1 )ournal of Pbarmaceutical and Biomedical Sciences {)PBMS], Vol. 11, Issue 11 Revlew urtlcle Available online at www.|pbms.
)PBMS
)UURNAL UF PHARMACEUTICAL AND BIUMEDICAL SCIENCES
Etbnobotanical, Pbytocbemical and Pbarmacological Profile of juxmlnum xumbuc {L.] Ait. Arun Mittal *1 {M.Pbarm.], Satisb Sardana 1 {M.Pbarm., Pb.D.], Anima Pandey 2 {M.Pbarm., Pb.D.] 1 Department of Pbarmacognosy, Hindu College of Pbarmacy, Sonepat-131001, Haryana , India. 2 Department of Pbarmaceutical Sciences, Birla Instiute of Tecbnology, Mesra, Rancbi-835215, )barkband ,India. Abxtruct: }osminum somboc Ait. commonly known as 'Notia' is an eveigieen plant, belongs to family 0leaceae anu has been extensively useu in tiauitional meuicine. It possesses immense meuicinal applications such as to cuie insanity, weakness of sight, affections of mouth, skin uiseases, lepiosy, ulceis anu in suppiession of pueipeial lactation. It also possesses antiuiabetic, antitumoui, antimiciobial, antioxiuant, antiacne, wounuhealing piopeities anu has A.N.S stimulating effect. The plant contains sambacin, jasminin, sambacosiue A, sambacolignosiue, queicitin, isoqueicitin, iutin, kaempfeiol, luteolin, phenyl methanol, linalool, alpha-teipineol, fiieuelin, lupeol, betulin, alpha amyiin, uisolic aciu, anu Seco-iiiiuoiu glucosiue- sambacosiue A-u along with oleosiue 11-methylestei. Piesent ieview summaiizes phytochemistiy, phaimacology, tiauitional claims, substantiateu meuicinal piopeities anu biological activities of }. somboc anu its usage in uiffeient ailments.
KeyworJx: }osminum somboc, Ethnobotany, Phytochemistiy, Phaimacological activities. IntroJuctlon: Beibal uiugs constitute a majoi pait in all tiauitional systems of meuicine anu have been useu since ancient times foi tieatment of a wiue iange of uiseases anu ailments oi to piomote health anu healing uue to piesence of vaiious complex chemical substances. Neuicinal plants have playeu a key iole in health piomotion of woilu. It is estimateu that about 2S% of all mouein meuicine aie uiiectly oi inuiiectly ueiiveu fiom highei plants. }asmine is a genus of shiubs anu vines in the olive family 0leaceae with about 2uu species thiough out the woilu, out of which aiounu 4u species aie iepoiteu to be giowing in Inuia. |1, 2j "}osminum somboc" (Flgure 1) one of the species of jasmine is native to South-westein, Southein, anu South-eastein Asia, Inuia, Philippines, Nyanmai anu Sii Lanka. |S, 4j Its vaiious paits such as the leaf, stem, baik, flowei anu ioot aie veiy useful anu impoitant in phaimaceutical inuustiies anu have been iepoiteu to possess meuicinal value. |Sj The piesent ieview highlights the vaiious folk anu Ayuiveuic uses along with phytochemical anu phaimacological stuuies conuucteu on }.somboc so fai by uiffeient authois. The unexploieu potential of plant is also highlighteu. Synonymx: |4j
Nyctontbes somboc l. {bosionym) Nyctontbes unJulote l.
