irregularities Sucrose monoesters is used as solubilizer for solubilization of (a) Vitamine (b) Essential oil (c) Volatile oil (d) All 2

4. 5. 6.

7. 8. 9. 10. 11. 12. 13. 14.

Sunil mokati

15. 16. 17.

18.

19 20.

21.

22. 23. 24. 25.

26. 27.

Iodoxuridine is indicated in (a) Herpes simplex keratitis (b) Herpes zoster (c) Chicken pox (d) All of the above Amount/volume of the sample used to applied to the adsorbent layer in HPTLC (a) 1 -100 l (b) 100-200 l (c) 1 -100 nl (d) 100-200 nl Which of the following statement is correct (a) Hard gelatin capsules contain higher water content than soft gelatin capsule (b) Shoft gelatin capsules contain higher water content than hard gelatin capsule (c) Both have equal moisture content (d) Both have zero moisture content The mechanism of action of immunosuppressants is (a) Cytotoxic drugs inhibit MHC expression (b) Glucocorticoids inhibit proliferation of helper T cells as well as expression of IL-2 (c) Cyclosporine block proliferation and differention of T and B cells (d) None The particle that are used to pack HPLC columns are small enough and they are (a) Less than 1 m (b) Less than 50 m (c) Less than 100 m (d) Less than 200 m The Erweka KEA is used in capsule industries for (a) Sorting of capsule (b) Finishig of filled gelatin capsule (c) Dedusting and polishing for hard gelatin (d) Dedusting and polishing for soft gelatin capsule capsule Solid that are not sufficiently soluble in liquids or in combinations of liquids are capsulated as suspensions. Such should be a) 80 mesh size (b) 120 mesh size (c) 60 mesh size (d) 40 mesh size The drug of choice in small pox is (a) Acyclovir (b) Idoxuridine (c) Foscarnet (d) Methisazone Select the antifungal drug which is administred only by the oral route (a) Amphotericin B (b) Ketoconazole (c) Griseofulvin (d) Tolnaftate Tacrolimus is newer immunosuppressant drug which is (a) 100 times more potent tham cyclosporine (b) It inhibit helper T cell via calcineurin (c) More valuable in liver transplantation (d) All the statement is correct Reducing the interfacial tension between the predominately aqueous solutions and the hydrophobic solute is the mechanism of action of (a) Cosolvent (b) Solubilizing agent (c) Complexing agent (d) Hydrotrophic agent Ion chromatography is recent development in HPLC which is useful for the quantitation of (a) Anions (b) Cations (c) Amino acid and proteins (d) All the above The most probable mechanism of action of imidazole antifungal drugs is (a) They bind to ergosterol in fungal cell membrane and make it leaky (b) They interfere with ergosterol synthesis by fungi (c) They interfere with fungal mitosis (d) They block oxidative phosphorylatin in fungi 3

Sunil mokati

28.

29. 30.

31. 32.

33. 34.

35 36. 37. 38.

39. 40. 41.

Sunil mokati

Which of the following statement is correct about precolomn in HPTLC (a) It is used mainly to protect the main (b) It is different from guard column column (c) The particle size of it is lesser than (d). All precolumn Adsorbent layer used in HPTLC gives are made up of (a) 3-5 m diameter purified silica gel (b) 3-5 m diameter purified alumina (c) 10-100 m diameter purified silica gel (d) 10-100 m diameter purified silica gel The mechanism of action of alkylating agents is/are EXCEPT (a) They produce highly reactive carbonium (b) They act on maily 7 of guanine residues ions in DNA (c) They cause abnormal base pairing or (d) They transfer alkyl groups to cellular scission of DNA strand macromolecules by forming covalent bonds Purpose of encapsulation of vitamin A palmitate is (a) Taste masking (b) Sustained release (c) Reduce gastric irritation (d) Solubilization to oxidation In some time capsule often show a soft spot at the site at which they lie next to the tray or against another capsule. This spot is the result of (a) Slower drying (b) Fast drying (c) Presence of iron (b) Not known Which of the following statement is INCORRECT (a) Asbestos fibres can cause cacer (b) Saccharin fibres can cause cacer (c) Sucrose can cause cap-locking (d) None In paper chromatography mobile phase runs across the paper by (a) Gravitational force (b) Capillary force (c) Differential solubility (d) Partition coefficient Mobile phase travels over the surface of paper to develoved chromatogram in the following ways a) Ascending or decending (b) Radial (c) Lnear horizontal or spiral (d) All of the above Cytarabine is (a) Pyrimidine antagonist (b) Purine antagonist (b) Folate antagonist (d) Miscellaneous drug Any material can be solubilized in any solvent by proper choice of (a) Solubilizing agent (b) pH (c) Temperature (d) Both B and C Which of the following drug come in the category of non nucleoside reverse transcriptase inhibitor (a) Zidovudine (b) Delavirdine (c) Ribavirin (d) Foscarnet Increase risk of kidney stone is side effect of (a) Idoxuridine (b) Ketokonazole (c) Indinavir (d) Amphotericine B Water insoluble resin used for microencapsulation is (a) Polyacrylic acid (b) Stearic acid (c) Shellac (d) Ethyl cellulose The following drug is used in cancer 4

(a) (c) 42. 43.

