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This month we bring you an opportunity to read the booklet by Jonathan V. Wright, M.D. 'D-Mannose & Bladder Infection'. The full text of this book is below for you to read at no cost.
Note that UTI is the American term for what the UK public more commonly call cystitis.
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bacteria.
How D-mannose accomplishes this substantial feat will be explained later. Suffice it to say that, because it gets rid of UTI-causing bacteria without committing bacteriacide, people who use it suffer none of the unwanted side effects of antibiotics: no GI side effects, no yeast infections, no resistance. In fact, D-mannose has no adverse side effects of any kind. And as a bonus, it actually tastes good. Where a spoonful of sugar helped the medicine go down in Mary Poppins day, with D-mannose for UTIs, a spoonful of sugar is the medicine. Because it is so effective and so benign, women (even pregnant women) who are susceptible to recurrent UTIs can safely take D-mannose as a preventative measure to head off future attacks. D-mannose is also ideally suited for children with UTI. Because it tastes so good (it is a sugar, after all!), children actually enjoy taking it. Although D-mannose is virtually unknown to practitioners of conventional medicine, many research reports have demonstrated its mode of action and effectiveness against E. coli,* the microorganism that causes most UTIs. Moreover, nearly 15 years of clinical experience have shown that it is just about as effective at curing UTIs as antibiotic drugs. At first glance D-mannose may sound too good to be true: a medicine thats highly effective, perfectly safe, pleasant to use, inexpensive, and available without a doctors prescription. Yes, it is true! Unlike virtually any conventional medication, and many natural or alternative treatments as well, D-mannose has no known drawbacks. If you or someone you love has a UTI or is prone to recurrent UTIs, we urge you to read this booklet and then try D-mannose. Odds are youll soon find that UTIs and antibiotics are a thing of the past.
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A note about terminology: In this booklet, we use the general term UTI (urinary tract infection) to refer to any infection of the bladder, ureters, or kidneys. The majority of us are more familiar with the term bladder infection , which refers to the most common form of UTI. Still, all these infections have a similar origin and are typically treated the same way.
Despite being a bit dubious that a simple sugar prescribed by a natural medicine doctor (remember, this was the 1980s) would do anything, she tried it. Within 48 hours, Amys infection vanished. She remained infection free for over two years, relapsing only when her family forgot to take the D-mannose with them on vacation. When she resumed taking it, the infection immediately cleared. Over the next ten years or so, Amy has had no further UTIs and, of course, has kept her kidneys. Although Amys case is extreme, UTI remains a common and distressing disease that affects up to 50% of all women and girls (and a much smaller number of men and boys) over the course of a lifetime. Each year, UTIs are responsible for 10 million doctor visits. Some people seem to be more susceptible than others; women who have suffered one UTI are very likely to experience a recurrence from time to time. 1-4 Some UTIs are merely painful (sometimes very painful) and annoying. However, as Amys case illustrates, other UTIs especially if theyre chronic, recurrent, or not treated promptly and properly can be quite dangerous. Under these conditions, bacteria may ascent to the kidneys, where infection can lead to serious damage and even kidney failure. Conventional medical treatment of UTIs involves the use of antibiotics. While these drugs are usually but not always effective, curing most infections in a few days, they also have some important drawbacks: Antibiotics are equal-opportunity microbe killers. Although they usually make quick work of the UTI-causing bugs, they dont just stop there. They also kill millions of other friendly bacteria that belong in the body where they serve numerous important functions. Because they kill off friendly bacteria living in the gastrointestinal (GI) tract, antibiotics can cause unwanted side effects, such as diarrhoea, constipation, nausea and occasionally, vomiting. If enough friendly bacteria are killed, not-so-friendly yeasts, moulds, and bacteria all of which can produce unwanted toxins are encouraged to take their places. Since friendly bacteria normally produce significant amounts of several vitamins folic acid and vitamin K are the best known examples antibiotic use can contribute to long-term hidden vitamin deficiency. In addition, many women who take antibiotics (to treat UTI or any other infection) soon come to expect that they will develop a vaginal yeast infection requiring them to take yet another drug this time an antifungal to kill the yeast. The reason is that friendly bacteria that normally inhabit the vagina keep the yeast (usually Candida
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albicans ) population under control. Once these friendly bacteria are taken out of the picture by the antibiotic, the yeast organisms are free to grow unchecked. Although most of us can tolerate antibiotics without immediate side effects, every year a few people are rushed to the hospital because of allergic reactions to these drugs. Lastly, the use of antibiotics promotes the development of bacterial species that are able to resist these drugs. Bacteria are very clever in their ability to mutate genes, making themselves immune to the effects of antibiotics. Those bacteria that have become immune then pass this ability on to their offspring or other bacteria. The likelihood that resistant bacteria will develop is enhanced by the misuse and overuse of antibiotics. The development of antibiotic-resistant bacteria is a major problem in medicine today that has many experts fearing the inevitable arrival of a superbug that is resistant to all known antibiotic drugs.
