BIOLOGY 1510

Faculty:

BIOLOGICAL PRINCIPLES

FALL 2013

Dr. Jung Choi (JC) 213 Cherry Emerson Building 4 4 !"4#!423 $ung.choi%&iology.gatech.edu '((ice )ours: *+ 2,3 -m . &y a--t Dr. *ichael /oodisman (*/) 011 Cherry Emerson Building 4 4 3!1#2311 michael.goodisman%&iology.gatech.edu '((ice )ours: *+ 1#2 -m . &y a--t 3ecitation 40: 5achery Dec6ner 7dec6ner3%gatech.edu '((ice hours: Director o( Biology 111 8a&s: Dr. 9atric6 Bardill 01 4 Cherry Emerson Building -atric6.&ardill%gatech.edu :ee 4#s;uare la& site <B='8 111 >

:ection
4ime 8ecture 8ocation 3ecitation 8ocation 4est 8ocation *astering Bio Class =D 9rere;uisites:

B='8 111 0
11: 1,11:11 am *+F 112 Clough Commons 112 Clough Commons 112 Clough Commons *B/4111 F130

B='8 111 B
3: 1,3:11 -m *+F )o?ey (9hysics) 82 112 Clough Commons )o?ey (9hysics) 82 *B/4111 F13B

/ood &ac6ground in high school &iology and chemistry.

Descri-tion: 4his is an active-learning class that introduces students to &asic -rinci-les o( modern &iology@ including &iomacromolecules@ &ioenergetics@ cell structure@ genetics@ homeostasis@ eAolution@ and ecological relationshi-s. 4his course ?ill (oster the deAelo-ment o( critical scienti(ic s6ills including hy-othesis testing@ eB-erimental design@ data analysis and inter-retation@ and scienti(ic communication. 4eBt&oo6: :cott Freeman (2 11). Biological Science@ 4th Edition. Ben$amin Cummings@ :an Francisco. +e haAe arranged s-ecial -ricing through the &oo6store (or hardcoAer@ looselea(#&ound and e#&oo6 Aersions o( the teBt&oo6 &undled ?ith access to the *astering Biology ?e&site (re;uired as -art o( course home?or6 assignments).

BIOLOGY 1510
8ectures:

BIOLOGICAL PRINCIPLES

FALL 2013

0ttendance in lecture correlates strongly ?ith -er(ormance in Biology 111 . +e ?ill ma6e our lecture slides aAaila&le Aia 4#:;uare and urge you to do?nload and -rint them (or use in ta6ing notes during lecture. 4he lectures and readings are com-lementary and some materials ?ill &e -resented only in lecture. 9lease com-lete each reading assignment &e(ore class. +e ?ill use 8earning Catalytics (htt-:CClcatalytics.com) (or interactiAe lecture sessions@ ?hich ?ill contri&ute to the D-artici-ationD -ortion o( your course grade. Eou can use you any internet#ena&led mo&ile deAice (la-to-@ ta&let@ cell -hone) to access 8C and res-ond to ;uestions.

8C:

8ecture EBams: Four midterm eBams and the (inal eBam. 4he midterm eBams ?ill &e held in the eAening@ are closed#&oo6 and ?ill &e made u- o( multi-le# choice ;uestions &ased on to-ics@ materials@ and discussions -resented in class@ in the assigned readings@ and in the *astering Biology assignments. EBams and ;ui77es may also &e giAen in the la&oratory and on#line on *astering Biology andCor 4#s;uare. *issed EBams: =( you miss an eBam (or any reason@ you ?ill receiAe a grade o( (7ero) on that eBam unless you etiti!n "# t! $ave t$e e%a& gra'e e%c"#e' (it$in 2) $ !* t$e #tart !* t$e &i##e' e%a& @ and ?e a--roAe your -etition. Eour -etition must &e su&mitted in ?riting (&y e# mail) and must include documentation o( a legitimate reason (or missing the eBam. Eou can@ o( course@ su&mit your -etition &e(ore the eBam i( you 6no? o( your scheduling con(lict in adAance. +e ?ill consider each -etition indiAidually. EBam-les o( legitimate reasons to miss an eBam include illness@ illness or death in your immediate (amily@ and -artici-ation in o((icial uniAersity actiAities. =( ?e a--roAe your -etition@ ?e ?ill remoAe the missed eBam (rom your grade calculation &y using the ?eighted mean o( your other eBam scores as your grade (or the missed eBam. Fui77es: :hort ;ui77es may &e administered in lecture@ la&@ and online.

