Health Correlator - Total Cholesterol and Cardiovascular Disease - A U-Curve Relationship PDF

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This blo- is about statistics, evolutio!, !utritio!, li&estyle, a!d health issues$ ' combi!atio! o& these issues$ The &ocus is o! Bua!titative research a!d how it ca! be applied i! practice$ =ut you may see other types o& posts here (e$-$, recipes, ideas, co!cepts, theories) &rom time to time$
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(See also u!der 56abels5 at the bottom"ri-ht area o& this blo-) 7"8ealth*orrelator &or 14cel (8*1)"9 7"8*1 posts"9 7":arp/6S"9 7":arp/6S posts"9 7";our!al o& 1volutio! a!d 8ealth"9 7"<y tra!s&ormatio!"9 7"*ompe!satory adaptatio!"9 7"The *hi!a Study"9 7"<y e4perie!ce"9 7"=ook reviews"9 7"Research reviews"9 7"1volutio!"9 7"Statistics"9 7"Recipes"9 7"3!teresti!- li!ks"9 7"See your doctor"9 >>> /6S 'pplicatio!s Symposium? @0 <ay " 1 ;u!e 201A? <o!treal, *a!ada >>>
Saturday, December 19, 2009
Total cholesterol and cardiovascular disease: A U-curve relationship