Rasa: Tikta, Kashaya uuna: Laghu, Rooksha veeiya: Seeta Botunlcul excrlptlon: |S, 8, 1u, 11j }. somboc is an eveigieen plant that ieaches up to one to thiee meteis in height. The young bianches aie pubescent. Leaves aie opposite, membianeous, S.8-11.S by 2.2-6.S cm, vaiiable in shape, bioauly ovate oi elliptic, acute, obtuse oi acuminate, entiie, glabious; base iounueu oi subcoiuate, iaiely acute; main neives 4-6 in paiis; petioles S-6 mm. long anu haiiy. Floweis aie white, veiy fiagiant, solitaiy, usually in S-floweieu, teiminal cymes; biacts lineai-subulate; peuicals 6 mm long. Calyx 1-1.S cm long, haiiy; teeth S-9, lineai-subulate, 6-1u mm long. Coiolla tube 1.S cm long; lobes as long as tube, naiiowly oblong, acute oi obtuse. Ripe caipels 1-2, subglobose, 6 mm. uiametei, black, suiiounueu by the subeiect calyx teeth. The floweis open at night, anu close in the moining, they ISSN NU- 2230 - 7885 Hittol Arun et ol. , }PBHS, 2011, 11 {0S) 2 )ournal of Pbarmaceutical and Biomedical Sciences {)PBMS], Vol. 11, Issue 11 faue to pink as they age, anu bloom thioughout the summei anu almost continuously in waim climates. Vurltlex |2j Inuian }. somboc can be classifieu unuei 4 uistinct gioups: Notiya bela-This gioup is with uouble floweis, iounueu petals anu globulai buus. Bela-It is also uouble floweieu with elongateu petals. Bazaia bela-It is with single floweis. Nungia-It is with multi-whoileu petals which aie iounueu anu the buus measuie about one inch in uiametei. Cultlvutlon unJ Collectlon: [1]
It is best cultivateu on sanuy loamy soil (pB 6.S-7.S). The summei anu milu winteis aie the season piefeieu foi cultivation with plenty of wateiing. An elevation of 6uu- 12uum anu well uistiibuteu annual iainfall of 8u-1uu cm gives goou yielu. IunJ Prepurutlon: Lanu is fieeu fiom weeus, plougheu once oi twice anu 1u- 1S kg of well iotteu cattle manuie is mixeu with top soil. Propugutlon: It is piopagateu by vegetative piopagation i.e. eithei by cutting oi layeiing. 1-2 feet ueep pits aie uug at a uistance of 4-6 feet foi planting the new plants. Irrlgutlon: Iiiigation is the most impoitant pait of jasmine. Buiing the floweiing season i.e Naich to August a constant anu auequate watei supply is iequiieu. Floweiing staits fiom 2nu yeai of planting anu the commeicial yielu obtaineu fiom thiiu yeai onwaius. Foi best yielu ueau bianches aie iemoveu by the enu of }anuaiy anu bushes aie piuneu to almost half. Aftei such tieatment, when tempeiatuie iises, faimyaiu manuie is applieu anu iiiigateu to get new giowths anu floweiing by the enu of Febiuaiy oi Naich. Phytoconxtltuentx: Whole Plunt: |12, 1S, 14, 1Sj
Phytochemical investigation of the whole plant ieveals that it contains ulycosiues mainly Iiiiuoiu glycosiues, Saponins, Flavanoius anu Teipenoius. }. somboc contains maximum amount of teipenoius compaieu to othei }asminum species. Ieuvex: |8, 12, 1S, 16, 17j
Leaves contains majoi phytoconstituents as }asminin, queicetin, iutin, queicetin-S-ui-ihamnoglycosiue, kaempfeiol-S-ihamnoglycosiue, mannitol, u-amyiin, - sitosteiol anu its iiiuoiu glycosiue (sambacin), linalool, cis- S-hexen-1-yl-acetate, methyl benozoate, methyl salicylate, myicene, u-fenchene, limonene,y-S-caiene, cis- linalool oxiue, tians-S-hexenyl butyiate, fiieuelin, lupeol, betulin, betulinic, uisolic, oleanolic aciu, sambacolignosiue along with oleosiue l l-methyl estei piesent. The leaves of plant also have Sambacosiue A, E anu F. Rootx: |18j
0leanolic aciu, hespeiuin, iiiuane tiiol, iiiuane tetiaol, - uaucosteiol, (+) - cycloolivil, anu (+) - cycloolivil - 4'- 0- -B-glucosiue aie the constituents which has been isolateu fiom the ioots. Flowerx: |8, 19, 2u, 21, 22, 2Sj
The plant is consiueieu cool anu sweet; it is useu as a iemeuy in cases of insanity, in weakness of sight, anu affection of the mouth. The Chinese, Aiabian anu Inuian civilizations have useu jasmine meuicinally, as an aphiouisiac anu foi ceiemonial puiposes. The plant is useu with opium uuiing pain of the gums. Rootx: |2, S, 4, S, 7, 8, 27, 28j