)ome?or6: *astering Biology o((ers animations@ Aideos@ interactiAe tutorials and simulations@ as ?ell as -ractice ;ui77es and an on#line Aersion o( the teBt&oo6 (see *asteringGs <:tudy 0rea> (or access to these resources). =ndiAidual access codes (or *astering Biology are included ?ith each ne? teBt&oo6@ or may &e -urchased se-arately (rom the -u&lisher at mastering&io.com. 4hroughout the semester you ?ill haAe assignments in *astering Biology. 4he *astering Biology assignment scores are recorded and ?ill com-rise 1H o( the oAerall course grade. +e encourage you to com-lete your assignments on timeI ho?eAer@ i( you miss a due date you should still com-lete the assignment and acce-t a late -enalty. 8ate assignments ?ill &e acce-ted until 1 -m on the last day o( classes. )ints are aAaila&le ?ith no -oint -enalty in *astering. )ome?or6 assignment deadlines are listed on the sylla&us and on *astering BiologyGs ?e&site. 9lease note that an assignment may &e due during the last ?ee6 o( classes and -lan accordingly.

BIOLOGY 1510

BIOLOGICAL PRINCIPLES

FALL 2013

/rou- 9ro$ects: For each module@ !,12 grou-s (o( 4#2 students each) ?ill each research an issue o( current interest related to the to-ic o( the module. Each student ?ill &e assigned to a grou- and a to-ic@ and each grou?ill com-lete only one grou- -ro$ect. Gr!" a##ign&ent#+ 'etail# an' 'ea'line# (ill ,e r!vi'e' !nce 'r! -a'' en'#. /rades ?ill &e &ased on instructorsG grades and -eer eAaluations. 4he same grou-ro$ect grade ?ill &e assigned to all mem&ers o( a grou-I each groumem&er is (ully res-onsi&le (or all su&mitted -ro$ect ?or6. 3ecitations: 8ecture recitations occur ?ee6ly and are led &y the recitation 4eaching 0ssistant. 0ttendance is o-tional &ut strongly encouraged@ as it is designed to im-roAe your understanding o( the lecture material. Bring your mo&ile deAices to recitation to receiAe -artici-ation credit (or your recitation attendance. 8a&s: La,# (ill ,egin t$e (ee/ !* A"g"#t 20. 4hat ?ee6@ youJll need the com&ined la& manualCnote&oo6 (=:BK "L!# #L3! #121L#1)@ a 1 H cotton la& coat@ and you must ?ear closed#toe shoes that coAer your entire (oot. Kote that ?hile no la,# &eet '"ring t$e *ir#t (ee/ !* cla##e#+ you ?ill haAe a Pre-la, a##ign&ent '"e ,e*!re 1!" &eet *!r la,2 art 1 i# '"e !n A"g"#t 22+ art 2 i# '"e ,e*!re 1!"r la, #ecti!n &eet# 3#ee la, 4-#5"are ann!"nce&ent *!r 'etail#6 . 8a&s are held in Clough Commons and taught &y 4eaching 0ssistants (40s)I your 40 contact in(ormation is aAaila&le on the B='8 111 la& 4# s;uare site. 0ll communications regarding la& should &e directed to your la& 40s. *ost F0F a&out la&s are ans?ered on the la& 4#s;uare site and la& sylla&us. 8a&oratory attendance is mandatory and each uneBcused a&sence ?ill lo?er your (inal course grade (not $ust your la& grade) &y 1H. Details o( the a&sence -olicy are in the B='8 111 la& sylla&us.

