NWABO KAMDJE, Armel Hervé

CURRICULUM VITAE

Office Address: Private Address:

Department of Pathology University of Ngaoundere
University of Verona (Italy) P.O.Box 454 Ngaoundere
Ospedale Policlinico “G.B. Rossi Phone: +237 77463063
email: kamdjewa@yahoo.fr Cameroon
Phone: (office) (+39)-045-812-8418
Fax: (office) (+39)-045-802-7403
Web: http://www.stemcellreslab-
verona.it/it/

Biographical Data

Date of birth: September 9, 1977

Place of birth: Pete (Cameroon)
Citizenship: Cameroonian
Marital status: Married

Education

v Senior Lecturer/Assistant professor at the University of Ngaoundere – Cameroon,

Department of Biomedical Sciences (2014/01-Present).

v Post doctorate Fellow at the University of Ngaoundere – Cameroon, Department of

Biomedical Sciences (2012/07-2013/12).

v Post doctorate Fellow in Human Oncological Pathology and Stem Cells Biology and
Clinical Applications under the supervision of Pr Mauro Krampera (7th April 2011-
2012/06), University of Verona, Italy.

v Ph.D in Human Oncological Pathology and Stem Cells Biology and Clinical applications
under the supervision of Pr Mauro Krampera (2008-7th April 2011), University of Verona,
Italy.

v Doctoral fellow in Biochemistry (2004 to 2007). University of Yaounde I, Cameroon.

v ‘’ D.E.A.’’ (M.SC) (2002-2004) University of Yaounde I (Cameroon) Specialization:

Molecular Biology and Microbiology

v ‘’Maîtrise’’ (Postgraduate Diploma) (2000-2001) University of Yaounde I

Specialization: Food science and Nutrition

v ‘’Licence’’ (Bachelor’s Degree), (1996-1999) University of Yaounde I, Cameroon

Specialization: Biochemistry

Research Experiences and Relevant Graduate Coursework

1996-2001
Biochemistry

- Extraction, fractionation and purification of proteins using precipitation and various

chromatographic processes.

- Spectrophotometric quantification of nucleic acids, proteins and carbohydrates.

2002-2007
- First research work: Evaluation of activities of Superoxide dismutases (SOD) and
Glucose-6-phosphate dehydrogenase (G6PDH), enzymes whose low level indicates
oxidative stress. The studies were done using red blood cell extracts from 50 AIDS
patients. 32 “healthy individuals” were followed in the same way as negative controls.
- Second project (suspended due to the lack of infrastructure): Analysis of the effects of
some antiretroviral drugs on the liver function.

2008-7th April 2011

Research Interest
Coculture of the Acute Leukemia cells with the Bone Marrow- Derived Mesenchymal
Stromal Cells (BM-MSCs) as in vitro models to study some signaling pathways in both Acute
Leukemia cells and BM-MSCs
Our research has the following objectives:
v The First aim is the understanding of the physiological role of some signaling pathways in
normal and Acute leukemia cells survival.
v The long-term objective will be to use our understanding of normal and Acute leukemia
cells biology and of molecular mechanisms to develop strategies for the therapeutic
manipulation of some signaling pathways in the treatment of Acute Leukemia. To confirm
our results in vivo by knocking out the downstream Notch gene responsible of the
antiapoptotic effect observed in vitro.
Techniques used: protein-RNA-DNA analysis (ChIP), FASC, Western blot, ChIP sequence,
PCR and novel imaging mass spectrometry techniques

7th April 2011-2012/06

Research Interest
Coculture of the Chronic Leukemia cells with the Bone Marrow- Derived Mesenchymal
Stromal Cells (BM-MSCs) as in vitro models to study some signaling pathways in both
Chronic Leukemia cells and BM-MSCs
Our research has the following objectives:
v The First aim is the understanding of the physiological role of some signaling pathways in
normal and Chronic leukemia cells survival.
v The long-term objective will be to use our understanding of normal and Chronic leukemia
cells biology and of molecular mechanisms to develop strategies for the therapeutic
manipulation of some signaling pathways in the treatment of Acute Leukemia. To confirm
our results in vivo by knocking out the downstream Notch gene responsible of the
antiapoptotic effect observed in vitro.
Techniques used: protein-RNA-DNA analysis (ChIP), FASC, Western blot, ChIP sequence,
PCR and novel imaging mass spectrometry techniques.

Other Interests
1- Microbial-triggered inflammation: Role against pathogens, in tissue fibrosis, in
carcinogenesis and in neurodegenerative diseases.
2- Epigenetic regulation in normal hematopoiesis and in hematological malignancies
3- Signaling Pathways in neuroinflammation.

Relevant teaching and work experience

2001-2007/12: Graduate assistant (Tutor), Department of Biochemistry, University of

Yaounde I, Cameroon. The duties include practical and tutorial teachings to undergraduates.

Publications with peer review

1. Importance of epigenetic changes in cancer etiology, pathogenesis, clinical profiling,

and treatment: What can be learned from hematologic malignancies?
Vecchio L, Seke Etet PF, Kipanyula MJ, Krampera M, Nwabo Kamdje AH.

Biochim Biophys Acta. 2013 Apr 17. doi:pii: S0304-419X(13)00021-8.

10.1016/j.bbcan.2013.04.001.

