Manesty Coating Presentation - 2009

Tablet film coating using side vented pan technology
Brian A. Helsdon. Customer Training Manager. OYSTAR Manesty
Film Coating Workshop Ludwigshafen, 16th -17th September 2009.

1 Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809 2 Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809
Side Vented Coating Pan Technology
Coating System
Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809
BASF Film Coating Workshop 16th 17th September 2009
brian.helsdon@oystar.manesty.com
Coating System
Coating System
Key Benefits
High process efficiency high air flow mixing ability Flexibility all forms of suspensions
sugar aqueous organic solvent tablets and pellets
Oystar Manesty Coating Systems
Reproducibility
Oystar Manesty Coater Range
Oystar Manesty XLTMLab Coater Range (XLTMLab01 - XLTMLab02)
All fitted with
10
Oystar XLCOTATM Range (150 350 750)
Oystar PremierTM Range (200 500 900)
11
12
M-tec Control System
M-tecTM Control System
13
14
HMI / PC
Recipe PC / Supervisor PC (Option)
PLC
COATER
INLET AIR HANDLER
EXHAUST SYSTEM
SPRAY SYSTEM
CIP
FILTER
15
16
M-tec Parameters Screen
Inlet and Exhaust Units - HVAC
17
18
Inlet Air Handler
Exhaust Filter / Fan Unit
19
20
Aqueous Film Coating System
Stand alone pump unit.
Aqueous Spray / Pump System
Utilises air atomised sprayguns for the

application of the coating solution.
All pneumatic supplies contained within the

coater and are controlled via the PLC Atomising air pressure Fan width air pressure Pilot air
21
22
Magnetic Solution Flowmeter
23
24
Solution Vessel
Coating solution is delivered to

sprayguns via a multi headed peristaltic pump.
Eliminates preferential spraying

between sprayguns
Common inlet solution manifold Overpressure monitoring of the solution

delivery to the sprayguns
25
26
Solution pumpheads are driven via a

combined motor and gearbox
Motor and gearbox are controlled via an

VFD / inverter
Film coating process
A Magnetic Solution Flowmeter is

utilised to determine the total solution delivery to the sprayguns
27
28
Side Vented Coating Pan
Side Vented Coating Pan
29
30
Process variables
Drum Mixing
Drum mixing Airflow Inlet, outlet and bed temperature Tablet size and shape Batch size
Gun design Spray position Spray rate
Factors Influencing mixing efficiency:
Batch size Drum speed
Droplet size Atomising air pressure Fan air pressure
Baffle design Process time
31
32
Drum Mixing
Drum Mixing
Increased batch size improves mixing due to formation of steeper

bed angle and hence increased tablet velocity
Smaller tablets pack together more tightly and rise higher up the
drum, increasing bed angle and hence tablet velocity
33
34
Drum speed
Mixing Baffles Types
Directly influences:
Mixing Tablet abrasion Spray rate Coating distribution Process time
Rabbit Ear Baffles Ploughshare Baffles Tubular Baffles
Fitted to older machines Available on current machines Low batch version also available Available on current machines
Ploughshare and Tubular are Interchangeable on most machine

Accelacota 10 with rabbit ear baffles
Oystar Manesty ploughshare baffles
37
38
Oystar Manesty tubular baffle
Mixing Baffles - Summary
M ixing efficiency Rabbit E ar B affles Low
T ype of m ixing G entle
B est suited Long processes Highly friable tablets S ugar coating and low batch sizes Film coating of Low friability tablet
Ploughshare Interm ediate B affles Tubular B affles V ery high
M oderate
Aggressive
39
40
10
Airflow
Temperature
Volume passing through drum Balance between inlet and outlet air volumes which control the
pressure in the drum
Adhesion on cohesion aided by applying warm solutions to a warm

tablet bed
High evaporation rate can adversely effect droplet mobility upon

tablet impingement
Drying efficiency is high in side vented pan Airflow can be influenced by tablet size and shape
Excessive heating can cause thermal degradation of active Consider thermal expansion of cores
41
42
Temperature
Core size and weight
Excessive heat can cause spray drying or pinhole formation Under steady conditions of inlet temperature, inlet air volume,
spray rate and batch size, exhaust temperature is a good guide to tablet bed temperature
The pattern of movement of cores in a coater will be influenced by

their size / weight.
This in turn may affect film formation due to changes in:

the time exposed to the atomised droplets when the core passes
through the spray
In general high temperature = high film stress
the length of time between each pass through the spray (circulation
time)
43
44
11
Core size and weight
Core shape
Core size will influence the amount of coating material needed to

give a particular coat thickness.
During coating the cores will be tacky while the applied coating
formulation is drying
For example, decreasing core size will: To minimise agglomeration cores must be in constant motion and
increase the specific surface area (m2/g) to be covered increase the amount of polymer needed to reach the required coat
level (i.e. thickness)
have a shape to minimise the contact area.
increase the time for the coating process
Easiest shapes to coat without agglomeration are therefore

