DMD STUDENTS
G U I D E B O O K R E S E A R C H
Table of Contents........................................................................................ HSDM Office of Research........................................................................... Welcome to HSDM...................................................................................... DMD 2014 Deadlines....................................................................... Overview of DMD Research Requirements................................................. Types of Research...................................................................................... Research Areas at HSDM........................................................................... Research Mentors....................................................................................... Examples of Research Mentors.................................................................. IRB/IACUC Guidelines................................................................................. Office of Enrichment Program Information................................................... Research Proposal Guidelines..................................................................... Research Essay Guidelines......................................................................... Thesis Information........................................................................................ Poster Information........................................................................................ Research Resources................................................................................... Additional Research Opportunities. DMD Forms.................................................................................................. Predoctoral Research Advisors...
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HSDM OFFICE OF RESEARCH: Below are several people you will get to know in the HSDM Office of Research.
Please do not hesitate to contact any of us with questions, or concerns regarding your project and/or research requirements at HSDM.
RESEARCH OVERVIEW:
Research activities at Harvard School of Dental Medicine aim to set the international standard and pace for basic discoveries, clinical application, and research training in an area that lies at the heart of dental medicine. By leveraging its scientific strengths and focusing on the area of skeletal development, growth and homeostasis, as well as clinical and health policy research, Harvard School of Dental Medicine has established a strategic direction for its research programs. Exciting opportunities, both scientific and organizational are on the horizon for clinical and translational research in areas where we already have basic science strength. As the only School within Harvard University with its own clinical facility, Harvard School of Dental Medicine continues to differentiate itself through a unique emphasis on basic and clinical research combined with exemplary patient care and education.
PROFESSOR & DEAN FOR RESEARCH bjorn_olsen@hms.harvard.edu REB 409 617-432-1874 Administrator, Yulia Pittel (yulia_pittel@hms.harvard.edu, 617-432-2359)
DAWN M. DECOSTA
ASSISTANT DIRECTOR, OFFICE OF RESEARCH dawn_decosta@hsdm.harvard.edu REB 404 617-432-1121 Staff Assistant, Liz Kervis (REB 408) (elizabeth_kervis@hsdm.harvard.edu, 617-432-5743)
WELCOME:
Welcome to the Harvard School of Dental Medicine. As you begin your professional training at Harvard, we would like to emphasize the importance of your research requirement. The primary goal of this requirement at HSDM is to stimulate and evaluate the student's ability and potential for entering the world of original scholarship and/or experimentation. Whatever you do in your future professional/academic career, the ability to identify problems that require research and in-depth study are key to success. Such research requires the definition of specific testable hypotheses based on evaluation of the relevant literature, identification of critical experiments or tests to prove or rule out the hypothesis and interpretation of outcomes in a way that indicates awareness of the limitation of the methods used. By being introduced to research as a Harvard student you become part of an environment at Harvard School of Dental Medicine that aims to set the international standard and pace for basic discoveries, clinical application, and research training in dental medicine. We welcome you to make the most of exciting opportunities for clinical and translational research in areas where we already have basic science strength and wish you success as you prepare yourself for a profession of patient care, learning, research and teaching.
I M P O R T A N T
D E A D L I N E S
F O R
D M D
2 0 1 4 :
You will meet the Office of Research staff and be assigned a Predoctoral Research Advisor. The Predoctoral Research Advisor will be responsible for working with students to ensure they are meeting their research requirements, selecting appropriate projects and mentors, and offering guidance as needed throughout their program. You will also get an overview of the research requirements at HSDM.
You must meet with your Predoctoral Research Advisor and begin to think about a research project and finalize your Research Mentor selection. The importance of mentor and project selection should not be overlooked: they are crucial to the quality of your experience and the successful completion of your requirements. Thus, you should expect to devote a considerable amount of time to this step, critically assessing the research environment offered by the mentor. Clearly, you should find the proposed project interesting and important. Simultaneously, think about whether you want to pursue an honors project or a non-honors project. Non-honors projects must be completed by the end of the 2nd year and honors projects must be completed by the end of your 4th year.
DECEMBER 1, 2010
1) Final deadline for the selection of a Research Mentor. (Please note: this is different from the HMS deadline.) Notify the following people: Kari Hannibal (Kari_Hannibal@hms.harvard.edu) in the Scholars In Medicine Office (SMO) Your society fellow The HSDM Office of Research (dawn_decosta@hsdm.harvard.edu) 2) Deadline for registering for the SIM course, to be taken in January. Register by completing this form online http://mycourses.med.harvard.edu/pub_forms.asp?sid=HMS_3910 (Please note: only students whose international projects meet specific criteria will be accepted to the PIC course.)
JANUARY 2011
1) PIC/SIM Research Courses at HMS 2) Attend Soma Weiss Research Day on January 13.
FEBRUARY 1, 2011
1) All students must submit a 3-5 page research proposal (hard and soft copy) along with a Proposal Routing Form to the HSDM Office of Research (dawn_decosta@hsdm.harvard.edu, REB 404). These proposals are reviewed by 2 HSDM faculty members and comments will be returned to you no later than February 15, 2011. 2) You must also submit the proposal to: Your society fellow AND Kari Hannibal (kari_hannibal@hms.harvard.edu) in SMO (if you require funding) They will provide feedback as well. You will have several weeks to make any changes and get signed off before resubmitting to the SMO.