)onor Code: 0ll students are eB-ected to a&ide &y the 0cademic )onor Code@ ?hich can &e Aie?ed online at ???.honor.gatech.edu. /rading: Eour (inal grade ?ill de-end on the (ollo?ing com&ination o( grades: =n#class eBams: 4 H Final eBam: 2 H /rou- actiAities: 1 H *astering Biology: 1H 9artici-ation: 1H 8a&oratory: 21H Kote that these com-onents total 1 1H@ though the maBimum oAerall score ?e ?ill allo? in this course is 1 H. 4his means that class -artici-ation or *astering Biology is e((ectiAely a source o( eBtra credit to?ard the ra? score o( your (inal grade. +e ?ill use the (ollo?ing -rocedure in calculating your (inal grade: 1. +e ?ill ?eight your 4 midterms 2H@ 1 H@ 1 H@ and 14H@ ?here your lo?est midterm score ?ill count 2H and your highest midterm

BIOLOGY 1510

BIOLOGICAL PRINCIPLES

FALL 2013

score ?ill count 14H o( your (inal grade. 2. +e ?ill com&ine your eBam@ la&@ and grou- actiAity and other scores into a ra? com-osite score ( , 1 H) using the ?eights sho?n a&oAe. 3. +e ?ill assign (inal letter grades using the (ollo?ing scale: 0: M " . H B: M ! . H and N " . H C: M L . H and N ! . H D: M 2 . H and N L . H F: N 2 . H 'rgani7ation: 4he course is organi7ed into (iAe modules@ each o( ?hich deals ?ith a ma$or area o( modern &iology. *odule =ntro *a$or theme 4eaching /oals O O O O O O O O O :cienti(ic method Earth history )istory o( li(e on Earth *echanism o( eAolution BehaAior and eAolution :im-le -o-ulation models Community structure *ass and energy (lo? through ecosystems 'AerAie? o( &iomolecules

O Course intro 1 O EAolution

2 O Ecology

3 O *olecules@ *em&ranes@ and *eta&olism

4 O /enetics

1 O Biomedicine

O =ntroduction to &ioenergetics: res-iration and -hotosynthesis. O Chemiosmosis in res-iration and -hotosynthesis O DiAersity o( meta&olic -ath?ays O *endelian genetics O DK0 and genomics O /ene regulation in -ro6aryotes and eu6aryotes O 3ecom&inant DK0 technology . &ioethics O /enetic diseases as model &iological systems O =mmunology O Course synthesis

BIOLOGY 1510

BIOLOGICAL PRINCIPLES

FALL 2013

Fall 2013 Cla## Cla## 4! ic# 1"#0ug 1

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Course oAerAie? Both =ntroduction to instructors

8a#tering Bi!l!g1 9 . 1 =ntro to *astering Biology (ungraded@ (or -ractice only)

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Start 8!'"le 12 Ev!l"ti!n +hat is scienceP +hat is JC the scienti(ic methodP +hat is dataP +hat is li(eP +hat is JC eAolutionP 0n eAolutionary (rame?or6 (or &iology Earth history JC Fossil record . radiometric dating Qey eAents in the history o( li(e 'rigin o( li(e 3K0 ?orld )istory o( li(e on Earth 8i(e and changes in the -hysical enAironment 9atterns o( &iological diAersity oAer time Biological classi(ication HOLIDAY EAolution EAidence (or eAolution Katural selection *echanisms o( eAolution

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1. 3 EAolution and the history o( li(e on earth 1. 4 *echanisms o( eAolution

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/enetic Aariation */ )ardy#+ein&erg *utation@ dri(t@ selection :-eciation */ +hat is a s-ecies *echanisms o( s-eciation Group project 1 videos due ( idnig!t" 8!'"le 1 revie( 8G activit1

22: 41!#4L1

1. 1 :-eciation

BIOLOGY 1510

BIOLOGICAL PRINCIPLES

FALL 2013

12#:e1!#:e-

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Start 8!'"le 22 Ec!l!g1 =ntro to Ecology 9hysical EnAironment BehaAioral ecology Foraging and -redation

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2. 1 Ecology =ntro 2. 2 BehaAiour

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*ate choice and seBual selection Qin selection and altruism 8!'"le 1 E%a& 30 &6 c!ver# 8!'"le 1 c!ntent !nl1. 9o-ulation ecology */ :tructure@ dynamics@ . */ regulation o( -o-ulations 8i(e histories Community ecology */ Com-etition@ 9redation@ -arasitism@ mutualism Ecosystems Energy and material (lo? through ecosystems Group project 2 videos due ( idnig!t" 8!'"le 2 revie( activit1 8!'"le 32 8!lec"le#+ 8e&,rane#+ 8eta,!li#& JC */ */

