G.M.Th. Schreuder
C.K. Hurley
S.G.E. Marsh
M. Lau
M. Fernandez-Vina
H.J. Noreen
M. Setterholm
M. Maiers
Key words:
alleles; antigens; histocompatibility; HLA;
serological equivalents; serology
Acknowledgments:
The efforts from the participants of the UCLA
International Cell Exchange are gratefully
acknowledged. We thank the typing laboratories
in the Netherlands, Belgium and Luxembourg
which participated in the HLA-Club Cell Exchange,
for submitting, typing and commenting on the
samples with new and rare HLA alleles. This work
was supported in part by the J.A. Cohen Institute
for Radiopathology and Radioprotection (IRS), by
the Dutch National Reference Center for
Histocompatibility and by the U.S. Office of Naval
Research N00014-99-2-0006 to the NMDP and
N00014-99-1-0551 to the C.W. Bill Young
Marrow Donor Recruitment and Research
Program.
Authors affiliation:
G.M.Th. Schreuder1,*,,z,
C.K. Hurley2,*,,{,
S.G.E. Marsh3,*,,
M. Lau4,*,,
M. Fernandez-Vina5,z,
H.J. Noreen6,{,
M. Setterholm7,{,
M. Maiers7,*,z,{,
1
Department of
Immunohematology and
Blood Transfusion, Leiden
University Medical Center,
Leiden, The Netherlands
Department of Oncology,
Georgetown University Medical
Center, Washington DC, USA
UCLA Immunogenetics
Center, Department of
Pathology and Laboratory
Medicine, David Geffen
School of Medicine, Los
Angeles, CA, USA
Several years ago, the World Marrow Donor Association initiated a study
aimed at identifying the serological types associated with each human
leucocyte antigen (HLA)-A, -B, -DRB allelic products. This work resulted
in a serology to DNA equivalents dictionary first published in 1997 with
Department of Laboratory
Medicine, The University of
Texas, M. D. Anderson Cancer
Center, Houston,TX, USA
Histocompatibility
Laboratory, Fairview-University
of Minnesota Medical Center,
Minneapolis, MN, USA
On behalf of:
*World Marrow Donor Association Quality Assurance and IT
Working Groups.
WHO Nomenclature Committee for Factors of the HLA system.
z13th International Histocompatibility Workshop Serology Component.
International Cell Exchange, UCLA.
{US National Marrow Donor Program.
Correspondence to:
G.M.Th. Schreuder, PhD
Department of Immunohematology and Blood Transfusion
E3-Q, Leiden University Medical
Center
PO Box 9600, NL-2300
RC Leiden
The Netherlands
Tel.: 31-71-5263824
Fax: 31-71-5248203
e-mail: g.m.t.schreuder@
lumc.nl
database update from October 2003. Alleles are presented with their
volunteer and umbilical cord blood banks. While most patients in need
sented by the fifth and sixth digit) do not influence the antigenic
pleteness. This disregards the fact that some null alleles are actually
HLA class I. In this respect, the dictionary can help in the search for donors
whose HLA phenotypes closely resemble that of the patient even though
to confirm the match. Since the publication of the 2001 dictionary (3) based
on the alleles listed in the 2000 WHO Nomenclature report (5), a large
to include newly defined alleles, has been implemented in this report. The
serologic equivalents that are presented in the regular updates of the WHO
above cell range were included to provide information for the rare
marizes our view on the most probable serologic equivalent for the alleles,
which may differ from the WHO HLA assigned type. For completeness, all
known alleles (four digits only) as included in the IMGT/HLA database (9)
tories, ranging from a low of 168 to a high of 229. The parallel typing
Although serological typing of HLA-C and -DQ antigens is notoriously difficult, often incomplete and unreliable, the information, when
available for a donor, may help in the selection procedure. For that
alpha and beta chains, the DQ serologic patterns correlate strongly with
updated with these alleles (Tables 16). During this time period,
DQB1, but not with DQA1 polymorphisms. For that reason, Table 6
not
analyzed
on
cell
also
expressing
B*4001
(cell
A1
A1
A1
A2
A2
A203/A2
A2
A2
A2
A2
A2
A2
A210/A2
A2
A2
A2
A2
not expressed
A2
A2
A*0106
A*0107
A*0108
A*0109
A*0201
A*0202
A*0203
A*0204
A*0205
A*0206
A*0207
A*0208
A*0209
A*0210
A*0211
A*0212
A*0213
A*0214
A*0215N
A*0216
A*0217
A2
A1
A*0104N
A*0220
not expressed
A*0103
A2
A1
A*0102
A2
A1
A*0101
A*0218
A1
HLA allele
A*0219
Expert
assigned
type
A2
A2
A2
A2
Null
A2
A2
A2
A2
A210
A2
A2
A2
A2
A2
A2
A203
A2
A2
A1
A1
Null
A1
A1
A1
WHO
assigned
type
25
74
26
Cells
tested
A2 [99]
A2 [100]
A2 [100]
A2 [100]
A2 [100]
A2 [99100]
A2 [99100]
A1 [99]
A1 [98100]
Assigned
type
[%]
International cell
exchange UCLA
16
51
20
228
135
636
462
28
472
859
6315
129
5612
Cells
tested
NMDP
A2 [75]
blank [100]b
A2 [100]
A2 [73]
A2 [55]
A2 [75]
A2 [75]
A2 [84]
A2 [74]
A2 [100]
A2 [74]
A2 [50]
A2 [80]
A2 [68]
A2 [81]
A2 [77]
A2 [64]
A2 [81]
A2 [98]
A1 [100]b
A1 [78]
A1 [95]
A1 [99]
Assigned
type
[%]
17
17
24
10
12
230
113
Cells
tested
IHW13 data
A2
A2
A2
A2
A2
A2
A203
A2
A2
A1
A1
Assignment
A2
A2
A2
A2
A2
NTi
A2
A2
A2
A2
A2
A2
A2
training
training
training
A2
A2
training
training
A1
A1
A1
A1
NTi
training
training
trainingc
assigned
type > 0.55d
Neural network
normal A2 (13)
ihw13: short A2
normal A1 (12)
Commentsh
A2
A2
A2
A2
A2
A2
A2
A2
not expressed
A2
A2
A2
A2
A2
A2
A2
A2
A2
A2
not expressed
A2
A2
A2
A2
A2
A2
A2
A2
A*0224
A*0225
A*0226
A*0227
A*0228
A*0229
A*0230
A*0231
A*0232N
A*0233
A*0234
A*0235
A*0236
A*0237
A*0238
A*0239
A*0240
A*0241
A*0242
A*0243N
A*0244
A*0245
A*0246
A*0247
A*0248
A*0249
A*0250
A*0251
A*0221
A2
A2
HLA allele
A*0222
Expert
assigned
type
continued
A2
A2
Null
A2
A2
A2
A2
Null
A2
A2
A2
A2
A2
A2
WHO
assigned
type
Cells
tested
Assigned
type
[%]
International cell
exchange UCLA
16
Cells
tested
NMDP
blank [72]
A2 [100]
blank [100]b
A2 [100]b
Cells
tested
A2
A2
Assignment
IHW13 data
A2 [100]b
A2 [100]
A2 [100]b
A2 [100]
A2 [100]
A2 [66]
A2 [67]
Assigned
type
[%]
A2
A2
A2
A2
A2
A2
A2
A2
NT
A2
A2
A2
A2
A2
A2
A2
A2
A2
A2
NT
A2
A2
A2
A2
A2
A2
A2
A2
A2
A2
assigned
type > 0.55d
Neural network
Normal A2 (17) k,
normal A2 (14)
normal A2 (15)
normal A2 (14)
Commentsh
A3
A3
not expressed
A*0301
A*0302
A*0303N
not expressed
A2
A*0267
A3/blank
A2
A*0266
A*0311N
A2/A19
A*0265
A*0310
A2
A*0264
A3
A2
A*0263
A*0309
A2
A*0262
A3
A2
A*0261
A*0308
A2
A*0260
A3
A2
A*0259
A3
A2
A*0258
A*0307
A2
A*0257
A*0306
A2
A*0256
A3/blank
A2/A28
A*0255
A3
A2
A*0254
A*0305
not expressed
A*0253N
A*0304
A2
A*0252
Null
A3
A3
Null
A3
A3
A2
A2
A2/19
A2
Null
31
A3 [99100]
A3 [99100]
342
3504
A3 [100]b
A3 [100]b
106
blank [80]
A3 [78]
A3 [99]
A3
A3/blank
blank
A3
A3
NT
A3
A3
A3
A3
A3
A3
A3
NT
training
training
A2
A2
not assigned
A2
A2
A2
A2
A2
A2
A2
A2
A2
A2f A28f
A2
NT
A2
ihw13: only reactive with some A311 and A3 1934 sera; normal A3 (15)
short A2 (18)
NN: A69
A11
A11
A11
A11
A11
A11
A11
A11
A11
A11
A23
A23
A23
A23
A23
A23
not expressed
A*1106
A*1107
A*1108
A*1109
A*1110
A*1111
A*1112
A*1113
A*1114
A*1115
A*2301
A*2302
A*2303
A*2304
A*2305
A*2306
A*2307N
A23
A11
A*1105
A*2310
A11
A*1104
not expressed
A11
A*1103
A23
A11
A*1102
A*2309
A11
A*2308N
A3
A*1101
Expert
assigned
type
A*0312
HLA allele
continued
Null
Null
A23(9)
A11
A11
A11
A11
A11
A11
A11
A11
A11
A11