Begin working on your IRB/IACUC application or ensure you are on your Mentors protocol. International projects require not only the local IRBs approval, but also an IRB approval from HMS. FINAL SUBMISSION DEADLINE Basic, Clinical, and Translational projects ONLY. Submit a 3-5 page research proposal incorporating all required changes to the Office of Research and SMO, if you require SMO funding.
FINAL SUBMISSION DEADLINE International and Community-based projects. Submit a 3-5 page research proposal incorporating all required changes to the Office of Research and SMO, if you require SMO funding. IRB proposals for students not being added onto existing protocols are due in the HMS Office for Research Subjects Protection for all proposed summer 2010 projects involving human or animal subjects.
You must attend Student Research Day. Note, all students are required to attend Student Research Day, as you will be required to complete an assignment.
JUNE 1, 2011
Research project begins. PLEASE NOTE: if you are being added onto an existing protocol and your project involves human or animal subjects, your IRB proposal is due in the HMS Office for Research Subject Protections at least 2 weeks before starting your project. DMD Guidebook Revised 9/22/10 PAGE 4
TYPES OF RESEARCH:
BASIC RESEARCH Basic research or bench research aims to improve human health with scientific discoveries. Such discoveries typically begin at the bench with basic research in which scientists study disease at a molecular or cellular level. This may include the use of animal models such as mice, chick and zebrafish. Basic scientists provide clinicians with new tools for use in patients and for assessment of their impact. CLINICAL/TRANSLATIONAL RESEARCH Clinical/translational research aims to improve human health by translating scientific discoveries into practical applications then progress to the clinical level, or the patient's bedside. Scientists are increasingly aware that this bench-to-bedside approach to translational research is really a two-way street. Clinical researchers make novel observations about the nature and progression of disease that often stimulate basic investigations. LITERATURE REVIEW A literature review is a body of text that aims to review the critical points of current knowledge on a particular topic. Most often associated with science-oriented literature, such as a thesis, the literature review usually precedes a research proposal, methodology and results section. Its ultimate goal is to bring the reader up to date with current literature on a topic and forms the basis for another goal, such as future research that may be needed in the area. A good literature review is characterized by: a logical flow of ideas; current and relevant references with consistent, appropriate referencing style; proper use of terminology; and an unbiased and comprehensive view of the previous research on the topic. REQUIRED READING: Research Methodology in the Medical and Biological Sciences Chapter 5, Literature Search and Personal Reference Databases
Although you are not limited to specific research areas, below is a list of the major research areas/topics being investigated at Harvard School of Dental Medicine. BIOMEDICAL AND TISSUE ENGINEERING HSDM faculty, students and colleagues participate in biomedical and tissue engineering projects with a focus on biomaterials, fracture healing, bone regeneration, wound repair, and tooth regeneration. CELL BIOLOGY HSDM faculty, students and colleagues participate in cell biology projects with a focus on skeletal and vascular biology and pathology, cell differentiation, embryonic development, tissue homeostasis, and signal transduction. CLINICAL SCIENCES HSDM faculty, students and colleagues participate in clinical science projects with a focus on cutting-edge technologies that address questions with human translational impact. DEVELOPMENTAL BIOLOGY AND PATHOLOGY HSDM faculty, students and colleagues participate in developmental biology and pathology projects with a focus on molecular basis for skeletal and vascular morphogenesis, genetics of birth defects and vascular anomalies. EDUCATION SCIENCE HSDM faculty, students and colleagues participate in education science projects with a focus on problem-based-learning, the
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use of information technology in education, and innovative methodologies in dental education. EXTRACELLULAR MATRIX BIOLOGY AND PATHOLOGY HSDM faculty, students and colleagues participate in extracellular matrix biology and pathology projects with a focus on wound healing, matrix remodeling and degradation, and matrix changes during ageing. GENETICS HSDM faculty, students and colleagues participate in genetics projects with a focus on genomic and proteomic technologies, genetic causes of degenerative joint disease and skeletal dysplasias. IMMUNOLOGY HSDM faculty, students and colleagues participate in immunology projects with a focus on oral mucosal and salivary gland diseases, oral manifestations of systemic diseases, infectious agents, and inflammatory bone loss. PUBLIC HEALTH AND HEALTH SERVICES HSDM faculty, students and colleagues participate in public health and health services projects with a focus on health promotion, access to care, disease prevention, pharmacological and behavioral interventions, epidemiology of dental diseases, and dental health care policy. SKELETAL BIOLOGY AND PATHOLOGY HSDM faculty, students and colleagues participate in skeletal biology and pathology projects with a focus on skeletogenesis, skeletal morphogenesis and growth, tooth formation, joint disorders and bone loss.
