Centre for Cell Therapy and Regenerative Medicine

INAUGUARAL MEETING 20 TH JUNE 2012

 Network of researchers with common research interests Support collaborative research into the development of novel approaches to enhance tissue repair and regeneration

The University of Western Australia

Our Vision New ideas leading to new therapies Scientific Rationale

Interactions between cells and matrix are vital to normal tissue homeostasis. Understanding the molecular basis of this homeostasis is key to understanding stem cell behaviour and the origins of cancer and many chronic diseases
The University of Western Australia

Our Aim

To foster transformational research in the area of stem cell therapy and regenerative medicine and to develop novel therapies and achieve improved health outcomes for our patients.

Our Goals
Create a network of researchers with synergistic interests Facilitate research in state of the art laboratories Develop collaborative research PhD training programmes Attract research funding and investment Attract new research leaders to Western Australia Develop industry partnerships to expand translational research programmes and improve patient care
The University of Western Australia

Deputy Director George Yeoh

Director Geoffrey Laurent

Clinical Director Fiona Wood

The University of Western Australia

Our Research

Respiratory

Bioengineering

CCTRM m

The University of Western Australia

Lung Research
Prof Geoff Laurent Prof Irmgard Irminger A/Prof Yuben Moodley A/Prof Steven Mutsaers A/Prof Cecilia Prele Prof Stephen Stick Dr Anthony Kicic

Lung Fibrosis

Lung fibrosis Stems cells in serosal repair and tumorogenesis Stem cell therapy for lung hAEC, ES, iPS Epithelial repair mechanisms in Asthma, COPD
The University of Western Australia

Liver
Prof George Yeoh Prof John Olynyk Dr Nina Trintz-Parker Liver Progenitor Cells Cancer Stem Cells Hepatocellular Carcinoma

Neurotrauma
Prof Alan Harvey A/Prof Stuart Hodgetts Gene therapy nervous system repair Human stem cell transplantation spinal cord repair

Rat model of spinal cord regneration

Liver precursor cells

The University of Western Australia

Burns and Reconstructive Surgery

W/Prof Fiona Wood A/Prof Mark Fear Cell delivery Cell differentiation Matrix-Cell interactions Scaffolds and Nano-fibres Improving sensory function Animal models, in vitro models scar in a jar

*** Project looking at the epigenetics of the fibroblasts within fibrosis similarities/differences related to tissue of origin ***
The University of Western Australia

Eye Retinal Repair A/Prof Fred Chen Macular degeneration Identifying new sources of retinal pigment epithelial cells (RPE) Developed new approaches to reprogramme cornea limbus cells to become RPE cells

Retina of AMD Patient

Retina of AMD Patient after RPE patch transplantation

The University of Western Australia

Musculoskeletal
Prof Miranda Grounds A/Prof Tea Shavlakadze Skeletal muscle repair myogenesis in post-natal skeletal muscle Role of extracellular matrix Myoblast transfer Stem cell therapies Sarcopenia (age-related loss of muscle mass and function)

The University of Western Australia

Orthopeadic Research
Prof Minghao Zheng Autologous tenocyte therapy Matrix-induced autologous chondrocyte implantation Development of collagen scaffolds for tissue regeneration Molecular machinery of bone resorption for targeted therapy

osteoclast

The University of Western Australia

Ear Sciences
Prof Rodney Dilley Stem cells and scaffold to repair the tympanic membrane

Scaffolds for Tissue Repair

Prof Deirdre Coombe Glycosaminoglycans Developing scaffolds to sustain cell growth
NH2 HO HO O OH NH2 O HO O HO HO NH2 O HO NH2 OH OH O HO NH2 NH2 O OH NH2 O HO O

NH2 OH OH

NH2 HO HO O OH NH2 O HO O HO HO

NH2 O OH NH2 O HO O OH NH2 OH HO NH2

NH2 O

NH2 O OH OH

HO

Perforated ear drum

The University of Western Australia

Opportunities for Collaboration

Development of collaborative projects across groups Expand local, national and international collaborations Collaborative NHMRC, ARC and other nationally/internationally competitive grant applications PhD Top up scholarships to support collaborative research

The University of Western Australia

For anyone interested in working with/in/ or associated with the centre please contact; cecilia.prele@uwa.edu.au WAIMR, B Block, QEII Medical Centre, M519

The University of Western Australia