A11
A11
WHO
assigned
type
22
58
Cells
tested
A23 [9798]
A11 [6369]
A11 [99]
A11 [99100]
Assigned
type
[%]
International cell
exchange UCLA
5119
18
42
2530
Cells
tested
NMDP
A23 [100]b
42
118
Cells
tested
A23
A23
A11
A11
A11
Assignment
IHW13 data
A23 [100]
A11 [100]b
A10 [33]b
A11 [67]
blank [50]b
A11 [50]
A11 [83]
A11 [76]
A11 [99]
Assigned
type
[%]
A23
A23
NT
NT
A23
A23
A23
A23
A23
training
A11
A11
A11
A11
A11
A10f
A11
A11
A11
A11
A11
A11
A11
A11
training
A3
assigned
type > 0.55d
Neural network
NN: A11
ihw13:short A11
Commentsh
A24
A24
A*2422
A*2423
A24
A*2414
A24
A24
A*2413
A24
not expressed
A*2411N
A*2421
A2403/A24
A*2410
A*2420
not expressed
A*2409N
A9
A24
A*2408
A*2419
A24
A*2407
A24/A3
A24
A*2406
A24
A24
A*2405
A*2418
A24
A*2404
A*2417
A2403/A24
A*2403
A24
A24/blank
A*2402L
A*2415
A24
A*2402
A24(9)
A9
A24(9)
A9
A24(9)/A3
A24(9)
A24(9)
Null
A2403
Null
A24(9)
A24(9)
A24(9)
A24(9)
A24(9)
A2403
Low A24(9)
A24(9)
16
81
A24 [97100]
A24 [97100]
11
32
30
320
15
10
282
3098
A24 [97]
A24 [100]b
A24 [67]
A24 [50]
A24 [83]
A24 [100]b
blank [18]
A24 [73]
blank [100]b
A2403 [3]
blank [16]
blank [100]b
blank [26]
A24 [47]
A24 [59]
A24
A24
A24
A24
A24
A24
17
blank
A24
A24
146
A24 [40]b
A2403 [10]
A24 [60]
A2403 [1]
A9 [4]
blank [20]
A24 [55]
A2403 [1]
A24
A24
A24
A24
A9
A24
A24
A24
A24
A24
NT
A24
NT
A24
A24
A24
A24
A9
A24
NT
training
A24 negative
A2403 (26)
reactive (26)
NN: A24
A24
A24
A24
A25
A25
A25
A25
A26
A26
A26
A26
A26
A26
A26
A26
A*2437
A*2438
A*2439
A*2501
A*2502
A*2503
A*2504
A*2601
A*2602
A*2603
A*2604
A*2605
A*2606
A*2607
A*2608
A24
A*2432
not expressed
A24
A*2431
A24
A24
A*2430
A*2436N
A24
A*2429
A*2435
A9
A*2428
A2403/A24
A24
A*2427
A24
A24
A*2426
A*2433
A24
A*2425
A*2434
A9
Expert
assigned
type
A*2424
HLA allele
continued
A26(10)
A26(10)
A26(10)
A26(10)
A26(10)
A26(10)
A26(10)
A26(10)
A10
A25(10)
A24
Null
A2403
WHO
assigned
type
21
Cells
tested
A26 [8195]
A26 [9099]
A25 [9499]
A24 [8893]
Assigned
type
[%]
International cell
exchange UCLA
65
10
38
31
1730
1375
Cells
tested
NMDP
A26 [95]
A26 [90]
A26 [81]
A10 [2]
A26 [97]
A25 [100]
A25 [80]
A24 [100]
A24 [100]b
A24 [50]
Assigned
type
[%]
47
18
Cells
tested
A26
A26
A26
A26
A25
A25
A24
A24
Assignment
IHW13 data
A26
not assigned
A26
A26
A26
training
training
training
A25
A25
A25
training
A24
A24
A24
NT
A24
A24
A24
A24
A24
A24
A24
A9, A2f
A24
A24
A24
A9g
assigned
type > 0.55d
Neural network
NN: A43
A2403 (26)
NN: A23
Commentsh
A29
A29
A29
A*2904
A*2905
A*2906
A30
A29
A*2903
A*3004
A29
A*2902
A30
A29
A*2901
A*3003
undefined
A*2619
A30
undefined
A*2618
A*3002
A26
A*2617
A30
A26
A*2616
A29
A10
A*2615
A*3001
A26
A*2614
A*2909
A26
A*2613
not expressed
A26
A*2612
A29
not expressed
A*2611N
A*2908N
A26
A*2610
A*2907
A26
A*2609
A30(19)
A30(19)
A30(19)
A30(19)
Null
A29(19)
A29(19)
Null
A10
A26(10)
10
20
10
A30 [9698]
A30 [9599]
A29 [9799]
85
2124
2895
1488
115
A30 [94]
A30 [68]
A30 [93]
A29 [100]
A29 [99]
A29 [96]
25
28
28
10
A26 [100]b
A10 [33]
A26 [33]
A30
A30
A30
A29
A29
A10
A26
training
A30
training
training
A29
NT
A29
A29
A29
A29
A29
training
training
assigned
not
assigned
not
A26
A26
A26
A26
A10
A26
NT
A26
A26
NN: A43
A-blank (17)
NN: A26
10
A30
A30
A30
A30
A30
A30
A31
A31
A31
A31
A31
A31
undefined
A31/A24
A31
A32
A32
A32
A32/A3
A32
A32
A32
A33
A33
A*3007
A*3009
A*3010
A*3011
A*3012
A*3101
A*3102
A*3103
A*3104
A*3105
A*3106
A*3107
A*3108
A*3109
A*3201
A*3202
A*3203
A*3204
A*3205
A*3206
A*3207
A*3301
A*3303
A33(19)
A33(19)
A32(19)
A32(19)
A31(19)
A31(19)
A31(19)
A30(19)
A30
A*3006
A*3008
WHO
assigned
type
Expert
assigned
HLA allele type
continued
19
20
21
Cells
tested
A33 [9299]
A33 [97100]
A32 [9799]
A31 [9799]
Assigned
type
[%]
International cell
exchange UCLA
887
687
A32 [67]
A33 [87]
A19 [17]
A32 [50]b
27
19
50
A31 [100]b
58
A31 [100]
11
A30 [75]b
Neural network
A33
A33
training
training
A32
A32
A32
assigned
not
A32
A0 32040
A32
training
A31
not assigned
not assigned
A31
A31
A31
A31
A31
training
A30
A30
A30
A30
A30
A30
A30
A32
A31
A30
Cells
assigned
tested Assignment type > 0.55d
IHW13 data
A30 [67]
Assigned
Cells type
tested [%]
NMDP
A3 with most A32 sera reactive [ihw13 and (15)]; NN: A3 A32
A9 A32 A23
Commentsh
A34
A36
A36
A36
A36
A43
A66
A*3405
A*3601
A*3602
A*3603
A*3604
A*4301
A*6601
A68
A34
A*3404
A*6801
A34
A*3403
A66
A34
A*3402
A*6604
A34
A*3401
A10
A33
A*3307
A*6603
A33
A*3306
A66
A33
A*3305
A*6602
A33
A*3304
A68(28)
A10
A66(10)
A66(10)
A43
A36
A36
A34(10)
A34(10)
A34(19)
A33(19)
24
13
10
22
A28 [3039]
A68 [6170]
A34 [715]
A66 [1524]
A26 [7]
28
A0 66020 [5365]
A26 [35]
blank [6]
A10 [5]]
49
19
A68
A66
A66
A36
A36
A34
A34
A34
25
11
A33
A33 [100]b
A33 [100]b
205
799
807
996
269
A10 [37]
A66 [3744]
A34 [9395]
A34 [9197]
training
A66
A10
A66
training
training
not assigned
A36
A36
training
A34
A34
A34
training
training
A33
A33
A33
A33
NN: A36 A1
reactive (27)
11
12
A68
A68
A68
A68
A68
not expressed
A28
A68
A68
A68
A68
A68
not expressed
A68
A68
A68
A68
A68
A68
A69
A*6806
A*6808
A*6809
A*6810
A*6811N
A*6812
A*6813
A*6814
A*6815
A*6816
A*6817
A*6818N
A*6819
A*6820
A*6821
A*6822
A*6823
A*6824
A*6901
A68
A*6805
A*6807
A68
A*6804
A*6802
A68
A68
HLA allele
A*6803
Expert
assigned
type
continued
A69(28)
Null
A68(28)
A28
Null
A68(28)
A68(28)
A68(28)
A68(28)
A68(28)
WHO
assigned
type
10
Cells
tested
A28 [3049]
A69 [4060]
A28 [53]
A68 [3845]
A28 [3146]
A68 [5268]
A28 [3644]
A68 [5461]
Assigned
type
[%]
International cell
exchange UCLA
289
59
202
2327
Cells
tested
NMDP
A28 [100]b
blank [100]b
18
Cells
tested
A69
A28
A28
A28
A68
A68
Assignment
IHW13 data
A68 [100]b
A28 [100]
Assigned
type
[%]
training
A68
A68
A68
A68
A68
A68
NT
A68
A68
A68f
A68
A68
A68
NT
A68
A68
A68
A68
A68
A68
A68
A68
training
assigned
type > 0.55d
Neural network
short A28
Commentsh
A74
A74
A74
A74
A74
A74
A74
A74
A80
A*7402
A*7403
A*7404
A*7405
A*7406
A*7407
A*7408
A*7409
A*8001
A80
A74(19)
A74(19)
A74(19)
A74(19)
11
11
A36 [03]
A80 [6888]
A74 [8991]
A74 [8795]
505
29
115
Table 1
A74
A*7401
blank [100]b
A74 [100]
11
A80
A74
A74
A74
training
A74
A74
A74
A74
A74
A74
A74
A74
training
13
14
B7
B7
B7
B7
B7
B7
B7
B7
B7
undefined
B7
B7
B7
B7
B7
B7
B7/blank
B7
B7
B7
B7
B7
B*0704
B*0705
B*0706
B*0707
B*0708
B*0709
B*0710
B*0711
B*0712
B*0713
B*0714
B*0715
B*0716
B*0717
B*0718
B*0719
B*0720
B*0721
B*0722
B*0723
B*0724
B*0725
B*0702
B703/B7
B7
HLA allele
B*0703
Expert
assigned
type
B7
B7
B7
B7
B7
B7
B7
B7
B7
B7
B703
B7
WHO
assigned
type
26
Cells
tested
B7 [9798]
B7 [9495]
B7 [7599]
B7 [9699]
Assigned
type
[%]
International
cell exchange
UCLA
13
23
42
44
15
10841
Cells tested
NMDP
B7 [100]
B7 [100]
B7 [100]
blank [100]
B7 [67]b
83
Cells
tested
IHW13 data
B7 [78]
B7 [92]
B7 [96]
B7 [95]
B7 [89]
B7 [93]
B7 [98]
Assigned
type
[%]
B7
B7
B7
B7
B7
B7
B7, blank
B703,
B7
Assignment
B7
B7
B7
B7
B7
B7
B7f
B7
B7
B7
B7
B7
B7
B7
B7
B7
B7
B7
B7
B7
training
training
B7
trainingc
Assigned
type > 0.55d
Neural network
similar to B703
negative
Commentsi
B8
B8
not expressed
B8
B8
B*0806
B*0807
B*0808N
B*0809
B*0810
not expressed
B8
B8
B13
B*0819N
B*0820
B*0821
B*1301
B8
B8
B*0805
blank
B8/blank
B*0804
B*0818
B8
B*0803
B*0817
B8
B*0802
B8
B8
B*0801
B8
B7
B*0736
B*0816
B7
B*0735
