NCHI - Board Members

Introduction 3

Integrated Health Platform 5

Interoperability 8

Open Interface Model 9

Programs and Grants 10

Partnership Network 10

Summary 11

Current Activities 12

Biographies 15

Contact information:

The National Coalition for Health Integration (NCHI)

2200 Santa Monica Blvd, Santa Monica, CA 90404
nchiconnect.org
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THE NATIONAL COALITION FOR HEALTH INTEGRATION - NCHI

The National Coalition for Health Integration (NCHI) is a public private coalition dedicated to working with
our partners to transform healthcare by enhancing the availability, privacy and integration of health information
across the country.

NCHI Vision: To create a robust, accessible, integrated health information platform that supports the
comprehensive management and exchange of biomedical data on a national scale.

NCHI Objective: To provide an organizational structure through which the secure, national sharing of biomedical
information will be feasible. NCHI seeks to develop collaborations through which the technological, financial
and institutional resources needed to share data over a comprehensive, low barrier to entry information platform
can be leveraged through economies of scale. NCHI will secure and facilitate the distribution of the necessary
resources including funding, technology and partnership to create a national health network that is available to
the public and private sectors with the goal of improving health for individuals.

BOARD OF DIRECTORS SCIENTIFIC ADVISORY BOARD

(In formation – in discussion with multiple thought leaders)
Dr. Patrick Soon-Shiong, Chairman
Dr. Ian Foster, Co-Chairman
Dr. Robert L. Comis
Carl Kesselman, Co-Chairman
Dr. Denis A. Cortese
Dr. Lyle Bootman
Senator Martha M. Escutia, Esq. (retired)
Dr. Basit Chaudhry
General Wesley K. Clark (retired)
Dr. Robert Kahn
MaryAnn Guerra
Lou Lazatin
Dr. Gregory H. Reaman
Dr. Eric E. Whitaker
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INTRODUCTION
The shape of the U.S. health care system and how it should be reformed are widely debated. One of the
few areas of broad agreement centers on the need for health information to become more available and
accessible. If the health care system is to be transformed the right care needs to be provided to the right
patient at the right cost. This will only be possible, however, if the right scientific and personal health
information are accessible at the right time.

Health care is a dynamic knowledge enterprise that evolves rapidly over short periods of time. Too often,
the knowledge and information generated is not put into practice at the point of care and not made accessible
to individuals and their families. In order to change this, what’s needed is a comprehensive, national health
information technology infrastructure. As researchers argued in a recent New England Journal of Medicine
Perspective article, “No Small Change for the Health Information Economy” this infrastructure should focus on
the development of a general purpose health care computing platform with low barriers to entry rather than on
pre-defined end user products. [1] The platform should in turn support a wide variety of health care applica-
tions through open architectures. This choice will allow stake holders such as patients, physicians, hospitals,
and employers to select the set of applications most appropriate for their local environments.

To address the needs for enhanced access and interoperability of health care information, the National
Coalition for Health Integration (NCHI) is assembling a national scale data sharing platform which will support
a diverse marketplace of health care applications. This information ecosystem will provide the infrastructure
to ensure that health information can be shared across disparate end user systems securely. This health
ecosystem will in turn allow for health care services to be provided in innovative new ways.

Just as the World Wide Web allowed people to communicate in new ways, the NCHI vision is to develop
a comprehensive, national network that will connect the fragmented parts of the U.S. healthcare system.
This vision will be achieved through partnership and collaborative efforts.
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NCHI’s Integrated Health Platform is a systematic approach to developing a comprehensive data

exchange infrastructure that will address each domain of the health system. NCHI’s multi-tiered approach
of linking technologies, stakeholders, and the delivery of health services across the nation will transform the
health system along four fronts:

• Transitioning to 21st century care: Creating a model of 21st century care that is data driven, evidence
based and integrates research and clinical practice into a continuum that will allow for personalized medicine.

• Decreasing costs and enhancing efficiencies: Facilitating data access that will decrease costs and
increase efficiency through the early detection and prevention of disease, increased transparency in costs,
administrative streamlining and improved care.

• Increasing access to care: Reducing disparities in care and variations in access to health resources by
leveraging technologies such as low cost telehealth that increase access in underserved urban and rural
areas as well as in primary care specialties such as pediatrics where access to neonatologists and
pediatricians is deficient.

• Enhancing patient-centered care: The NCHI network architecture assembles data longitudinally over
time with the patient as the starting point. The patient-centered integrated health record is a self-assembly
of dynamically changing health information secured and utilized over the lifetime of the patient and their
care-givers to maintain health rather than episodic treatment of disease. Information is drawn from the silos
where it currently resides and self-assembles around the needs of individuals.