12: 1 3L#1 11

2. 3 9o-ulation Ecology

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2. 4 Community Ecology

14: 1 !3#11 2

2. 1 Ecosystems

20

8G htt-:CC&io111 .&iolo gy.gatech.eduCmod ule#3#molecules# mem&ranes#and# meta&olismC &io111 ?e&site module3 class 1 3. 1 Biomolecules

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Biomolecules JC :mall molecules *a$or classes o( macromolecule Cellular :tructure JC 8i-id &ilayer mem&ranes 0rchaeal mem&ranes :erial endosym&iosis and eu6aryote eAolution 8!'"le 2 E%a& 30 c!ver# 8!'"le 2 &6

2.1#2.2: !2#!" &io111 ?e&site module 3 class 2

3. 2 Cell Biology

10-Oct

BIOLOGY 1510

BIOLOGICAL PRINCIPLES

FALL 2013

11#'ct

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1#-Oct 12#'ct

24

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c!ntent !nl1. *em&rane (unction and trans-ort systems *em&rane com-osition and ada-tation *em&rane -roteins 4rans-ort: -assiAe di((usion@ osmosis@ (acilitated di((usion@ actiAe trans-ort $all Brea% Energetics and en7ymes 4hermodynamics and (ree energy Catalysis and 6inetics@ and en7ymes (eed&ac6 regulation 3edoB reactions *em&rane -otential Cellular res-iration 'Bidation o( (ood and reduction o( an e# acce-tor chemiosmosis oBidatiAe -hos-horylation

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3. 4 3es-iration and 'B 9hos

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*eta&olic -ath?ays JC /lycolysis 9yruAate oBidation Citric acid cycle Fermentation JC 9rotein and li-id meta&olism 9hotosynthesis JC 'AerAie?: reduce C'2 to organic C 9igments and light a&sor-tion 'rigin o( -hotosynthesis: single 9:@ cyclic -hoto-hos-horylation Car&on (iBation JC 9hotosynthetic strategies JC

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BIOLOGY 1510

BIOLOGICAL PRINCIPLES
module 3 class 1

FALL 2013

31#'ct 1-N!v 31

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C3@ C4@ and C0* -hotosynthesis 3eca-: com-are and contrast res-iration . -hotosynthesis@ mitochondria . chloro-lasts. Group project & videos due ( idnig!t" 8!'"le 3 revie( activit1 8!'"le )2 Genetic# Chromosomes and Cell DiAision *itosis *eiosis *endelian genetics 8!'"le 3 E%a& 30 &6 c!ver# 8!'"le 3 c!ntent !nl1. /enetic analysis *onohy&rid and dihy&rid crosses :eB#lin6age and -edigree analysis 9ro&a&ilities o( genetic outcomes /enetics o( human disease DK0 as the &asis o( inheritance EB-erimental eAidence (or role o( DK0 DK0 structure :emi#conserAatiAe re-lication o( DK0 /ene eB-ression: DK0 to -rotein Basics o( transcri-tion and translation 9ro6aryotic and eu6aryotic genomics /enome organi7ation Group project # videos

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11.1@ 11.2 (1"4# 2 2) 12.1@ 12.2 (211# 223) 13: 23 #212

4. 1 *eiosis

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33

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4. 2 *endelian /enetics

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34

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JC

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BIOLOGY 1510

BIOLOGICAL PRINCIPLES

FALL 2013

20-N!v

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21-N!v

22#KoA 25-N!v 2L#KoA 2'-(ov 2#Dec 4#Dec

4 41 42

due ( idnig!t" 8!'"le ) revie( */ activit1 Start 8!'"le 52 Bi!&e'icine 8!'"le ) E%a& 30 &6 c!ver# 8!'"le ) c!ntent !nl1. /ene 3egulation . lac JC o-eron 3ecom&inant DK0 JC :tem cells@ cloning and &ioethics 4han6sgiAing holiday =mmunology and in(ectious diseases )uman health and eAolution Balancing selection :ic6le cell@ 4halassemia@ Cystic Fi&rosis Course ?ra-#u- and reAie? Final E%a& 3lect"re $all6 JC

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43 44

JC JC

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1. 2 =mmunology

2#Dec 4BA

41

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*Mastering Biology assignments due by 11:59 pm on day before lecture.