B*0815
B7
B*0734
B8
B7
B*0733
B8
blank
B*0732
B*0814
B7/B42
B*0731
B*0813
B7
B*0730
B8
B7
B*0729
B8
B7
B*0728
B*0812
undefined
B*0727
B*0811
B7
B*0726
B13
Null
B8
B8
B8
B8
Null
B8
B8
B8
B8
B8
B7/B42
B7
B7
B13 [100]
B59 [67]
B8 [517]
B8 [99100]
238
6518
B13 [97]
B8 [100]
B8 [100]
B8 [100]
B8 [99]
61
B13
B8
B8
B8
B0 08020
B8
training
B8
B8
NT
B8
not assigned
B8
B8
B8
B8
B8
B8
B8
B8
NT
B8
B8
B8
B8
not assigned
B8
training
B7
B7
B7
B7
not assigned
B7
B7
B7
B-blank (30)
short B8
B8Bw4; NN B8
extra reactions
Bw4pos
B742, short B7
B7var
not assignede
B7
normal B7 (28)
NN: B7
B7
15
16
B13
not expressed
B13
undefined
undefined
B13
B64
B65
B14
B14
B14
B14
B62
B75
B72
B62
B62
B62
B*1307N
B*1308
B*1309
B*1310
B*1311
B*1401
B*1402
B*1403
B*1404
B*1405
B*1406
B*1501
B*1502
B*1503
B*1504
B*1505
B*1506
B*1303
B*1306
B49/B15
B*1302
B49/B15
B13
HLA allele
B*1304
Expert
assigned
type
continued
B62(15)
B62(15)
B62(15)
B72(70)
B75(15)
B62(15)
B14
B14
B65(14)
B64(14)
Null
B15/B21
B13
WHO
assigned
type
13
15
20
Cells
tested
B62 [88]
[2837]
B62 [9499]
B64 [111]
[4045]
B65 [1139]
[1137]
10
22
29
2569
1035
1906
40
2244
1003
b
b
B14 [100]
B65 [10]
B13 [100]
25
18
64
22
11
17
B62
B62
B72
B75
B62
B65
B65
B64
B 1304
B13
Assignment
B62
B62
B62
training
training
training
B14
B14
B14
B14
training
training
B13
not assigned
not assigned
B13
NTk
B13
B13
B13
training
Assigned
type > 0.55d
Neural network
Commentsi
B65l
NN: B13
Cells
tested
IHW13 data
B13 [100]
B13 [99]
Assigned
type
[%]
1307
Cells tested
NMDP
B13 [99100]
Assigned
type
[%]
International
cell exchange UCLA
B62
B*1520
B75
B*1515
B76
B76
B*1514
B*1519
B77
B*1513
B71
B76
B*1512
B63
B75
B*1511
B*1518
B71
B*1510
B*1517
B70
B*1509
B63
B75/B62
B*1508
B*1516
B62
B*1507
B62(15)
B76(15)
B71(70)
B63(15)
B63(15)
B62(15)
B76(15)
B77(15)
B76(15)
B75(15)
B71(70)
B70
B75(15)
B62(15)
10
B75 [5]
B75 [7]
[2832]
B63 [9296]
B63 [8792]
B63 [5]
B63 [016]
B77 [4653]
B45 [36]
B76 [7688]
B0 15110 [019]
B46 [612]
B15 [2138]
B75 [3151]
B71 [2539]
B70 [5559]
B0 15080 [1114]
B62 [619]
B15 [1935]
B75 [3048]
B62 [93]
101
552
797
816
138
116
12
68
1204
65
45
B62 [79]
B62 [100]
11
B62
B62
B71
B63
B63
B75
B76
B77
B76
B75
B71
B71
B75
training
B15f
B76
training
training
training
B15
B62
training
training
B15
training
training
B15
17
18
B62
B62
not expressed
B62
B62
B70
B62
B75
B62
B62
B62
B62
undefined
B70
B62
B62
B62/blank
B*1524
B*1525
B*1526N
B*1527
B*1528
B*1529
B*1530
B*1531
B*1532
B*1533
B*1534
B*1535
B*1536
B*1537
B*1538
B*1539
B*1540
B62(15)
B70
B62(15)
B15
B15
B62(15)
B75(15)
B62(15)
B15
B62(15)
B62(15)
Null
B62(15)
B62(15)
B70/B5/blank
B*1523
B62 [4548]
B62 [9298]
B62 [8895]
B62 [8696]
B0 15240 [2324]
26
20
24
34
12
98
21
76
116
54
B62 [75]b
B62 [79]
B13 [100]b
B62 [100]
B62 [100]
B62 [50]
B62
B62
B75
B62
B71
B62
B62
B62
B0 15230
B75
B62
B62
B62
B71
B77
training
B62
B62
B62
B15
training
B71
B62
training
NT
training
B15
not assigned
training
B570-Bw4, B5/53/77var;
short B62
Bw4pos
B62 (14)
B62Bw4
Commentsi
blank [55]
Neural network
Cells
Assigned
tested Assignment type > 0.55d
IHW13 data
11
132
Assigned
type
Cells tested [%]
NMDP
B0 15230 [17] B5
B75(15)
B75
B*1521
16
WHO
Assigned
assigned Cells
type
type
tested [%]
International
cell exchange UCLA
Expert
assigned
HLA allele type
continued
B71
B62
B*1573
B72
B*1562
B62
B72
B*1561
B*1572
B62
B*1560
B*1571
B62
B*1558
B62
B62
B*1557
B72
B62
B*1556
B*1570
B15
B*1555
B*1569
B72
B*1554
B72
undefined
B*1553
B63
B70
B*1552
B*1568
B70
B*1551
B*1567
B62
B*1550
B62
B72
B*1549
B62
B62
B*1548
B*1566
B70/blank
B*1547
B*1565
B72
B*1546
B71
B62
B*1545
B*1564
B75
B*1544
B62
B62
B*1543
B*1563
B15
B*1542
B62(15)
B62(15)
B62(15)
B62(15)
B15
B15
B70
B62(15)
B72(70)
B62(15)
16
18
B62 [100]b
B62 [100]b
B62 [100]b
B72 [100]b
blank [50]
B62 [100]
B62 [46]
B62
B62
B71
B62
B62
B72
B72
B63
B62
B62
B71
B62
B72 h
B72
B62
B62
B62
B62
B15g
B72
not assigned
B71
B62
B72
B62
B72
not assigned
B62
B75
B62
B62f
Bw4pos
communication)
B71
Bw4pos
short B15; reactive with some B22 sera (15); NN: B15
19
20
B18
B18
B18
B18
B18
B18
B18
not expressed
B18
B18
B*1810
B*1811
B*1812
B*1813
B*1814
B*1815
B*1817N
B*1818
B*1819
B18
B*1803
B*1809
B18
B*1802
B18
B18
B*1801
B18/blank
B62
B*1582
B*1808
B62
B*1581
B*1807
B70
B*1580
B18
not expressed
B*1579N
B*1806
B15
B*1578
B18
B62
B*1577
B18
undefined
B*1576
B*1804
B62
B*1575
B*1805
B72
Expert
assigned
type
B*1574
HLA allele
continued
Null
B18
B18
B18
B18
B18
B18
B62(15)
Null
B15
WHO
assigned
type
10
Cells
tested
B18 [9799]
Assigned
type
[%]
International
cell exchange
UCLA
29
31
1641
Cells tested
NMDP
blank [100]b
53
Cells
tested
B18
B18
B18
B18
B18
B18
Assignment
IHW13 data
B18 [100]b
blank [100]
B18 [50]b
B18 [75]
B18 [90]
B18 [96]
Assigned
type
[%]
B18
B18
NT
B18
B18
B18
B18
B18
B18f
not assigned
B18
B18
B18
B18
B18
B18
training
training
B62
B62
B71
NT
B62
B62
not assigned
B62
B72
Assigned
type > 0.55d
Neural network
communication)
B62A30/31(Dormoy, personal
B70 (32)
Commentsi
B35
B35
B35
B*3504
B*3505
undefined
B*2718
B35
B27
B*2717
B*3503
B27
B*2716
B*3502
blank
B*2715
B35
B27
B*2714
B27
B27
B*2713
B*3501
blank
B*2712
B*2725
B27
B*2711
undefined
B27
B*2710
B*2724
B27
B*2709
undefined
B2708/B7
B*2708
B*2723
B27
B*2707
B27
B27
B*2706
B*2721
B27
B*2705
B27
B27
B*2704
B27
B27
B*2703
B*2720
B27
B*2702
B*2719
B27
B*2701
B35
B35
B35
B35
B35
B27
B27
B27
B27
B27
B27
B27
B2708
B27
B27
B27
B27
B27
B27
B27
19
B35 [9899]
B35 [95100]
B35 [9499]
B35 [92100]
231
26
1226
1013
2023
16
B35 [94]
B35 [100]
B35 [94]
B35 [72]
B35 [98]
B27 [83]
22
58
blank [75]
B27 [100]b
B27 [100]b
B27 [100]b
22
B27 [100]m
B27 [99]
B27 [97]
B27 [99]
B27 [97]
B27 [88]
B27 [87]
B27 [100]
B27 [1119]
18
17
29
1194
31
26
417
[1941]
B2708 [3658] B7
B27 [99100]
B27 [99100]
B27 [97]
B27 [97]
B35
B35
B35
B35
blank
B2708
B27
B27
B27
B27
B27
B27
training
B35
training
training
training
B27
not assigned
not assigned
B27f
B27f
B27
not assigned
B27
B27
B27
B27
B27
not assigned
B27f
B27
B27
blank [22]
B27
B27f
B27
training
B27
training
training
B27
NN: B27
Bw6pos
B73 B7 blank
21
22
B35
B35
B35
B35
B35
B35
B35
B35
B35
B35
B35
B35
B35
B35
B35
B35
B35/B40
B35
B*3516
B*3517
B*3518
B*3519
B*3520
B*3521
B*3522
B*3523
B*3524
B*3525
B*3526
B*3527
B*3528
B*3529
B*3530
B*3531
B*3532
B35
B*3512
B*3515
B35
B*3511
B35
B35
B*3510
B35
B35
B*3509
B*3513
B35
B*3514
B35
B*3506
B*3508
B35
HLA allele
B*3507
Expert
assigned
type
continued
B35
B35
B35
B35
B35
B35
B35
B35
B35
B35
B35
B35
B35
B35
B35
B35
B35
B35
B35
WHO
assigned
type
Cells
tested
B35 [8488]
B35 [97100]
B35 [99100]
B35 [9599]
Assigned
type
[%]
International
cell exchange
UCLA
23
261
41
29
422
17
12
345
10
Cells tested
NMDP
B35 [100]b
B35 [100]b
B61 [20] B48 [20]b
B35 [100]b
B35 [100]b
B35 [33] blank [67]
B35 [50]b
B35 [32]
B35 [100]b
B35 [75]
B35 [40]b
B35 [100]b
Cells
tested
B35
B35
B35
B78
B35
blank
B35
B35
B35
B35
B35
Assignment
IHW13 data
B35 [93]
B35 [79]
B35 [100]
B35 [78]
B35 [67]
B35 [75]
B35 [68]
B35 [91]
B35 [79]
Assigned
type
[%]
B35
B35
B35
B35
B35
B35
B35
B35
B35
B35
B35
B35
B35
B35
B35
training
B35
B35
B35
B35
B35
B35
B35
B35
training
B35
B35
Assigned
type > 0.55d
Neural network
short B35
reactive.
