PATHOLOGY 2ND SEM 1st LE: REPRODUCTIVE SYSTEM AND BREAST, DERMA and MALE GENITAL TRACT DERMAPATHO

recall 1. Bullae = Pemphigous vulgaris 2. Munros = Psoriasis 3. Tzancks = Herpes 4. Basal cell carcinoma = Pallisading 5. Soles and palms = Lucidum 6. Parakeratosis = Nuclei retention 7. Vitiligo = Destruction of melanocytes 8. Hidradenous papilla = sweat glands 9. Impetigo = most common case 10. Halo of halo nevi = lymphocytic infiltration 11. Seborrheic keratitis = Squamous eddy 12. Collagen deposition withing scar = keloid/hypertrophic 13. Molluscum contagiosum = molluscum bodies 14. Clarkes staging = suprabasal 15. Cancer sun exposure UV = UV B FGT, MGT, BREAST 1. a. b. c. 2. a. b. c. d. 3. a. b. c. d. 4. Most common malignant neoplasm in the vulva: Squamous cell carcinoma Malignant melanoma Lymphoma This is characterized by atypical pleomorphic cells seen in the bottom one third of the vulvar epithelium: VAIN I VAIN II VIN I VIN II This is characterized by atypical pleomorphic cells seen in the bottom two thirds of the vulvar epithelium: VAIN I VAIN II VIN I VIN II Neoplastic squamous cells confined above the basement membrane and involving the full thickness of the vulvar epithelium: VIN III VIN II VAIN II VAIN III Virus associated with condyloma acuminatum: Human papilloma virus Herpes simplex Pox virus Umbilicated lesions with cytophatic manifestations: Herpes simplex Human papilloma virus Molluscom contagiosum Varacells mulloscoid bodies as

9. a. b. c. d.

This is a fungal infection of the cervix: Trichomoniasis Leptotrix Cocobacilli Candida sp.

10. This is cell on pap smear is equivalent to carcinoma in situ of the cervix in biopsy: a. Atypical squamous cell undetermined potential b. Low grade intraepithelial neoplasia c. High grade intraepithelial neoplasia 11. This is a pedunculated lesion in the cervix with benign cervical glands disposed in a fibrovascular core: a. Endocervical polyp b. Squamous metaplasia c. Glandular adenosis 12. This consists of endometrial glands embedded within the myometrial wall a. Endometrial polyp b. Adenomyosis c. Leiomyoma and stroma

13. This is a proliferation of benign smooth muscle cells in whorls and fascicles with well defined borders: a. Endometrial polyp b. Adenomyosis c. Leiomyoma 14. This is an increase in gland to stroma ratio with back to back configuration of atypical glands in a sparse stroma: a. Complex hyperplasia with atypia b. Complex hyperplasia without atypia c. Simple hyperplasia with atypia 15. This pedunculated lesion consists of benign endometrial glands lining and embedded in a fibrovascular stroma attached to the endometrial wall: a. Endocervical polyp b. Endometrial polyp c. Hyperplastic Endometrium 16. a. b. c. d. This is a malignant lesion in the myometrium: Leiomyoma Leiomyosarcoma Fibrioid Polyp

a. b. c. d. 5. a. b. c. 6. a. b. c. d. 7. a. b. c. d. 8. a. b. c. d.

17. Presence of immature chorionic villi and deciduas tissues within fallopian tube lumen a. Ectopic pregnancy b. Choriocarcinoma c. Intraabdominal pregnancy 18. Fallopian tubes infiltrated by numerous neutrophils with concomitant necrotic debris: a. Acute salphingitis b. Chronic salphingitis c. Tubal pregnanacy 19. Epithelial malignant neoplasm of the histologically similar to the endometrial tissues a. Endometrial carcinoma b. Serous carcinoma c. Mucinous carcinoma ovary

The most common carcinoma in the cervix: Adenocarcinoma Squamous cell carcinoma Small cell carcinoma Clear cell carcinoma This cervical carcinoma shows keratrin pearls and keratinization of the cytoplasm of neoplastic squamous cells: Non keratinizing type Neuroendocrine type Adenocarcinoma type Keratinizing type

20. Epithelial malignant neoplasm of the ovary having malignant mucin filled cells with pleomorphic basally located nuclei and stroma invasion a. Endometrial carcinoma b. Serous carcinoma c. Mucinous carcinoma Page 1 of 4

21. Neoplasm of the ovary with transitional type epithelial tumor nests a. Brenner tumor b. Serous carcinoma c. Borderline mucinous tumor d. NOTA 22. a. b. c. d. 23. a. b. c. All of the following are germ cells tumor except: Yolk sac tumor Embryonal carcinoma Dysgerminoma Fibroma Ovarian tumor that is associated with Meigs syndrome Fibroma Brenner tumor Dysgerminoma

33. a. b. c. 34. a. b. c. d.

