DEVELOPMENT OF SOME NOVEL DRUG DELIVERY SYSTEMS A drug delivery system (DDS) is defined as a formulation or a device that enables

the introduction of a therapeutic substance in the body and improves its efficacy and safety by controlling the rate, time, and place of release of drugs in the body. This process includes the administration of the therapeutic product, the release of the active ingredients by the product, and the subsequent transport of the active ingredients across the biological membranes to the site of action. Drug delivery system is an interface between the patient and the drug. It may be a formulation of the drug to administer it for a therapeutic purpose or a device used to deliver the drug. To obtain a given therapeutic response, the suitable amount of the active drug must be absorbed and transported to the site of action at the right time and the rate of input can then be adjusted to produce the concentrations required to maintain the level of the effect for as long as necessary. The distribution of the drug-to-tissues other than the sites of action and organs of elimination is unnecessary, wasteful, and a potential cause of toxicity. The modification of the means of delivering the drug by projecting and preparing new advanced drug delivery devices can improve therapy. Surface solid dispersions In the present study the surface solid dispersions (SSD) of various drugs are to be prepared to carry the drugs to the required site of action to overcome the shortcomings due to the direct application drug. Unlike the conventional solid dispersion, the carriers used in the surface solid dispersion are the water-insoluble, porous materials with hydrophilic property. They can immediately disperse upon contact with water, rendering rapid release of the drug particles into the medium. The dissolution of the drug particles is facilitated by the same mechanisms

exhibited by the conventional solid dispersion. Surface solid dispersion had been demonstrated as a successful method to improve the dissolution rate and the solubility of many drugs. Preparation of SSDs is a technique that provides deposition of the drug on the surface of certain materials that can alter the dissolution characteristics of the drug. Deposition of drug on the surface of an inert carrier leads to a reduction in the particle size of the drug, thereby providing a faster dissolution rate. Various hydrophilic materials with high surface area can be utilized for deposition of the drug on their surfaces. Surface modification and solid-dispersion formulations using hydrophilic excipients can significantly alter the dissolution behavior of hydrophobic drug materials. Preparation of surface solid dispersions with the following different super disintegrates is proposed: 1. Croscarmellose 2. Sodiumstarch glycolate 3. Crospovidone 4. Pregelatinized starch The prepared surface solid dispersions will be characterized by P-XRD, DSC, FTIR and SEM. Physical mixtures will also be prepared and compared. The drug content will be estimated with UV-Visible Spectrophotometry. The calculations involve mean dissolution time and dissolution efficiency. The drug and excipient interactions will also be investigated.