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accurate to say that DHA is beneficial for the development of the human brain during its
formation and throughout infancy (1). It may be deduced then, that DHA may also
provide some benefit to the brain at all stages of life. As the brain ages, it begins to
deteriorate, reversing the cerebral-genesis of infancy. It has been proven that the addition
of DHA to the diet "can improve the cognitive dysfunction due to aging or organic brain
damages" (2). It is also possible that DHA can be added as a prophylactic before aging
(1,3). DHA has been proven to produce significant improvements in immediate memory
and attention scores in clinical tests (2). However, DHA is not a cure for the aging or
Alzheimer's brain. Because Alzheimer's disease is rarely diagnosed early enough in its
projected that omega -3 fatty acids could be useful in the prevention of deferent
DHA is a very long unsaturated fatty acid chain. The fatty acid, DHA, makes up
the phospholipid layer of neural cells in the human brain (3). DHA performs several
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other important functions in the brain including monitoring synaptic firing and
monitoring all parts of the ion channel needed for signal transfer (3). Because of DHA's
impact on neural signaling, research shows that neural membrane fluidity is directly
related to the concentration of unsaturated fatty acids present in the brain (3,5,7).
Although necessary, the human body cannot manufacture DHA, nor can humans
must come from diet or supplementation (1,4). Further, "National studies suggest that the
Western diet is deficient in long-chain omega-3 fatty acids" (3). It is found mainly in
fatty fish like salmon, herring, and tuna (3,5). Because the fish do not make the DHA, it
can also be found in the plankton and algae that the fish consume (3).
Infants' brains are constantly growing and developing (1,3,5). Since 2002, DHA has been
deemed vital enough for infant neural development, that most formula companies now
fortify their products with it (3,4). This rise in fortification resulted from many research
studies confirming that DHA is positively linked to the brain development of fetuses and
infants (3,5). In stark contrast to the rapidly growing brain of an infant, aging adults with
Alzheimer's disease suffer extreme deterioration of the brain. It can be assumed, then,
that DHA is beneficial for the maintenance of those neural cell membrane phospholipids
The elderly are particularly susceptible to malnutrition (6). They tend to eat less
and consume a smaller variety of foods (6). Many factors contribute to the development
of poor nutritional habits in later adulthood (6). Physical problems such as illness,
weakness, and the effect of medications negatively affect the desire to eat (6). Also,
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factors like low income, little person to person interaction, or restricted diets that require
extra energy to prepare, deter the elderly from cooking nutritious meals for themselves
(6). An elderly person's poor nutritional status is directly related to his or her health
status, including mental health. A particularly important factor in healthy aging is the
maintenance of cognitive function (1). In the past several years, research has been
conducted regarding the benefits of DHA for the aging brain. Further, DHA has been
"approximately 10% of the population over the age of 65 y and 47% of the population
over 80 y of age in Western countries as the leading cause of dementia" (5). This disease
global cognitive impartment" (5). These symptoms result from "massive neuronal cell
loss in the association, hippocampus and limbic regions of the human brain, and
signaling" (7).
AD may begin, in some cases, as many as twenty years before diagnosis (8).
During that time, nerve cell death and tissue loss begins, eventually causing the brain to
shrink significantly and fluid filled spaces to increase in size (8). Researchers do not
know the exact cause of AD but many are led to believe that the formation of plaques and
tangles could be causes (5,8). Plaques are "abnormal clusters of protein fragments, built
up between nerve cells that block cell to cell signaling at the synapses" (8). These
plaques are made up a beta-amyloid, which are pieces of protein that collect and stick
together, blocking synaptic transmission and the delivery of nutrients to the cell (3,8).
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Tangles are "twisted strands of protein of dead and dying nerve cells" (8). They are
formed when the track-like structures that transport food, cell parts and other necessary
materials collapse (8). Therefore, they also deprive nerve cells of needed energy and
eventually kill them (1,8). This places the brain into a cycle of potentially exponential
cell death. The disruption of synaptic transmission, especially in the cortex, "damages
thinking, planning, and long term memory" (8). These symptoms are usually evident in
and may last for 2-10 years. The last stage may increasingly affect the hippocampus, and
perception" (5). This usually marks the final and most sever stage of AD progression
where the victim may have difficulty with activities of daily living. Therefore, the
associated with several forms of cognitive decline in the elderly, particularly Alzheimer's
disease" (1). Pharmaceuticals are available that treat the symptoms of Alzheimer's
disease like NSAID (non-steroidal anti-inflammatory drug), but do not protect the brain
from further deterioration (7). Further, AD is usually diagnosed in the second or third
stage of the disease. At that point, there is much damage to the brain (8). Therefore, it
may be concluded that supplementation will be most effective if administered before the
onset of AD (1,3).