What is UTI?
A UTI is a bacterial infection (caused by the bacteria E. coli over 90% of the time) that affects the inside lining tissue of the urinary system (or tract). This system includes two kidneys, which form urine from liquid waste in the blood: two narrow ureters , tubes that carry urine from the kidneys to the muscular bladder, which stores it; and a single urethra, the final common path from the bladder to the outside world. The urinary tract reacts to a bacterial infection in much the same way that the upper respiratory system reacts to a cold virus. The tissues become inflamed, irritated and swollen. Just as it's hard to breathe through swollen and inflamed nasal passages, swollen and inflamed urinary ducts can partially obstruct normal flow, making it painful and difficult to pass urine. Ordinarily, the urinary system is hostile territory for bacteria, viruses or any other microorganisms. Bugs that do make their way into a healthy urinary tract are likely to find an inhospitable acidic environment (pH <5.5). They are also subject to attack by the bodys immune defenses. (Adult men have the added protection of a specific bacterial growth inhibitor squirted directly into the urinary system by their prostate gland.) Even if micro organisms manage to overcome these considerable obstacles, they would typically be flushed out with the normal flow of urine. So effective are these natural antibacterial defenses that in a study in which bacteria were instilled into the bladders of guinea pigs, simple urination expelled 99.9% of the bugs. 5 Despite all these built-in safeguards, each year millions of people, overwhelmingly women, still develop UTIs. Most UTIs begin when bacteria originating in the bowels travel to and grow in the urethra. Infections limited to the urethra are known as urethritis. When bacteria travel upstream to the bladder, the infection is called . Infections that reach the kidneys are known as nephritis or pyelonephritis.
cystitis
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The E. coli that cause most UTIs are among the most common friendly bacteria in the GI tract, where they aid digestion, produce a few vitamins, and in general, behave themselves without bothering us. If, however, when E. coli and other bugs exit the lower GI tract, they manage to gain entry to the urinary tract via the urethra, then they attach to the internal lining of the bladder, multiply and spread. Although up to 90% of UTIs are caused by E. coli, the remaining 10% are caused by bacteria known as Chlamydia, Mycoplasma, Neisseria gonorrhoeae, and others. Unlike E. coli, these bugs tend to be transmitted via sexual contact and rarely cause the more serious bladder and kidney infections. Chlamydia, Mycoplasma and N. gonorrhoeae infections do not respond to D-mannose treatment and will probably require antibiotic treatment. In addition, a few UTIs are caused by other bacteria, such as Proteus or Staphylococcus (Staph). Still, all of these non-E. coli infections combined amount to no more than 10% of all UTIs.
cystitis.
