Endometriosis Definition Endometriosis is a disorder of the female reproductive system.

. In endometriosis, the endometrium, which normally lines your uterus, grows in other places as well. Most often, this growth is on your fallopian tubes, ovaries or the tissue lining your pelvis. When endometrial tissue is located elsewhere in your body, it continues to act as it normally would during a menstrual cycle: It thickens, breaks down and bleeds each month. Because there s nowhere for the blood from this displaced tissue to e!it your body, it becomes trapped, and surrounding tissue can become irritated. "rapped blood may lead to cysts, scar tissue and adhesions # abnormal tissue that binds organs together. "his process can cause pelvic pain, especially during your period. Endometriosis also can cause fertility problems. Symptoms Endometriosis can be mild, moderate or severe, and without treatment, it tends to get worse over time. $ome women with endometriosis have no signs and symptoms at all, and the disease is discovered only when bits of endometrial tissue %implants& are found outside the uterus during an unrelated operation, such as a tubal ligation. 'ther women may e!perience one or more of the following signs and symptoms:

Painful periods (dysmenorrhea). (elvic pain and cramping may begin before and e!tend several days into your period and may include lower back and abdominal pain. $everity of pain isn t necessarily a reliable indicator of the e!tent of the condition. $ome women with mild endometriosis have intense pain, while others with more severe scarring may have little pain or even no pain at all. Pelvic pain at other times. )ou may e!perience pelvic pain during ovulation, a sharp pain deep in the pelvis during intercourse, or pain during bowel movements or urination. Excessive bleeding. )ou may e!perience occasional heavy periods %menorrhagia& or bleeding between periods %menometrorrhagia&. Infertility. Endometriosis is first diagnosed in some women who are seeking treatment for infertility. Endometriosis is sometimes mistaken for other conditions that can cause pelvic pain, such as pelvic inflammatory disease %(I*& or ovarian cysts. It may be confused with irritable bowel syndrome %IB$&, a condition that causes bouts of diarrhea, constipation and abdominal cramping. IB$ can accompany endometriosis, which can complicate the diagnosis.

When to see a doctor $ee your doctor if you have signs and symptoms that may indicate endometriosis. "he cause of chronic or severe pelvic pain may be difficult to pinpoint. But discovering the problem early may help you avoid unnecessary complications and pain. auses "he cause of endometriosis remains uncertain. E!perts are studying the roles that hormones and the immune system play in this condition. 'ne theory holds that menstrual blood containing endometrial cells flows back through the fallopian tubes, takes root and grows. +nother hypothesis proposes that the bloodstream carries endometrial cells to other sites in the body. $till another theory speculates that a predisposition toward endometriosis may be carried in the genes of certain families. + faulty immune response also may contribute to the development of endometriosis. 'ther researchers believe that certain cells present within the abdomen in some women retain their ability to become endometrial cells. "hese same cells were responsible for the growth of the women s reproductive organs at the embryo stage. It s believed that genetic or environmental influences in later life allow these cells to give rise to endometrial tissue outside the uterus. !is" factors +mong the factors that place you at greater risk of developing endometriosis are:

,ever giving birth to an infant -aving endometriosis diagnosed in your mother -aving menstrual cycles shorter than ./ days with bleeding lasting longer than eight days -aving a medical condition that prevents the normal passage of menstrual flow E!periencing damage to cells that line the pelvis by previous infection Being white or +sian Endometriosis usually takes several years after the onset of menstruation %menarche& to develop. When menstruation ends permanently with menopause or temporarily with pregnancy, the signs and symptoms of endometriosis stop. "hey can begin again after pregnancy when menstruation resumes. 0arely, hormone replacement therapy after menopause can reactivate the disorder.

omplications

"he main complication of endometriosis is impaired fertility. +ppro!imately one1 third to one1half of women who have endometriosis have difficulty getting pregnant. 2or pregnancy to occur, an egg must be released from an ovary, travel through the fallopian tube, become fertili3ed by a sperm cell and attach itself to the uterine wall to begin development. Endometriosis can produce adhesions that can trap the egg near the ovary. It may inhibit the mobility of the fallopian tube and impair its ability to pick up the egg. In most cases, however, endometriosis probably interferes with conception in more comple! ways. *espite these possible complications, many women with endometriosis are still able to conceive. It may take them a little longer to get pregnant, but most women with mild to moderate endometriosis can become pregnant. *uring pregnancy, most women have no signs or symptoms of endometriosis. *octors sometimes advise women with endometriosis not to delay having children because endometriosis tends to worsen with time. "he longer you have endometriosis, the greater your chance of becoming infertile. +lthough cancerous changes may occur in endometrial implants, the rate of cancer in this tissue hasn t been shown to be higher than that in other tissues. -aving endometriosis doesn t increase your risk of uterine cancer or ovarian cancer. Preparing before your appoitment )our first appointment will be with either your primary care physician or a gynecologist. If you re seeking treatment for infertility, you may be referred to a doctor who speciali3es in reproductive hormones and optimi3ing fertility %reproductive endocrinologist&. Because appointments can be brief, and it can be difficult to remember everything you want to discuss, it s a good idea to prepare in advance of your appointment. What you can do

Write do#n any symptoms you$re experiencing. Include all of your symptoms, even if you don t think they re related. %a"e a list of any medications or vitamin supplements you ta"e. Write down doses and how often you take them. &ave a family member or close friend accompany you' if possible. )ou may be given a lot of information at your visit, and it can be difficult to remember everything. (a"e a noteboo" or notepad #ith you. 4se it to write down important information during your visit.