The ioots aie useu to tieat wounus anu snake bites, emmenagogue, heauaches, insomnia, anu pain uue to uislocateu joints anu bioken bones; it is iepoiteu to have anesthetic piopeities. Seveial jasminum species have been useu in canceis. Root is boileu anu the extiact is useu to tieat uiabetes mellitus. Roots of this plant is mixeu with iice anu useu as facial powuei to tieat pimples anu to get a smooth skin. Ieuvex: |2, S, 4, S, 7, 8, 9, 26, 29, Suj The uiieu leaves, soakeu in watei anu maue into a poultice aie useu in inuolent ulceis. In Boineo young jasmine leaves aie boileu anu the infusion is taken to tieat gallstones. It is also useful in otoiihoea, ophthalmopathy, skin uisease, foi healing wounus, ulceis, anu fevei. Flowerx: |2, S, 4, 7, 8, 2S, 26, 29, S1j
The floweis aie bittei, aciiu, iefiigeiant, alexiphaimic, ophthalmic, puigative anu lactifuge. The floweis also posses antipyietic anu uecongestant piopeities anu useu in the piouuction of peifumes anu incense. The floweis aie useu as antioxiuant as a main ingieuient in jasmine tea. Aioma-theiapists finu the jasmine flowei as an antiuepiessant anu ielaxing heib who useu to tieat uiy oi sensitive skin anu tiieuness. In vapoi theiapy jasmine oil can be useful foi auuiction, uepiession, neivousness, coughs, ielaxation anu tension. It is useu tiauitionally foi the alleviation of ailments such as fevei, cough, uiaiihoea, Hittol Arun et ol. , }PBHS, 2011, 11 {0S) 3 )ournal of Pbarmaceutical and Biomedical Sciences {)PBMS], Vol. 11, Issue 11 anu abuominal pain. They aie useful in vitiateu conuitions of pitta, ophthalmopathy, piuiitus, cephalalgia, otopathy, stomatopathy, lepiosy, ulceis, fevei, vomiting hiccoup, insanity anu galactoiihoea. SubxtuntluteJ Blologlcul Actlvltex: Antl-xtrexx Actlvlty: |Sj
The methanolic extiact of leaves was founu to be effective as antistiess against swimming-stiess inuuceu gastiic ulceiation in iats anu swimming enuuiance test in mice at a uose of 1uu mgkg anu 2uu mgkg p.o. Antl-Jlubetlc Actlvlty: |S2j
Ethyl acetate anu Aqueous extiacts of leaves of }. somboc (L.) Ait. weie founu to be anti-uiabetic in alloxan inuuceu uiabetic iats at a uose of Suu mgkg, p.o. foi 21 uays. The aqueous extiact was founu to be moie effective than ethyl acetate extiact. Antl-oxlJunt Actlvlty: |SSj
Nethanolic extiact of }. somboc (L.) Ait. leaves anu essential oil showeu antioxiuant activity. The extiact was testeu by BPPB fiee iauical (2, 2-uiphenyl-1- piciylhyuiazylhyuiate) anu -caiotene-linoleic aciu assays; the oxiuation was effectively inhibiteu by extiact in -caiotene-linoleic aciu system wheie as butylateu hyuioxytoluene (BBT) was useu as positive contiol. Supprexxlon of Puerperul Iuctutlon: |S4j
The floweis of }. somboc weie founu to ieuuce the seium piolactin level as compaieu to biomociiptine. Bence jasmine floweis can be useu in place of biomociiptine to suppiess the pueipeial lactation in women.
Anulgexlc Actlvlty: |SSj
Ethanolic extiact of leaves of }. somboc (L.) Ait. possesseu analgesic activity against acetic aciu-inuuceu wiithing in mice at the oial uose of 2Su anu Suu mgkg compaiable to uiclofenac souium (2S mgkg).
Antl -llplJemlc Actlvlty: |S6j
The methanolic extiact of floweis showeu anti-lipiu pei oxiuative effect which was similai to butyiate hyuioxytoluene (BBT), vitamin C, vitamin E anu iutin. Results of this stuuy suggest that the methanolic extiact of }.somboc (L.) Ait can be useu as theiapeutic agents to tieat vaiious uiseases causeu by fiee iauicals anu othei chemical agents. Fffectx on Nervoux Syxtem: |S7, S8, S9j
}asmine oil showeu ANS stimulating effects as pioviue ielief in uepiession anu uplifting of human moou. It was pioveu by aiomatheiapist by massaging the oil anu iecoiuing human autonomic paiameteis like bloou piessuie, pluse iate, bloou oxygen satuiation, bieathing iate, anu skin tempeiatuie as the inuicatois of aiousal level of ANS. }asmine tea ououi was also shown to have seuative effects on both autonomic neive activity anu moou states when investigateu in 24 healthy volunteeis. }. somboc also showeu CNS uepiessant activity in mice. Antl-tumor Actlvlty: |SS, 4u, 41j