Poor hygiene. Failure to remove bacteria from the region surrounding the urethra is an important cause of UTI. Because the urethra is in front of the anus, mothers teach their small daughters to always wipe from front to back to avoid introducing bacteria from the anus into the urethra. In uncircumcised males, the foreskin, if not cleansed properly, can serve as an excellent breeding ground for bacteria, which could then easily gain access to the urethra. Blocking the flow of urine. Normally, the flow of urine from kidneys to bladder to the urethra washes out most bacteria. However, anything that inhibits the flow of urine can increase the risk of UTI. Thus, people with certain anatomic anomalies, as well as blood clots, stones, tumours or strictures (narrowings) are more likely to have recurrent UTIs. In men, enlargement of the prostate gland can impede the flow of urine. Bladder weakness due to diabetes, stroke, or other neurologic disorder can sometimes lead to the pooling of urine in the bladder after urination. In time, this stagnant, residual urine can serve as a growth medium for bacteria. UTI is also quite
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common in people who are severely debilitated and require a urinary catheter (a tube inserted into the urethra to drain the bladder), which can easily become contaminated. Although blockages can promote infection in both sexes, they are the primary cause of UTI in males. Taking the joy out of sex. For many women, the best way to get UTI is to have sexual intercourse. Honeymoon cystitis results when bacteria move from the vagina and the perianal area to the urethra during intercourse. (In a similar manner, it is possible to inoculate the urethra during masturbation and same-sex sexual activity). Some contraceptive methods also increase the chances of UTI. Research has shown that women who use a diaphragm with a spermicidal jelly or foam, or just the spermicide itself, are much more likely to develop a UTI the next day. The same thing is true for condoms with spermicide. 7 Not only do spermicides promote the growth of E. coli, they also allow yeasts and other bacteria to thrive in the vagina. 8 It seems that nonoxynol-9, the most commonly used spermicide, kills a lot more than just sperm. It also kills the friendly bacteria, known as Lactobacilli that inhibit the vagina. One of Lactobacillis main functions is to produce lactic acid, which lowers the pH of the vagina. The relatively acidic normal environment helps keep the population of yeasts and unfriendly bacteria, like E. coli, under control. With Lactobacilli out of the way, the pH rises (less acid), allowing pathogenic organisms to grow unchecked. Nonoxynol-9 may also promote infection by making it easier for E. coli to stick to the epithelial cells that line the vagina, urethra, and bladder. 9 Antibiotics! Yes, its true that antibiotics are widely used to treat UTI, but its also true that antibiotics given for UTI or any other infection can actually increase the risk of UTI. How can that be? Like spermicide, many antibiotics kill vaginal Lactobacilli. Once the antibiotic treatment ceases, the absence of Lactobacilli leaves the vagina vulnerable to E. coli (and yeast) infection. 10 Once in the vagina, E. coli can more easily reach the urethra and bladder and begin the infection cycle all over again. Getting older. The incidence of UTI increases after women reach menopause. The lack of youthful levels of oestrogen leads to a loss of Lactobacilli with a subsequent rise in vaginal pH leading to E. coli (and yeast) colonisation. 11 In very old (and very young) people, urinary and faecal incontinence can also pave the way to UTI. In the genes. Some people have a genetic predisposition to UTI. In other words, if your mother had recurrent UTI, you have a good chance of having it too. The reasons are not entirely clear, but one possibility is that some UTI-prone women have a protein that makes it easier for E. coli to stick to their urinary tract tissue. Other women seem to lack certain antigens that normally inhibit bacterial adhesion (stickiness). Still other women have elements in their urine, such as low pH, that actively discourage bacterial growth, making them more resistant to infections. In some fortunate instances, urine may be naturally fatal to many bacteria. 12 Immune impairment. Any condition that impairs normal immune function can
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make the urinary tract a more hospitable place for bacteria. Thus, people with diseases, such as diabetes or AIDS or people taking immunosuppressive drugs (e.g., corticosteroids), should be extra careful.