Prepare a list of )uestions to as" your doctor. 5ist your most important 6uestions first, in case time runs out. 2or endometriosis, some basic 6uestions to ask your doctor include:

-ow is endometriosis diagnosed7 -ow much e!perience do you have in diagnosing and treating endometriosis7 What medications are available to treat endometriosis7 Is there a certain medication that can improve my symptoms7 What side effects can I e!pect from medication use7 4nder what circumstances do you recommend surgery7 Will I take a medication before or after surgery7 Will endometriosis affect my ability to become pregnant7 8an treatment of endometriosis improve my fertility7 8an you recommend any alternative treatments I might try7 Make sure that you understand completely everything that your doctor tells you. *on t hesitate to ask your doctor to repeat information or to ask follow1up 6uestions for clarification. What to expect from your doctor $ome potential 6uestions your doctor might ask include:

-ow often do you e!perience these symptoms7 -ow long have you been e!periencing symptoms7 -ow severe are your symptoms7 *o your symptoms seem to be related to your menstrual cycle7 *oes anything improve your symptoms7 *oes anything make your symptoms worse7 (ests and diagnosis "o diagnose endometriosis and other conditions that can cause pelvic pain, your doctor will ask you to describe your symptoms, including the location of your pain and when it occurs. "ests to check for physical clues of endometriosis include:

Pelvic exam. *uring a pelvic e!am, your doctor manually feels %palpates& areas in your pelvis for abnormalities, such as cysts on your reproductive organs or scars behind your uterus. 'ften it s not possible to feel small areas of endometrial implantation, unless they ve caused a cyst to form.

*ltrasound. *uring a vaginal ultrasound, a wand1shaped scanner %transducer& is inserted into your vagina. In an ultrasound of the pelvis via the abdomen, a small scanner is moved across your abdomen. Both tests use sound waves to provide a video image of your reproductive organs. 4ltrasound imaging won t definitively tell your doctor whether or not you have endometriosis, but it is a useful tool for identifying cysts associated with endometriosis %endometriomas&. +aparoscopy. "he only way for your doctor to know for certain that you have endometriosis is by looking inside your abdomen %direct visuali3ation& for signs of endometrial tissue. 8ommonly, this is accomplished during a minor surgical procedure called laparoscopy. )ou receive a general anesthetic before the procedure begins. 4sing a special needle, your abdomen is e!panded %distended& with carbon dio!ide gas so that the reproductive organs are easier to see. + tiny incision is made near your navel, and a slender viewing instrument %laparoscope& is inserted. By moving the laparoscope around, the surgeon can view the pelvic and other abdominal organs, looking for signs of endometrial implants. If you have endometriosis, laparoscopy will tell you and your doctor the e!tent, si3e and location of endometrial tissue outside your uterus. "his information will help your doctor guide you through treatment options. $ometimes, symptoms and signs are obvious enough that a laparoscopy isn t necessary.

,lood test. 8ancer antigen 9.: %8+ 9.:& is a blood test often used to detect tumor markers for certain cancers, but it s also used to detect a certain protein found in the blood of women with endometriosis. +lthough 8+ 9.: commonly reveals an elevation in such blood protein in women with advanced endometriosis, it s not as sensitive to mild or moderate disease. +s with cancer, 8+ 9.: doesn t perform well as a screening test for endometriosis because it s least sensitive when the disease is in its earliest stages. (reatments and drugs "reatment for endometriosis is usually with medications or surgery. "he approach you and your doctor choose depends on the severity of your signs and symptoms and whether you hope to become pregnant. ;enerally, doctors recommend trying conservative treatment approaches first, opting for surgery as a last resort. Pain medications )our doctor may recommend that you take an over1the1counter pain reliever, such as ibuprofen %+dvil, Motrin IB, others&, to help ease painful menstrual cramps. -owever, if you find that taking the ma!imum dose doesn t provide full relief, you may need to try another treatment to manage your signs and symptoms. &ormone therapy

$upplemental hormones are effective in reducing or eliminating the pain of endometriosis. "hat s because the rise and fall of hormones during a woman s menstrual cycle causes endometrial implants to thicken, break down and bleed. In fact, if hormonal therapy has little to no effect on your symptoms, consider 6uestioning the diagnosis of endometriosis or its relationship to your symptoms. -ormonal therapies used to treat endometriosis include:

&ormonal contraceptives. Birth control pills, patches and the vaginal ring help control the hormones responsible for the buildup of endometrial tissue each month. Most women have lighter and shorter menstrual flow when they re using a hormonal contraceptive. 4sing hormonal contraceptives # especially continuous cycle regimens # can reduce or eliminate the pain of mild to moderate endometriosis. -onadotropin.releasing hormone (-n.!&) agonists and antagonists. "hese drugs block the production of ovarian1stimulating hormones. "his action prevents menstruation and dramatically lowers estrogen levels, causing endometrial implants to shrink. ;n10- agonists and antagonists can force endometriosis into remission during the time of treatment and sometimes for months or years afterward. "hese drugs create an artificial menopause that can sometimes lead to troublesome side effects, such as hot flashes and vaginal dryness. + low dose of estrogen may be taken along with these drugs to decrease such side effects. Dana/ol. +nother drug that blocks the production of ovarian1 stimulating hormones, preventing menstruation and the symptoms of endometriosis, is dana3ol. In addition, it suppresses the growth of the endometrium. -owever, dana3ol may not be the first choice because it can cause unwanted side effects, such as acne and facial hair. %edroxyprogesterone (Depo.Provera). "his in<ectable drug is effective in halting menstruation and the growth of endometrial implants, thereby relieving the signs and symptoms of endometriosis. Its side effects can include weight gain, decreased bone production and depressed mood. 0romatase inhibitors. "hese agents, known for their effectiveness in treating breast cancer, also may be useful for endometriosis. +romatase inhibitors work by blocking the conversion of hormones such as androstenedione and testosterone into estrogen and by blocking the production of estrogen from endometrial implants themselves. "his deprives endometriosis of the estrogen it needs to grow. Early studies suggest that aromatase inhibitors are at least as good as other hormonal approaches and may be better tolerated. -ormonal therapies aren t a permanent fi! for endometriosis. It s possible that you could e!perience a recurrence of your symptoms after stopping treatment.

onservative surgery

If you have endometriosis and are trying to become pregnant, surgery to remove implants may increase your chances of success. If you have severe pain from endometriosis, you may also benefit from surgery. 8onservative surgery removes endometrial growths, scar tissue and adhesions without removing your reproductive organs. )our doctor may do this procedure laparoscopically, or through traditional abdominal surgery in more e!tensive cases. In laparoscopic surgery, a slender viewing instrument %laparoscope& is inserted through a small incision near your navel. ;uided by the laparoscope, your doctor inserts other instruments through another small incision to remove endometrial implants. $uch instruments might include a laser, small surgical instruments or a cautery # an instrument that destroys tissue with heat. +ssisted reproductive technologies to help you become pregnant are sometimes preferable to conservative surgery, and doctors often suggest these approaches if conservative surgery is ineffective. &ysterectomy In severe cases of endometriosis, a total hysterectomy and the removal of both ovaries may be the best treatment. -ysterectomy alone is also effective, but removing the ovaries ensures that endometriosis will not return. Either type of surgery is typically considered a last resort, especially for women still in their reproductive years. )ou can t get pregnant after a hysterectomy. +ife style and home remedies If your pain persists or if finding a treatment that works takes some time, you can try measures at home to relieve your discomfort. Warm baths and a heating pad can help rela! pelvic muscles, reducing cramping and pain. 2inding a doctor with whom you feel comfortable is crucial in managing and treating endometriosis. )ou may also want to get a second opinion before starting any treatment regimen to be sure you know all of your options and the possible outcomes. 0lternative medicine $ome women report relief from endometriosis pain after acupuncture treatment. -owever, research is sparse on this # or any other # alternative treatment for endometriosis. If you re interested in pursuing this therapy in the hope that it could help you, ask your doctor to recommend a reputable acupuncturist. 8heck with your insurance company beforehand to see if the e!pense will be covered. oping and support

5eft undiagnosed or untreated, endometriosis can be a frustrating condition. (ainful periods can cause you to miss work or school and can strain relationships. 0ecurring pain can lead to depression, irritability, an!iety, anger and feelings of helplessness. Infertility linked to endometriosis also can cause emotional distress. "hat s why it s important to seek treatment if you suspect you may have endometriosis. =eeping a record of your symptoms can aid your doctor in your diagnosis. If you re dealing with endometriosis or its complications, you may want to consider <oining a support group for women with endometriosis or fertility problems. $ometimes it helps simply to talk to other women who can relate to your feelings and e!periences. If you can t find a support group in your community, look for one on the Internet. Prevention Because the causes of endometriosis remain elusive, no definite techni6ues to manage the risk of endometriosis have been developed. +lthough it appears that women who have given birth are less likely to develop endometriosis than are women who have not, many other factors play a more important role in the decision to have a child.

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