(3). Studies have also revealed that there is a positive link between brain function in
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aging adults and a decline in DHA concentration in the brain (2). Research on AD model
rats has revealed that DHA consumption before the onset of AD has a "beneficial effect
on the decline on avoidance learning ability associated with the increase in the cortico-
hoppocampal DHA and ALA rats and a decrease in bata-amyloid production" (3). As
has been proven to do, it reduces the amount of plaque buildup, and the blockage on
neural traffic pathways. More energy reaching the living cells will greatly reduce the rate
the very least, slows in its rate of decline (2,7). DHA is best used as a prophylactic
because neural cells, once they have lost their connections, cannot be repaired (1,3).
but not demented (CIND), and group of elderly control subjects with normal cognitive
function" (5). Conquer and her associates determined that the "DHA levels of AD
patients are 17-18% lower than those of normal elderly individuals, suggesting that they
have lower dietary intake of the n-3 fatty acids" (5). Researchers discovered that low
fatty acid concentrations, which cause the cell membranes in the brain to destabilize, are
not a result of aging but are rather due to low intake (5). Conquer concluded that low
intake of DHA is a risk factor for the development of AD. Further support from resent
research indicated that intake of fatty fish is "inversely correlated with the development
of dementia, and in particular Alzheimer's disease, in Western countries" (5). Along with
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the cell membrane damage that accompanies AD, they suggested that oxidative damage
complementary roles in brain function and the function of nutrition in cognitive decline
was conducted by Fremantle (1). He began by informing the reader that a main function
of omega-3 fatty acids, which include DHA, is to supply energy to the brain (1). That
(PET) scans (1). In a study that researchers conducted on rats, when the rats received 80-
90% less DHA it resulted in lower brain DHA and a decrease in glucose uptake by 30-
40% (1). Impaired glucose uptake leads to brain energy starvation and cell death. Thus,
impaired glucose uptake is also a risk factor for AD (1). Finally, in this study, Freemantle
briefly mentions that elderly populations have difficulty converting ALA to DHA and are
An article compiled by Mazza, was an overview of the roles of fatty acids and
other antioxidants and their possible therapeutic value for neurological disorders. She
and her associates sighted several research studies that determined that "Omega-3 fatty
disorders"(3). Two separate studies, one done by McGahon in 1999 and one conducted
3 fatty acids" (3). Many other studies suggested that "High DHA consumption is
associated with reduced AD risk and that DHA could represent a possible prophylactic
mean for preventing the learning deficiencies of AD" (3). Further, a study by Barberger-
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Gateau, conducted in 2002, provided evidence to support taking fish oil supplements to
slow cognitive decline and decrease one's risk of developing dementia. (3).
DHA is beneficial for the maintenance of phospholipids in the human brain at all
stages of life, specifically the aging population (1,2,3,7). It is proven that there is a
strong link between low concentrations of DHA in the brain and the onset of AD
(1,2,3,5,7). While it is not a cure for AD, DHA has been proven effective in increasing
brain fluidity and supporting the transportation of nutrients to neural cells (3,5,7).
Many studies, even outside the ones sighted, document the importance of DHA
for the mental health of aging populations. Some studies have been unable to provide a
positive a correlation between DHA and AD brains, but the positive reports far outweigh
reports with less conclusive findings. "The health benefits of DHA involve learning and
memory, in the protection, regeneration and repair of neurons, in reducing the effects of
neuronal injury" (7). The benefits of DHA support healthy aging and can be integrated
into one's lifestyle by increasing the amount of fatty fish and DHA enriched foods one
fatty acids to improve cognitive fluidity and function should also take antioxidants like
"Vitamins E, A, and C, flavonoids, plyhenol, carotenoids, lipoic acid and co-enzyme Q,"
to avoid over consumption of DHA and for basic neurological health (3).