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Trimethoprim/sulfamethoxazole (Bactrim, Septra, Cotrim) Amoxicillin (Amoxil, Trimox, Wymox) Nitrofurantoin (Macrodantin, Furadantin; technically termed urinary tract antispetics) Fluoroquinolones (Floxin, Noroxin, Cipro, Trovan) Ampicillin (Many brands)
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oranges and certain berries, like cranberries and blueberries. Extracted in the form of D-mannose,* a white crystal sugar similar to glucose, it can be easily dissolved in a liquid and swallowed. (Mannose can also be synthesized from other simple sugars.) When someone with UTI consumes a dose of D-mannose, the sugar is absorbed in the upper GI tract, but at a much slower rate than most other sugars. (For example, glucose is absorbed more than eight times faster.) Moreover, unlike other sugars, D-mannose is not readily converted to glycogen (and stored) in the liver, but instead passes directly into the bloodstream largely unchanged. 18,19 As the D-mannose-laden blood passes through the kidneys, a considerable proportion of the sugar is extracted and added to the urine. The D-mannose-sweetened urine flows from the kidneys through the ureters to the bladder and on to the urethra, literally sugar-coating any free-floating E. coli it might encounter, so they cans stick to cells any more. It also unsticks most of the E. coli already Velcro-ed to the inner surface of the bladder and urinary tract, ultimately flushing them all down the drain. (* Not all varieties of E. coli find the mannose molecule such a treat. Those that do are said to be mannose-specific, and they are the ones that can potentially cause UTI.14 + Many molecules have D- (dextro-) and an L- (levo-) (literally, right and left) forms. It is not uncommon for the D- and L- forms of a molecule to have very different activity profiles. In the case of mannose, only the D- form is useful for dislodging E. coli.)
Preventing infections
Start with quantities noted above, Adjust amounts downward if Possible Preventing honeymoon cystitis 1 teaspoonful one hour prior to immediately afterwards.
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What is the proof that D-mannose really works? First, the molecular mechanism of the action of D-mannose on E. coli is scientifically proven. Theres no argument at all about this among researchers whove studied it. Second, literally tens of thousands of women working with natural medicine doctors have successfully applied this science to their won UTIs. Considerable circumstantial evidence, combined with common sense and over 15 years of clinical experience, makes a compelling case for the therapeutic value of D-mannose. In one laboratory study, for example, rats urinary tracts were inoculated with E. coli. Within one day, those rats also given D-mannose were found to have significantly lower levels of bacteria in their urine. 20 In another study, administering a mannose-like substance (methyl a-D-mannopyranoside) to E. coli-infected mice led to a 90% reduction in bacterial attachment to the urinary tract. Research in humans shows that ingesting D-mannose significantly elevates blood mannose levels, a prerequisite if urinary levels are to rise. 21 Perhaps the best available evidence, though, comes from the experience of people who have used it. At the Tahoma Clinic, we have been recommending D-mannose to people with UTI since the mid-1980s with great success. While it would certainly be nice to have the results of a double-blind, placebo-controlled study to prove this, its hard to doubt the value of D-mannose when we see case after case like that of Amy, described at the beginning of this booklet, or of four-year-old Anne Marie, who had a very serious genetic disease called galactosemia: Among her other problems, Anne Marie had been suffering from an E. coli -based urinary tract infection for almost two years. Nearly constant antibiotic treatment had been ineffective in clearing her infection. As part of Anne Maries overall treatment plan, I advised her parents to take her off the antibiotics and begin giving her D-mannose (to 1 teaspoon (approximately to 1 gram)) stirred into some water or juice every three to four hours. Her UTI vanished within two weeks and never returned. When Anne Maries parents took her back to her urologist for what had previously been monthly or bimonthly visits, they were told to check back again in another two years! D-mannose can also be very effective in cases of honeymoon cystitis . Caroline was a married woman, who was avoiding sex because she would get a bladder infection every time she and her husband had intercourse. Not surprisingly, this was causing some discord in her marriage. Since a culture of her urine showed the presence of E. coli , she started taking D-mannose, 1 teaspoon one prior to intercourse and again shortly afterwards. The result? No further infections. We have found that women prone to very frequent recurrent UTIs not necessarily related to sexual intercourse can also often benefit from taking D-mannose preventively at the same dose. To save expense, some women have been able to taper down their dosage and dose frequency. By far the most frequent use of D-mannose has been by thousands of women who have suffered single (nonrecurrent) episodes of bladder infection. In over 90% of such cases, 1 teaspoon of D-mannose every two to three hours clears
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the infection in one to three days. It is not just Tahoma Clinic patients who are achieving these remarkable results with D-mannose. We often hear from other medical practitioners who give it to their patients. The following is typical: During my 38 years of practice, I have tried everything imaginable for kidney and bladder problems with mixed results or at least not reproducible results. To this day, we have not had a single patient that did not improve with D-mannose. Even some of the ones that were of chronic nature have improved to the point that a single weekly dose of D-mannose is keeping them problem-free.