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THE NCHI INTEGRATED HEALTH PLATFORM:

An accessible health information technology platform

Health Care and Complexity

Health care is marked by dynamic change and interactions amongst vast arrays of individuals and institutions.
In its landmark report, “Crossing the Quality Chasm,” the Institute of Medicine argues that health care should be
considered a complex adaptive system. A complex adaptive system is a collection of individual agents that have
the freedom to act in ways that are not always predictable and whose actions are interconnected such that one
agent’s actions changes the context for other agents.[2] Complex systems such as health care demonstrate
characteristics that include the following [3]:

• Non-linear and dynamic

• Composed of agents are independent and intelligent

• Demonstrate goals and behaviors often in conflict

• Exhibit self-organization through adaptation and learning

• Have no single point(s) of control

• Hierarchical decomposition has limited value

Individuals and institutions in the health care system operate in a space between top down command and control
and chaos:

The purpose of the NCHI technology platform is to promote the sharing of the information and data individuals,
and institutions need to navigate through the health care system’s zone of complexity.
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Health Care and Virtual Organizations

A patient is referred by his primary care physician to a sub-specialist who orders tests that require the patient to
get blood drawn at one laboratory facility and an X-ray at an imaging center, with each group sending bills to the
patient’s insurer. Such complex chains of interactions are the norm in the health care system. A major challenge
to providing high-quality cost-effective care is the need for all of the disparate entities involved in the care delivery
process to interact efficiently. The primary care physician, sub-specialist, laboratory, radiology center, and
insurer may all be completely separate institutions. However, to meet the patient’s needs all of these different
institutions need to come together dynamically to function as a single “virtual” organization.

A virtual organization is a set of individuals and/or institutions engaged in the controlled sharing of
resources in pursuit of a common goal. The health care system is composed of multiple, overlapping
virtual organizations. In the highly fragmented U.S. health system, virtual organizations have to form and
reform over and over to achieve purposes ranging from providing care to billing to research.

However, currently, even when information is in digital formats, data are not accessible because they reside
in different “silos” within and between organizations. In turn, the U.S. health system is hampered by inefficient
virtual organizations that lack the mechanisms needed to engage in coordinated action.

Health Care and Grid Computing

Grid computing is a technology model designed to promote the coordinated sharing of resources in dynamic,
multi-institutional virtual organizations. Grid computing focuses on the loose coupling of data and services.
This approach allows different institutions to come together to achieve a particular goal while still maintaining
local autonomy in issues ranging from information system architecture to institutional policy. This flexibility and
focus on controlled sharing makes grid computing particularly well suited to address the complexity of the
fragmented health care system.
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The NCHI Integrated Health Platform

The NCHI health platform is built on grid computing technologies. Its focus is to create an infrastructure that will
allow for the interoperable, secure sharing of healthcare data between institutions that likely have different infor-
mation systems and policies. The NCHI infrastructure will also be open to end user applications that will form a
seamless ecosystem of functionalities that together form a distributed, “virtual” electronic health record platform.
Rather than trying to consolidate health data into physical databases, this “virtual” electronic health record will
allow data to be stored locally and to be assembled in a dynamic fashion.

The NCHI Integrated Health Platform Architecture

The NCHI platform architecture encapsulates and loosely couples data and services. This structure approach
allows for the dynamic composition of resources aimed at achieving discrete aims.

In the NCHI architecture data is held locally and integrated virtually. The publication layer makes data available
in a remotely accessible and reusable fashion through secure gateways using technologies such as GridFTP.
The data management layer allows for the naming and moving of data. Naming mechanisms allow for the
persistent, global naming of digital health objects regardless of their type. The management layer of the
architecture also coordinates the movement of data between services. The data integration layer addresses
interoperability through data mediation approaches. On top of these platform specific services, the NCHI
architecture adds value services that allow for analytics, facilitate the integration of outside applications, and
provide for cognitive support.
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THE NCHI INTEGRATED HEALTH PLATFORM AND INTEROPERABILITY:

Defining terms and establishing a platform to exchange data

Given the complexity and high level of fragmentation in the health care system, the interoperable sharing of
data is one of the chief potential benefits of information technology in health care. To date, however, applications
such as electronic health records have achieved limited gains with respect to the interoperability. Facilitating the
interoperable exchange of health data a primary goal of the NCHI infrastructure.

The NCHI architecture considers interoperability as a three part problem:

• Systems Interoperability: Communicating among system elements in a secure and reliable fashion.

• Data Interoperability: Data interoperability is considered in terms of syntactic and semantic interoperability.
Syntactic interoperability is considered the movement of structured data among system elements. Semantic
interoperability is considered the use of information across system elements.

• Process Interoperability: Supporting the integration of work across healthcare enterprises.

These three facets of healthcare interoperability are addressed by different layers of the NCHI architecture.
Systems interoperability is handled through the publication and management layers. Data interoperability
is handled through the integration layer. Process interoperability is primarily handled in the analysis and
applications layers.

The NCHI approach towards healthcare interoperability is centered on information integration through mediation
methods. Data mediation is based on the construction of frameworks to map between data models. Integration
is scoped by targeting it to particular domains of use. These approaches makes it possible to support multiple
overlapping integrations as data stays at its source and local data models can be maintained.