Men can develop breast cancers. This statement is: True False Only if he has liver disease Breast enlargement in men is called: Fibroadenoma Gynecomastia Fibrocystic change Ductal hyperplasia

35. Which of the following is a non proliferative breast lesion a. Fibroadenoma b. Fibrocystic change c. Atypical ductal hyperplasia d. Complex fibroadenoma 36. The following features are seen in fibrocystic change except for: a. Cysts b. Stromal fibrosis c. Adenosis d. Stromal overgrowth 37. a. b. c. d. The following are proliferative lesions except for: Fibrocystic change Duct hyperplasia Sclerosing adenosis Fibroadenoma with complex features

24. Consists of developed tissue derivatives from the three germ layers seen in this ovarian lesion a. Mature cystic teratoma b. Thecoma c. Sertoli leydig cell tumor d. Serous carcinoma 25. Type of germ cell tumor predominance of colloid forming thyroid tissues in the ovary: a. Mature cystic teratoma b. Struma ovarii c. Immature teratoma d. Fibroma 26. Consists of immature germ cells with central nuclei and are arranged nests dwlimited by stroma with lymphocytic infiltrates a. Dysgerminoma b. Teratoma c. Yolk sac tumor 27. Trophoblastic lesion characterized by hydrophic villi with cisterns and the lack of fetal parts a. Complete hydatidiform mole b. Partial hydatidiform mole c. Choriocarcinoma 28. A malignant biphasic neoplasm of cytotrophoblasts and areas of necrosis a. Complete mole b. Partial mole c. Choriocarcinoma 29. a. b. c. syncitioand

38. Features seen in severe ductal hyperplasia are the following except for: a. Intact myoepithelial cells b. Intense proliferation of ductal cells c. Stromal invasion 39. The most common histologic type of breast carcinoma is: a. Invasive ductal carcinoma, no special type b. Medullary carcinoma c. Lobular carcinoma d. Tubular carcinoma 40. The most important prognostic indicator for breast carcinoma is: a. Tumor differentiation b. Lymph node metastases c. Lymphovascular space invasion d. Nuclear grade 41. This tumor marker is a reflection of gene amplification in breast carcinomas and are usually associated with high grade breast lesions: a. Her2 neu b. Estrogen receptor c. Progesterone receptor d. Proliferative index 42. This is a benign mesenchymal breast lesion characterized by compressed slit like ducts and proliferative stroma: a. Fibroadenoma b. Fibrocystic change c. Tubular adenosis d. Apocrine metaplasia 43. Gynecomastia is seen in the following conditions except: a. Exogenous estrogens b. Artificial breast implants c. Liver disease d. Puberty

Inflammation of the placental memebranes: Chorioamnionitis Choriocarcinoma Salpingitis

30. Twinpregnancy with a single chorion and amnion on placental examination: a. Monochorionic monoamnionic b. Dichorionic diamnionic c. Monochorionic diamnionic 31. In invasive ductal carcinoma,the componenet of the lesion are the: a. Ducts b. Stroma c. Myoepithelian cells d. Blood vessels malignant

