GENERAL PATHOLOGY PROGRAM

ROOM: 111.
#: TOPICS & REFERENCES: DATE & TIME:

1 Welcome Aug-25, 10:00

Introduction to pathology
Cellular responses to stress
Cellular adaptations of growth & differentiation
Cell injury & death. Part I
- Introduction
- Causes
- Mechanisms
Ref: pp. 4-18 & lecture’s information

2 Cell injury & death. Part II Aug-29, 08:00

- Reversible & irreversible
- Apoptosis
- Intracellular accumulations
Ref: pp. 19-32, 34-40 & lecture’s information

3 Inflammation (Acute & chronic) Aug-30, 13:00

General features
Historical highlights
Acute inflammation
- Stimuli
- Vascular changes
- Cell events
End of acute inflammation
Ref: pp. 48-62 & lecture’s information

4 Inflammation (Acute & chronic) Aug-31, 08:00

Chemical mediators
- General features
- Origin
- Types
Outcomes of acute inflammation
Ref: pp. 63-76 & lecture’s information

5 Chronic inflammation Sep-01, 13:00

- Causes
- Morphology (cells)
- Granulomatous
Systemic effects of inflammation
Consequences of defective or excessive inflammation
Ref: pp. 78-85 & lecture’s information
6 Tissue renewal & repair: regeneration, healing & fibrosis Sep-04, 10:00
Definitions
Control of normal cell proliferation & tissue growth
Mechanisms of tissue regeneration
Repair by healing, scar formation & fibrosis
Cutaneous wound healing
Fibrosis & overview.
Ref: pp. 88-103, 107-116 & lecture’s information

7 Hemodynamic disorders I Sep-05, 08:00

General features
Edema
Hyperemia & congestion
Hemorrhage
Ref: pp. 119-124 & lecture’s information

8 Hemodynamic disorders II Sep-06, 13:00

Thrombosis
D.I.C.
Embolism
Infarction
Shock
Ref: pp. 130-142 & lecutre’s information

9 Genetic disorders I Sep-07, 13:00

General features
Mutation
Mendelian disorders
- Transmission patterns
- Biochemical & molecular basis
- Disorders asociated with defects in:
- Structural proteins
- Receptor proteins
Ref: pp. 145-158 & lecture’s information

10 Genetic disorders II Sep-08, 13:00

Disorders associated with defects in
- Enzymes
- Regulators of cell growth
Multifactorial disorders
Ref: pp. 158-170 & lecture’s information
11 Genetic disorders III Sep-11, 13:00
Cytogenetic disorders
- Types of ch. Rearrangements
- Disorders involving:
- Autosomes
- Sex chromosomes
- Single disorders with nonclassic inheritance
- Triplet-repeat mutations
- Mitochondrial genes mutations
- Genomic imprints
Ref: pp. 173-187 & lecture’s information

12 Diseases of immunity I Sep-12, 13:00

General features of the immune system
- Innate & adaptive
- Cells & tissues
- Mechanisms (HLA)
Disorders of the immune system:
- Hypersensitivity reactions: I, II, III, IV.
Ref: pp- 194-217 & lecture’s information

13 Disorders of immunity II Sep-13, 08:00

Autoimmune diseases
- Immune tolerance
- Mechanisms of autoimmunity
- SLE
- RA
- SS
- Scleroderma
Ref: pp. 223-239 & lecture’s information

14 Disorders of immunity III Sep-14, 08:00

Immunologic deficiency syndromes
- Primary
- Secondary
- AIDS
Ref: pp. 240-258 & lecture’s information

15 Workshop (review) Sep-15, 13:00

16 Mid-term exam: Topics 1-15 Sep-18, 13:00

17 Neoplasia I Sep-19, 08:00

General features
Definitions, nomenclature
Biology of tumor growth (characteristics of benign & malignant nature)
Epidemiology
Ref: pp. 270-287 & lecture’s information
18 Neoplasia II Sep-20, 13:00
Molecular basis of cancer
- Normal cell cycle
- 7 fundamental changes that determine malignant phenotype
(& discussion of six of them)
Ref: pp. 288-309 & lecture’s information