Preventing UTI
In addition to taking D-mannose, people can do many things to avoid getting bladder infections and other UTIs. Some are hygienic, while others involve diet. None of them requires taking any drugs: Drink a lot of water or other fluids, 48 to 64 ounces daily, if possible. Fluids keep the urine flowing, so invading bacteria are likely to be washed out. Drink cranberry juice. For many years, UTI-prone women, who wanted to avoid antibiotics, have tried drinking cranberry juice. It turns out that cranberry juice works, in part, because it contains some D-mannose, as well as a substance called proanthocyanidin that works in a slightly different way to make it difficult for E. coli to stick around, 22,23. However, the amount of D-mannose (even with proanthocyanidin) in a glass of cranberry juice is far less than the therapeutic dose we recommend in this booklet. Plus, most cranberry juice products are loaded with added sugars, the kind of sugars that are known to suppress the activity of the white blood cells that destroy unfriendly bacteria (see below). Although drinking large volumes of cranberry juice would probably not, by itself, be sufficient to cure an established infection, drinking unsweetened cranberry juice may help prevent future infections. Take vitamin C supplements. Use the ascorbic acid form of vitamin C, which can help acidify the urine and thus, discourage bacterial growth. Hygiene: For women: front to Back wiping. (As guys, we apologise for repeating what every woman learned from her mother, but wed be open to scientific criticism if we didnt.) Men whove been lucky enough to escape circumcision should keep their foreskin area clean. In uncircumcised infants, foreskin infections are up to 20 times more common compared with circumcised infants. 1 For both: Cleanse the genital and anal areas before sexual intercourse. Dont hold it in. Its always best to urinate when we feel the need, if possible. Resisting the urge to urinate too often or for too long can damage the delicate tissue that lines the urinary tract and permit bacteria to thrive. For just a few of us: take showers, not baths. Bath water contains millions of
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bacteria that get washed off our bodies. It is quite possible that E. coli from the anus could float over to the vagina or urethra. If youve had frequent UTIs, but cant resist a long, hot soak in the tub, take a cleansing shower first. Avoid using feminine hygiene sprays and scented douches. These products may irritate the urethra, which could lead to infection.
By law passed in 1992, pharmaceutical companies are permitted to pay the FDA hundreds of millions of dollars to help expedite new drug approvals. Not surprisingly, this practice, known as Prescription Drug User Fees, leads to scandalous conflicts of interest that have recently been decried in an editorial the British medical journal, The Lancet, 2001;357:1544-1545.
2
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interfere with the function of the immune system. As long ago as 1976, results were reported from a study of 50 children (aged 4 to 18 years) who had chronic recurrent UTI despite urologic examinations that were otherwise completely normal. All the children had an allergic background, including hay fever, persistent coughing, nasal obstruction or other breathing difficulty (e.g. asthma, eczema, hives, or recurrent skin rashes). All were asked to follow elimination diets, take anti-allergic medication, and to receive specific allergy desensitisation. Of the 50 children, 42 (84%) definitely benefited, while nine had a rapid and spectacular cure, 19 had cures after six to nine months, and 14 were noticeably improved. Only eight of the fifty children showed no improvement. 25,26 Doctors working with the natural approach to health care find that eliminating sugar and food allergies is frequently sufficient to significantly reduce the incidence of any recurrent infection, including UTI, in both children and adults.
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Summary
D-mannose is a simple sugar that can be used to treat or prevent the 90% or more of UTIs that are caused by the bacteria E.coli. Although D-mannose can eliminate UTIs as quickly as conventional antibiotic drugs, it is far safer because it does not kill E. coli or any friendly bacteria. Instead, it makes it impossible for E. coli bacteria to stick to the lining of the urinary tract, which allows the normal flow or urine to wash the bugs down the drain. By using this remarkably safe, effective, inexpensive, natural treatment, women can usually treat their own UTIs without the need for expensive doctor visits, prescription drugs, and insurance company reimbursements. A WORD OF CAUTION If a UTI treated with D-mannose does not show significant improvement within 24 hours (about 10% of cases), it is likely that the causative organism if not E. coli, and a visit to the doctor for a conventional antibiotic drug is therefore necessary.