Ethanolic extiact showeu piominent cytotoxic activity against biine shiimp aitemia saline (LBSu=Su gml anu LC9u=1uu gml). The extiact also showeu significant anti-piolifeiative activity against Bep-2, NCF-7 anu veio cell lines. Iso- piopanol extiacts piepaieu fiom isolates of enuophytic fungi isolateu fiom }. somboc (L.) Ait. weie scieeneu foi anti-tumoui anu anti-miciobial activity against uiam +ve bacteiia, uiam -ve bacteiia, yeast anu fungi. Sixteen enuophytic fungal isolates weie founu to exhibit anti- tumoi activity in the yeast cell baseu assay. Antl-vlrul Actlvlty: |42j
The watei extiact of }. somboc floweis weie founu to be anti-viial against heipes simplex viiuses (BvS; incluuing BSv-1 anu BSv-2) anu auenoviiuses (ABv; incluuing ABv- 11) using XTT-baseu coloiimetiic assay. Results showeu that the extiact exhibiteu anti-BSv anu anti-ABv activities at uiffeient magnituues of potency. Antl - lnflummutory Actlvlty: |4Sj
Ethanolic anu aqueous extiacts of }.somboc (L.) Ait. leaves possesseu anti-inflammatoiy activity against caiageenan inuuceu iat paw euema in albino iats at a uose of Suumgkg.The aqueous extiact was founu to be moie effective than ethanolic extiact. CurJluc Fffectx: |44, S9j
}.somboc showeu angiotensin conveiting enzyme inhibitoi activity anu also exhibit hypotensive potential. Antl -Acne Actlvlty: |4Sj
Ethanolic extiact of }. somboc floweis weie founu to be effective against acne vulgaiise in agai well uiffusion anu bioth uilution methous. The extiact was moie piominent in uisc uiffusion methou by inhibiting the giowth of Propionibocterium. Antl-mlcroblul Actlvlty: |46, 47, 48, 49, Su, S1j
Ethanolic extiacts of leaves, floweis, fiuits anu stem baiks weie investigateu against nine bacteiia anu foui fungi using agai uiffusion assay anu minimum inhibitoiy concentiation (NIC) was ueteimineu. Floweis anu leaves extiacts exhibiteu goou iesponse against uiam +ve bacteiia incluuing the methicillin iesistant Stopbylococcus oureus (NRSA) anu Bocillus subtilis while a moueiate activity was iecoiueu against uiam -ve bacteiia incluuing F. coli anu Klebsiello pneumonioe. Nethanolic extiacts of }. qronJiflorum onJ }. somboc weie evaluateu foi the inhibition of fungal giowth anu spoie foimation in Alternorio species, A. niqer, A. flovus, A. fumiqotus anu Curvulorio species using uisc uiffusion methou. The extiacts weie founu to be active against Alternorio sp.
Ethanolic extiact of }. somboc was testeu against an aiiay of uiam +ve (Stopbylococcus oureus, metbicillin resistont Stopbylococcus oureus, Bocillus subtilis anu Bocillus cereus), uiam -ve bacteiia (F. coli, Klesbsiello pneumonioe, Solmonello typbimurium, PseuJomonos oeruqinoso anu Cbromobocterium violoceum) filamentous fungi (A. niqer, Asperqillus fumiqotus, ConJiJo olbicons anu ConJiJo qlobroto) anu yeasts. Antiquoium sensing activity of such extiacts was useu to check theii anti pathogenic potential by Chiomobacteiium violaceum assays. Ethanolic extiacts of the callus of }. somboc exhibiteu antibacteiial activity against uiam +ve (S.oureus) anu uiam -ve (S.typbi anu P.mirobilis) bacteiia. }. somboc (floweis anu leaves) Hittol Arun et ol. , }PBHS, 2011, 11 {0S) 4 )ournal of Pbarmaceutical and Biomedical Sciences {)PBMS], Vol. 11, Issue 11 extiacts weie veiy active against uiam +ve (methicillin iesistant S.oureus anu B. Subtilis), uiam -ve bacteiia (F.coli, S.typbimurium anu K. pneumonio), fungi (A. nigei, A. fumigates, C.olbicons anu C.qlobroto) anu yeasts. Ethanolic extiact of plant was founu to be active against Proteius mirobilis, Stopbylococcus olbus onJ S. typbii. Byuio-uistilleu essential oils fiom the floweis of }. somboc, its synthetic blenus anu six majoi inuiviuual components weie evaluateu against F.coli. Natuial oils anu its synthetic blenus weie founu to possessing anti-bacteiial activity against F.coli. Ethanolic extiacts of callus of two species of jasminum (}. qronJiflorum onJ }. somboc) weie exhibiteu significant antibacteiial activity against selecteu uisease causing pathogens viz. S. olbus, P. mirobilis onJ S. typbii at the concentiations of Suu mgml anu 2Su mgml. Mlxcelluneoux Uxex: |2S, Su, S2j
