Association Between Serum Ferritin and Retinopathy Diabetes in Type 2 Diabetes Mellitus Patients in RS Dr Moewardi Surakarta Nurhasan A.

1, Arifin2, Sugiarto2, Supriyanto K.2, Djoko Hardiman2

2

Resident of internal edi!ine Se"elas aret #ni$ersity Department %ndo!rinology and eta"oli! Se"elas aret #ni$ersity Abstract

Background Serum ferritin le$el is related to "ody iron stores, and is influen!ed "y diseases su!h as !hroni! inflammation. &t 'as suggested that an e(!essi$e a!!umulation of "ody iron stores may !ontri"ute to the pathogenesis of type 2 dia"etes mellitus and its !ompli!ations. )he aim of the study 'as to e$aluate the relationship "et'een dia"etes retinopathy and serum ferritin le$els in type 2 dia"etes mellitus patients. Methods * &n!lusion !riteria 'ere type 2 dia"etes mellitus patients. %(!lusion !riteria 'ere smoking, history of !oronary heart disease or symptomati! !arotid artery disease, !hroni! diseases like malignan!y, se$ere !hroni! lung disease, !hroni! li$er disease, inflammatory "o'el diseases, and autoimmune disorders, "lood pressure +1,-./- or treatment 'ith more than 2 antihypertensi$e medi!ations, serum !reatinine +1., mg.d0 and.or urine protein +1, mg.d0, hemoglo"in 21- g.d0 and.or any kno'n hematologi! disorders and treatment 'ith iron. 3e used t test and spearman !orrelation test for statisti!, signifi!ant if p2-,-, Result 3e !ondu!ted !ross se!tional study to ,, type 2 dia"etes mellitus patients 'ith mean age ,14/,1,, mean ferritin 15-,2 4 15,/ 6g.m0, 51 patients 'ith retinopathy dia"etes 'ith mean ferritin 178 487,8 6g.m0 and 27 non retinopathy 'ith mean ferritin 1-/49-,17 6g.m0. )here 'as different "et'een ferritin serum in retinopathy and 'ithout retinopathy :p;-,--1< and there 'as positi$e !orrelation "et'een ferritin serum and rethinopathy :r ; -,529, p;-,-17<. !onclusion )his study demonstrates that ele$ated serum ferritin 'as asso!iated 'ith an in!reased risk retinopathy dia"etes in type 2 dia"etes mellitus patient "eyword diabetes# retinopathy# $erritin

Association between Serum Ferritin and %lycosilated &aemoglobin in Type 2 diabetes mellitus Patients in RS Dr Moewardi Surakarta Ratih A.1, Arifin2, Sugiarto2, Supriyanto K.2, Djoko Hardiman2
2

Resident of internal edi!ine Se"elas aret #ni$ersity Department %ndo!rinology and eta"oli! Se"elas aret #ni$ersity Abstract

Background Serum ferritin le$el is related to "ody iron stores, and is influen!ed "y diseases su!h as !hroni! inflammation. &t 'as suggested that an e(!essi$e a!!umulation of "ody iron stores may !ontri"ute to the pathogenesis of type 2 dia"etes mellitus and its !ompli!ations. Serum ferritin in!rease 'as asso!iated 'ith higher "lood glu!ose. )he aim of the study 'as to e$aluate the relationship "et'een gly!osilated haemoglo"in and serum ferritin le$els in type 2 dia"etes mellitus patients. Methods &n!lusion !riteria 'ere type 2 dia"etes mellitus patients. %(!lusion !riteria 'ere !hroni! diseases like* malignan!y, se$ere !hroni! lung disease, !hroni! li$er disease, inflammatory "o'el diseases and autoimmune disorders, serum !reatinine +1., mg.d0 and.or urine protein +1, mg., hemoglo"in 21- g.d0 and.or any kno'n hematologi! disorders and treatment 'ith iron. Result 3e !ondu!ted !ross se!tional study to ,, type 2 dia"etes mellitus patients 'ith mean age ,7 4 7,5, mean ferritin 127 4 5-,2, 2, patients and h"a1! mean 9,, 4 2,7. 3e anali=ed 'ith pearson !orrelation and the result 'as positi$e !orrelation :r ; -,1,1> p;-,--1<. !onclusion )his study demonstrates that ele$ated serum ferritin 'as asso!iated 'ith an in!reased gly!osilated haemoglo"in in type 2 dia"etes mellitus patient in Dr oe'ardi Hospital Surakarta "eyword diabetes# glycosilated haemoglobin# $erritin

Association Between Serum Ferritin with Total !holesterol# 'D' !holesterol# &D' !holesterol# And Trigliseride in Type 2 Diabetes Mellitus Patients in RS Dr Moewardi Surakarta Atika ?.1, Arifin2, Sugiarto2, Supriyanto K.2, Djoko Hardiman2
2