RESEARCH MENTORS:
The importance of mentor and project selection should not be overlooked: they are crucial to the quality of your experience and the successful completion of your requirements. Thus, you should expect to devote a considerable amount of time to this step, critically assessing the research environment offered by the mentor. Clearly, you should find the proposed project interesting and important. Beyond that, it is essential that the specific aims of the project be clearly delineated and feasible within the available timeframe. The mentor should have the resources to enable you to achieve the specific aims. If your project involves human subjects, you should ask whether the mentor has obtained the necessary IRB approval. If the mentor has not obtained approval, you should plan for additional time so that the mentor can obtain such approval. Remember that no research involving human subjects can be started before the project has received IRB approval. Ideally, a mentor will have demonstrated productivity by a record of publication and a record of private or public funding in a given area. A mentor does not have to be in the field of dentistry. Students have chosen research mentors at HSDM, Forsyth as well as throughout the Longwood Medical Area and beyond. We have basic science laboratories in the REB (details at http://www.hsdm.harvard.edu/asp-html/principal.html as well as clinical, translational, and health policy researchers. Faculty profiles are listed at the following websites and we have listed some of our faculty mentors by subject area on the next several pages. HSDM FACULTY
http://www.hsdm.harvard.edu/asp-html/Faculty-list.html
CELL BIOLOGY
RICARDO BATTAGLINO http://www.forsyth.org/research/scientists/profiles/rbattaglino.html EILEEN BOYE http://staging.catalyst.harvard.edu/Profiles/ProfileDetails.aspx?From=SE&Person=EKB1 ANTONIO CAMPOS NETO http://www.forsyth.org/research/scientists/profiles/acampos.html PATRICIA DAMORE http://www.hms.harvard.edu/dms/bbs/fac/damore.html BEATE LANSKE http://www.hsdm.harvard.edu/faculty/faculty-lanske.html BJORN OLSEN http://www.hsdm.harvard.edu/faculty/faculty-olsen.html VICKI ROSEN http://www.hsdm.harvard.edu/faculty/faculty-rosen.html MALCOLM WHITMAN http://www.hsdm.harvard.edu/faculty/faculty-whitman.html
CLINICAL SCIENCES
NINA ANDERSON http://connects.catalyst.harvard.edu/Profiles/ProfileDetails.aspx?From=SE&Person=NKA1 RACHEL BADOVINAC-RAMONI http://staging.catalyst.harvard.edu/Profiles/ProfileDetails.aspx?From=SE&Person=RLB8 GERMAN GALLUCI http://staging.catalyst.harvard.edu/Profiles/ProfileDetails.aspx?From=SE&Person=GOG2 JIM GARVEY http://www.hsdm.harvard.edu/faculty/faculty-Garvey.html
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DONALD GIDDON http://www.brown.edu/Courses/Community_Health/giddon/biography.html MEREDITH AUGUST http://www.mgh.harvard.edu/omfs/doctors/doctor.aspx?id=16698 GREGORY CONNOLLY http://www.hsph.harvard.edu/faculty/Gregory%20N.Connolly.html JOHN DASILVA http://staging.catalyst.harvard.edu/Profiles/ProfileDetails.aspx?From=SE&Person=JDD2 THOMAS DODSON http://www.massgeneral.org/omfs/doctors/doctor.aspx?id=17237 BRUCE DONOFF http://www.hsdm.harvard.edu/faculty/dean-faculty.html ANNE HAFFAJEE http://www.forsyth.org/research/scientists/profiles/ahaffajee.html ELSBETH KALENDERIAN http://www.linkedin.com/pub/elsbeth-kalenderian/7/bab/274 NADEEM KARIMBUX http://www.hsdm.harvard.edu/faculty/faculty-Karimbux.html DAVID KIM http://staging.catalyst.harvard.edu/Profiles/ProfileDetails.aspx?From=SE&Person=DMK7 TARU KINNUNEN http://www.hsdm.harvard.edu/faculty/faculty-Kinnunen.html WINSTON KUO http://www.hsdm.harvard.edu/faculty/faculty-Kuo.html MARK LERMAN http://www.hsdm.harvard.edu/faculty/faculty-lerman.html CHIN-YU LIN http://staging.catalyst.harvard.edu/Profiles/ProfileDetails.aspx?From=SE&Person=GL48 JARSHEN LIN http://staging.catalyst.harvard.edu/Profiles/ProfileDetails.aspx?From=SE&Person=JL2 SHIGEMI NAGAI http://www.hsdm.harvard.edu/depts/restor/department.htm LINDA NELSON http://children.photobooks.com/directory/profile.asp?dbase=main&setsize=5&last=nelson&pict_id=9901110 SHELDON PECK http://connects.catalyst.harvard.edu/Profiles/ProfileDetails.aspx?From=SE&Person=SP2 JEFF SCHAEFER http://www.mgh.harvard.edu/omfs/doctors/doctor.aspx?id=17311
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ANDREW SONIS http://children.photobooks.com/directory/profile.asp?dbase=main&setsize=5&service=338&view=program&shellid=361&classificatio n_deptview=Faculty&pict_id=9901150 STEVE SONIS http://www.hsdm.harvard.edu/faculty/faculty-sonis.html NIKOS SOUKOS http://www.forsyth.org/research/scientists/profiles/nsoukos.html ANNE TANNER http://www.forsyth.org/research/scientists/profiles/annetanner.html MARY TAVARES http://www.forsyth.org/research/scientists/profiles/mtavares.html PEGGY TIMOTHE http://www.hsdm.harvard.edu/faculty/faculty-timothe.html NATHANIEL TREISTER http://www.hsdm.harvard.edu/faculty/faculty-treister.html MARIA TROULIS http://www.mgh.harvard.edu/omfs/doctors/doctor.aspx?id=17191 HANS-PETER WEBER http://www.hsdm.harvard.edu/faculty/faculty-hpweber.html SOOK BIN WOO http://www.hsdm.harvard.edu/faculty/faculty-woo.html ROBERT WHITE http://www.hsdm.harvard.edu/faculty/faculty-rwhite.html ROBERT WRIGHT http://www.hsdm.harvard.edu/faculty/faculty-wright.html ATHANASIOS ZAVRAS http://www.hsdm.harvard.edu/faculty/faculty-Zavras.html