Commentsi
B3901/B39
B3902/B39
B39
B*3901
B*3902
B*3903
blank
B*3705
B38
B37
B*3704
B38
not expressed
B*3703N
B*3809
B37/B27
B*3702
B*3808
B37
B*3701
B38
B35
B*3546
B*3807
B35
B*3545
B38
B35
B*3544
B38
B35
B*3543
B*3806
B35
B*3542
B*3805
B35
B*3541
B38
not expressed
B*3540N
B38
B35
B*3539
B*3804
B35
B*3538
B*3803
B35
B*3537
B38
B35
B*3536
B38
B35
B*3535
B*3802
B35
B*3534
B*3801
B35
B*3533
B39(16)
B3902
B3901
B38(16)
B16
B38(16)
B38(16)
Null
B37
B35
B35
B35
B35
B35
Null
B35
B39 [9099]
B39 [99]
B38 [8996]
B38 [9899]
B37 [9899]
B35 [79]
20
96
476
788
2317
1721
379
B39 [77]
B39 [87]
B39 [95]
blank [25]
B37 [93]
21
15
43
27
B35 [100]b
B35 [100]b
B39
B39
B39
B38
B38
B37
B37
B35
B39
B39f B16f
training
B38
B38
B38
B38
B38
B38
B16
training
training
B37
B37
NT
not assigned
training
not assigned
B35
not assigned
not assigned
B35
B35
NT
B35
B35
B35
B35
B35
B35
B35
normal B38(41)
negative, Korean(40)
NN: B35
normal B35(38)
23
24
B39(16)
B39(16)
B39
B39
not expressed
B39
B39
B39
B60
B*3923
B*3924
B*3925N
B*3926
B*3927
B*3928
B*4001
B60(40)
B39(16)
Null
B16
B39
B*3920
B39(16)
B39(16)
B39(16)
B39(16)
B39(16)
B39(16)
B39(16)
B39(16)
B16
B39(16)
WHO
assigned
type
B*3922
B39
B*3913
B39
B39
B*3912
B*3919
B39
B*3911
B*3918
B39
B*3910
B39
B39
B*3909
B39
B39
B*3908
B*3917
B39
B*3907
B*3916
B39
B*3906
B39
B39
B*3905
B39
B39
B*3904
B*3914
B39
HLA allele
B*3915
Expert
assigned
type
continued
31
10
Cells
tested
B60 [9199]
B39 [9599]
B39 [9699]
B16 [35]
B39 [8691]
B39 [9699]
B16 [29]
B39 [9096]
Assigned
type
[%]
International
cell exchange
UCLA
3854
16
127
13
57
508
245
Cells tested
NMDP
B39 [100]
blank [100]
48
B39 [100]b
B39 [100]b
B39 [100]
B39 [100]b
B39 [69]
B39 [97]
blank [50]b
B39 [48] blank [41]
B39 [94]
B39 [100]b
B39 [82]
Cells
tested
B60
B39
B39
B39
B39
B39
B39
B39
B39
B39
Assignment
IHW13 data
Assigned
type
[%]
B39
training
B39
B39
B39
NT
B39
B39f B16f
B39
B16
B39
B39
B39f
B39
B39
B39
B16f
B39
B39
NN: B39
B39
NN: B39
B16f
Commentsi
B16g
training
B39
B39
Assigned
type > 0.55d
Neural network
B61
B61
B*4019
B*4020
B60/B48
B*4012
B61
B61
B*4011
B*4018
B60
B*4010
B61
B61
B*4009
B*4016
B61/blank
B*4008
B40
B60
B*4007
B*4015
B61
B*4006
B60
B4005/B50
B*4005
B*4014
B61
B*4004
undefined
B61
B*4003
B*4013
B61
B*4002
B61(40)
B60(40)
B40
B60(40)
B61(40)
B60(40)
B61(40)
B4005
B61(40)
B61(40)
B61(40)
18
B61 [7590]
138
B61 [100]b
B60 [100]b
blank [50]b
B61
B 4019
B61
B61
not assigned
B61
B40f
B40f
B60
not assigned
B48
B61
B60
B61
B61
B60
training
BFu0
B40Bw4 (43)
CREG sera
B60
B61
B61
B61
BN21, B21var
17
B61
B61
B61
training
16
B61 [11]
7
9
B40 [9]
B60 [100]
12
B61
B61
B61
33
B48 [23]
B61 [47]
B40 [419]
B60 [7093]
[2030] B 4008
585
B21 [59]
57
293
31
1460
B50 [2836]
B4005 [4157]
[216]
25
26
Expert
assigned
type
B40/B15
not expressed
B60
B61
B40
B21
B61
undefined
B61
B60
B60
undefined
B60
B60
B61
B60
B61
B60
B61/B41
B61
B60
B60
B61
B40
B60
HLA allele
B*4021
B*4022N
B*4023
B*4024
B*4025
B*4026
B*4027
B*4028
B*4029
B*4030
B*4031
B*4032
B*4033
B*4034
B*4035
B*4036
B*4037
B*4038
B*4039
B*4040
B*4042
B*4043
B*4044
B*4045
B*4046
continued
B41
B60(40)
B60(40)
B61(40)
B61(40)
B21
Null
WHO
assigned
type
Cells
tested
Assigned
type
[%]
International
cell exchange
UCLA
Cells tested
NMDP
Assigned
type
[%]
Cells
tested
B60
B61
Assignment
IHW13 data
B60
B40
B61
B60
B60
B61
B61
B60
B61
B60
B61
B40g
B60
not assigned
B60
B40g
B61
not assigned
B61
not assigned
B60
B61
B60
NT
not assigned
Assigned
type > 0.55d
Neural network
NN: B60
negative (44)
NN: B60
NN: B40
Commentsi
B44
B44
B44
B44
B44
B44
B44
B*4402
B*4403
B*4404
B*4405
B*4406
B*4407
B*4408
B44
B42
B*4205
B*4414
B42
B*4204
B44
B42
B*4202
B44
B42
B*4201
B*4413
B41
B*4106
B*4412
B41
B*4105
B44
B41
B*4104
B*4411
B41
B*4103
B44
B41
B*4102
B*4410
B41
B*4101
B45
B60
B*4048
B*4409
B40
B*4047
B12
B44(12)
B44(12)
B44(12)
B12
B44(12)
B44(12)
B44(12)
B44(12)
B44(12)
B44(12)
B44(12)
B42
B42
B41
B41
B41
B60(40)
B40
17
10
11
B44 [99100]
B44 [99100]
[012]
B42 [9697]
(14)
B41 [9195]
B41 [9495]
37
130
42
2854
6959
80
1015
11
478
543
B44 [100]
B44 [70]
b
B44 [100]b
B44 [100]b
B45 [88]
65
55
16
14
B44 [92]
B44 [65]
B44 [94]
B44 [98]
B42 [95]
B41 [91]
B41 [87]
B41 [87]
B45
B44
B44
B44
B44
B44
B44
B42
B42
B41
B41
B44
B44
B44
B44
B12g
B12
B44
B44
B12f
B44
B44
training
training
B42
B42
training
training
B41
B41
B41
B41
training
training
B60
B60
NN: B44
Bw4pos (45)
27
28
not expressed
B44
B44
B44
B44
B44
B44
B44
B44
B44
B44
B44
B44
B44
B44
B44
B44
B*4424
B*4425
B*4426
B*4427
B*4428
B*4429
B*4430
B*4431
B*4432
B*4433
B*4434
B*4435
B*4436
B*4437
B*4438
B*4439
B44
B*4423N
B44
B*4422
B*4418
B*4421
B44
B*4417
not expressed
B44
B*4416
B44
B47/B44
B*4415
B*4420
B12
HLA allele
B*4419N
Expert
assigned
type
continued
B44(12)
B44(12)
B44(12)
Null
Null
B44(12)
B47
B12
WHO
assigned
type
Cells
tested
Assigned
type
[%]
International
cell exchange
UCLA
Cells tested
NMDP
B44 [100] b
B44 [84]
B44 [100] b
B44 [100] b
Cells
tested
blank
B44
Assignment
IHW13 data
B44 [100]b
Assigned
type
[%]
B44
B44
B44
B44
B44
B44
B44
B44
not assigned
B44
B44
B44
B44
B44
B44
B44
NT
B44
B44
B44
NT
B12
B44
B44
B12g
short B44
observation)
Commentsi
Assigned
type > 0.55d
Neural network
B45
B45
B45
undefined
B45
undefined
B46
B46
B47
B47
B47
undefined
B48
B48/B70
B48
B48
B48
undefined
B48
undefined
B49
B49
B49
B50
B45
B*4501
B*4502
B*4503
B*4504
B*4505
B*4506
B*4601
B*4602
B*4701
B*4702
B*4703
B*4704
B*4801
B*4802
B*4803
B*4804
B*4805
B*4806
B*4807
B*4808
B*4901
B*4902
B*4903
B*5001
B*5002
B45(12)
B50(21)
B49(21)
B49(21)
B48
B48
B48
B48
B48
B48
B47
B47
B46
B46
B45(12)
15
10
B44 [5]
B50 [8799]
B49 [9295]
B48 [8497]
B40 [67]
B61 [78]
B60 [49]
B47 [7077]
B47 [9096]
B46 [8090]
B45 [9699]
79
1700
3002
32
39
610
311
1487
2307
B45 [96]
B45 [1]
B49 [100]
B48 [100]
B48 [67]
B40 [25]
B45 [75]
20
22
11
12
30
16
B45
B50
B49
B49
B48
B48
B71
B48
B47
B61
B47
B46
B45
training
training
B21f
NN: B7 B48
B49
training
not assigned
B48
NN: B48
NN: B7
not assigned
NN: B47
B47Bw4, B4713
sera.