Mediation approaches leverage standards when they are available but can still facilitate interoperability in
situations where a standards are immature, not agree upon, are implemented in different ways or are absent
altogether. In this respect, mediation approaches allow for greater fault tolerance in achieving interoperability.

Currently if standard data models exist, these models will facilitate the sharing of information across participants
in the health care system. However, standard data models for desired data don’t always exist. In addition,
if standards do exist, there are often also alternative standards for the same data. Standards are not static.
Generally they will evolve over time. For these reasons, rather than assuming that a standard data model exists,
NCHI’s approach assumes that there will likely be alternative representations of data in use. NCHI is thus creat-
ing an infrastructure that can mediate between these alternatives.

The core component of this approach is the ability to map between data models as a fundamental property.
Information is mapped into one or more global models when it is published and remapped to local conventions
when it is retrieved. When standards exist they can be exploited, however, they are not required for
interoperability within the grid framework. This technique has been used successfully in the grid infrastructure
in a number of different data types, most recently in enabling exchange of pathology data integration in the
ECOG 5202 trial.

More specifically, this novel approach is supported in NCHI’s technical architecture in several ways:

• Mapping and data translation functions are fundamental components of the solution. These functions pro-
vide the ability to map between data representations at point of publication and retrieval. Thus consistency
at the source and target are not required. In fact, knowledge of the target is at the time of publication is not
required as this approach enables exchange between systems in situations where one does not know, in
advance, where the data is going.
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• Uses extensible sharing frameworks rather than hard coded data formats to create structure for exchange.
Domain specific details are encapsulated and separated from the underlying data models and information
sharing methods while factoring out the domain specific details of those information sharing. For example,
in NCHI’s image sharing pilot, the wide area information exchange knows nothing about the syntax and
semantics of DICOM data. This approach is very different then HL7 (or even DICOM), which co-mingle
the structure and semantics of the data with the methods used to exchange the data.

• Leverage rich (potentially non-standard) representations in the network level to limit the number of mappings
required. In the imaging case, the DICOM data model fit as a good choice. In the case of other types of
records, NCHI’s technology can identify one or more semantically rich and flexible data models that can be
used to exchange information between HL7 implementations, between clinical and research systems,
or between HL7 and other data models. In the NCHI model, HL7 becomes a lower-level transport mecha-
nism used at the points of publication and retrieval rather than as a means for exchanging (and interpreting)
clinical information.

• Publish meta-information about the data models to facilitate conversion between them via mapping services
that we publish as part of the system. NCHI applies innovative technology to semi-automate the creation of
mappers, and allow for sharing of information across different mappers. Examples of this type of approach
can be found in web scraping technology that infers data structure by looking at the data in question.

• NCHI’s model provides general purpose data integration and data mediation services that leverage
published meta-data to compose the appropriate mapping services and wrappers to ensure that data is
transformed and delivered to an end system in a format that can be interpreted and used by that system.

This bottom up approach towards interoperability allows for the leveraging of standards when they are
in place and implemented in a uniform fashion while still allowing interoperability to be facilitated under
conditions of heterogeneity, incompleteness and uncertainty.

NCHI’S OPEN ARCHITECTURE AND INTERFACE MODEL:

Third parties leveraging the NCHI platform

NCHI Platform technologies are based on open architectures with open interfaces. NCHI is actively encouraging
third parties to join the network and to utilize the platform to develop innovative ways of delivering services. It is
anticipated that this platform will stimulate new industries and economic growth based on both technology and
data access.
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PROGRAMS AND GRANTS AWARDED BY NCHI AND ITS AFFILIATES:

Grants Awarded To Date:

• Chan Soon-Shiong Center for Life Science, Saint John’s Health Center ($35M)

• Chan Soon-Shiong Center for Translational Science, John Wayne Cancer Center ($20M)

• Chan Soon-Shiong Center for Health Informatics, USC ($20M)

• Center for Health Informatics, UCLA ($1M)

• Center for Health Informatics and the Chan Soon-Shiong Scholars, University of Chicago, Argonne National
Laboratory ($3.2M)

• California Nanosystems Institute, UCLA ($10M)

• Endowed Professorship for Health Justice, Urban Health Initiative, University of Chicago ($2.5M)

• Dossia Foundation ($1.5M)

• Biomarkers, Clinical Trail and Biorespository, St. Johns, UCLA ($40M)

• Chan Soon-Shiong Scholars at, UCLA and USC ($2.5M)

• Coalition for Cancer Cooperative Groups ($7M)

• Catapult Bio ($4M)

Grants Pending:

• Children’s Oncology Group

• California TeleHealth Network

NCHI’S PARTNERSHIP NETWORK:

A comprehensive public-private partnership network to share data securely
NCHI is assembling a diverse set of organizations to develop new technologies, enhance existing technologies
and to promote health data exchange on a national scale. Pilot projects to test technologies are also being
identified to incubate and scale technologies for use on a state and national level. Partnerships established
and under discussion include:

• AltaMed

• CalOptima

• Center for Health Informatics, St. Johns Hospital

• Coalition for Cooperative Cancer Groups

• College of Pharmacy, University of Arizona

• Computation Institute, University of Chicago and Argonne National Laboratory

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• Dossia

• Information Science Institute, University of Southern California

• March Vision

• Marshfield Clinic, Wisconsin

• Regenstrief Institute, Indiana

• The Urban Health Initiative, University of Chicago

• The California Telehealth Network

• The California Emerging Technology Fund

• The Children’s Oncology Group

• The X Prize Foundation (WellPoint Health X PRIZE)

• Wireless Health Institute, UCLA

• Zirmed, Inc

• Vitality, Inc.