RACHEL BADOVINAC-RAMONI http://staging.catalyst.harvard.edu/Profiles/ProfileDetails.aspx?From=SE&Person=RLB8 ROLAND BARON http://www.hsdm.harvard.edu/faculty/faculty-baron.html RICARDO BATTAGLINO http://www.forsyth.org/research/scientists/profiles/rbattaglino.html EILEEN BOYE
http://staging.catalyst.harvard.edu/Profiles/ProfileDetails.aspx?From=SE&Person=EKB1
PATRICIA DAMORE
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http://www.hms.harvard.edu/dms/bbs/fac/damore.html FLOYD DEWHIRST http://www.forsyth.org/research/scientists/profiles/fdewhirst.html LAURIE GLIMCHER http://www.hsph.harvard.edu/faculty/laurie-glimcher PETER HAUSCHKA http://www.childrenshospital.org/cfapps/research/data_admin/Site81/mainpageS81P0.html PETER JEZEWSKI http://www.forsyth.org/research/scientists/profiles/pjezewski.html TOSHI KAWAI http://www.forsyth.org/research/scientists/profiles/tkawai.html BEATE LANSKE http://www.hsdm.harvard.edu/faculty/faculty-lanske.html YEFU LI http://www.hsdm.harvard.edu/faculty/faculty-li.html YIPING LI http://www.forsyth.org/research/scientists/profiles/ypli.html RICHARD MAAS http://www.hms.harvard.edu/dms/bbs/fac/maas.html BJORN OLSEN http://www.hsdm.harvard.edu/faculty/faculty-olsen.html MOHAMMED RAZZAQUE http://www.hsdm.harvard.edu/faculty/faculty-Razzaque.html SUSAN RITTLING http://www.forsyth.org/research/scientists/profiles/srittling.html VICKI ROSEN http://www.hsdm.harvard.edu/faculty/faculty-rosen.html STEVE SONIS http://www.hsdm.harvard.edu/faculty/faculty-sonis.html RICARDO TELES http://www.forsyth.org/research/scientists/profiles/rteles.html NATHANIEL TREISTER http://www.hsdm.harvard.edu/faculty/faculty-treister.html MALCOLM WHITMAN http://www.hsdm.harvard.edu/faculty/faculty-whitman.html SOOK BIN WOO http://www.hsdm.harvard.edu/faculty/faculty-woo.html
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LIN XU http://staging.catalyst.harvard.edu/Profiles/ProfileDetails.aspx?From=Pinfo&Person=LX2
EDUCATION SCIENCE
JOHN BARTLETT http://www.forsyth.org/research/scientists/profiles/jbartlett.html EILEEN BOYE http://staging.catalyst.harvard.edu/Profiles/ProfileDetails.aspx?From=SE&Person=EKB1 PATRICIA DAMORE http://www.hms.harvard.edu/dms/bbs/fac/damore.html BEATE LANSKE http://www.hsdm.harvard.edu/faculty/faculty-lanske.html YIPING LI http://www.forsyth.org/research/scientists/profiles/ypli.html BJORN OLSEN http://www.hsdm.harvard.edu/faculty/faculty-olsen.html VICKI ROSEN http://www.hsdm.harvard.edu/faculty/faculty-rosen.html MALCOLM WHITMAN http://www.hsdm.harvard.edu/faculty/faculty-whitman.html
GENETICS
RACHEL BADOVINAC-RAMONI http://staging.catalyst.harvard.edu/Profiles/ProfileDetails.aspx?From=SE&Person=RLB8 EILEEN BOYE http://staging.catalyst.harvard.edu/Profiles/ProfileDetails.aspx?From=SE&Person=EKB1 MARY ELEN DAVEY http://www.forsyth.org/research/scientists/profiles/mdavey.html FLOYD DEWHIRST http://www.forsyth.org/research/scientists/profiles/fdewhirst.html PORSCHE JUMLONGRAS http://staging.catalyst.harvard.edu/Profiles/ProfileDetails.aspx?From=SE&Person=DJ2 WINSTON KUO http://www.hsdm.harvard.edu/faculty/faculty-Kuo.html
BEATE LANSKE http://www.hsdm.harvard.edu/faculty/faculty-lanske.html BJORN OLSEN http://www.hsdm.harvard.edu/faculty/faculty-olsen.html VICKI ROSEN http://www.hsdm.harvard.edu/faculty/faculty-rosen.html STEVE SONIS http://www.hsdm.harvard.edu/faculty/faculty-sonis.html CLIFF TABIN http://www.hms.harvard.edu/dms/bbs/fac/tabin.html ANNE TANNER http://www.forsyth.org/research/scientists/profiles/annetanner.html
IMMUNOLOGY
JOHN BARTLETT http://www.forsyth.org/research/scientists/profiles/jbartlett.html TOSHI KAWAI http://www.forsyth.org/research/scientists/profiles/tkawai.html YIPING LI http://www.forsyth.org/research/scientists/profiles/ypli.html CHARLES SERHAN http://connects.catalyst.harvard.edu/Profiles/ProfileDetails.aspx?From=SE&Person=CNS3 DAN SMITH http://www.forsyth.org/research/scientists/profiles/dsmith.html STEVE SONIS http://www.hsdm.harvard.edu/faculty/faculty-sonis.html MARTIN TAUBMAN http://www.forsyth.org/research/scientists/profiles/mtaubman.html RICARDO TELES http://www.forsyth.org/research/scientists/profiles/rteles.html
GREGORY CONNOLLY http://www.hsph.harvard.edu/faculty/Gregory%20N.Connolly.html JIM GARVEY http://www.hsdm.harvard.edu/faculty/faculty-Garvey.html ELSBETH KALENDERIAN http://www.linkedin.com/pub/elsbeth-kalenderian/7/bab/274 TARU KINNUNEN