Resident of internal edi!ine Se"elas aret #ni$ersity Department %ndo!rinology and eta"oli! Se"elas aret #ni$ersity Abstract

Background Serum ferritin le$el is related to "ody iron stores, and is influen!ed "y diseases su!h as !hroni! inflammation. &t 'as suggested that an e(!essi$e a!!umulation of "ody iron stores may !ontri"ute to the pathogenesis of type 2 dia"etes mellitus and its !ompli!ations. Serum ferritin in!rease 'as asso!iated 'ith the insulin resistan!e syndrome :&RS<, defined "y the presen!e of one or more of the follo'ing !riteria* in!reased "ody mass inde( :@ &<, dia"etes, hyperlipidemia or hypertension. )he aim of the study 'as to e$aluate the relationship "et'een total !holesterol, 0D0 !holesterol, HD0 !holesterol, and trigliseride 'ith serum ferritin le$els in type 2 dia"etes mellitus patients. Methods &n!lusion !riteria 'ere type 2 dia"etes mellitus patients. %(!lusion !riteria 'ere !hroni! diseases like* malignan!y, se$ere !hroni! lung disease, !hroni! li$er disease, inflammatory "o'el diseases and autoimmune disorders, serum !reatinine +1., mg.d0 and.or urine protein +1, mg., hemoglo"in 21- g.d0 and.or any kno'n hematologi! disorders and treatment 'ith iron. 3e used spearman !orrelation test for statisti!, signifi!ant if p2-,-, Result 3e !ondu!ted !ross se!tional study to ,, type 2 dia"etes mellitus patients 'ith mean age ,14/,1,, mean ferritin 15-,2 4 15,/ 6g.m0, mean HD0 ,1,1417,1,mean 0D0 15-,74 58,9, total !holesterol 1/,,184 5/,,, and trigliseride 1714 88,71. )here 'as positi$e !orrelation "et'een ferritin and 0D0 :r ; -,75/>p;-,--1<, no !orrelation in HD0 :r ; A-,1//> p;-,178<, positi$e !orrelation in total !holesterol :r ; -,7-8> p;-,-2<, positi$e !orrelation in trigliseride :r ; -,217> p;-,-75<. !onclusion )his studydemonstrates that ele$ated serum ferritin 'as asso!iated 'ith an in!reased total !holesterol, 0D0 !holesterol, and trigliseride in type 2 dia"etes mellitus patient in Dr oe'ardi Hospital Surakarta "eyword diabetes# total cholesterol# 'D'# trigliseride# $erritin

Association Between Serum Ferritin with Body Mass (nde) in Type 2 Diabetes Mellitus Patients in RS Dr Moewardi Surakarta &ndah ?.1, Arifin2, Sugiarto2, Supriyanto K.2, Djoko Hardiman2
2

Resident of internal edi!ine Se"elas aret #ni$ersity Department %ndo!rinology and eta"oli! Se"elas aret #ni$ersity Abstract

Background Serum ferritin le$el is related to "ody iron stores, and is influen!ed "y diseases su!h as !hroni! inflammation. &t 'as suggested that an e(!essi$e a!!umulation of "ody iron stores may !ontri"ute to the pathogenesis of type 2 dia"etes mellitus and its !ompli!ations. Serum ferritin in!rease 'as asso!iated 'ith the insulin resistan!e syndrome, defined "y the presen!e of one or more of the follo'ing !riteria* in!reased "ody mass inde(, dia"etes, hyperlipidemia or hypertension. )he aim of the study 'as to e$aluate the relationship "ody mass inde( 'ith serum ferritin le$els in type 2 dia"etes mellitus patients. Methods * &n!lusion !riteria 'ere type 2 dia"etes mellitus patients. %(!lusion !riteria 'ere smoking, history of !oronary heart disease or symptomati! !arotid artery disease, !hroni! diseases like malignan!y, se$ere !hroni! lung disease, !hroni! li$er disease, inflammatory "o'el diseases, and autoimmune disorders, "lood pressure +1,-./- or treatment 'ith more than 2 antihypertensi$e medi!ations, serum !reatinine +1., mg.d0 and.or urine protein +1, mg.d0, hemoglo"in 21- g.d0 and.or any kno'n hematologi! disorders and treatment 'ith iron. 3e used t test dan pearson !orrelation test for statisti!, signifi!ant if p2-,-, Result 3e !ondu!ted !ross se!tional study to ,, type 2 dia"etes mellitus patients 'ith mean age ,14/,1,, mean ferritin 15-,2 4 15,/ 6g.m0, 21 o"ese patients and 29 'ith normal 'eight. )here 'as different ferritin serum in o"ese and non o"ese :p;-,--1< and there 'as mild positi$e !orrelation :r ; -,582, p;-,--1<. !onclusion )his study demonstrates that ele$ated serum ferritin 'as asso!iated 'ith an in!reased "ody mass inde( in type 2 dia"etes mellitus patient "eyword diabetes# body mass inde)# $erritin