• ITA Partners


SUMMARY:
NCHI is creating a comprehensive technology platform and an association of partners positioned to create
radical improvements to the U.S. Healthcare System. NCHI seeks to obtain state and federal funding as a
national, public-private collaborative that will accelerate change in this area. Funding will be used to:

• Enhance, advance and accelerate technology development, deployment and maintenance among partner
organizations.

• Support the existing projects to provide clear evidence of the value of the technology infrastructure in
achieving NCHI and the nation’s objective of transforming healthcare by enhancing the availability, privacy
and integration of health information across the country amongst diverse organizations.

• Establish additional partnerships that will expand the information technology platform and create outcomes
that deliver improved healthcare at lower cost.
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SUMMARY OF CURRENT ACTIVITIES

Select Pilot Project Initiatives in Development

A. Transitioning to 21st Century Care: Creating a model of 21st century care that is data driven, evidence
based and integrates research and clinical practice into a continuum that will allow for personalized
medicine.

1. Clinical Trial Support Platform - Eastern Cooperative Oncology Groups (ECOG):

The ECOG 5202 clinical trial utilizes advanced biomarkers as part of the patient enrollment and treatment
protocol. NCHI platform technologies are being implemented to support clinical and research data
management interoperably, across the seven hundred institutions that will be involved in the trial.

2. National Scale Data Exchange:

Efforts are underway to develop methods for exchanging clinical data for chronic diseases between
disparate information systems in Los Angeles, Chicago and rural areas in Central California using the
NCHI platform.

3. Scaling Healthcare Innovation – The X Prize for Health Sciences:

The X Prize Foundation seeks to promote innovation through competition. The X PRIZE Foundation’s
Health Prize is now collaborating with NCHI to explore how grid computing technologies that can facilitate
healthcare innovators scale community based interventions aimed at improving healthcare quality and value.

B. Decreasing costs and enhancing efficiencies: Facilitating data access that will decrease costs and
increase efficiency through the early detection and prevention of disease, increased transparency
in costs, administrative streamlining and improved care.

1. The California Telehealth Network:

Supported by both the FCC and the State of California, the
California Telehealth Network is one of the country’s largest
information exchange organizations with over three hundred
clinics participating members. The California Telehealth Network
is currently collaborating with the NCHI to develop programs
that utilize the NCHI computing platform to support telehealth
and interoperable data exchange between its memberprovider
organizations. The map of this network depicts the breadth of
this partnership and its potential to provide impact across the U.S.

Digital Telehealth Screening for the Early Detection of Diabetic Retinopathy:

NCHI’s image management and exchange technologies have been developed to support screening for
diabetic retinopathy via telehealth in order to decrease costs through early detection of disease progression
and by developing economies of scale. Digital cameras are used to image the retinas of diabetics. Those
images are then be transmitted over the NCHI grid platform to ophthalmologists for reading. The initial
piloting of this technology will take place in Los Angeles at the Cope Clinic health system and the images will
be transmitted to the Doheny Eye Institute at USC. Image exchange will then be expanded in phase two of
the project with retinal image data being sent between Los Angeles and Chicago to better utilize available
ophthalmologist capacity in both cities.
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C. Increasing Access to Care: Reducing disparities in care and variations in access to health resources
by leveraging technologies such as low cost telehealth that increase access in underserved urban
and rural areas as well as in primary care specialties such as pediatrics where access to
neonatologists and pediatricians is deficient.

1. Urban Health Initiative, Chicago and

Cope Clinic, Los Angeles:
The Urban Health Initiative is a collaborative effort
between the University of Chicago Health Center and
safety net clinics on the south side of Chicago focused on
promoting community health. NCHI is currently partnering
with the Urban Health Initiative to develop a community
health data exchange over NCHI’s grid platform and to
support adoption of open source electronic health records.
The Cope Health system is a key part of the safety net
system in Los Angeles. NCHI is developing telehealth and
electronic health record technologies that will be deployed
at clinics in the Cope system.

2. The California Telehealth Network:

An explicit goal of the California Telehealth Network is to
expand access to care in rural areas. NCHI’s is working
with the California Telehealth Network in order to evalu-
ate how scalable health grid computing technologies can
be used to support distance medicine and data exchange
between small office practices.