http://www.hsdm.harvard.edu/faculty/faculty-Kinnunen.html MARY TAVARES http://www.forsyth.org/research/scientists/profiles/mtavares.html PEGGY TIMOTHE http://www.hsdm.harvard.edu/faculty/faculty-timothe.html ATHANASIOS ZAVRAS http://www.hsdm.harvard.edu/faculty/faculty-Zavras.html
ROLAND BARON http://www.hsdm.harvard.edu/faculty/faculty-baron.html PATRICIA DAMORE http://www.hms.harvard.edu/dms/bbs/fac/damore.html LAURIE GLIMCHER http://www.hsph.harvard.edu/faculty/laurie-glimcher PETER HAUSCHKA http://www.childrenshospital.org/cfapps/research/data_admin/Site81/mainpageS81P0.html PETER JEZEWSKI http://www.forsyth.org/research/scientists/profiles/pjezewski.html TOSHI KAWAI http://www.forsyth.org/research/scientists/profiles/tkawai.html BEATE LANSKE http://www.hsdm.harvard.edu/faculty/faculty-lanske.html YEFU LI http://www.hsdm.harvard.edu/faculty/faculty-li.html YIPING LI http://www.forsyth.org/research/scientists/profiles/ypli.html RICHARD MAAS http://www.hms.harvard.edu/dms/bbs/fac/maas.html BJORN OLSEN http://www.hsdm.harvard.edu/faculty/faculty-olsen.html MOHAMMED RAZZAQUE http://www.hsdm.harvard.edu/faculty/faculty-Razzaque.html SUSAN RITTLING http://www.forsyth.org/research/scientists/profiles/srittling.html VICKI ROSEN http://www.hsdm.harvard.edu/faculty/faculty-rosen.html MALCOLM WHITMAN http://www.hsdm.harvard.edu/faculty/faculty-whitman.html
LIN XU http://staging.catalyst.harvard.edu/Profiles/ProfileDetails.aspx?From=Pinfo&Person=LX2
Students performing research at institutions, organizations, or clinics not at HMS or HSDM, domestically or internationally, are required to also have a site-mentor (a mentor at the institution, organization, clinic, etc.). Site Mentor letters should include the following: The site mentor will be available to help the student set-up their research project. The site mentor will be available to help the student with any questions/problems that arise with the research/materials. The site mentor is familiar with the ethical conduct of research, or confidentiality/privacy issues.
The site mentor's connection/role to the site in which the student is working.
IRB TRAINING Harvard University requires that all researchers with human subjects responsibilities complete a human subjects protection training course at least every two years. Students must complete the mandatory online IRB training even if they are working on their Mentor/PIs protocol. http://hethr.harvard.edu/hirbert/hethr/HethrLogin.jsp INSTITUTIONAL IRB APPROVALS Students are required to obtain all appropriate HMS/HSDM institutional and site approvals (domestic or international) before commencing research activities. The deadline for submission is at least eight weeks prior to proposed protocol implementation. Summer research proposals are due by April 1st of every year. Please Note: Submit all components of the application together at one time. STUDENT RELEVANT DOCUMENTS http://www.hms.harvard.edu/orsp/human/IRBStudentDocuments.html STUDENT SUBMISSION INFORMATION http://www.hms.harvard.edu/orsp/human/IRBStudentSubmissions.html Independent Student Summer Research Projects: Submission Deadline: April 1 HMS and HSDM Student Submissions to the CHS should include: Cover letter CHS application signed by student and mentor. A copy of the grant, contract, and/or Scholars in Medicine Office (SMO) or research fellowship application. Informed Consent Forms or request for waiver (also HIPAA authorization or request for waiver of same). Research materials: recruitment fliers, survey instruments, questionnaires, telephone scripts, focus group questions, etc. Human Subjects Protection Training certificate for student and HMS mentor. Resumes/CVs or biosketches for student and HMS mentor. IRB approvals from other institutions/sites*. Mentor letters from HMS faculty and on-site supervisor.
Students Receiving Funding from HMS/HSDM (ex. OEP) who are joining IRB Approved Research Projects: Submission Deadline: at least two weeks prior to start date Students who wish to work on an already existing (or soon to be approved), research project and are receiving funding from HMS/HSDM must submit: A cover letter explaining the students role in the research project. A copy of the Scholars In Medicine Office (SMO) application. Human Subjects Protection Training certificate. A copy of the IRB approved research protocol that includes the student as research personnel, or an amendment documenting the addition of the student to the research protocol, and IRB approval documentation*. If the student will be performing additional research activities involving human participants not included in the original IRB protocol, then the student or PI must submit an amendment to the appropriate IRB to include this work. Documentation of the amendment and the IRB approval must be submitted to the HMS/HSDM IRB office.