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Antibiotic Drugs Eliminates UTI within 1-2 days Kills friendly bacteria Can safely sto treatment in a few days Can ca!se "I ! set Can romote yeast infections Can ca!se aller#ic reactions $ell-s!ited for re#nant women $ell-s!ited for infants and Yo!n# children $ell-s!ited for lon#-term% &re'entati'e !se (e)!ires a doctor*s rescri tion Yes Yes No Yes Yes Yes No No No Yes
References
1. Harrington RD, Hooton TM. Urinary tract infection risk factors and gender. J Gend Specif Med. 2000;3:27-34. 2. Kunin CM. Urinary tract infections in females. Clin Infect Dis. 1994;18:1-10; quiz 11-12. 3. Ikaheimo R. Siitonen A, Heiskanen T, et al. Recurrence of urinary tract infection in a primary care setting: analysis of a 1-year follow-up of 179 women. Clin Infect Dis. 1996;22:91-99. 4. Foxman B. Recurring urinary tract infection: incidence and risk factors. Am J Public Health. 1990;80:331-333. 5. Norden CW, Green GM, Kass EH. Antibacterial mechanisms of the urinary bladder. J Clin Invest. 1968;47:2689-2700. 6. Hooton TM, Stapleton AE, Roberts PL, et al. Perineal anatomy and urine-voiding characteristics of young women with and without recurrent urinary tract infections. Clin Infect Dis. 1999;29:1600-1601. 7. Hooton TM, Scholes D. Hughes JP, et al. A prospective study of risk factors for symptomatic urinary tract infection in young women. N Engl J Med. 1996;335:468-474. 8. Hooton TM, Hillier S, Johnson C, Roberts PL, Stamm WE, Escherichia coli bacteriuria and contraceptive method. Jama. 1991;265:64-69. 9. Hooton TM, Fennell CL, Clark AM, Stamm WE, Nonoxynol-9: differential antibacterial activity and enhancement of bacterial adherence to vaginal epithelial cells. J Infect Dis. 1991;164:1216-1219. 10. Smith HS, Hughes JP, Hooton TM, et al. Antecedent antimicrobial use increases the risk of uncomplicated cystitis in young women. Clin Infect Dis. 1997;25:63-68. 11. Sobel JD. Pathogenesis of urinary tract infection. Role of host defenses. Infect Dis Clin North Am. 1997;11:531-549. 12. Mulholland SG. Lower urinary tract antibacterial defense mechanisms. Invest Urol. 1979;17:93-97. 13. Fowler JE, Jr., Stamey TA. Studies of introital colonisation in women with recurrent urinary infections. VII. The role of bacterial adherence. J Urol. 1977;117:472-476. 14. Ofek I, Goldhar J, Eshdat Y, Sharon N. The importance of mannose specific adhesins (lectins) infections caused by Escherichia coli. Scand J Infect Dis Suppl. 1982;33:61-67. 15. Ofek I, Crouch E, Keisari Y. The role of C-type lectins in the innate immunity against pulmonary pathogens. Adv Exp Med Biol. 2000;479:27-36. 16. Ofek I, Beachey EH. Mannose binding and epithelial cell adherence of Escherichia coli. Infect Immun. 1978;22:247-254. 17. Bar-Shavit Z, Goldman R, Ofek I, Sharon N, Mirelman D. Mannose-binding activity of Escherichia coli: a determinant of attachment and ingestion of the bacteria by macrophages. Infect Immun. 1980;29:417-424. 18. Herman RH. Mannose metabolism. I. Am J Clin Nutr. 1971;24:488-498. 19. Deuel H, Hallman L. Murray S, Hilliard J. Studies on ketosis: XV. The comparative metabolism of d-mannose and d-glucose. J Biol Chem. 1938;125:79-85. 20. Michaels E, Chmiel J, Plotkin B, Schaeffer A. Effect of D-mannose and D-glucose on Escherichia coli bacteriuria in rats. Urol Res. 1983;11:97-102. 21. Alton G, Kjaergaard S, Etchison JR, Skovby F, Freeze HH. Oral ingestion of mannose elevates blood mannose levels: a first step toward a potential therapy for carbohydrate-deficient glycoprotein syndrome type I. Biochem Mol Med. 1997;60:127-133. 22. Brown D. Antiadherence factor for cranberry discovered. Quart Rev Nat Med. 1998;Dec. 31, 1998:269-270. 