ORGANISM

1) Actinomyces spp. 2) Bacillus atrophaeus 3) Bacillus pumilus 4) Bordertella pertussis 5) Brevundimona diminuta 6) Clostridium sporongenes 7) Clostridium tetani 8) Corynebacterium diphtheriae 9) Escherichia coli 10) Geobacillus stearothermophilus 11) Haemophilus influenzae (Type B) 12) Leuconostoc mesenteroides 13) Neisseria meningtidis 14) Pseudomans aeruginosa 15) Proteus vulgaris 16) Salmonella enterica sevovar typhi 17) Staphylococcus aureus

PHARMACEUTICAL RELEVANCE
Antibiotic Reproduction Validate & Monitor DRY-HEAT and Ethylene Oxide sterilization process V & M Radiation Sterilization process Vaccine (Whooping cough) 0.22 filter challenge test Confirm anaerobic growth Vaccine (tetanus) Vaccine (Diphtheria) Kesley-sykes disinfectant capacity test V & M MOIST HEAT sterilization process Vaccine (Hib infections) Dextran Production Vaccine (Meningitis C) Allginate Production Kesley-sykes disinfectant capacity test Kesley-sykes disinfectant capacity test Chick-martin RIdeal Walker } disinfectant coefficient test Kesley-sykes disinfectant capacity test Preservative limit test PHARMACEUTICAL RELEVANCE Wound Infection Causative agent of whooping cough Severe enteritis Causative agent of tetanus Causative agent of bacteria Food poisoning, Severe enteritis Causative agent of Infantile Meningitis Chronic bronchitis Causative agent of Legionnaires disease Causative agent of tuberculosis Disinfectant resistant Intracellular pathogen General environmental contaminant Quintessential opportunist pathogen High resistance to antibiotics & biocides Biofilm former Varying degrees of food poisoning & typhoid fever Skin contaminant, Food poisoning, toxic shock syndrome, pyogenic infections Implanted medical/prosthetic device contaminant Biofilm former Causative agent of tonsillitis & scarlet fever

1.) 2.) 3.) 4.) 5.) 6.)

ORGANISM Bacteroides fragilis Bordertella pertussis Campylobacter jejuni Clostridium tetati Corynebacterium diphtheriae Escherichia coli

7.) Haemophilus influenzae 8.) Leoginella pneumophila 9.) Mycobacterium tuberculosis

10.) Pseudomonas aeruginosa

11.) Salmonella spp. 12.) Staphylococcus aureus 13.) Staphylococcus epidermidis 14.) Streptococcus spp.

ORGANISM

PHARMACEUTICAL RELEVANCE
Antibiotic Reproduction Validate & Monitor DRY-HEAT and Ethylene Oxide sterilization process V & M Radiation Sterilization process Vaccine (Whooping cough) 0.22 filter challenge test Confirm anaerobic growth Vaccine (tetanus) Vaccine (Diphtheria) Kesley-sykes disinfectant capacity test V & M MOIST HEAT sterilization process Vaccine (Hib infections) Dextran Production Vaccine (Meningitis C) Allginate Production Kesley-sykes disinfectant capacity test Kesley-sykes disinfectant capacity test Chick-martin RIdeal Walker } disinfectant coefficient test Kesley-sykes disinfectant capacity test Preservative limit test

ORGANISM

PHARMACEUTICAL RELEVANCE Wound Infection Causative agent of whooping cough Severe enteritis Causative agent of tetanus Causative agent of bacteria Food poisoning, Severe enteritis Causative agent of Infantile Meningitis Chronic bronchitis Causative agent of Legionnaires disease Causative agent of tuberculosis Disinfectant resistant Intracellular pathogen General environmental contaminant Quintessential opportunist pathogen High resistance to antibiotics & biocides Biofilm former Varying degrees of food poisoning & typhoid fever Skin contaminant, Food poisoning, toxic shock syndrome, pyogenic infections Implanted medical/prosthetic device contaminant Biofilm former Causative agent of tonsillitis & scarlet fever

ORGANISM

PHARMACEUTICAL RELEVANCE
Antibiotic Reproduction Validate & Monitor DRY-HEAT and Ethylene Oxide sterilization process V & M Radiation Sterilization process Vaccine (Whooping cough) 0.22 filter challenge test Confirm anaerobic growth Vaccine (tetanus) Vaccine (Diphtheria) Kesley-sykes disinfectant capacity test V & M MOIST HEAT sterilization process Vaccine (Hib infections) Dextran Production Vaccine (Meningitis C) Allginate Production Kesley-sykes disinfectant capacity test Kesley-sykes disinfectant capacity test Chick-martin RIdeal Walker } disinfectant coefficient test Kesley-sykes disinfectant capacity test Preservative limit test

ORGANISM

PHARMACEUTICAL RELEVANCE Wound Infection Causative agent of whooping cough Severe enteritis Causative agent of tetanus Causative agent of bacteria Food poisoning, Severe enteritis Causative agent of Infantile Meningitis Chronic bronchitis Causative agent of Legionnaires disease Causative agent of tuberculosis Disinfectant resistant Intracellular pathogen General environmental contaminant Quintessential opportunist pathogen High resistance to antibiotics & biocides Biofilm former Varying degrees of food poisoning & typhoid fever Skin contaminant, Food poisoning, toxic shock syndrome, pyogenic infections Implanted medical/prosthetic device contaminant Biofilm former Causative agent of tonsillitis & scarlet fever

ORGANISM

PHARMACEUTICAL RELEVANCE
Antibiotic Reproduction Validate & Monitor DRY-HEAT and Ethylene Oxide sterilization process V & M Radiation Sterilization process Vaccine (Whooping cough) 0.22 filter challenge test Confirm anaerobic growth Vaccine (tetanus) Vaccine (Diphtheria) Kesley-sykes disinfectant capacity test V & M MOIST HEAT sterilization process Vaccine (Hib infections) Dextran Production Vaccine (Meningitis C) Allginate Production Kesley-sykes disinfectant capacity test Kesley-sykes disinfectant capacity test Chick-martin RIdeal Walker } disinfectant coefficient test Kesley-sykes disinfectant capacity test Preservative limit test

ORGANISM

PHARMACEUTICAL RELEVANCE Wound Infection Causative agent of whooping cough Severe enteritis Causative agent of tetanus Causative agent of bacteria Food poisoning, Severe enteritis Causative agent of Infantile Meningitis Chronic bronchitis Causative agent of Legionnaires disease Causative agent of tuberculosis Disinfectant resistant Intracellular pathogen General environmental contaminant Quintessential opportunist pathogen High resistance to antibiotics & biocides Biofilm former Varying degrees of food poisoning & typhoid fever Skin contaminant, Food poisoning, toxic shock syndrome, pyogenic infections Implanted medical/prosthetic device contaminant Biofilm former Causative agent of tonsillitis & scarlet fever