For students conducting research at Massachusetts General Hospital or Brigham and Women's Hospital, please read the Partners Policy Regarding Non-Employees (http://www.hms.harvard.edu/orsp/human/IRBStudentDocuments.html)
IACUC INFORMATION FOR MEDICAL AND DENTAL STUDENTS Requirements for Harvard Medical School students performing summer research involving animals (according to federal and institutional guidelines and overseen by the Harvard Medical Area Standing Committee on Animals, the IACUC Institutional Animal Care and Use Committee) Working at Harvard Medical School (HMS) on an approved HMS protocol: Principal Investigator (PI) must add student to personnel list on protocol PI must amend protocol to include any procedures that student will be performing that are not already described and approved on the existing protocol. Student must receive appropriate Occupational Health training (check with Office for Research Subject Protection (ORSP) for upcoming training) PRIOR to work with animals as well as Center for Animal Resources and Comparative Medicine (ARCM) facility access orientations (check with ARCM). PRIOR to beginning summer work, ORSP requires: Copy of students research proposal approved by the Scholars in Medicine Office (SMO) Evidence that PI has added student to protocol If applicable, copy of approved amendment to protocol for students work
Working at an institution other than HMS but funded through the HMS/HSDM SMO: PRIOR to beginning summer work, ORSP requires: Copy of students research proposal approved by the Scholars in Medicine Office (SMO) Copy of sponsoring PIs protocol approval letter, INCLUDING the institutions Public Health Service (PHS) Office of Laboratory Animal Welfare (OLAW) Assurance Number. Evidence that PI has added student to protocol If applicable, copy of approved amendment to protocol for students work Once all requirements described above are met, ORSP will send a letter via email to the student and the Office of Enrichment Programs confirming HMA Standing Committee on Animals approval.
For most projects, SMO will not issue funding without matching funding from the students mentor. Students should check with his/her mentor to make sure they can match the SMO funding of $2000 for summer basic science or clinical research projects.
Applying for funding from the SMO office is optional. If a student chooses to not apply for funding, he/she must still submit a 3-5 proposal to the Office of Research. Students should make sure that his/her mentor has seen this proposal prior to submission.
If you are applying for funding from the SMO for basic science or clinical research for summer research, you must obtain matching funding from the research site. The stipend for summer work (8 weeks, full time) is a total of $4000, which is $2000 from SMO for approved projects and a matching $2000 from the site. (Note: students who are doing basic science or clinical research abroad who are unable to get matching funding may apply to the international committee, not the student research committee in these instances, students will get much less than $4000 for the summer that is the trade off.)
Students must confer with their Society Research Fellow and obtain their approval BEFORE submitting the proposal to SMO for review by the full Committee. Note: the Society Research Fellow is separate from your mentor and separate from your Academic Society Fellow. Make sure you give your Society Research Fellow enough time to review your proposal.
If your project involves human or animal studies, please work with your mentor on obtaining the appropriate approvals. You may have the option of being added to your mentors approved protocol. Please note, new IRB applications take approximately 8 weeks from receipt of all materials to approval.
The SMO application/proposal will be reviewed by 2 members of the Research Committee and comments will be sent back to the students. It is up to the students to edit their statement of intent essay and submit the statement of intent materials to the SMO office.
RESEARCH PROPOSAL:
All students are required to write a 3-5 page research proposal due March of their first year. The purpose of this proposal is to describe what you intend to do for your summer research project. This proposal must be written with your Research Mentor and will be reviewed by Faculty from the HSDM Research Training Committee. It serves as a basis for your application for funding to the Office of Enrichment Programs. The proposal must include the following items: COVER PAGE List the title of your project, your name, Research Mentor and Research Advisor. PROPOSAL ROUTING FORM Signatures from your Research Mentor and Research Advisor (form in Guidebook). BACKGROUND AND SIGNIFICANCE Why is this area interesting and important, what impact will it have,and what has been done before? Remember to include a complete literature review. GOAL AND SPECIFIC AIMS What is the ultimate goal of this research? The specific aims are aptly named: they should be a specific outline of the research questions you would like to answer. These provide the foundation for your research. MATERIALS AND METHODS What are the specific steps by which you will achieve this goal? The information you provide should be sufficiently detailed to allow a reader to carry out your methods independently. Include the specific statistical methods, if any, that you intend to use. REFERENCES
RESEARCH ESSAY:
All students are required to write a 10-page, single-spaced research essay describing their summer research experience due by the end of their second year. The 10-page essay can be written in the first person, and does NOT need to be in the same official format as a written thesis. For students who have already turned in a scientific paper, or followed a thesis format, please disregard these instructions. Please consider the following guidelines when writing your 10-page essay: Why was the study done? How was the study done? What were the results? What do the study results mean? What did you learn from the project?