NN: B45
B48f
B48
not assigned
training
not assigned
B47
not assigned
training
B46
training
B22
B45
B50
B45
B45
training
29
30
B51
B51
B51
B*5119
B*5120
B*5121
B51
B*5112
B51
not expressed
B*5111N
B51
B51
B*5110
B*5118
B51
B*5109
B*5117
B51
B*5108
B5
B51
B*5107
undefined
B51
B*5106
B*5116
B51
B*5105
B*5115
B51
B*5104
B51
B5103/B51
B*5103
B51
B5102/B51
B*5102
B*5113
B51
B*5101
B*5114
B50
Expert
assigned
type
B*5004
HLA allele
continued
B51(5)
B51(5)
B52(5)
Null
B51(5)
B51(5)
B51(5)
B5
B51(5)
B51(5)
B5103
B5102
B51(5)
B50(21)
WHO
assigned
type
10
30
Cells
tested
B53 [816] B5
B5102 [2133]
B51 [3857]
B51 [9699]
Assigned
type
[%]
International
cell exchange
UCLA
43
154
68
42
25
B51 [100]
B51 [100]
B51 [100]
B51 [86]
B52 [16]
B5103 [100]
1899
B50 [67]
Assigned
type
[%]
218
Cells tested
NMDP
88
Cells
tested
B51
B51
B51
B51
B51
B51
B51
B5102
B51
Assignment
IHW13 data
B51
B51
B51
B51
B51
B51
not assigned
B51
B51
B51
NT
B51f
training
training
training
B51
B51
B51
B51
B51
training
B50
Assigned
type > 0.55d
Neural network
NN: B59
Commentsi
B53
B53/B35
B*5302
B*5303
B55
B53
B*5301
B*5501
B52
B*5205
B54
B52
B*5204
B*5402
B5
B*5203
B54
B52
B*5202
B53
B52
B*5201
B*5401
B51
B*5134
B*5309
B51
B*5133
B53
B51
B*5132
B53
B51
B*5131
B*5308
B51
B*5130
B*5307
B51
B*5129
B53/B51
B51
B*5128
B53
not expressed
B*5127N
B*5306
B51
B*5126
B*5305
B51
B*5124
B53
B5
B*5123
B*5304
B51
B*5122
B55(22)
B54(22)
B54(22)
B53
B53
B52(5)
B52(5)
B51(5)
B51(5)
B51(5)
Null
B51(5)
19
13
B55 [8997]
B54 [8588]
B53 [8995]
B52 [9395]
453
631
3054
2823
B35 [25]b
B52 [100]
21
20
20
B52 [100]b
B53 [1]
32
B51 [100] b
B55
B54
B51
B53
B52
B51
B51
training
B54
training
B53
B53
not assigned
B53
B53
B53
B53f B35f
B53
training
B52
B52
B5g
B52
training
B51
B51
B51
B51
B51
B51
B51
NT
B51
B51
B5g
B51
normal B52(38)
NN: B52
NN: B51
31
32
B55
B55
undefined
B55
B55
B56
B56
B56
B56
B56
B78/blank
B56
B22
B22
B*5514
B*5515
B*5516
B*5601
B*5602
B*5603
B*5604
B*5605
B*5606
B*5607
B*5608
B*5609
B22
B*5509
B*5513
B56
B*5508
B*5512
B54
B*5507
B55
B55
B*5505
B55
B55
B*5504
B*5510
B55
B*5511
B55
B*5503
Expert
assigned
type
B*5502
HLA allele
continued
B56(22)
B56(22)
B56(22)
B22
B56(22)
B56(22)
B22
B55(22)
B22
B55(22)
B56(22)
B54(22)
B22
B55(22)
B55(22)
B55(22)
WHO
assigned
type
Cells
tested
[36]
B56 [9496]
Assigned
type
[%]
International
cell exchange
UCLA
11
13
671
10
309
Cells tested
NMDP
blank [100]b
B56 [46]
B56 [25]b
blank [8]
B55 [100]
23
B54 [50]b
11
Cells
tested
B56
B56
B56
B56
B56
B56
B56
B55
Assignment
IHW13 data
B55 [70]
Assigned
type
[%]
B22
B22
B22f
not assigned
not assigned
B56
not assigned
training
training
B55
B55
not assigned
B55
B55
B55
B55
B22
B22f
B54
B55
not assigned
B55
training
Assigned
type > 0.55d
Neural network
NN: B56
B78war, some B35- and B15 CREG sera positive, all B22
B55v (53)
NN: B56
Commentsi
B73
B78
B78
B*7801
B*7802
B17/B5
B*5808
B*7301
B58
B*5807
B67
B58
B*5806
B*6702
B58
B*5805
B67
B58
B*5804
B59
B58
B*5802
B*6701
B58
B*5801
B*5901
B57
B*5709
B17
B57
B*5809
B57
B57
B*5704
B*5708
B57
B*5703
B*5707
B57
B*5702
B57
B57
B*5701
B57
B55
B*5612
B*5705
B56
B*5611
B*5706
B55
B*5610
B78
B78
B73
B67
B59
B17
B58(17)
B58(17)
B57(17)
B57(17)
B57(17)
B57(17)
B57(17)
B55(22)
B56(22)
B55(22)
16
B73 [8187]
B55 [08]
B42 [09]
[1214]
B59 [8996]
B58 [82]
B58 [8592]
B57 [9097]
B57 [9699]
B57 [9596]
B57 [100]
210
106
B39 [100]b
123
B58 [100]
81
837
2096
32
412
65
3670
10
28
28
B78
B73
B67
B59
B58
B58
B57
B57
B57
B57
B78f
training
training
B67f
training
training
B58
B5 B17
B58
B58
B58
B58
training
training
B57
B57
B57
B57
B57
B57
training
training
training
B22
B22
B55
communication
(56)
communication)
(55)
33
34
B78
B35
undefined
B81
B81
undefined
undefined
undefined
HLA allele
B*7803
B*7804
B*7805
B*8101
B*8102
B*8201
B*8202
B*8301
B81
B81
WHO
assigned
type
10
Cells
tested
B22 [9]
146
B0 82010 [28]
657
Cells tested
NMDP
B81 [7089] B7
Assigned
type [%]
International
cell exchange
UCLA
B35 [79]
Assigned
type [%]
Table 2
Expert
assigned
type
continued
Cells
tested
B0 820
B0 820
B81
Assignment
IHW13 data
not assigned
B56
B56
B81
training
not assigned
B35f
B78
Assigned
type > 0.55d
Neural network
B2245, reactive with some B45 and B22 sera; IHW13: pattern
Commentsi
Cw1
Cw1
undefined
undefined
undefined
blank
undefined
Cw1
Cw2
Cw2
undefined
undefined
undefined
undefined
Cw2
Cw10
Cw9
Cw10
Cw3
Cw10
Cw3
undefined
Cw10
Cw3
undefined
undefined
undefined
undefined
undefined
blank
Cw4
Cw4/Cw6
HLA alleles
Cw*0102
Cw*0103
Cw*0104
Cw*0105
Cw*0106
Cw*0107
Cw*0108
Cw*0109
Cw*0202
Cw*0203
Cw*0204
Cw*0205
Cw*0206
Cw*0207
Cw*0208
Cw*0302
Cw*0303
Cw*0304
Cw*0305
Cw*0306
Cw*0307
Cw*0308
Cw*0309
Cw*0310
Cw*0311
Cw*0312
Cw*0313
Cw*0314
Cw*0315
Cw*0316
Cw*0401
Cw*0403
Cw4
Cw3
Cw3
Cw3
Cw10(w3)
Cw9 w3)
Cw10(w3)
Cw2
Cw2
Cw1
Cw1
Cw1
25
78
43
31
21
46
Cells tested
C 403 [19]
Cw4 [6277]
Cw2 [6775]
Cw1 [6181]
NMDP
736
603
446
41
382
260
Cells tested
IHW13 data
114
11
Cw4 [98]
blank [100]c
51
75
11
Cw3 [100]c
Cw3 [100]
Cw3 [83]
Cw3 [100]
67
Cw2 [91]
Cw2 [100]c
104
Cw1 [92]
Cells tested
Cw1 [100]c
Cw4
Cw4
Cw10
Cw10
Cw9
Cw10
Cw2
Cw1
Assigned type
short Cw1
Comments
35
36
International cell exchange UCLA
Cw5
Cw5
undefined
undefined
Cw5
undefined
Cw6
Cw6
Cw6
Cw6
undefined
undefined
undefined
undefined
Cw7
Cw7
Cw7
Cw7
Cw7
Cw7
undefined
Cw7
Cw7
Cw7
undefined
Cw*0501
Cw*0502
Cw*0503
Cw*0504
Cw*0505
Cw*0506
Cw*0602
Cw*0603
Cw*0604
Cw*0605
Cw*0606
Cw*0607
Cw*0608
Cw*0609
Cw*0701
Cw*0702
Cw*0703
Cw*0704
Cw*0705
Cw*0706
Cw*0707
Cw*0708
Cw*0709
Cw*0710
Cw*0711
Cw7
Cw7
Cw7
Cw7
Cw6
Cw6
Cw5
Cw5
Cw5
undefined
Cw*0411
Cw4
undefined
Cw*0408
Null
Cw4
Cw*0407
Cw4
Cw4/Cw6
Cw*0406
Cw*0410
Cw4
Cw*0405
Cw4
Cw*0404
14
74
24
31
10
NMDP
Cw7 [6276]
Cw7 [5972]
Cw7 [5276]
Cw7 [6875]
Cw6 [3169]
Cw5 [5765]
54
976
304
665
579
Cw7 [100]c
