REAL MEDICAL RESEARCH ON THE HCG WEIGHT LOSS DIET

Summary: Medical research on the HCG weight loss diet is unclear. Studies that seem
to follow the exact protocol according to Dr. Simeons contradict one another. How to
decide who is right.

Author Bio: Dr. Dennis Clark is a retired university research scientist with more than 30
years of experience in natural products medicine. Before you embark on any HCG
program, you must arm yourself with Dr. Clark's objective scientific analysis of the HCG
weight loss phenomenon. This program is not new, and it is not revolutionary. Get his
latest report, "Myths and Truths About HCG Weight Loss," at BestHCGWeightLoss.com.

The Original Research by Dr. A.T.W. Simeons

The research by Dr. Simeons was published in 1954 in his book, ‘Pounds and Inches’,
which is widely available at no cost on many websites. He designed his protocol to be
very precise regarding the amount of HCG required for injection, for the number of
calories and the types foods allowed, and for the optimal duration of the program. He
also published a brief synopsis of his program in the British medical journal Lancet (vol.
2, pp. 946-947, 1954).

This weight loss program has attracted considerable attention from the medical
community and from people who have undergone treatment. Its popularity is one reason
why so many people, including medical doctors, have decided to offer opinions on
whether it works. The success of HCG for weight loss has been so great that it has
attracted negative attention from the FDA.

Before I go further, I want to note that the FDA is not an agency that serves human
health. It is an agency that serves the financial interests of pharmaceutical companies.
Negative attention from the FDA almost always means that the health benefits of the
treatment in question might undermine drug profits. Indeed, seeing the statement that
HCG is not approved by the FDA for weight loss is, in my opinion, support for the
effectiveness of this protocol.

Medical Studies

The government’s PubMed database lists more than 18,000 journal articles on HCG,
with less than a few dozen of these having anything to do with weight loss. Most of the
research on this hormone involves fertility, pregnancy, and the detection of cancerous
tumors. What I want to do is call your attention to just three studies as examples of the
confusion that is rampant in the medical literature on HCG and weight loss.

1963 Study

This study was published in the American Journal of Clinical Nutrition (vol. 12, pp. 230-
234, 1963), at the height of popularity of the HCG diet plan in the U.S. In my reading of
this article, it looks to me as though the researchers behind this study, from the
University of California, San Francisco, School of Medicine, followed the Simeons
protocol to the letter. There was one exception: the consumption of a baked potato each
day, which is not on Simeons’ list of allowed vegetables. The main result of the study
was an average loss of 6.5 pounds in the HCG-treated group, compared with an
average loss of 8.8 pounds in the untreated (control) group. The authors concluded that
the hormone did not cause weight loss.

This study is remarkable for a couple reasons. One is that, in spite of following the
Simeons protocol for 40 days, neither the treatment group nor the control group came
close to the amount of weight loss that is expected. A starvation diet alone (i.e., 550
calories per day) should have caused more weight loss than reported. In fact, one
subject on HCG even gained weight. The other reason that this study is remarkable is
that the number of study subjects (i.e., 10 in the treatment group, 9 in the control group)
and the variability of the results within each group provided insufficient statistical power
to explain anything at all! Indeed, this study offered no comparative statistical analysis
of weight loss. In other words, the results did not support any conclusions whatsoever.

Nevertheless, one or more factors are not obvious in this study. Generally when a study
has such insignificant results, the subjects were not compliant – i.e., they did not follow
the protocol very well. The researchers offered no comment on this possibility, so we will
never know why both the treatment group and the control group underperformed.

1973 Study

This study was published 10 years later, also in the American Journal of Clinical
Nutrition (vol. 26, pp. 211-218, 1963). The researchers who conducted it, at the
American Society of Bariatric Physicians Research Council, studied about twice as
many subjects as the 1963 study above. The final result was an average loss of 19.96
pounds in the HCG group and 11.05 pounds in the control group. More importantly, the
statistical analysis supported this difference as being significant. The conclusion of this
study was that HCG did cause weight loss.

1995 Meta Analysis

Meta analysis refers to a comparison of multiple studies on the same topic. This meta
analysis was published in the British Journal of Clinical Pharmacology (vol. 40, pp. 237-
243, 1995) by researchers at Vrije University, Netherlands. They evaluated 16 studies
and observed that most of them were of ‘poor methodological quality’ (meaning, bad
science). Only one of the 12 articles of acceptable quality showed an effect on weight
loss by HCG. The researchers concluded that ‘there is no scientific evidence that HCG
is effective in the treatment of obesity’.

Meta analysis studies have become very popular in medicine because of the notion that
a trend over multiple studies shows the truth. Unfortunately, the basic rules of statistics
invalidate any such comparisons. Moreover, when even one study stands out against
the majority, it is wrong to ignore it completely as these researchers have done. It would
be much more valuable to figure out why some studies give contradictory results to one
another.

This meta analysis also reveals what I call the dirty laundry of medical science – i.e.,
most research is so flawed that it is almost useless for saying anything at all with
certainty. In fact, this is kind of a scary thought, isn’t it?

Take Home Lesson

Human subject research is the most difficult kind of study because of so many variables
that are out of the control of the experimental design. Determining cause and effect is
almost impossible. Nevertheless, we can see from some research that HCG can and
does drive weight loss. My view is that studies that show this result are better in terms
of sticking more closely to the Simeons protocol in the experimental design, then having
the study subjects adhere closely to it.

What I conclude regarding HCG and weight loss is based on what I have seen for
myself. This includes many, many people who have had the same results that Simeons
documented based on his clinical experience with thousands of patients. I have also
had the same results for myself. There is nothing like personal experience! The key to
my experience, however, was monitoring my body fat composition. Weight loss is
almost irrelevant by itself. My result was a reduction of 20 pounds AND of 6% body fat
in less than 30 days. Reduction in body fat is supposed to be the main effect of HCG.

Medical researchers are apparently going to argue the merits of HCG and weight loss
until the end of time, citing whichever research results support their arguments. As a
scientist myself, I have no doubt whatsoever that Simeons was right and that my body
changes occurred because of HCG.

One More Thing

Early studies on lab animals are now beginning to show that HCG interacts with the
hormone leptin. Leptin is the new master fat hormone that has been known only since
1994. Like HCG, leptin also carries a signal to the hypothalamus. I predict that the more
we find out about the interaction between these two hormones, the more we will
understand how ingenious the Simeons protocol really is.