THESIS INFORMATION:
Note: this section pertains to Honors Track Students only. WRITING YOUR THESIS The format to be used for the thesis should be either that of a journal article or that of a formal thesis. The student should work closely with the mentor during the writing phases of the project. In either case, there are no page requirements or limitations. If you intend to use the journal article format, consult the requirements of the journal to which you intend to submit the manuscript. Please note that you should follow the format for the full journal article. Please refer to the New England Journal of Medicine Manuscript Submission Guidelines at http://authors.nejm.org/Misc/NewMS.asp. At your mentors discretion the format can be either one of the following: (1) A journal article of publishable quality, or (2) A formal thesis with the following thesis guidelines:
DMD Guidebook Revised 9/22/10 PAGE 19
TITLE PAGE
TITLE OF PROJECT A Thesis Presented by Full Name, including Middle Name of Author with No Abbreviations to The Faculty of Medicine In partial fulfillment of the requirements for the degree of Doctor of Dental Medicine Research Mentor: Name, Title Institutional affiliation if other than HSDM Harvard School of Dental Medicine Boston, Massachusetts Month and Year of Submission
ABSTRACT (In 500 words or less, summarize your project) INTRODUCTION/HYPOTHESIS/BACKGROUND This section should review the pertinent literature and outline the major purpose of the research. Reference should be made to previous relevant studies in order to explain what has been done as well as to explain the purpose of this research. The Introduction should include a succinct articulation of the hypothesis tested. MATERIALS AND METHODS Describe clearly and carefully the procedures and materials used; a reader should be able to repeat your exact methodology. This section should also include the overall research design and statistical methods. RESULTS AND DISCUSSION Report the results in a well-organized fashion with minimal subjective comment or reference to the literature. This section serves mainly to introduce tables and figures and to call attention to their significant parts. CONCLUSION AND FUTURE DIRECTION The data should be explained and interpreted with reference to the previous literature. The significance of the results may also be included. This is the section in which to emphasize subjective comment. In a thesis, the scope of the discussion extends beyond that of a journal article. For example, you may discuss why your first experiments failed, or how you arrived at the design for a particular protocol, or what you would do next if you were continuing the study REFERENCES References must be double-spaced and numbered consecutively as they are cited. References first cited in a table or figure legend should be numbered so that they will be in sequence with references cited in the text at the point where the table or figure is first mentioned. SELECTING A THESIS DEFENSE COMMITTEE Once you are ready to defend your thesis, you must email your abstract to Dawn DeCosta. The Dean for Research will suggest potential committee members and you will arrange your defense according to their schedules. You must select three faculty to serve on your defense committee. Your mentor may attend as a non-voting participant.
THESIS DEFENSE The oral presentation is no more than 10-15 minutes and usually includes slides and/or overheads. The following discussion between the student and the committee usually lasts approximately 45 minutes. At that point the student will be excused from the room, the committee will discuss the work, and the student will then be invited back in to review the deliberations. The committee may make suggestions for alterations in the thesis, and following the revisions, provide the student with a signed thesis and evaluation. The Final Thesis Grade Sheet and Thesis Signature must be signed by all committee members in order for final approval to be recorded. The committee may make suggestions for alterations to your thesis before providing their approval. These sheets then need to be returned to the Office of Research.
POSTER INFORMATION:
Each DMD student must present a poster at Student Research Day prior to graduation. Poster presentation will occur either the April of your second year (non-honors track), or the April prior to graduation (honors track). There are some exceptions to these dates. Please note, if your Mentor/PI does not have resources to pay for your poster printing, the HSDM Office of Research will pay for your printing as long as you adhere to the printer deadlines. The Office of Research has negotiated a very competitive price for poster printing with Fleming Printing Company, Somerville, MA. To take advantage of this opportunity, you can email your poster file to Fleming and they will deliver the printed poster to HSDM. The best way to output a poster is by converting the PowerPoint file to a PDF file. This way, the printer will not lose content related to images, charts or fonts. Then the PDF file can be compressed if necessary, and emailed to Stan Boliver <stan@flemingprinting.com>. As a rule of thumb the turnaround time for a poster using a PDF is 2 days. Again, Fleming Printing will deliver the poster to HSDM. If you have any questions, please contact Dawn DeCosta in the HSDM Office of Research. POSTER SIZE Each presenter will have a space of 4 feet x 4 feet for his or her poster. The stationary, double-sided poster boards stand 7 feet high and are 8 feet long. Thus two posters 4 x 4 will occupy each side of a poster board. Each presentation space will be assigned and clearly marked on Research Day. POSTER LAYOUT Keep in mind that the poster is a guide for your verbal talking-points therefore, the best use of space is usually for an abstract, minimal bulleted highlights of your project, (e.g.: Specific Aims, Significance, Methods, Results, and Conclusions,) and multiple graphics. It is a good idea to include the abstract at the beginning. Remember, small fonts are not viewer friendly while graphics are viewer friendly. If you need HSDM, HMS, Forsyth or other institutional shields/logos in jpg format, please see Dawn DeCosta. POSTER SAMPLES The Office of Research has samples of student and faculty posters. Please see Dawn DeCosta for more information.
RESEARCH RESOURCES:
HARVARD AUTHORSHIP GUIDELINES Authorship is an explicit way of assigning responsibility and giving credit for intellectual work. The two are linked. Authorship practices should be judged by how honestly they reflect actual contributions to the final product. Authorship is important to the reputation, academic promotion, and grant support of the individuals involved as well as to the strength and reputation of their institution. The Faculty Council of Harvard Medical School has endorsed the following statement. Although authorship practices differ from one setting to another, and individual situations often require judgment, variation in practices should be within these basic guidelines.
DMD Guidebook Revised 9/22/10 PAGE 21
Everyone who is listed as an author should have made a substantial, direct, intellectual contribution to the work. For
example (in the case of a research report) they should have contributed to the conception, design, analysis and/or interpretation of data. Honorary or guest authorship is not acceptable. Acquisition of funding and provision of technical services, patients, or materials, while they may be essential to the work, are not in themselves sufficient contributions to justify authorship. Everyone who has made substantial intellectual contributions to the work should be an author. Everyone who has made other substantial contributions should be acknowledged. When research is done by teams whose members are highly specialized, individual's contributions and responsibility may be limited to specific aspects of the work. All authors should participate in writing the manuscript by reviewing drafts and approving the final version. One author should take primary responsibility for the work as a whole even if he or she does not have an in-depth understanding of every part of the work.