spheres and most difficult are cubes.
If the droplet size is not tightly controlled, batch variation in release

characteristics may result.
45 Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809
46
Core shape
Core shape
Flat-faced tablets tend to form stacks unless great care is taken

during coating to minimise drying times.
Sharp edges are more vulnerable to physical damage during

coating.
Most tablets for coating should have rounded surfaces - the more
convex, the less likely is agglomeration.
Shape of the intagliation may be important in governing if

intagliation bridging occurs.
Larger and/or deeper intagliations are less susceptible to bridging
47
48
12
Batch size
Spray rate
Influences mixing efficiency Influences air flow Can influence process efficiency
Apply at as fast a rate as possible but avoid overwetting Low spray rates can lead to small droplet size which spread poorly
and can lead to orange peel effect
High spray rates can lead to picking or twinning Spray rate can influence process efficiency
49
50
Spray Position
Gun Position
Sprays should be positioned radially so that the spray hits the bed
at the undisturbed area between where baffles enter and leave
Guns are spaced at equally distance

position around the centre line of the drum mesh
Use maximum number of sprays which cover the largest area of

the bed but which do not overlap
Gun to bed distance controls droplet size and hence spreading and
coalescence of droplets at tablet bed
Avoid overwetting or spray drying
51
52
13
Gun Position
Gun Position
1/3
900 Angle
Gun to Bed Distance
2/3
Drying area
53
54
Atomising air pressure
Fan air pressure
Increasing atomising air pressure decreases mean droplet size Increasing atomising air pressure decreases the range in droplet
diameter
Increase fan air pressure changes spray shape from a solid to a flat
ellipse
At high fan air pressures droplet size distribution widens Different gun designs are influenced differently by changes in
atomising or fan air pressure
55
56
14
Increasing fan air pressure
Opti Coat spray gun
57
58
Opti Coat spray gun
Opti Coat spray gun - Key benefits
Optimum performance & anti-bearding cap
Anti-bearding system with superior spray pattern
Enhanced droplet performance The Opti Coat spray gun is the ultimate choice
for Pharmaceutical tablet film coating.
Low profile shape with integral connections for

reduced airflow turbulence
59
60
15
Opti Coat spray gun - Key benefits
Opti Coat spray gun
Tool free, GMP compliant design
Retro-fit capability to upgrade existing coating equipment (Manesty

and non-Manesty equipment)
Recirculation option
Opti Coat spray gun
OYSTAR Manesty Kitling Road Knowsley Merseyside England L34 9JS T +44 (0)151 547 8000 F +44 (0) 151 547 8001 Info@oystar.manesty.com www.oystar.manesty.com
16

Manesty Coating Presentation - 2009

Diunggah oleh

Informasi Dokumen

Hak Cipta

Format Tersedia

Bagikan dokumen Ini

Bagikan atau Tanam Dokumen

Opsi Berbagi

Apakah menurut Anda dokumen ini bermanfaat?

Apakah konten ini tidak pantas?

Hak Cipta:

Format Tersedia

Manesty Coating Presentation - 2009

Diunggah oleh

Hak Cipta:

Format Tersedia

Tablet film coating using side vented pan technology

Brian A. Helsdon. Customer Training Manager. OYSTAR Manesty

Film Coating Workshop Ludwigshafen, 16th -17th September 2009.

Side Vented Coating Pan Technology

Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809

Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809

BASF Film Coating Workshop 16th 17th September 2009

Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809

Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809

Oystar Manesty Coating Systems

Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809

Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809

BASF Film Coating Workshop 16th 17th September 2009

Oystar Manesty Coater Range

Oystar Manesty XLTMLab Coater Range (XLTMLab01 - XLTMLab02)

All fitted with

Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809

Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809

Oystar XLCOTATM Range (150 350 750)

Oystar PremierTM Range (200 500 900)

Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809

Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809

BASF Film Coating Workshop 16th 17th September 2009

M-tec Control System

M-tecTM Control System

Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809

Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809

M-tec Control System

M-tec Control System

Recipe PC / Supervisor PC (Option)

INLET AIR HANDLER

Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809

Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809

BASF Film Coating Workshop 16th 17th September 2009

M-tec Parameters Screen

Inlet and Exhaust Units - HVAC

Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809

Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809

Inlet Air Handler

Exhaust Filter / Fan Unit

Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809

Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809

BASF Film Coating Workshop 16th 17th September 2009

Aqueous Film Coating System

Stand alone pump unit.

Aqueous Spray / Pump System

Utilises air atomised sprayguns for the

All pneumatic supplies contained within the

Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809

Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809

Aqueous Film Coating System

Magnetic Solution Flowmeter

Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809

Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809

BASF Film Coating Workshop 16th 17th September 2009

Aqueous Film Coating System

Coating solution is delivered to

Eliminates preferential spraying

Common inlet solution manifold Overpressure monitoring of the solution

Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809

Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809

Aqueous Film Coating System

Solution pumpheads are driven via a

Motor and gearbox are controlled via an