Cw7 [100]c
Cw7 [100]
blank [50]c
Cw7 [67]c
30
144
129
Cw7 [100]
Cw7
Cw7
Cw7
Cw7
Cw6 [100]c
Cw6
Cw5
Cw4
blank
Cw6 [100]c
blank [100]
69
IHW13 data
Cw5 [100]c
Cw4 [100]
Cw4 [100]
Cw4 [50]c
HLA alleles Expert assigned type WHO assigned type Cells tested Assigned type [%]
continued
undefined
undefined
blank
blank
blank
undefined
undefined
undefined
undefined
undefined
undefined
undefined
Cw*0808
Cw*0809
Cw*1202
Cw*1203
Cw*1204
Cw*1205
Cw*1206
Cw*1207
Cw*1208
Cw*1209
Cw*1210
Cw*1211
blank
undefined
Cw*0807
Cw*1505
undefined
Cw*0806
blank
undefined
Cw*0805
Cw*1504
Cw8
Cw*0804
blank
Cw8
Cw*0803
blank
Cw8
Cw*0802
Cw*1503
Cw8
Cw*0801
Cw*1502
undefined
Cw*0720
blank
undefined
Cw*0719
undefined
undefined
Cw*0718
Cw*1405
undefined
Cw*0717
Cw*1404
Cw7
Cw*0716
Cw1/blank
undefined
Cw*0715
Cw1/blank
Cw7
Cw*0714
Cw*1402
undefined
Cw*0713
Cw*1403
Cw7
Cw*0712
Cw8
Cw8
Cw8
Cw8
Cw7
Cw7
Cw7
23
15
19
10
16
44
Cw2 [039]
blank
blanka
blank
blank
blank
18
107
93
238
85
234
31
blanka
Cw8 [4359]
Cw8 [813]
Cw8 [4769]
Cw8 [5363]
Cw8 [100]c
blank [100]c
blank [100]c
56
blank [90]
10
36
blank [100]c
blank [89]
blank [93]
75
blank [50]c
27
blank [94]
blank [100]c
30
40
blank
blank
blank
Cw1
Cw1
blank
blank
blank
Cw8
Cw8
37
38
undefined
undefined
undefined
blank
undefined
undefined
blank
blank
blank
undefined
Cw7/blank
undefined
Cw7/blank
Cw6/blank
Cw6/blank
Cw*1506
Cw*1507
Cw*1508
Cw*1509
Cw*1510
Cw*1511
Cw*1601
Cw*1602
Cw*1604
Cw*1606
Cw*1701
Cw*1702
Cw*1703
Cw*1801
Cw*1802
24
27
Cells tested
Table 3
NMDP
20
22
276
Cw7 [013]
Cells tested
blankb
HLA alleles
continued
IHW13 data
Cw6 [50]c
blank [100]c
blank [90]
blank [100]c
57
Cells tested
blank [97]
blank [94]
blank [67]c
blank
blank
blank
Assigned type
Comments
DR3
DR3
DR3
DRB1*0321
DR3
DRB1*0309
DRB1*0320
DR3
DRB1*0308
DRB1*0319
DR3
DRB1*0307
DR3
DR3
DRB1*0306
DRB1*0318
DR17
DRB1*0305
DR3
DR17
DRB1*0304
DRB1*0317
DR18
DRB1*0303
DR3
DR18
DRB1*0302
DR17
DR17
DRB1*0301
DRB1*0316
DR1
DRB1*0111
DRB1*0315
DR1
DRB1*0110
DR3
DR1
DRB1*0109
DR3
DR1
DRB1*0108
DRB1*0314
DR1
DRB1*0107
DRB1*0313
DR1
DRB1*0106
DR3
DR1
DRB1*0105
DRB1*0312
DR1
DRB1*0104
DR17
DR103/DR1
DRB1*0103
DRB1*0311
DR1
DRB1*0102
DR17
DR1
DRB1*0101
DRB1*0310
HLA allele
DR3
DR3
DR17(3)
DR17(3)
DR3
DR3
DR17(3)
DR17(3)
DR18(3)
DR18(3)
DR17(3)
DR1
DR1
DR1
DR103
DR1
DR1
10
24
16
Cells tested
DR1 [8695]
DR1 [95100]
NMDP
317
9698
1186
2035
6317
Cells tested
Neural Network
DR17
DR17
DR17
DR17
DR3g
DR17
DR17
DR17
DR17
DR17
DR17
DR3 [100]b
DR17
DR17
DR3 [100]b
DR17
DR17
DR17
DR3 [100]
DR17
DR17
DR18
training
training
DR1
DR1
DR1
DR1
DR1
DR1
DR1
DR1 [100]b
DR1
training
training
traininge
DR1 [95]
DR1 [97]
NN: DR18
Commentsi
39
40
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DRB1*0408
DRB1*0409
DRB1*0410
DRB1*0411
DRB1*0412
DRB1*0413
DRB1*0414
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DRB1*0421
DRB1*0422
DRB1*0423
DRB1*0424
DRB1*0425
DRB1*0426
DRB1*0427
DRB1*0428
DRB1*0429
DR4
DR4
DRB1*0407
DR4
DR4
DRB1*0406
DRB1*0420
DR4
DRB1*0405
DRB1*0419
DR4
DRB1*0404
undefined
DR4
DRB1*0403
DR4
DR4
DRB1*0402
DRB1*0418
DR4
DRB1*0401
DRB1*0417
DR3
DRB1*0325
DR4
DR3
DRB1*0324
DR4
DR3
DRB1*0323
DRB1*0415
DR3
DRB1*0322
DRB1*0416
HLA allele
continued
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR3
12
16
Cells tested
DR4 [100]
DR4 [100]
DR4 [98]
DR4 [100]
DR4 [97100]
DR4 [89100]
DR4 [94100]
DR4 [95100]
DR4 [97100]
DR4 [84100]
DR4 [100]
NMDP
76
29
13
258
846
83
505
2164
748
1029
5118
Cells tested
Neural Network
DR4 [100]
DR4 [100]b
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4f
DR4
not assignede
DR4
DR4
DR4
DR4f
DR4 [100]b
DR4 [67]
DR4
DR4 [67]b
DR4
DR4
DR4 [93]
DR4
DR4
DR4
training
DR4
training
training
training
training
training
DR17
DR3
DR17
DR17
DR4 [100]b
DR4 [84]
DR4 [95]
DR4 [86]
DR4 [86]
DR4 [89]
DR4 [91]
DR4 [89]
DR4 [92]
DR4 [92]
DR4 [98]
short DR4
DR43
DR411
NN: DR17
Commentsi
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR7
DR7
DR7
DR7
DR7
DR7
DR7
DR8
DR8
DR8
DR8
DR8
DR8
DR8
DR8
DR8
DR8
DRB1*0435
DRB1*0436
DRB1*0437
DRB1*0438
DRB1*0439
DRB1*0440
DRB1*0441
DRB1*0442
DRB1*0443
DRB1*0444
DRB1*0445
DRB1*0446
DRB1*0447
DRB1*0448
DRB1*0701
DRB1*0703
DRB1*0704
DRB1*0705
DRB1*0706
DRB1*0707
DRB1*0708
DRB1*0801
DRB1*0802
DRB1*0803
DRB1*0804
DRB1*0805
DRB1*0806
DRB1*0807
DRB1*0808
DRB1*0809
DRB1*0810
DR4
DRB1*0432
DRB1*0433
DR4
DRB1*0431
DRB1*0434
DR4
DRB1*0430
DR8
DR8
DR8
DR8
DR8
DR8
DR8
DR8
DR8
DR7
DR7
DR7
DR4
DR4
DR4
12
29
DR8 [89]
DR8 [96100]
DR8 [8899]
DR8 [96100]
DR8 [9699]
DR8 [95100]
DR7 [100]
DR7 [95100]
DR4 [100]
DR4 [100]
13
186
230
265
1076
7390
DR8 [71]
DR8 [100]
DR8 [92]
DR8
DR8
DR8
DR8
DR8
training
DR8
DR8 [93]
training
training
training
DR7
DR7
DR7
DR7
DR7
DR7
training
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR4
DR8 [100]b
DR8 [96]
DR8 [95]
DR7 [99]
DR8var
41
42
DR8
DR8
DR8
DR8
DR8
DR8
DR8
DR8
DR8
DR8
DR8
DR8
DR9
DR9
DR10
DR11
DR11
DR11
DR11
DRB1*0814
DRB1*0815
DRB1*0816
DRB1*0817
DRB1*0818
DRB1*0819
DRB1*0820
DRB1*0821
DRB1*0822
DRB1*0823
DRB1*0824
DRB1*0825
DRB1*0901
DRB1*0902
DRB1*1001
DRB1*1101
DRB1*1102
DRB1*1103
DRB1*1104
DR11
DR11
DR11
DR11
DR11
DR11
DR11
DR11
DR11
DRB1*1107
DRB1*1108
DRB1*1109
DRB1*1110
DRB1*1111
DRB1*1112
DRB1*1113
DRB1*1114
DRB1*1115
DR11
DR8
DRB1*0813
DR11
DR8
DRB1*0812
DRB1*1105
DR8
DRB1*0811
DRB1*1106
Expert assigned
type
HLA allele
continued
DR11(5)
DR11(5)
DR11(5)
DR11(5)
DR11(5)
DR11(5)
DR11(5)
DR11(5)
DR11(5)
DR11(5)
DR11(5)
DR11(5)
DR11(5)
DR11(5)
DR10
DR9
DR8
DR8
DR8
DR8
DR8
WHO assigned
type
12
13
18
Cells tested
DR11 [100]
DR11 [100]
DR11 [100]
DR11 [90]
DR11 [94100]
DR11 [84100]
DR11 [89100]
DR11 [94100]
DR10 [94100]
DR9 [89100]
DR8 [74]
DR8 [94]
NMDP
15
2119
397
430
3474
894
1058
Cells tested
Neural Network
DR11 [75]
DR11 [100]
DR11
DR11
DR11
DR11
DR11