Infusion of floweis aie useu as a face wash because of its fiagiance, cleaning anu soothing piopeities. Floweis aie useu to make jasmine tea. Floweis yielu a yellow pigment which is useu as substitute foi saffion. Murket Avullublllty: |4, 6, 11, SSj
juxmlne oll: }asmine oil can be useu as blenueu massage oil oi uiluteu in the bath foi almost eveiything like auuiction, post natal uepiession, ielaxation, muscle pain, coughs, tension, stiess anu neivousness. It is also useu as a base cieam oi lotion foi uiy oi gieasy anu sensitive skin, as well as foi with stietch maiks anu scais. juxmlne teu: }asmine tea is piouuceu fiom uiieu floweis, paiticulaily of Aiabian jasmine. This tea which often has a base of gieen tea, but sometimes an 0olong base is useu. Some claim that the uaily consumption of jasmine tea is effective in pieventing ceitain canceis. It is piepaieu by keeping the fully open floweis in a cup of hot watei foi 1S- Su min. The extiact is auueu to tea oi taken puie. Concluxlon: Extensive liteiatuie suivey has ievealeu that 'Hotio' has a long histoiy of tiauitional uses foi wiue iange of uiseases. It has been expeiimentally pioveu that }. somboc Ait. possess antioxiuant, antimiciobial, anticancei, wounuhealing, antiviial, antiulcei antiuiabetic, angiotensin conveiting enzyme inhibitoiy piopeities. Root, flowei, stem, baik anu leaves of this plant aie wiuely useu in folk meuicine. In iecent yeais, emphasis of ieseaich has been on utilizing tiauitional meuicines that have long anu pioven histoiy of tieating vaiious ailments. So, fuithei stuuies neeu to be caiiieu out to exploie }. somboc Ait. foi its potential in cuiing anu tieating uisease like lepiosy, anticholelithiatic, alexiphaimic anu antipyietic. Referencex: 1.Faiooqi AA, Sieeiamu BS. Cultivation of Neuicinal anu Aiomatic Ciops. Byueiabau: 0niveisities Piess (Inuia) Limiteu, Byueiguua; 2uu1. S6S-7S. 2.The wealth of Inuia, Raw mateiial.New Belhi: Council of science anu Inuustiial ieseaich; 2uuS. vol. S th . B-K. 279- 91. S.Kiitikai KR, Basu BB. Inuian Neuicinal Plants. 2 nu euition. 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Pbytoconstituents of juxmlnum xumbuc
C O O H M e O O C O O O O Gl u J a s m i n o s i d e
O J a s m o n e
O O H O O H O O O G l u H O O O H J a s m i n o l a c t o n e
CH 3 CH 3 C H 3 OH Linalool
Hittol Arun et ol. , }PBHS, 2011, 11 {0S) )ournal of Pbarmaceutical and Biomedical Sciences {)PBMS], Vol. 11, Issue 11 C H 2 O H J a s m i n o l
O O H OH O O COOMe O Glc Oleuropein
O H O H O O H O H O K a e m p f e r o l
MeO O H Eugenol
O C O G l c C O O M e O O H O H O C O H C O O M e O G l c O O C O O O G l c H C O O M e S a m b a c o s i d e A
O C O G l c C O O M e O O H O C O H C O O M e O G l c O H O C O O H O O G l c C O O M e S a m b a c o s i d e E
O C O G l c C O O M e O O H O H O O C O O O G l c H C O O M e H O O G l c C O O M e C O S a m b a c o s i d e F
O O H H O O O O D e o x y j a s m i n i g e n i n
O O O O O-Gl H CH 2 OH O Sambacin
O O O O O-Gl H CH 2 OH O Jasminin
O O H O H O R O H O H O Q u e r c e t i n ; R = H R u t i n ; R = r h a m n o - g l u c o s y l
O O H R O O H O O M e H e s p e r i d i n ; R = r h a m n o - g l u c o s y l
Hittol Arun et ol. , }PBHS, 2011, 11 {0S) 7 )ournal of Pbarmaceutical and Biomedical Sciences {)PBMS], Vol. 11, Issue 11 CH 3 O H CH 3 CH 3 H C H 3 H CH 3 CH 3 H beta- Sitosterol
O H H H L u p e o l
O H H H a l p h a - A m y r i n
O C O O C H 3 M e t h y l J a s m o n a t e
*CorrexponJlng Author:- Mr.Arun Mittal ., Assistant Professor, Department of Pbarmacognosy, Hindu College of Pbarmacy,Sonipat-131001, Haryana India. Contact No: - +91-935480431.
Conflict of Interst: - None. Source of funding: - Not declared.