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ESPERANZA, SHEBA RAE P.

MSN 4006 DR. EMILIANO IAN B. SUSON II, MAN, RN

MEGALOBLASTIC ANEMIA

ESPERANZA, SHEBA RAE P. MSN 4006 DR. EMILIANO IAN B. SUSON II, MAN, RN MEGALOBLASTIC ANEMIA

AGENT: Vitamin B 12 and Folic Acid

Food
Food

Vitamin B 12 and Folic Acid Oral intake

ESPERANZA, SHEBA RAE P. MSN 4006 DR. EMILIANO IAN B. SUSON II, MAN, RN MEGALOBLASTIC ANEMIA

Into the gastrointestinal tract

ESPERANZA, SHEBA RAE P. MSN 4006 DR. EMILIANO IAN B. SUSON II, MAN, RN MEGALOBLASTIC ANEMIA

HOST:

overcooked food/vegetables LIFESTYLE: Alcoholism MEDICATIONS: (VitB 12 Def) Metformin, Proton Pump Inhibitor (Omeprazole), H 2 Blocker (Zantac), Antacid, Antibiotic; (FolicAcidDef) Antimetabolite (Methotrexate), Anticonvulsant (Phenytoin, Phenobarbital) HFD: Vitamin B 12 GIF

AGE: ˂10 years old; ˃40 or 50 years old; elderly RACE: African American; Northern European (English, Irish, Scottish) GENDER: Female DIET: (VitB 12 Def) strict vegetarian; (FolicAcidDef)↑intake of

ESPERANZA, SHEBA RAE P. MSN 4006 DR. EMILIANO IAN B. SUSON II, MAN, RN MEGALOBLASTIC ANEMIA

ENVIRONMENT:

Developing countries Depressed areas

ESPERANZA, SHEBA RAE P. MSN 4006 DR. EMILIANO IAN B. SUSON II, MAN, RN MEGALOBLASTIC ANEMIA
ESPERANZA, SHEBA RAE P. MSN 4006 DR. EMILIANO IAN B. SUSON II, MAN, RN MEGALOBLASTIC ANEMIA

Destruction of gastric mucosa that contains parietal cells which secretes intrinsic factor

ESPERANZA, SHEBA RAE P. MSN 4006 DR. EMILIANO IAN B. SUSON II, MAN, RN MEGALOBLASTIC ANEMIA

↓ or absence of intrinsic factor

Gastric conditions
Gastric conditions
ESPERANZA, SHEBA RAE P. MSN 4006 DR. EMILIANO IAN B. SUSON II, MAN, RN MEGALOBLASTIC ANEMIA

Partial or total gastrectomy affecting distal ileum and proximal small intestines

Faulty gastrointestinal absorption

Faulty gastrointestinal absorption

Faulty gastrointestinal absorption
ESPERANZA, SHEBA RAE P. MSN 4006 DR. EMILIANO IAN B. SUSON II, MAN, RN MEGALOBLASTIC ANEMIA
↓ Vit B 12 (↓200pg/mL) and Folic Acid (↓1.8 ng/mL) absorption [only few amounts of Folic
↓ Vit B 12 (↓200pg/mL) and Folic Acid (↓1.8 ng/mL) absorption
[only few amounts of Folic Acid can be stored in the body and it can also be depleted so quickly.]
↓ production of matured RBC Anemia *RBC↓4.2M/mm ]
↓ production of matured RBC Anemia *RBC↓4.2M/mm ]
   

↓ production of

matured RBC

 
↓ production of matured RBC Anemia *RBC↓4.2M/mm ]
 

Anemia *RBC↓4.2M/mm 3 ]

 
 
↓ production of matured RBC Anemia *RBC↓4.2M/mm ]
↓ production of matured RBC Anemia *RBC↓4.2M/mm ]
Tissue hypoxia
Tissue hypoxia

Leads to macrocytosis (hypochromic and macrocytic)

Inadequate Oxygen transport

↓ production of matured RBC Anemia *RBC↓4.2M/mm ] Tissue hypoxia Leads to macrocytosis (hypochromic and macrocytic)

-confused

-paresthesia

-gait & balance

problem -depression

Brain, spinal cord & nerves

-disrupts functions of the brain, spinal cord and peripheral nerves -psychotic behavior

-CHF Heart -tachycardia (↑120bpm) -pump failure -angina pectoris -↓work capacity
-CHF
Heart
-tachycardia
(↑120bpm)
-pump failure
-angina pectoris
-↓work capacity

Lungs -dyspnea -↓respiratory reserve -impaired O 2 CO 2 exchange

-renal Kidney insufficiency
-renal
Kidney
insufficiency
 

GI

-smooth sore red

tongue

-mild diarrhea

-peptic ulcers

-gastric carcinoma -benign gastric polyps

 
   
 

Musculo-skeletal

-weakness

-fatigue

 
   
IF LEFT UNTREATED Permanent damage on the different organs affected Leads to cardiac and renal failure
IF LEFT UNTREATED Permanent damage on the different organs affected Leads to cardiac and renal failure
IF LEFT UNTREATED Permanent damage on the different organs affected
IF LEFT UNTREATED
Permanent damage on
the different organs
affected

Leads to cardiac and renal failure

DEATH
DEATH

MANAGEMENT & TREATMENT:

-blood transfusions -corticosteroids or other medicines that suppresses the immune system -erythropoietin, a medicine that helps your bone marrow makes more blood cells -supplements of Vitamin B 12 and folic acid

RECOVERY
RECOVERY