The hypothesis that blood cholesterol levels are positively correlated with heart disease (the lipid hypothesis) dates back to Rudolph irchow i! the mid"1#00s$ %!e &amous study that supported this hypothesis was '!cel (eys)s Seve! *ou!tries Study, co!ducted betwee! the 19+0s a!d 19,0s$ This study eve!tually served as the &ou!datio! o! which much o& the advice that we receive today &rom doctors is based, eve! thou-h several other studies have bee! published si!ce that provide little support &or the lipid hypothesis$ The -raph below (source. ca!ibaisereis$com, with ma!y tha!ks to % /rimitivo) shows the results o& o!e study, i!volvi!- ma!y more cou!tries tha! (ey)s Seve! *ou!tries Study, that actually su--ests a 012'T3 1 li!ear correlatio! betwee! total cholesterol a!d cardiovascular disease$
Ned Kock
About Me
3 stro!-ly believe that li&estyle, !utritio! a!d e4ercise habits that are compatible with our evolutio!ary past are the key to optimal health$ %! the other ha!d, 3 do !ot believe that closely mimicki!- li&e i! the /aleolithic is optimal &or health, or eve! viable$ 3 am a researcher, so&tware developer, co!sulta!t, a!d colle-e
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pro&essor$ Two o& my mai! areas o& research are !o!li!ear varia!ce"based structural eBuatio! modeli!-, a!d evolutio!ary biolo-y as it applies to the study o& huma!"tech!olo-y i!teractio!$ <y de-rees are i! e!-i!eeri!(=$1$1$), computer scie!ce (<$S$), a!d busi!ess (/h$D$)$ 3 am i!terested i! the applicatio! o& scie!ce, statistics, a!d tech!olo-y to the u!dersta!di!- o& huma! health a!d behavior$ 3 blo- about evolutio!, health, statistics, a!d tech!olo-y$ <y perso!al web site co!tai!s li!ks to my co!tact i!&ormatio! a!d &reely available articles related to the topics o& my blo-s. !edkock$com$
0ow, most relatio!ships i! !ature are !o!li!ear, with Buite a &ew &ollowi!- a patter! that looks like a C"curve (plai! or i!verted)? sometimes called a ;"curve patter!$ The -raph below (source also. ca!ibaisereis$com) shows the C"curve relatio!ship betwee! total cholesterol a!d mortality, with cardiovascular disease mortality i!dicated throu-h a dotted red li!e at the bottom$
Ned Kock on the Web 0ed(ock$com, Eacebook, 6i!ked3!, Twitter ooks b! Ned Kock 1volutio!ary /sycholo-y a!d 3!&ormatio! Systems Research. ' 0ew 'pproach to Studyi!- the 1&&ects o& <oder! Tech!olo-ies o! 8uma! =ehavior ('maDo!, Spri!-er) *ompe!satory 'daptatio!. C!dersta!di!- 8ow %bstacles *a! 6ead to
This -raph has bee! obtai!ed throu-h a !o!li!ear a!alysis, a!d 3 thi!k it provides a better picture o& the relatio!ship betwee! total cholesterol (T*) a!d mortality$ =ased o! this -raph, the best ra!-e o& T* that o!e ca! be at is somewhere betwee! 210, where cardiovascular disease mortality is mi!imiDed? a!d 220, where total mortality is mi!imiDed$ The total mortality curve is the o!e i!dicated throu-h the &ull blue li!e at the top$ 3! &act, it su--ests that mortality i!creases sharply as T* decreases below 200$ 0ow, these -raphs relate T* with disease a!d mortality, a!d say !othi!- about 6D6 cholesterol (6D6)$ 3! my ow! e4perie!ce, a!d that o& ma!y people 3 k!ow, a T* o& about 200 will typically be associated with a sli-htly elevated 6D6
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(e$-$, 110 to 1+0), eve! i& o!e has a hi-h 8D6 cholesterol (i$e$, -reater tha! F0)$ Get, most people who have a 6D6 -reater tha! 100 will be told by their doctors, usually with the best o& the i!te!tio!s, to take stati!s, so that they ca! 5keep their 6D6 u!der co!trol5$ (6D6 levels are usually calculated, !ot measured directly, which itsel& creates a whole !ew set o& problems$) 'las, reduci!- 6D6 to 100 or less will typically reduce T* below 200$ 3& we -o by the -raphs above, especially the o!e showi!- the C"curves, these &olks) risk &or cardiovascular disease a!d mortality will -o up " e4actly the opposite e&&ect that they a!d their doctors e4pected$ '!d that will cost them &i!a!cially as well, as stati! dru-s are e4pe!sive, i! part to pay &or all those T ads$
/osted by 0ed (ock at A.0+ /< 6abels. cardiovascular disease, cholesterol, ; curve, research, C curve
Success ('maDo!, =uy=ooks%!The:eb) 6i!ks to other books by 0ed (ock ooks cited in posts Biochemistry and Molecular Biology Biological Anthropology Biology for Bodybuilders Dawn of Art Designing Resistance Training Programs Eve Spo e Evolution and !uman Behavior
"# co$$ents: Deadsu!rise said$$$ 8i 0ed, 3 posted a spa!ish tra!slatio! o& this article o! http.HHdeadsu!rise$!et H2010HcolesterolIyIe!&ermedadIcardiovascular$html 8ope you do!)t mi!d$ 3 state the source with a li!k at the be-i!!i!- o& the article$ Tha!ks &or the whole blo-, it)s &asci!ati!-$
;uly 2A, 2010 at #.@+ '<
Evolutionary "enetics E#ercise Physiology Ending Aging "enes in $onflict "enome "ood $alories% Bad $alories "rooming% "ossip% and the Evolution of &anguage !ow the Mind 'or s !uman (niversals Mathematical Models of Social Evolution )utrition and Physical Degeneration *n the *rigin of Species Perfect !ealth Diet Personality
0ed (ock said$$$ 8i Deadsu!rise$ Sure, !o problem$ Tha!ks$

