A. 1.
ARE THE STUDY RESULTS VALID? Was the assignment of patients to treatment groups truly randomized? Yes No Can't tell
2.
Were all patients who entered the study accounted for appropriately at the end?
i) Is the number randomized the same as in results? (Try a best case/ worse case scenario.) ii) Were patients analysed in the groups they were allocated to at the start of the study?
3.
Were patients, physicians, and those doing the assessments "blind" to treatment?
4.
5.
Aside from the intervention, were the groups treated in the same way?
B. 1.
WHAT WERE THE RESULTS? How large was the treatment effect?
2.
C. 1.
CAN THE RESULTS BE APPLIED TO YOUR PATIENT(S)? Can the results be applied to my patient (care)?
i) Are study patients similar to your patient?
2.
3.
Are the likely treatment benefits greater than the potential harms and costs?
CONCLUSIONS The results or recommendations are valid (from A). The results are clinically important (from B). The results are relevant to my practice (from C). Yes Yes Yes No No No Cant tell Cant tell Cant tell
F o rR e s idents
A. 1.
ARE THE STUDY RESULTS VALID? Was there an independent "blind" comparison with a reference standard? Yes No Can't tell
2.
Did the patient sample include an appropriate spectrum of patients to whom the diagnostic test will be applied in clinical practice?
3.
Did the results of the test being evaluated influence the decision to perform the reference standard?
4.
Were the methods for performing the test described in sufficient detail to permit replication?
B. 1.
WHAT WERE THE RESULTS? Consider the pre-test and post-test possibilities.
i) Are likelihood ratios for the test results presented or data necessary for their calculation provided?
C. 1.
CAN THE RESULTS BE APPLIED TO YOUR PATIENT(S)? Will the reproducibility of the test result and its interpretation be satisfactory in my setting? Yes No Can't tell
2.
3.
4.
CONCLUSIONS The results or recommendations are valid (from A). The results are clinically important (from B). The results are relevant to my practice (from C). Yes Yes Yes No No No Cant tell Cant tell Cant tell
F o rR e s idents
A. 1.
ARE THE STUDY RESULTS VALID? Was there a representative and well-defined sample of patients at a similar point in the course of the disease? Yes No Can't tell
2.
3.
4.
B. 1.
WHAT WERE THE RESULTS? How large is the likelihood of the outcome event(s) in a specific period of time?
2.
C. 1.
CAN THE RESULTS BE APPLIED TO YOUR PATIENT(S)? Were the study patients similar to my own? Yes No Can't tell
2.
CONCLUSIONS The results or recommendations are valid (from A). The results are clinically important (from B). The results are relevant to my practice (from C). Yes Yes Yes No No No Cant tell Cant tell Cant tell
F o rR e s idents
A. 1.
ARE THE STUDY RESULTS VALID? Did the overview address a focused clinical question? Yes No Can't tell
2.
3.
4.
5.
6.
B. 1.
WHAT WERE THE RESULTS? What are the overall results of the review?
2.
C. 1.
CAN THE RESULTS BE APPLIED TO YOUR PATIENT(S)? Can the results be applied to my patient (care)? Yes No Can't tell
2.
3.
CONCLUSIONS The results or recommendations are valid (from A). The results are clinically important (from B). The results are relevant to my practice (from C). Yes Yes Yes No No No Cant tell Cant tell Cant tell
F o rR e s idents
A. 1.
ARE THE STUDY RESULTS VALID? Were all important options and outcomes clearly specified? Yes No Can't tell
2.
Was an explicit and sensible process used to identify, select and combine evidence?
3.
Was an explicit and sensible process used to consider the relative value of different outcomes?
4.
5.
B. 1.
WHAT WERE THE RESULTS? Are practical, clinically important, recommendations made?
2.
3.
What is the impact of uncertainty associated with the evidence and values used in the guidelines?
C. 1.
CAN THE RESULTS BE APPLIED TO YOUR PATIENT(S)? Is the primary objective of the guideline consistent with your objective? Yes No Can't tell
2.
CONCLUSIONS The results or recommendations are valid (from A). The results are clinically important (from B). The results are relevant to my practice (from C). Yes Yes Yes No No No Cant tell Cant tell Cant tell