23. Kontiokari T, Sundqvist K, Nuutinen M, Pokka T, Koskela M, Uhari M. Randomised trial of cranberry-lingonberry juice and Lactobacillus GG drink for the prevention of urinary tract infections in women. BMJ. 2001;322:1-5. 24. Sanchez A, Reeser JL, Lau HS, et al. Role of sugars in human neutrophilic phagocytosis. Am J Clin Nutr. 1973;26:1180-1184. 25. Horesh AJ. Allergy and recurrent urinary tract infections in childhood. II. Ann Allergy. 1976;36:174-179. 26. Horesh AJ. Allergy and recurrent urinary tract infections in childhood. I. Ann Allergy. 1976;36:16-22. 27. Raz R. Postmenopausal women with recurrent UTI. Int J Antimicrob Agents. 2001;17:269-271. 28. Raz R, Stamm WE. A controlled trial of intravaginal estriol in postmenopausal women with recurrent urinary tract infections. N Engl J Med. 1993;329:753-756.
This book is general information, not individualised to any person or circumstance. For specific advice concerning any individual episode of any illness, contact your
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physician. Discuss the information in this book with your pharmacist or physician to learn whether it is useful and relevant to your family.
D-mannose is exactly the right treatment for bladder infections caused by E. coli, and thats over 90% of them. As Linus Pauling said: the right molecule in the right place at the right time. A perfect example of orthomolecular medicine. John Parks Trowbridge, M.D. Author of The Yeast Syndrome I had heard about D-Mannose at your seminar, and also read about it in your Nutrition & Healing newsletterI decided to try it personally as I had been having bladder infections nearly every time I had intercourse with my husband. I took teaspoonful before and sometimes teaspoonful after and had no more bladder infections! I have also recommended it to several patients at the clinic where I work and they have had excellent results as well. Terri Crosby-Hornbaker, CH, CN When she was younger, our daughter had one bladder infection after another until we started her on D-mannose. We had no problem giving it to her, she loved the taste. Shes had no further infections, except when we forgot to take the D-mannose on vacation with us once. Jeri Reddick My wife recently had a urinary tract infection. I had just read your article on D-mannose and quickly ordered someit took only a couple of days on the D-mannose and she felt better. T.S.M. (via e-mail)
The effectiveness of D-mannose against bladder and other urinary tract infections was first described in the June 1999 issue of
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Tahoma Clinic, Kent, Washington, USA and Kerry Bone, MCPP, FNHAA, FNIMH, of Warwick, Queensland, Australia. Kerry Bone is a master of herbal therapy and scholarship, and author (along with Simon Mills) of the #1 textbook in herbal medicine, Principles and Practice of Phytotherapy. Dr Wright is a graduate of Harvard University and the University of Michigan Medical School. In medical practice since 1970, hes also been author of monthly columns in Prevention magazine (1976-1986) and Lets Live magazine (1986-1996). Books by Dr Wright include: Why Stomach Acid is Good For You (with Lane Lenard, Ph.D.) The Patients Book of Natural Healing (with Alan R. Gaby, M.D.) Maximise Your Vitality and Potency for Men Over 40 (with Lane Lenard Ph.D.) Natural Hormone Replacement for Women Over 45 (with John Morgenthaler) The Natural Pharmacy (with six co-authors) Dr Wrights Guide to Healing with Nutrition Dr Wrights Book of Nutritional Therapy
Internet shopping websites 2012 Dimestream
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