Estrogen Androgen

(b) (d)

Antiestrogen Antiandrogen

44. 45. 46 47. 48. 49.

50.

Capsulation of hygroscopic vehicles requires (a) Low viscosity high bloom (b) High viscosity high bloom (c) High viscosity low bloom (d) Low viscosity low bloom Triple therapy used in used in induction regimen during organ transplantation are the combination of (a) Tacrolimus + prednisolone + (b) Cyclosporine + prednisolone + methotrexate azathioprine (c) Tacrolimus + chlorambucil + (d) Tacrolimus + methotrexate + azathioprine cyclophosphamide The IUPAC name of metronidazole is (a) 2-methyl-5-nitroimidazole-1-ethanol (b) 3-methyl-5-nitroimidazole-1-ethanol (c) 2-ethyl-5-nitroimidazole-1-ethanol (d) 3-methyl-4-nitroimidazole-1-ethanol Which of the anticancer is G2 cell cycle specific (a) Bleomycin (b) Doxorubicin (c) Daunorubicin (d) Mitomycin C Ethy vanillin is a component of the gelatin mass of soft gelatin capsule. It is used as (a) Preservative (b) Colorants (c) Opacifier (d) Flavoring agent st The 1 choice drug in treatment of syphilis is/are (a) Doxycycline (b) Cotrimazole (c) Penicilline (d) Erythromycin Strategy used to decrease resistance and to prolong the effect of flucytocine is (a) Increase dose of the drug (b) Administer it with tetracyclin (c) Administer pyridine with it (d) Administer AMB with it The most frequently used instrument is an UV spectrometer and the simplest of these are fixed ar one wavelength, usually at 254 nm because at this wavelength (a) Most aromatic organic compounds (b) The aromatic amino acid of proteins and absorb strongly peptides absorb (c) Isolated double bond absorb strongly (d) All In which microencapsulation process, the only solid core material is applicable (a) Wurster process (b) Solvent evaporation (c) Spray drying and congealing (d) Coacervation phase separation DATA FOR 51-52 Capsule at equilibrium with 20 to 30% RH at 21 to 240C are considered dry The shell of such capsule contain (a) 6- 14% Water (b) 1-6% water (c) 6-10% water (d) 14% water The moisture content of the shell is determined by (a) Benzene distillation method (b) Burman distillation method (c) Kirbay distillation method (d) Tolune distillation method DATA FOR 53-54 Silica gel is the most frequently used stationary phase for TLC analysis. It is best suited to the analysis of (a) Acidic compounds (b) Basic compounds (c) Amphoteric compounds (d) None The analysis of above compound is due to the presence of 5

51. 52.

53. 54.
Sunil mokati

(a) (c)

Free carboxyl groups Free amide groups

(b) (d)

Many silanol hydroxyl proups Many double groups

55.

LINKED QUESTION Now a days, breast carcinoma is most common type of carcinoma. The drug of choice in it is (a) VAMP regimen (b) MOPP regimen (c) Tamoxifen (d) Vincristine The above drug/regimen is effective in (a) Positive as well as negative breast (b) Premenopausal women cancer (c) Postmenopausal women (d) All the above case DATA FOR 57-58 A 45 yr old patient with diabetes mellitus received the renal transplant 2 yr ago. She was maintaing cyclosporine 200 mg twise daily, azathioprine 100 mg daily, and prednisolone 2 mg daily; her serum creatinine was 1. mg/ml. one weak ago, she developed a resipatory infection and her physician started erythromycin 500 mg three times a day. Three days later, her creatinine level rose to 2.6 mg/day with a cyclosporine trough level of 450 ng/ml (therapeutic range 100200ng/ml). What is the likely cause of her recent renal function deterioration. (a) Azathioprine is a nephrotoxic drug (b) Erythromycin has synergistic nephrotoxicicity with cyclosporine (c) Erythromycin inhibits cyclosporine (d) Prednisolone is a nephrotoxic drug metabolism The patient in above question had severe joint pain with a serum uric acid level of 15 mg/dl. Her physician prescribed allopurinol 300 mg daily for treatment of gout. What is the pharmacists appropriate response to this prescription. The pharmacist should (a) Advise her physician to reduce her (b) Advise her physician to reduce her azathioprine dose by 80% cyclosporine dose by 80% (c) Advise her physician to increase her (d) Advise her physician to stop prednisole azathioprine dose by 80% DATA FOR 59-60 A interferons which is produced by fibroblast and epithelial cells and induced by double strandard viral DNA. The interferon is (a) interferon (b) interferon (c) interferon (d) None The above interferon encoded on chromosomes number (a) 9 (b) 12 (c) 14 (d) 22

56.

57.

58.

59. 60.

Sunil mokati