This primary author should assure that all authors meet basic standards for authorship and should prepare a concise, written description of their contributions to the work, which has been approved by all authors. This record should remain with the sponsoring department. ORDER OF AUTHORSHIP Many different ways of determining order of authorship exist across disciplines, research groups, and countries. Examples of authorship policies include descending order of contribution, placing the person who took the lead in writing the manuscript or doing the research first and the most experienced contributor last, and alphabetical or random order. While the significance of a particular order may be understood in a given setting, order of authorship has no generally agreed upon meaning. As a result, it is not possible to interpret from order of authorship the respective contributions of individual authors. Promotion committees, granting agencies, readers, and others who seek to understand how individual authors have contributed to the work should not read into order of authorship their own meaning, which may not be shared by the authors themselves.
The authors should decide the order of authorship together. Authors should specify in their manuscript a description of the contributions of each author and how they have
assigned the order in which they are listed so that readers can interpret their roles correctly.
The primary author should prepare a concise, written description of how order of authorship was decided.
IMPLEMENTATION Research teams should discuss authorship issues frankly early in the course of their work together. Disputes over authorship are best settled at the local level by the authors themselves or the laboratory chief. If local efforts fail, the Faculty of Medicine can assist in resolving grievances through its Ombuds Office. Laboratories, departments, educational programs, and other organizations sponsoring scholarly work should post, and also include in their procedure manuals, both this statement and a description of their own customary ways of deciding who should be an author and the order in which they are listed. They should include authorship policies in their orientation of new members. Authorship should be a component of the research ethics course that is required for all research fellows at Harvard These policies should be reviewed periodically because both scientific investigation and authorship practices are changing. CORE RESEARCH FACILITIES There are numerous core research facilities available in the Longwood Medical Area. Below are links to just a few of the Core Facilities available. These cores are listed on the HSDM Office of Research website at http://www.hsdm.harvard.edu/depts/research/Hmsareacores.html. Please contact Jim McBride, Director of Core Labs at HSDM if you are interested in learning more about our facilities or have questions regarding facilities, equipment, or training.
DMD Guidebook Revised 9/22/10 PAGE 22
It is important to note that you must be trained to use equipment and access laboratories at HSDM. SUBMITTING A GRANT APPLICATION If you do plan on submitting a grant application, please work with the Office of Administration and Finance. They must be notified prior to the submission deadline. All grant applications must be approved through the Office of Administration and Finance as well as your Research Mentor prior to submission. This pertains to all funding (including but not limited to government awards, foundation awards, dental society awards) even if they do not require institutional approval. If you have any questions about this policy, please speak with barbara_rankin@hsdm.harvard.edu
Student
Date
DMD FORMS:
(Examiner 1 Name)
(Signature)
(Examiner 2 Name)
(Signature)
EXAM GRADE: H = Honors P = Pass F = Fail I = Incomplete Criterion: Scientific Validity Thesis as a Document Students Knowledge Overall Committee Recommendation:
Please return this form to the Office of Research (REB Room 408).
Evaluator 1
Evaluator 2
DMD FORMS:
(Evaluator Name)
(Signature)
ESSAY GRADE: P = Pass F = Fail I = Incomplete Criterion: Adequate Background/Introduction Clear Rationale/Purpose Are Methods Clearly Des5.cribed/Understood Reasonable Conclusions Overall Recommendation:
Please return this form to the Office of Research (REB Room 408).
DMD FORMS:
Please make any necessary changes to the information printed on this evaluation and answer the questions below. When complete, sign and return to the HSDM Office of Research, REB Room 408.
Student: Date: Project Title: Mentors Name: (Signature)
Amount of time spent in research environment: _______________ (Please give approximate hours per week) Using the four point scale below, please evaluate these additional aspects of the students performance in his/her research work : 1 =
Outstanding; 2 = Very Good; 3 = Acceptable; 4 = Unacceptable (FAIL) 1 Theoretical Understanding Lab/Office Performance Research Skills Intellectual Curiosity Originality Organizational Ability Motivation Perseverance Integrity 2 3 4
Do you recommend this student for Honors Consideration? ____________ Additional Comments:
Please return this form to the Office of Research (REB Room 408).
DMD Guidebook Revised 9/22/10 PAGE 27
DMD FORMS:
IRB/IACUC Protocol #: Please circle study type: Mentors Signature: Is this a long-term project that should be considered for honors? Please choose one of the following options. This is for informational purposes only and is not binding.
DMD Guidebook Revised 9/22/10 PAGE 28
Yes, this will likely be an honors track project. No, this is most likely completed during years 1 & 2 and should not be considered for honors.
Please return this form to the Office of Research (REB Room 408).
DMD FORMS
Raghav Khandelwal
Esther Levine* Chelsea Aldridge Kanika Sharma Bernard James Boback Lauren Kai
Lisa Siu
Victor Chiang
Chiara Rivas-Morello
Shigemi Nagai, PhD REB 213 Shigemi_nagai@hsdm.harvard.edu 617-432-2928 Mohammed Razzaque, PhD, MB, BS REB-312 mrazzaque@hms.harvard.edu 617-432-5768 Joel N.H. Stern, PhD joel_stern@hms.harvard.edu 617-432-1894 Mary Tavares, DMD MPH
Erica Shapiro Miguel Ortiz Derek Hou Kathryn Coyle Lauren Feldman Gino Inverso Peter Fung Alan Carlotto
Nathaniel Treister, DMD, DMSc ntreister@partners.org 617-732-6570 Xiu-Ping Wang, DMD, MD, PhD REB-407 xiuping_wang@hsdm.harvard.edu 617-432-0577 Lin Xu, PhD REB 415 Lin_xu@hsdm.harvard.edu 617-432-1764
Paiyal Popat*