32. In phyllodes tumor, the proliferative part of the lesion is/are the: a. Ducts b. Stroma c. Myoepithelial cells

Page 2 of 4

44. Males can also develop invasive ductal carcinoma: a. True b. False 45. Malignanat phyllodes tumors are characterized by cellular stroma with sarcomatous differentiation, increased mitotic activity and stromal overgrowth. a. True b. False 46. These features are seen in medullary carcinoma except for: a. Tubule formation b. *Pushing defined tumor borders c. Lymphoplasmacytic rimming d. Syncitial ductal cells 47. Papillary lesions that are fully lined by myoepithelial cells at the cyst periphery and within the fibrovascular core a. Papillary ductal carcinoma in situ b. Intraductal carcinoma, micropapillary type c. Intraductal papilloma d. Invasive papillary carcinoma 48. True of lobular carcinoma except for: a. Arise from terminal duct lobular units b. Consists of monomorphic cells sometimes with signet ring features c. They infiltrate the stroma on picket fence or Indian file patterns d. *Well formed tubular formations are seen 49. a. b. c. d. 50. a. b. c. 51. a. b. c. d. 52. a. b. c. d. 53. a. b. c. d. Tubular carcinomas are associated with: Good prognosis Negative for estrogen receptors Propensity for lymph node metastases Solid sheets of tumor cells True of ductal carcinoma in situ: Intact myoepithelial cell layer Stromjal desmoplasia Invasion of ductal cells into the stroma Most common complication of phimosis: Retrograde ejaculation Infection Carcinoma Infertility Clinical findings in paraphimosis except: Phimosis Swelling Tenderness Ventral located orifice True of condyloma acuminatum except: Hyperplasia of the epidermal cells Due to HPV types 6 & 11 Premalignant lesion Sexually transmitted

56. a. b. c. d.

The testicular cells which secrete testosterone are the: Primary germ cells Sertoli cells Leydig cells Spermatozoa

57. Malignancies of germ cell origin include the following except: a. Seminoma b. Choriocarcinoma c. Leydig cell tumor d. Teratocarcinoma 58. a. b. c. d. 59. a. b. c. d. 60. a. b. c. d. 61. a. b. c. d. 62. a. b. c. d. 63. a. b. c. d. 64. a. b. c. d. 65. a. b. c. d. 66. a. b. c. d. e. Testicular tumor most radiosensitive and with best prognosis is: Seminoma Adenocarcinoma Choriocarcinoma Rhabdomyosarcoma Carcinoma of the prostate develops most often in the: Periurethral region Peripheral zone Anterior lobe Bladder neck region True of carcinoma of the prostate except: Common in Asians Adenocarcinoma commonly Peak at age 50 Bone metastasis in the norm Proof of malignancy in a prostatic cancer Nuclear grooving Hyperchromatic nuclei Prominent nucleoli Hemorrhage Typical microscopic finding in a cryptorchid testis: Leydig cell atrophy Thickening of basement membrane Increase in lymphocytic infiltrates Immature spermatozoa Most common malignancy of the penis: Adenocarcinoma Condyloma Squamous cell carcinoma Melanoma Early to produce urinary obstruction: Nodular hyperplasia of the prostate Prostatic adenocarcinoma Both Neither Nodular hyperplasia of the prostate usually arise in the: Periurethral region Peripheral zone Anterior lobe Bladder neck region Usual management of prostate cancer except: Bone scan Orchiectomy Prostatectomy PSA determination No exception

54. A serosal lined sac at the testicular adnexae containing clear serous fluid: a. Hydrocele b. Varicocele c. Hematocele d. Spermatocele 55. Sterility in the male can be caused by any of the following except: a. Mumps orchitis b. Gonococcal urethritis c. Hydrocele d. Radiation to the gonad

67. The percentage of the presence of nodular hyperplasia in men age 40 years old: a. 10% b. 20% c. 40% d. 60% Page 3 of 4

68. a. b. c. d. 69. a. b. c. d. 70. a. b. c. d. 71. a. b. c. d.

Causes of granulomatous prostatitis except: Reactions to secretions of ruptured prostatic ducts After BCG instillation of certain bladder cancer Both are correct statement and no exceptions B only True of lymphoma of testis except: Poor prognosis Most common in men age 60 Commonly as diffuse large cell NON HODGKIN type All are correct and no exception Capacity to metastasize Sertoli cell tumor Leydig cell tumor Both Neither Testicular tumor which carries the poorest prognosis: Teratocarcinoma Choriocarcinoma Seminoma Yok sac tumor tumor in children and

72. Most common testicular adolescents: a. Teratocarcinoma b. Choriocarcinoma c. Seminoma d. Yok sac tumor 73. a. b. c. d.

Chromosome involve in most testicular tumors: 5 21 12 33

74. Percentage association of cryptorchidism to testicular cancers: a. 1% b. 3% c. 10% d. 20% 75. a. b. c. d. Crytals of Reinke Sertoli cell tumor Leydig cell tumor Seminoma Yolk sac tumor

Page 4 of 4