PATHOPHYSIOLOGY OF DENGUE

Bite of a Virus carrying Aedes mosquito

Mosquito injects fluid into victim’s skin

Virus enters blood stream

Infects cells and generate cellular response

Initiates immune response

(Stimulates release of cytokines)
Cytokines destroys cell membrane and cell wall
(Viral antigens found in monocytes)
Fluid shift

When treated early with doctor prescribed when illness become severe
medications and managed to prevent the damage cells due to both cytokines and virus
appearance of other symptoms fluid shift from ICF-ECF
IVF’s and Electrolyte replacements
and precautions
patient recovers
manifest evanescent rashes rashes in
several areas of the
body
bloody vomitus, urine, and stool
circulatory collapse
shock
DEATH