BioMEMS

Enabling Killer Apps in Healthcare & Lifestyle

BioMEMS Chronic diseases Enabling Killer Apps stem in large part in Healthcare & Lifestyle from lifestyle related risk factors
Chris Van Hoof, imec, Belgium

LAST MONTH

I LEARNED ABOUT MY HEALTH RISKS

from lifestyle related risk factors

Bill Davenhall, geo-medicine guru, ESRI

HEALTH Chronic diseases = stemGenetics in large part

LANDSCAPE OF POC DX
Well-serviced Solutions exist
No compelling solutions on the market yet

Type Where? What?

Benchtop Clinical lab

Expensive and dedicated instrument, low-cost disposable

Portable Clinical lab or Drs office

Lower cost dedicated instrument, low-cost disposable

Smartphone Home or Drs office

No instrument. More functions integrated into disposable. Data processing in smartphone or cloud.

Instrument cost Disposable cost

$10-100k $10-200

$5-20k $10-200

$0 $0.50-10

smart phone

iLab

TECHNICAL CONCEPT ONE PLATFORM - MANY MARKERS

DNA/RNA
Mutations miRNA: marker for cancer and other diseases Pathogen DNA/RNA: infectious diseases (HepC, HIV, et.)

health tracking app + web services

Proteins
Wireless link
disposable microfabricated test flexible: blood, saliva, urine

Biomarkers for disease (cancer, Alzheimers, infectious diseases, heart disease, etc.)

Small molecules and metabolites

Metabolic information (e.g. cholesterol)

Microscopy
Blood cell count (e.g. HIV CD4+) Blood disorders (e.g. sickle cell anemia)

smart phone

iLab

TECHNICAL CONCEPT
Exploded view
health tracking app + web services

Detection chip Wireless link Fluidics chip

disposable microfabricated test flexible: blood, saliva, urine

PCB with radio, power, control Package

2-4 cm

~1 cm

200MM BIOMEMS WAFER

MICRO-PILLAR ARRAY FILTER

inlets outlet

Injection volume

distributor supply channel

micropillars

200m injection area

50m distribution area

5m separation area

MICRO-REACTOR FOR DNA AMPLIFICATION

Conv. ChipPCR PCR

HALF CREDIT CARD SIZE BIOMEMS

achieving on-chip DNA amplification and detection from whole blood sample
SEPARATION OF 11 DNA STRANDS IN 2CM LONG CHANNEL
DNA fragments are 10, 15, 20, 25, 35, 50, 75, 100, 150, 200 and 300bp

Panasonic-imec result

http://www.diginfo.tv/v/13-0022-r-en.php

HEALTH Chronic diseases = stemGenetics in large part from lifestyle related + Lifestyle risk factors + Environment
Bill Davenhall, geo-medicine guru, ESRI

Chronic diseases 3 lifestyle-related RISK FACTORS stem in large part are responsible from lifestyle related for all chronic diseases risk factors

PREVENTION
TRACK RISK FACTORS & ADAPT LIFESTYLE
Behavioral / lifestyle risk factors Intermediate risk factors

Unhealthy diet Physical inactivity Tobacco use

Raised blood pressure Raised blood glucose Overweight/obesity Abnormal blood lipids

GENETICS MAIN CHRONIC DISEASES

ENVIRONMENT

Heart disease | Stroke | Cancer | Chronic pulmonary diseases | Diabetes

PREVENTION WORKS !
REDUCING DIABETES AND HYPERTENSION PREVALENCE BY 5% WOULD SAVE APPROXIMATELY $9 BILLION ANNUALLY IN THE NEAR TERM

PREVENTION WORKS !
Source: Woodcock et al, Int J of Epidemiology, 2010

Reduction in global risk mortality by increasing physical activity

Review over 1M people

16

Total expenditure on health, % GDP

14

UNITED STATES GERMANY SWITZERLAND UNITED KINGDOM

12

10

OECD OE ECD da data at ta 1980 1990 2000 2008

1970

Technology should

EMPOWER
people towards disease prevention

QUALITY OF DATA

DESIRABLE FORMFACTOR

in SENSOR, CIRCUIT, SYSTEM, INTEGRATION TECHNOLOGY, ALGORITHM & DATA ANALYTICS

REQUIRES RADICAL INNOVATIONS

LOW COST LOW POWER

KILLER APPS THAT SAVE LIVES

Chronic diseases KILLER APP #1 stem in large part from STAY lifestyleFIT related risk factors

THE ADVERSE EFFECT OF EVOLUTION

18 kcal/kg/day

4.3 kcal/kg/day

WITH DRAMATIC CONSEQUENCES

NEEDS A BEHAVIOR CHANGE

A MULTITUDE OF DEVICES

IMECs CIRCUITS, SYSTEMS & ALGORITHMS FOR ENERGY EXPENDITURE

90%
Accuracy

Reliable
in everyday situations

1 month
Autonomy

GRAND CHALLENGE: ENERGY INTAKE

imec HYPERSPECTRAL SENSOR SEN

imec PHYSIOLOGICAL SENSOR

CHANGING BEHAVIOR IS TOUGH

KILLERdiseases APP #2 Chronic stem in large part MANAGE from lifestyle related STRESS risk factors

 Stressed person

30-40% $42-300B 25% 4/10

STRESS MANAGEMENT APPS

STRESS BIOMARKERS
Sympathetic and Parasympathetic Autonomic Nervous System Heart rate Respiration rate Salivation Perspiration Pupil dilation

EMERGING tools

 arameters P measured today

Skin conductance 3D-accelerometer Skin temperature Skin humidity Ambient temperature Ambient humidity

STRESS AT WORK
80% accuracy
in classifying stress from rest

STRESS PATIENTS
75% accuracy
in classifying patients from controls

SALIVA STRESS SENSOR

KILLERdiseases APP #3 Chronic stem in large part DISPOSABLE from lifestyle related HEALTH PATCH risk factors

REDESIGN FOR

ROLL-TO-ROLL MANUFACTURING

TAKE AN IMEC WIRELESS SENSOR DESIGN

ADAPT IT FOR FOIL INTEGRATION

INTEGRATE PASSIVES AND ICS

LOW-COST SKIN TEMPERATURE PATCH

HEALTH Chronic diseases = stemGenetics in large part from lifestyle related + Lifestyle risk factors + Environment
Bill Davenhall, geo-medicine guru, ESRI

Chronic diseases KEEP YOUR stem in large part ENVIRONMENT IN from lifestyle related risk factors CHECK

KILLER APP #4

imec ENVIRONMENTAL NO2 SENSOR

CONTINUOUS MEASUREMENT
at ambient temperature in varying humidity

EMERGING ppb NO2 MONITORING

Relative response (%)

-20 -40 -60 -80 -100 -120

Parking garage

12

14

16 18 Time (hours)

20

22

Clean air in nature

EMERGING environmental MONITORING

Chronic diseases stem in large part from lifestyle related risk factors
Basic NOSE functionality: array of eNose sensors on single chip

MEDICAL QUALITY DATA

IN

CONSUMER HANDS

Technology must EMPOWER PEOPLE towards disease prevention and towards a healthier lifestyle

ENCOURAGE & MOTIVATE

BioMEMS
Enabling Killer Apps in Healthcare & Lifestyle