DR11f
DR11
DR11
not assigned
DR11
DR11
training
training
training
training
training
DR9
training
DR8
DR8
DR8
DR8
DR8
DR8f
DR8
DR11 [100]
DR9 [95]
DR8
DR8
DR8 [100]b
DR8
DR8
DR8
DR8
DR8
DR8
DR8 [100]
DR1114
DR1113
Commentsi
DR11
DRB1*1138
DR12
DR11
DRB1*1137
DRB1*1202
DR11
DRB1*1136
DR12
DR11
DRB1*1135
DRB1*1201
DR11
DRB1*1134
DR11
DR11
DRB1*1133
DR11
DR11
DRB1*1132
DRB1*1147
DR11
DRB1*1131
DRB1*1146
DR11
DRB1*1130
DR11
DR11
DRB1*1129
DR11
DR11
DRB1*1128
DRB1*1145
DR11
DRB1*1127
DRB1*1144
DR11
DRB1*1126
DR11
DR11
DRB1*1125
DR11
DR11
DRB1*1124
DRB1*1143
DR11
DRB1*1123
DRB1*1142
DR11
DRB1*1122
DR11
DR11
DRB1*1121
DR11
DR11
DRB1*1120
DRB1*1141
DR11
DRB1*1119
DRB1*1140
DR11
DRB1*1118
DR11
undefined
DRB1*1117
DRB1*1139
DR11/DR13
DRB1*1116
DR12(5)
DR12(5)
DR11(5)
DR11(5)
DR11(5)
DR11(5)
DR11(5)
DR11(5)
DR11(5)
DR11(5)
DR11(5)
DR11(5)
17
DR12 [91100]
DR11 [100]
DR11 [97]
DR11 [100]
162
893
DR12 [89]
DR11 [2]
training
training
DR11
DR11
DR11
DR11
DR11
DR11
DR11
DR11
DR11
DR11
DR11
DR11
DR11
DR11
DR11
DR11
DR11
DR11
DR11
DR11
DR11
DR11
DR11
DR11
DR11
DR11f
DR11
DR13
DR11
DR11
DR14
DR6g
NN: DR4
DR1113
43
44
DR12
DR12
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DRB1*1208
DRB1*1209
DRB1*1301
DRB1*1302
DRB1*1303
DRB1*1304
DRB1*1305
DRB1*1306
DRB1*1307
DRB1*1308
DRB1*1309
DRB1*1310
DRB1*1311
DRB1*1312
DRB1*1313
DRB1*1314
DRB1*1315
DRB1*1316
DRB1*1317
DRB1*1318
DRB1*1319
DRB1*1320
DRB1*1321
undefined
DR12
DRB1*1207
DRB1*1324
DR12
DRB1*1206
DR13
DR12
DRB1*1205
DR13
DR12
DRB1*1204
DRB1*1322
DR12
DRB1*1203
DRB1*1323
Expert assigned
type
HLA allele
continued
DR13(6)
DR13(6)
DR13(6)
DR13(6)
DR13(6)
DR13(6)
DR13(6)
DR13(6)
DR13(6)
DR13(6)
DR13(6)
DR13(6)
DR13(6)
DR13(6)
DR13(6)
DR13(6)
DR13(6)
DR13(6)
DR13(6)
DR12(5)
DR12(5)
DR12(5)
WHO assigned
type
11
16
11
Cells tested
DR13 [95]
NMDP
305
127
948
3081
3788
Cells tested
Neural Network
DR13 [100]
DR11
DR13h
DR13
DR13
not assigned
DR6g
DR6
not assigned
DR13
DR13 [50]b
DR13
NN: DR6
NN: DR6
DR11f
DR11 [53]b
DR1312
DR52-neg; NN: DR13 DR8
DR13
DR6f
DR11
NN: DR6
NN: DR13
DR1211
Commentsi
DR13
DR13
DR13 [100]b
DR13
not assigned
DR13
DR6g
DR13
training
training
training
DR12
DR12
DR13 [100]
DR13 [78]
DR13 [87]
DR12
DR12
DR12 [100]b
DR12
DR12
DR12
DR12 [100]
undefined
undefined
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
undefined
DR13
undefined
undefined
DR13
DR6
DR6
DR13
DR13
DR13
DR14
undefined
DR6
DR13
DR6
DR13
DR6
DRB1*1325
DRB1*1326
DRB1*1327
DRB1*1328
DRB1*1329
DRB1*1330
DRB1*1331
DRB1*1332
DRB1*1333
DRB1*1334
DRB1*1335
DRB1*1336
DRB1*1337
DRB1*1338
DRB1*1339
DRB1*1340
DRB1*1341
DRB1*1342
DRB1*1343
DRB1*1344
DRB1*1345
DRB1*1346
DRB1*1347
DRB1*1348
DRB1*1349
DRB1*1350
DRB1*1351
DRB1*1352
DRB1*1353
DRB1*1354
DRB1*1355
DRB1*1356
DRB1*1357
DRB1*1358
DRB1*1359
DRB1*1360
DR13(6)
DR14(6)
DR13(6)
DR13(6)
DR13(6)
DR6
DR13(6)
DR6
DR13
DR6
DR13
DR6
not assigned
DR11
DR13
DR13
DR13
DR6f
DR6
DR13
DR8
DR11f
DR13
not assigned
DR13
DR6f
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR13
DR14
DR11
NN: DR13
NN: DR6
NN: DR11
NN: DR13
DRblank-DR52pos
45
46
DR14
DR14
DR14
DR6
DRB1*1422
DRB1*1423
DRB1*1424
DR6
DRB1*1417
DR14
DR6
DRB1*1416
DRB1*1421
DR8
DRB1*1415
DRB1*1420
DR14
DRB1*1414
DR14
DR14
DRB1*1413
DR14
DR14
DRB1*1412
DRB1*1418
DR14
DRB1*1411
DRB1*1419
DR14
DRB1*1410
DR14
DRB1*1407
DR14
DR14
DRB1*1406
DR14
DR14
DRB1*1405
DRB1*1408
DR1404/DR14
DRB1*1404
DRB1*1409
DR1403/DR14
DR14
DRB1*1401
DRB1*1403
undefined
DRB1*1362
DR14
DR13
DRB1*1361
DRB1*1402
Expert assigned
type
HLA allele
continued
DR14(6)
DR14(6)
DR14(6)
DR14(6)
DR6
DR6
DR6
DR8
DR14(6)
DR14(6)
DR14(6)
DR14(6)
DR14(6)
DR14(6)
DR14(6)
DR14(6)
DR14(6)
DR1404
DR1403
DR14(6)
DR14(6)
WHO assigned
type
17
Cells tested
DR14 [94]
DR8 [010]
DR13 [019]
NMDP
10
117
58
80
37
204
Cells tested
DR6 [100]b
DR14 [100]
DR6
DR14
DR14
DR13
DR14
DR14
DR14
DR13
DR6
DR8
DR14
DR14
DR14h
not assigned
not assigned
DR14
DR14
DR14
DR14
DR14
DR14
DR14
training
training
DR11
DR13
DR13 [100]b
Neural Network
Assigned type > 0.55d
DR14 [100]b
DR14 [100]
DR14 [90]
DR1404 [3]
DR13 [3]
DR14
DR8DR52
NN: DR6
Commentsi
DR6
DR14
DR14
DR14
DR14
DR6
DR14
DR14
DR6
DR14
DR14
DR14
DR6
DR14
DR14
DR14
DR14
undefined
DR14
DR14
DR6
DR14
DR14
DR14
DR15
DR15
DR15
DR15
DR15
DR15
DR15
DR15
DR15
DR15
DR15
DRB1*1425
DRB1*1426
DRB1*1427
DRB1*1428
DRB1*1429
DRB1*1430
DRB1*1431
DRB1*1432
DRB1*1433
DRB1*1434
DRB1*1435
DRB1*1436
DRB1*1437
DRB1*1438
DRB1*1439
DRB1*1440
DRB1*1441
DRB1*1442
DRB1*1443
DRB1*1444
DRB1*1445
DRB1*1446
DRB1*1447
DRB1*1448
DRB1*1501
DRB1*1502
DRB1*1503
DRB1*1504
DRB1*1505
DRB1*1506
DRB1*1507
DRB1*1508
DRB1*1509
DRB1*1510
DRB1*1511
DR2
DR15(2)
DR15(2)
DR15(2)
DR15(2)
DR15(2)
DR15(2)
DR15(2)
DR14(6)
DR14(6)
DR14(6)
14
22
286
676
6428
DR15
DR15
DR15
DR15
DR15
DR15
DR15
DR15
b
DR15 [100] b
DR15 [50]
training
training
training
DR14
DR14
DR14
DR6
DR14
DR14
DR11f
DR14
DR14
DR14
DR14
DR6
DR14
DR14
DR14
DR6g
DR14
DR14
DR6
DR14
DR14
DR14
DR14
DR6
NN: DR14
NN: DR13
NN: DR14
NN: DR14
47
48
DR15
DR2
DR16
DR16
DR16
DR16
DR16
DR16
DR16
DRB1*1512
DRB1*1513
DRB1*1601
DRB1*1602
DRB1*1603
DRB1*1604
DRB1*1605
DRB1*1607
DRB1*1608
DR16(2)
DR16(2)
DR2
DR16(2)
DR16(2)
12
Cells tested
Table 4
HLA allele
continued
NMDP
239
703
Cells tested
Neural Network
DR16
DR16
DR16
DR16
DR16 [100]b
DR16
training
training
DR2
DR15
Commentsi
Cells tested
DRB3*0101
DR52
DR52
67
DR52 [95100]
DRB3*0102
DR52
DR52
DR52 [99]
DRB3*0103
undefined
DRB3*0104
undefined
DRB3*0105
undefined
DRB3*0106
DR52
DR52
DRB3*0107
DR52
DR52
DRB3*0108
undefined
DRB3*0109
undefined
DRB3*0110
DR52
DR52
DRB3*0201
DR52
DR52
DR52 [9799]
DRB3*0202
DR52
DR52
100
DR52 [90100]
DRB3*0203
DR52
DR52
DR52 [100]
DRB3*0204
undefined
DRB3*0205
undefined
DRB3*0206
undefined
DRB3*0207
DR52
DR52
DRB3*0208
DR52
DR52
DRB3*0209
DR52