;uly 2A, 2010 at 12.+@ /<
% /rimitivo said$$$ *holesterol, lo!-evity, i!telli-e!ce, a!d health$ " http.HHraypeat$comHarticlesHarticlesHcholesterol" lo!-evity$shtml
December 11, 2010 at 9.@1 /<
ivek Rau said$$$ <y -uess is that o!e would have to correct this data &or smoki!- a!d alcohol co!sumptio! (at least)
Physiology of Sport and E#ercise
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be&ore drawi!- co!clusio!s about cholesterol vs cardiovascular disease$ %bserve some 3slamic cou!tries like =a!-ladesh a!d Saudi 'rabia o! the le&t o& the -raph, i$e$ lower cholesterol tha! the C$S$ but hi-her heart disease$ The prohibitio! o& alcohol i! those cou!tries will de&i!itely have a! impact o! heart disease rates$ <a!y o& the less developed cou!tries have hi-her rates o& smoki!- a!d less adva!ced cardiac care tha! the C$S$, so that will also a&&ect mortality &rom cardiovascular disease$
;a!uary 9, 2011 at 9.A# '<
Population "enetics Population "enetics% Molecular Evolution% and the )eutral Theory Principles of Population "enetics Science and Practice of Strength Training Sugar )ation The Descent of Man% and Selection in Relation to Se# The Evolutionary Synthesis The "enetical Theory of )atural Selection The "od "ene The Evolution of Desire The Mating Mind The Paleo Diet The Primal Blueprint The Selfish "ene +anomamo lo%s and sites &here Ned co$$ents Animal Pharm
% /rimitivo said$$$ 8i 0ed$ ;ust to clari&y that both those -raphs were e4tracted &rom my 14cel database o! cholesterol mortality " http.HHwww$ca!ibaisereis$comH2009H09 H19Hlow"cholesterol"certai!ly"!ot"healthyH
;a!uary 1A, 2011 at #.22 '<
0ed (ock said$$$ Tha!ks Ricardo$ 3 have edited the post, !ow i!dicati!- the ori-i!al source$ 's always, tha!ks muchJ
;a!uary 1A, 2011 at 12.@@ /<
ia-ra %!li!e said$$$ &or a simple lack o& i!&ormatio! about this a perso! could save their ow! li&e, a &ather o& my best &rie!d die about a year a-o, this me! !eeded a !ormal bypass sur-ery, but duri!- the operatio! doctors &ou!d that really !eed a triple baypass, some hours later he die$
'pril 1, 2011 at 10.+9 '<
0ed *lack said$$$ These data are mai!ly -athered i! populatio!s that eat moder! diets$ Erom time to time 3 read low"carbers talki!- about tryi!- to -et their T* up beyo!d 200 but does a!ybody k!ow where the bottom o& the C is &or people with paleolithic habitsK <a!y tha!ks &or your work 0ed
;u!e 2#, 2011 at 1.A@ /<
$ooling ,nflammation Evolutionary Psychiatry -at !ead -ree the Animal "nolls !unt% "ather% &ove
<att Sto!e said$$$ Sorry 3 did!)t &i!d this earlier$ This is awesome 0edJ
December 9, 2011 at 2.1F /<
!yperlipid &ow.$arb for +ou Mar /s Daily Apple Michael Bar er/s Type 0
'!o!ymous said$$$
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8ello, 3 wa!ted to cite the &i-ures you have here i! a discussio! r$e$ cholesterol levels a!d mortality, but the li!ks you i!clude seem !o lo!-er to work, a!d 3 ca!)t &i!d the -raphs$ 3& you have a!y su--estio!s o! how to track them dow!, it would be much appreciated$ 3 do!)t &eel com&ortable citi!u!traceable data$
;u!e A, 2012 at #.+2 /<
1etosis Prone Diabetes My $arb Sane.Asylum Paleo!ac s Perfect !ealth Diet Primal 'isdom Protein Power Ramblings of a $arnivore
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201@ (20) 2012 (@A) 2011 (+1) 2010 (11A) 2009 (A) December (A) 2rowth hormo!e. The &ou!tai! o& youth 8al&"hearted 'tki!s diet a!d cardiovascular diseas$$$ Total cholesterol a!d cardiovascular disease. ' C"$$$ Re&i!ed carbs, su-ar, a!d cholesterol. <y ow! e4pe$$$
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Health Correlator - Total Cholesterol and Cardiovascular Disease - A U-Curve Relationship PDF

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Saturday, December 19, 2009

Total cholesterol and cardiovascular disease: A U-curve relationship