19 Neoplasia III Sep-21, 08:00

Invasion & metastasis
Molecular basis of multi-step carcinogenesis
Carcinogenic agents & their mechanisms
- Chemical
- Radiation
- Microbial
- Viral
- H.p.
Ref: pp. 309-328 & lecuture’s information

20 Neoplasia IV Sep-22, 13:00

Clinico-pathologic consequences:
- Tumoral effects
- Local & hormonal
- Cachexia
- Paraneoplastic syndromes
- Grading & staging
- Diagnosis of cancer
- Cytology
- Conventional histopathology:
- Biopsy
- Surgical specimens
- Special techniques:
- Immunohistochemistry
- Flow cytometry
- “Tumor markers”
Ref: pp. 332-339 & lecture’s information

21 Infectious diseases I Sep-25, 10:00

General features
History
Categories of infectious agents
Trasmission & dissemination of microbes
Mechanisms of injury:
- Viral
- Bacterial
- Effects of host immunity
Immune evasion
Infection in immunosuppressed hosts
Special techniques for dx.
Ref: pp. 344-361 & lecutre’s information
22 Infectious diseases II Sep-26, 13:00
Viral infections
- Transient
- Latent
- Productive
- Transforming
Bacterial infections
- Gram (+)
- Gram (-)
Mycobacteria
- TB
- Atypical
- Leprosy
Ref: pp. 363-387

23 Infectious diseases III Sep-27, 13:00

Spirochetes
- Syphilis
- Lyme dis.
Anaerobic bacteria
- Clostrida
Obligate intracellular bacteria
- Chlamydia
- Rickettsia
Fungal infections
- Yeasts
- Molds
Parasitic infections
- Protozoa
- Metazoa (Infestations)
Ref: pp. 388-411 & lecture’s information

24 Infectious diseases IV Sep-28, 13:00

Emerging & re-emerging infectious diseases
- General features
- Old diseases
- New diseases
- Infections with increased frecuency
- Re-emerging diseases
- Major concerns
- Some notes on bioterrorism
Ref: pp. 345-346, review of the chapter & a lot of lecture’s information
25 Selected topics on environmental pathology Sep-29, 13:00
Mechanisms of toxicity
Addictions:
- Tobbacco
- Alcohol
- Sedative-hypnotics
- Stimulants
- Opioids
Lead poisoning
UV radiation
Ref: pp. 417-426, 432-433, 441-442 & lecture’s information

26 Nutritional pathology Oct-02, 13:00

Nutritional deficiencies
- Protein-energy malnutrition
- Anorexia nervosa & bulimia
- Vitamin def.
- “ADEK”
- Thiamine
- Riboflavine
- Niacin
- Vit C
- Folate
- Mineral def.
- Zinc
- Selenium
Ref: pp. 447-461 & lecture’s information

27 Diseases of the Infancy & childhood I Oct-03, 08:00

General features
Congenital anomalies
Birth wight & gestational age
Birth injuries
Perinatal infections
Neonatal RDS
Necrotizing enterocolitis
GM-intraventricular hemorrhage
Fetal hydrops
Ref: pp. 470-486 & lecture’s information
28 Diseases of Infancy & childhood II Oct-04, 13:00
Some inborn errors of metabolism
- PKU
- Galactosemia
- CF
SIDS
Benign neoplasias
- Hemangiomas
- Teratomas
Malignant neoplasias
- Incidence & types
- The neuroblastic tumors
- Wilms tumor
Ref: pp. 487-506 & lecture’s information

29 Workshop (review) Oct-05, 08:00

30 Final exam (topics 17-29) Oct-09, 13:00

IMPORTANT: IN EVERY TOPIC, PAY SPECIAL ATTENTION TO THE MEDICAL

(CLINICAL) SIGNIFICANCE, WITH PARTICULAR EMPHASIS IN THE DISEASES
DISCUSSED IN EVERY LECTURE.