DR52
DRB3*0210
DR52
DR52
DRB3*0211
DR52
DR52
DRB3*0212
undefined
DRB3*0213
undefined
DRB3*0214
undefined
DRB3*0215
undefined
DRB3*0216
undefined
DRB3*0217
undefined
DRB3*0218
undefined
DRB3*0301
DR52
DR52
36
DR52 [95100]
DRB3*0302
DR52
DR52
DRB3*0303
undefined
DRB4*0101
DR53
DR53
38
DR53 [95100]
DRB4*0102
DR53
DR53
DRB4*0103
DR53
DR53
49
DR53 [89100]
DRB4*01030102N
not expressed
Null
14
DR53 [1788]a
DRB4*0104
undefined
DRB4*0105
DR53
DR53
DRB4*0106
undefined
DRB4*0201N
not expressed
Null
DRB4*0301N
not expressed
Null
DRB5*0101
DR51
DR51
28
DR51 [7196]
DRB5*0102
DR51
DR51
DR51 [8695]
DRB5*0103
undefined
Comments
49
continued
International cell exchange UCLA
HLA alleles
Cells tested
DRB5*0104
undefined
DRB5*0105
undefined
DRB5*0106
undefined
DRB5*0107
DR51
DR51
DRB5*0108N
not expressed
Null
DR51 [43]
DRB5*0109
undefined
DRB5*0110N
not expressed
Null
DRB5*0202
DR51
DR51
13
DR51 [8694]
DRB5*0203
undefined
DRB5*0204
undefined
DRB5*0205
undefined
Comments
False-postive assignments.
Table 5
antigen. These cases are indicated in the tables. The NMDP data
by the participating laboratories are given with the lowest and high-
For some less frequent alleles, such as A*0202 and A*0203, the
NMDP
Cells from unrelated donors from the US were HLA typed using
serological and molecular methods by NMDP affiliated laboratories.
Neural network
uals for HLA-C, 68,188 individuals for HLA-DRB1 and 51,382 individuals for HLA-DQB1. Tables 1, 2, 3, 4 and 6 present the number of
serologic type(s) associated with that allele. For example (Table 1),
other sources. The NN was trained with the polymorphic amino acid
and split specificities, were included in the training set. After training
of five independent NN for each locus, the NN were used to predict the
of the remaining allelic products and the results summarized from five
networks. Alleles not in the training set but with known serologic types
50
NMDP
HLA allele
Cells tested
Cells tested
DQB1*0201
DQ2
DQ2
16
DQ2 [75100]
9175
DQ2 [98]
DQB1*0202
DQ2
DQ2
15
DQ2 [87100]
656
DQ2 [87]
DQB1*0203
DQ2
DQ2
DQ2 [67]b
DQB1*0301
DQ7
DQ7(3)
47
DQ7 [4792]
12220
DQ3 [844]
DQB1*0302
DQ8
DQ8(3)
22
DQ9
DQ9(3)
14
6687
Comments
2653
DQB1*0304
DQ7
DQ7(3)
111
DQB1*0305
DQ8
DQ8(3)
70
DQ7negDQ8neg
DQB1*0306
DQ3
DQ3
DQ8 [100]
DQB1*0307
undefined
DQB1*0308
undefined
DQB1*0309
undefined
DQB1*0310
DQ8
DQ8(3)
DQ7 [100]
DQB1*0311
undefined
DQB1*0312
undefined
DQB1*0313
undefined
DQB1*0401
DQ4
DQ4
DQ4 [8889]
142
DQB1*0402
DQ4
DQ4
13
DQ4 [78100]
1085
DQB1*0501
DQ5
DQ5(1)
19
5539
919
1327
48
675
5151
2807
1592
DQ5
DQ5(1)
13
DQB1*0503
DQ5
DQ5(1)
10
DQB1*0504
DQ5
DQ5(1)
DQB1*0601
DQ6
DQ6(1)
DQB1*0602
DQ6
DQ6(1)
13
DQB1*0603
DQ6
DQ6(1)
DQB1*0604
DQ6
DQ6(1)
DQ1 [5052]
DQB1*0605
DQ6
DQ6(1)
358
DQB1*0606
DQ1
DQ5 [100]
DQB1*0607
DQ1
DQ1 [100]
DQB1*0608
DQ6
DQ6(1)
DQB1*0609
DQ6
DQ6(1)
149
DQ6 [4344]
DQ6
51
continued
International cell exchange, UCLA
NMDP
HLA allele
Cells tested
Cells tested
DQB1*0610
DQ1
DQ1 [100] b
DQB1*0611
DQ1
DQ1
DQB1*0612
DQ1
DQ1
DQB1*0613
undefined
DQB1*0614
DQ6
DQ6(1)
DQB1*0615
undefined
DQB1*0616
undefined
DQB1*0617
undefined
DQB1*0618
undefined
DQB1*0619
undefined
DQB1*0620
undefined
DQB1*0621
undefined
a
b
Comments
Table 6
alleles listed in this dictionary, and the two sets of five NN each were
ments are described in the comments column of the tables, but only if
these values were >0.40 in both sets of analyses. Allelic products with
at the four digit level. The final analysis cell panel consisted of 846
blanks; e.g. B*2718). Due to the random nature of each NN, the results
of each serologic specificity and group (7). The Tables 13 show for
second set of networks run later produced A28 as the primary specifi-
each allele the number of panel cells included in the analysis, the
One of the goals of this 13th IHWG component was to determine the
52
It was considered that the use of the dictionary would greatly improve
if as many as possible serologic equivalents could be provided. There-
fore, we include now an expert assigned type for HLA-A, -B, -C,
combined. This expert assigned type may in some cases differ from
tion of some of these variant reaction patterns for HLA allelic pro-
provided (see for example A*3108 and A*3204 in Table 1). Sometimes,
of officially named HLA specificities. Both NMDP and the UCLA cell
A203, A2403, B5102 and B703, are rarely used. They are usually desig-
nated by their associated or broad specificities (A2, A24, B51 and B7,
respectively). Even specificities such as A66, B64 and B65 are poorly
identified. Therefore, the percentage recognition in the included tables
The dictionary can be used to develop unrelated donor search strategies. First, the number of individuals tested as carrying a particular
allele by the NMDP laboratories provides a rough estimate of allele
With the use of the serologic reagents of the 13th IHWG, a computational
analysis was developed to map the amino acid residues that determine
donor typed as B*07 (or B7) is most likely to carry B*0702. It also
the epitopes in the different HLA alleles (11). Through this analysis, the
complete 13th IHWG serum set and the most likely serotype can be
laboratories 48% of the time and typed as B53 24% of the time. The
search report will include B51 (B5)-positive donors for a patient carrying
assignments.
accessible web site and to provide more frequent updates to the informa-
References
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with serologically defined HLA-A, -B, -DR
antigens. Tissue Antigens 1997: 50: 40118.
53
54
54. Lyou J-Y, Yang KL, Lee A, Lin PY, Lee TD.
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55. Wu G-G, Cheng L-H, Zhou D et al.
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55