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  • Surface Molecules: Molecule Location Ligand Action Other

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    mcwnotes
    71 tayangan1 halaman
    CTL ligands Can activate TH cells, dendritic cells, Skin-homing T cells and platelets. T cells in High Endothelial Venules in lymph nodes Trafficking to lymphoid organs Slowing of rolling (weak adhesion) activation of death pathway High affinity state T cell response Lost on activated T cells.

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    CTL ligands Can activate TH cells, dendritic cells, Skin-homing T cells and platelets. T cells in High Endothelial Venules in lymph nodes Trafficking to lymphoid organs Slowing of rolling (weak adhesion) activation of death pathway High affinity state T cell response Lost on activated T cells.

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    71 tayangan1 halaman

    Surface Molecules: Molecule Location Ligand Action Other

    Diunggah oleh

    mcwnotes
    CTL ligands Can activate TH cells, dendritic cells, Skin-homing T cells and platelets. T cells in High Endothelial Venules in lymph nodes Trafficking to lymphoid organs Slowing of rolling (weak adhesion) activation of death pathway High affinity state T cell response Lost on activated T cells.

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    Attribution Non-Commercial (BY-NC)
    Unduh sebagai DOC, PDF, TXT atau baca online dari Scribd
    Tandai sebagai konten tidak pantas
    dari 1

    Surface Molecules

    Molecule Location Ligand Action Other


    CD3 All T cells Signal transduction by TCR
    CD4 TH Cells MHC-II Adhesion w/ APCs and signal
    transduction
    CD8 CTL MHC-I Adhesion w/ APC, CTL target cells,
    signal transduction
    CD28 Naïve T B7 Signal transduction (costimulation)
    lymphocyte
    CD40 B cells, APC CD40L Activate MØ via ↑ gene expression “Emeril effect”
    CD40L T cells CD40 Activate MØ via ↑ gene expression
    B7 APC CD28, CTLA-4 2nd signal for T cell (+ or -) Expression ↑↑ by
    IL-2
    CTLA-4 T cells B7 ↓ T cell activation (negative Higher affinity
    regulation) than CD28
    CR2 B cells Complement Can provide 2nd signal to activate B
    bound to Ag cells w/o T cell
    CCR7 Dendritic cells Drives emigration to lymph node
    CCR10 Skin-homing T
    cell
    CCL17 Vascular
    endothelium
    CCL25 Small Intestine
    CCL27 Skin keratinocytes
    CCL28 Large Intestine
    MAdCAM-1 Gut epithelium Bind w/ L-selectin and integrin
    LFA-1 T cell, MØ, PMN, ICAM on Firm Adhesion w/ APC, endothelium High affinity state
    dendritic endothelium ↑ T cell response
    VLA-4 T cell VCAM Firm Adhesion w/ endothelium
    VLA-5 Monocytes, MØ Fibronectin
    L-Selectin Naïve T cells L-Selectin Slowing of T cells in High Lost on activated
    Ligand Endothelial Venules in lymph nodes T cells
    Trafficking to lymphoid organs
    E-Selectin Peripheral E-Selectin Slowing of rolling (weak adhesion
    endothelium Ligand (Sialyl-
    Lewisx)
    P-Selectin Peripheral P-Selectin Slowing of rolling (weak adhesion)
    endothelium and Ligand (PSGL-
    platelets 1)
    FasL CTL FasR Activation of death pathway

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