3. The Children’s Cancer Care Grid:

To date, relatively few health information technology
applications have been developed for pediatrics. NCHI,
through its collaborations with the Children Oncology
Group and the New Approaches to Neuroblastoma
Therapy Consortium, is exploring how open source grid
computing technologies can be developed to
support children’s health.
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D. Enhancing Patient Centered Care: The NCHI network architecture assembles data longitudinally over
time with the patient as the starting point. The patient-centered integrated health record is a self-
assembly of dynamically changing health information secured and utilized over the lifetime of the
patient and their care-givers to maintain health rather than episodic treatment of disease. Information
is drawn from the silos where it currently resides and self-assembles around the needs of individuals.

1. Dossia:
Dossia is a non-profit consortium of large employers that seeks to enhance consumer engagement in
their own health care through the use of personal health records. Founding members include large U.S.
companies representing over five million employees, including Abraxis Bioscience, Applied Materials,
AT&T, BP America, Inc., Cardinal Health, Intel, Pitney Bowes, sanofi-aventis and Walmart.

Dossia and NCHI are developing a collaborative relationship centered on harnessing the NCHI architecture
for intereoperability so that the Dossia personal health record technologies can better aggregate dispersed
health data for consumers.

2. The Medical Home – the University of Chicago’s South Side Health and Vitality Study:
NCHI and the University of Chicago are exploring how grid computing technologies can facilitate the devel-
opment of primary care “medical homes” for people living on the South Side of Chicago. The goal of the
“medical home” is to develop care delivery structures that center on patient needs in community settings.

E. Open Interface Pilot Projects: Third Parties Leveraging the NCHI Platform: NCHI virtual electronic
health record technologies are based on an open architecture with open interfaces. NCHI is actively
encouraging third parties to join the network and to utilize the platform to develop innovative ways of
delivering services.

1. Vitality:
Vitality manufacture a “smart medication” cap designed to improve quality of care by enhancing prescription
drug adherence in a patient-centered fashion. The Vitality technology senses when the cap is opened
and wirelessly transmits the data to Vitality service centers. Vitality is currently collaborating with NCHI
to determine how its technology can be best integrated into the NCHI grid computing healthcare platform
through open interfaces.

2. Zirmed:
Zirmed manages billing, eligibility and related administrative matters. They currently connect over 100,000
physicians to 2500 payers. Zirmed is currently working with NCHI to integrate it’s technology into the grid
technology platform to generate economies of scale the company would otherwise be unable to leverage.

3. ITA Partners:
ITA Partners is currently specializing in oncology and end-stage renal disease, ITA improves medical
outcomes for patients and thus delivers quantifiable cost savings for them and for payers.  ITA’s medical
professionals and patent-pending health information support systems ensure treatment meets latest
standards; patients receive correct, timely, ongoing care; and patients and their families are prepared
to make informed healthcare decisions.
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BIOGRAPHIES
NCHI

Patrick Soon-Shiong, MD - Chairman

Dr. Soon-Shiong holds a degree in Medicine from the University of the Witwatersrand, Johannesburg, South
Africa, and a Master of Science from the University of British Columbia. He is a fellow of the American College of
Surgeons and the Royal College of Physicians and Surgeons of Canada. Dr. Soon-Shiong performed the world’s
first encapsulated islet transplant in a diabetic patient. He developed the first FDA approved protein nanopar-
ticle delivery technology for the treatment of metastatic breast cancer and this drug is being developed for lung,
melanoma, gastric and pancreatic cancer. He is a co-inventor of over 50 issued U.S. patents, has published
more than 100 scientific papers, and founder of 2 publicly traded pharmaceutical companies, American Pharma
Partners and Abraxis Bioscience .

Dr. Soon-Shiong’s research has been recognized by national and international awards such as the Association
for Academic Surgery Award for Research, the American College of Surgeons Schering Scholar, the Royal
College Physicians and Surgeons Research Award, the Peter Kiewit Distinguished Membership in Medicine
Award, and the International J.W. Hyatt Award for Service to Mankind. Dr. Soon-Shiong received the 2006 Gilda
Club Award for the advancement of cancer medicine and is a recipient of a 2007 Ellis Island Medal of Honor as
well as the St. Mary Medical Center Life Achievement Award in 2007 and the St. John’s Health Center Caritas
Award in 2007. In 2008 he received the Medical Visionary Award from the Pancreatic Cancer Action Network for
his work in pancreatic cancer.

Dr. Soon-Shiong currently serves on the Board of Directors for the National Institute of Transplantation as well
as the Technology Council for the new Center for Cancer Nanotechnology Excellence at Northwestern University
which is part of the National Cancer Institute’s (NCI) five-year initiative for nanotechnology in cancer research.
He also serves on two advisory boards for the RAND Corporation, the RAND Center for Asia Pacific Policy and
the RAND Health Board of Advisors. Dr. Soon-Shiong recently joined the Board of Trustees for the Saint John’s
Health Center in Los Angeles, California and the Advisory Board of the California NanoSystems Institute at
UCLA. He also recently joined the Advisory Board for the Institute for Technology Advancement (ITA) at UCLA
School of Engineering & Applied Science, as well as the Board of Councilors of the USC Viterbi School of
Engineering.

In 2009 he was appointed to the President’s Council at RAND Corporation, Chairman of the Steering Committee
of Life Sciences of the X-Prize Foundation and Founding Board member to Dossia Foundation.
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MaryAnn Guerra - President (interim)

MaryAnn brings more than 25 years of experience in business, health, technology transfer, and research
management to NCHI as it established and launches it national and global efforts. Her extensive research and
management background includes operating major national programs at the National Institutes of Health, estab-
lishing not-for-profit organizations across the US and creating for-profit companies based on academic research
outcomes. She will be responsible for assisting NCHI in establishing its infrastructure to support the execution
of its core programs and operation. She will also play a critical role in establishing the important partnership that
are fundamental to NCHI’s vision and mission.

Ms. Guerra also founded Catapult Bio where she serves as the Chairman and CEO and is responsible for providing
strategic leadership for the company by working with the Board of Directors and the Executive Management
Team to establish long-range goals, strategies, plans and policies with a focus on long term growth and sustain-
ability. Catapult Bio’s mission is to drive economic development through commercialization of late-stage basic
and applied research in the life sciences. MaryAnn also serves as Executive Advisor for the Life Sciences Prize
Group for the X PRIZE Foundation, providing senior level expertise to this important prize area.

Prior to joining Catapult BIO, Ms. Guerra served as President of TGen Accelerators, LLC and Chief Business
Officer at TGen. Ms. Guerra is well experienced in creating novel programs to accelerate the transfer of technology
from the lab into useful products and new business opportunities thus enabling TGen to quickly advance its
research agenda. Ms. Guerra has spent the past 20 years managing and operating successful and progressive
health, science and technology businesses, as well as interacting with private, public and academic institutions.
Ms. Guerra is an expert at business development and strategic planning initiatives that create organizations
poised to deliver clinical and research outcomes. Her knowledge and experience in the field provides for effective
leadership when responding to and creating specialized services that reflect the unique and distinct requirements
needed across the health and technology arenas.

Ms. Guerra served as Executive Vice President of the Matthews Media Group, where she was responsible for
developing and implementing a strategic business plan that expanded and enhanced services and extended
relationships with the pharmaceutical and biotechnology industries. Ms. Guerra has also held various senior
level positions at the National Institutes of Health, including: Deputy Director of Management at the NCI; Executive
Officer of the National Heart, Lung, and Blood Institute; and Chief of the Technology Transfer and Intramural
Management Branch at the National Institute of Allergy and Infectious Disease.

As the Deputy Director for Management, National Cancer Institute (NCI), Ms. Guerra oversaw all the business
operations of an organization with an annual budget in excess of $4 billion in appropriated funds and a staff of
over 5,000. Ms. Guerra has received numerous awards for her work, including the Business Journal’s “Power
People” award, the Girl Scouts “Women of the Future World Award,” and Vice President Gore’s National
Partnership for Reinventing Government Hammer Award for the NIH IntraMall.

Ms. Guerra holds an undergraduate degree from The Ohio State University and an MBA from George Washington
University in Science, Innovation and Technology.
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Katherine Tavitian, JD - Executive Director

Katherine brings more than 25 years of diverse healthcare, business, legal and financial experience to NCHI, where
she will be responsible as Executive Director for providing strategic, business development and operational leadership
for the organization. She brings to this role an innovative, future-oriented vision and a passion for developing and
leading initiatives that promote high quality, safe, value-driven and accessible health care services.

Prior to joining NCHI, Katherine served in increasingly responsible roles at Walgreen Co., a Fortune 50 company, most
recently as Senior Vice President of Healthcare Business Development for Walgreens Health Services, a division of
Walgreen Co., where she contributed to executive-level vision and strategy and developed and executed entre-
preneurial business-to-business initiatives and breakthrough business strategies from the ground up that contributed
several hundred million dollars to the company’s annual revenue. She also led the design and adoption of innovative
health care delivery solutions that enhanced the delivery of quality patient care. During her 15 year career at Walgreens,
Katherine gained a broad perspective of the health care industry and collaborated with C-level executives in multiple
health care industry stakeholder groups, including health systems and other provider organizations, employer groups,
health plans, PBMs, pharmaceutical companies, health care quality organizations, specialty and infusion pharmacies,
and governmental entities.

She also brings extensive legal and financial experience to her role, having practiced corporate and transactional law
for over 15 years with firms including Sonnenschein, Nath & Rosenthal and having worked in the public accounting
industry as a C.P.A. for KPMG before attending law school. Katherine holds an undergraduate degree in business from
Purdue University and a J.D. from Yale Law School.

Basit Chaudhry, MD, PhD - Vice President and Chief Medical Officer

Dr. Chaudhry is a board certified primary care internal medicine physician with expertise in health information
technology, quality improvement methodology and public health. Dr. Chaudhry completed his undergraduate
education at Columbia University, his medical education at New York University, and his post-graduate medical
training at UCLA. Dr. Chaudhry went on to do fellowship training through the UCLA Robert Wood Johnson
Clinical Scholars Program. He completed his PhD at the UCLA School of Public Health. His dissertation
focused on national physician adoption of electronic health records. Dr. Chaudhry worked in the UCLA
Division of General Internal Medicine and as a research scientist at the Health Division of RAND Corporation.
Dr. Chaudhry’s research has focused on factor’s driving adoption of information technology in the healthcare
industry, assessments of the impact that information technology use has improving care, privacy and security,
digital healthcare identity and use of health data standards. He has expertise in a range of health information
technology areas including electronic prescribing standards, HL7, SNOMED, and the National Library of
Medicine’s UMLS. He has expertise in quality improvement methodologies including quality of care measure-
ment and continuous quality improvement.
18

Dr. Carl Kesselman - Chief Technology Officer

Dr. Carl Kesselman is Professor of Industrial and Systems Engineering and a Fellow in the Information Sciences
Institute in the Viterbi School of Engineering at the University of Southern California. He is the co-Director of the
Medical Information Systems Division at ISI and co-Director of the Center for Health Informatics.. He received a
Ph.D. in Computer Science from the University of California, Los Angeles, a Master of Science degree in Electrical
Engineering from the University of Southern California, and Bachelors degrees in Electrical Engineering and
Computer Science from the University at Buffalo. Dr. Kesselman also serves as Chief Scientist of Univa Corporation,
a company he founded with Globus co-founders Ian Foster and Steve Tuecke.

Dr. Kesselman’s current research interests include health informatics as well as all aspects of Grid computing,
including basic infrastructure, security, resource management, high-level services and Grid applications. He is
the author of many significant papers in the field. Together with Dr. Ian Foster, he initiated the Globus Project™,
one of the leading Grid research projects. The Globus project has developed the Globus Toolkit®, the de facto
standard for Grid computing.

Dr. Kesselman received the 1997 Global Information Infrastructure Next Generation Internet award, the 2002
R&D 100 award, the 2002 R&D Editors choice award, the Federal Laboratory Consortium (FLC) Award for
Excellence in Technology Transfer and the 2002 Ada Lovelace Medal from the British Computing Society for
significant contributions to information technology. Along with his colleagues Ian Foster and Steve Tuecke, he
was named one of the top 10 innovators of 2002 by InfoWorld Magazine. In 2003, he and Dr. Foster were named
by MIT Technology Review as the creators of one of the “10 technologies that will change the world.” In 2006
Dr. Kesselman received an Honorary Doctorate from the University of Amsterdam. In 2007, he received the
Internet2 Idea award, and the ComputerWorld Horizon Award along with Dr. Stephan Erberich.

NCHI Associates

Dr. Ian Foster

Ian Foster was born in Wellington, New Zealand. He has a bachelor of science (Hons I) degree from the University of
Canterbury in Christchurch, New Zealand and a doctorate from Imperial College, London, both in computer science.
He is currently director of the Computation Institute, Arthur Holly Compton Distinguished Service Professor of Com-
puter Science, Argonne Fellow, and a Chan Soon-Shiong Scholar at The University of Chicago and Argonne National
Laboratory.

Dr. Foster’s research deals with distributed, parallel, and data-intensive computing technologies; the applications of
those technologies to scientific problems; and the mechanisms and policies needed to create and operate scalable
scientific “cyberinfrastructures.”  He has published six books and over 300 articles and technical reports on these and
related topics. He has also played a leading role in the development of grid computing, co-founding the influential
Open Grid Forum, co-editing (with Dr. Carl Kesselman) the book “The Grid: Blueprint for a New Computing
Infrastructure,” and co-leading development of the widely used Globus grid software. 

Dr. Foster’s work has been recognized by numerous awards, including the Lovelace Medal, R&D Magazine’s Innovator
of the Year, and DSc Honoris Causa from the University of Canterbury. Ian Foster is a fellow of the American
Association for the Advancement of Science and the British Computer Society.
 19

Dr. Stephan G. Erberich

Dr. Stephan G. Erberich is a senior computer scientist with more then 14 years of experience in medical informatics.
He received his B.Sc., M.Sc., and Ph.D. degree in Computer Science and Medical Informatics from the RWTH Aachen
University, Aachen, Germany and in Imaging Informatics as research fellow at the University of California San Fran-
cisco (UCSF). Dr. Erberich established and directed the Neuro-Functional Imaging Laboratory (NFIL) at the University
Hospital in Aachen – a leading medical center in Europe with more than 5000 staff, physicians and scientists and 1500+
beds. During his tenure NFIL integrated 11 Departments providing, Enterprise-wide clinical and research imaging proce-
dures, image analytics and computing and has been the Informatics lead on 20+ clinical research projects. Dr. Erberich
pioneered functional MRI brain mapping as a routine diagnostic technique for interventional and therapeutic procedures
in collaboration with Philips Medical Systems and performed more the 2000 patient studies. In 2001 he joined the
University of Southern California, where he was appointed as a joint faculty in Research Radiology, Keck School of
Medicine, and Biomedical Engineering, Viterbi School of Engineering. Dr. Erberich also directs the Functional
Imaging and Biomedical Informatics program at Children’s Hospital Los Angeles (CHLA) where he pioneered non-
invasive functional brain mapping in pre-/term neonates. He led the original functional neuro-imaging studies in
neonates as principal investigator using the first MR-compatible incubator and was instrumental to its FDA approval.
During his tenure at CHLA he also focused on image informatics for large-scale multi-center clinical trials. Dr. Erberich
is the founder of Globus MEDICUS, a medical image management system using Grid technologies, and directed the
deployment of the National Institute of Health and Department of Defense awarded projects for the Children’s Oncol-
ogy Group, which became one of the first and largest HealthGrid deployments in the US and Canada encompassing
more then 40 medical centers. In 2008 he joined the Information Sciences Institute (ISI/USC) as Research Professor in
Biomedical Engineering, USC Viterbi School of Engineering, and Professor of Research Radiology, USC Keck School
of Medicine, and Co-Director Medical Information Systems Division and Co-Director Center for Health Informatics. Dr.
Erberich is well published in Medical Informatics and Clinical Imaging Research. He received numerous honors and
awards for his academic work including Scientific Merit Awards from the Radiological Society of North America and the
Optical Engineering Society (SPIE), innovation award from the Internet2 consortium for high-performance networking
and the 2007 Computerworld New Horizon Award for most innovative technology in the field of Medicine. He serves
as board member of the International Brain Mapping and Intraoperative Surgical Planning Society (IBMISPS) and is
elected IT committee chair of the Optical Engineering Society (SPIE).

Jonathan C. Silverstein, MD, MS, FACS, FACMI

Jonathan C. Silverstein, associate director of the Computation Institute of the University of Chicago and Argonne
National Laboratory is associate professor of Surgery, Radiology, and The College, scientific director of the
Chicago Biomedical Consortium, and president of the HealthGrid.US Alliance. He focuses on the integration of
advanced computing and communication technologies into biomedicine, particularly applying Grid computing,
and on the design, implementation, and evaluation of high-performance collaboration environments for anatomic
education and surgery. He holds an M.D. from Washington University (St. Louis) and an M.S. from Harvard
School of Public Health. He is a Fellow of the American College of Surgeons and a Fellow of the American
College of Medical Informatics. Dr. Silverstein provides leadership in information technology initiatives intended
to transform operations at the University of Chicago Medical Center and is informatics director for the University of
Chicago’s Clinical and Translational Science Award (CTSA) program. He has served on various national advisory
panels and currently serves on the Board of Scientific Counselors for the Lister Hill Center of the NIH National
Library of Medicine. Dr. Sliverstein is a Chan Soon-Shiong Scholar at the University of Chicago and Argonne
National Laboratory.
20

Steve Tuecke, Staff, CI

Steve Tuecke is Associate Directory of Technology at The University of Chicago’s Computation Institute (CI), where
he is responsible for leading and contributing to projects in computational science, high-performance and distributed
computing, and biomedical informatics. Dr. Tuecke is s a Chan Soon-Shiong Scholar at the University of Chicago and
Argonne National Laboratory.

Prior to CI, Steve was co-founder, Chief Technology Officer, and on the board of Univa Corporation from 2004-2008,
and also served as Univa’s first Chief Executive Officer. Univa provides open source and proprietary software for the
high-performance computing and cloud computing markets. Steve helped lead Univa through several new product
launches, multiple venture capital investment rounds, and the acquisition of United Devices. He continues to serve on
Univa’s board and as CTO advisor.

Prior to Univa, Steve co-founded the Globus Project, with Dr. Ian Foster and Dr. Carl Kesselman. He was responsible
for managing the architecture, design, and development of Globus software, as well as the Grid and Web Services
standards that underlie it.

He began his career in 1990 as a software engineer for Foster in the Mathematics and Computer Science division at
Argonne National Laboratory. In 1995, Tuecke helped create the Distributed Systems Laboratory at Argonne which,
under his management and technology leadership, became the premier Grid research and development group in the
world. In 2001, Tuecke focused on Globus architecture and design, creating Grid and Web Services standards, and
expanding corporate relationships. In 2002, Tuecke received Technology Review magazine’s TR100 award, which
recognized him as one of the world’s top 100 young innovators. The same year, he also was named to Crain’s Chicago
Business “Forty Under 40” and described as one of the Chicago area’s “best and brightest.” In 2003, he was named
(with Foster and Kesselman), by InfoWorld magazine as one of its Top 10 Technology Innovators of the year.

Tuecke graduated summa cum laude with a B.A in mathematics and computer science from St. Olaf College.