2. Insulin resistance and cancer: the role of insulin and IGFs.

Djiogue S, Nwabo Kamdje AH, Vecchio L, Kipanyula MJ, Farahna M, Aldebasi Y, Seke
Etet PF.

Endocr Relat Cancer. 2013 Jan 7;20(1):R1-R17. doi: 10.1530/ERC-12-0324. Print 2013.

3. Signaling pathways bridging microbial-triggered inflammation and cancer.

Kipanyula MJ, Seke Etet PF, Vecchio L, Farahna M, Nukenine EN, Nwabo Kamdje AH.

Cell Signal. 2013 Feb;25(2):403-16. doi: 10.1016/j.cellsig.2012.10.014. Epub 2012 Oct 30.

4. Normal hematopoiesis and hematologic malignancies: role of canonical Wnt signaling

pathway and stromal microenvironment.
Seke Etet PF, Vecchio L, Bogne Kamga P, Nchiwan Nukenine E, Krampera M, Nwabo
Kamdje AH.

Biochim Biophys Acta. 2013 Jan;1835(1):1-10. doi: 10.1016/j.bbcan.2012.08.002. Epub 2012

Sep 5.

5. Role of stromal cell-mediated Notch signaling in CLL resistance to chemotherapy.

Nwabo Kamdje AH, Bassi G, Pacelli L, Malpeli G, Amati E, Nichele I, Pizzolo G, Krampera
M.

Blood Cancer J. 2012 May;2(5):e73. doi: 10.1038/bcj.2012.17. Epub 2012 May 25.
 6. Signaling pathways in chronic myeloid leukemia and leukemic stem cell maintenance:
key role of stromal microenvironment.
Seke Etet PF, Vecchio L, Nwabo Kamdje AH.

Cell Signal. 2012 Sep;24(9):1883-8. doi: 10.1016/j.cellsig.2012.05.015. Epub 2012 May 31.

7. Comparison of epithelial differentiation and immune regulatory properties of

mesenchymal stromal cells derived from human lung and bone marrow.
Ricciardi M, Malpeli G, Bifari F, Bassi G, Pacelli L, Nwabo Kamdje AH, Chilosi M,
Krampera M.

PLoS One. 2012;7(5):e35639. doi: 10.1371/journal.pone.0035639. Epub 2012 May 2.

8. Interactions between bone marrow stromal microenvironment and B-chronic

lymphocytic leukemia cells: any role for Notch, Wnt and Hh signaling pathways?
Seke Etet PF, Vecchio L, Nwabo Kamdje AH.

Cell Signal. 2012 Jul;24(7):1433-43. doi: 10.1016/j.cellsig.2012.03.008. Epub 2012 Mar 13.

9. Notch signaling in acute lymphoblastic leukemia: any role for stromal

microenvironment?
Nwabo Kamdje AH, Krampera M.

Blood. 2011 Dec 15;118(25):6506-14. doi: 10.1182/blood-2011-08-376061. Epub 2011 Oct 6.

10. Notch-3 and Notch-4 signaling rescue from apoptosis human B-ALL cells in contact
with human bone marrow-derived mesenchymal stromal cells.
Nwabo Kamdje AH, Mosna F, Bifari F, Lisi V, Bassi G, Malpeli G, Ricciardi M, Perbellini
O, Scupoli MT, Pizzolo G, Krampera M.
Blood. 2011 Jul 14;118(2):380-9. doi: 10.1182/blood-2010-12-326694. Epub 2011 May 20.

11. Paul Faustin Seke Etet, Armel Herve Nwabo Kamdje, Jeremie Mbo Amvene, Yousef
Aldebasi, Mohammed Farahna, Lorella Vecchio. Stromal control of chronic lymphocytic
leukemia cells. Research and Reports in Biology. 2013:4 23–32.

12. Maulilio John KIPANYULA, Wahabu Hamisi KIMARO, Faustin N. YEPNJIO,

Yousef H. ALDEBASI, Mohammed FARAHNA, Armel Herve NWABO KAMDJE,
Eltuhami M. ABDEL-MAGIED. Signaling pathways bridging fate determination of neural
crest cells to glial lineages in the developing peripheral nervous system. Cellular Signalling.
2013. (accepted).

Manuscripts submitted or in preparation

1. Bernardi S, Tononi P, Marin Vargas S, Bassi G, Perbellini O, Ambrosetti A,

Meneghini V, Scaffidi L, Ferrarini I, Bonalumi A, Martinelli G, Lacobucci I, Nwabo
 Kamdje AH, Russo D, Pizzolo G, Delledonne M, Krampera M. Genomic analysis
of Notch mutations in a case of Alagille syndrome with acute lymphoblastic
leukemia. Cancer Research Journal. 2013. (Submitted).

2. Bruno Phelix TELEFO; Sylvain Nguedia NJINA; Stéphanie Marie Chekem GOKA;
Didiane Mefokou YEMELE; Landry Lienou LIENOU; Gildas Tetaping MBEMYA;
Nathalie Jiatsa DONFACK, Paul Fewou MOUNDIPA; Armel Hervé NWABO
KAMDJE. In Vivo Anti-androgenic, anti-oestrogenic and antioxidant activities of the
aqueous extract of Eremomastax speciosa. 2013. (submitted).

Books Publications

v AH Nwabo Kamdje. Hematology-Oncology and Therapy. LAP LAMBERT Academic

Publishing GmbH & Co. KG. 2011, 14th March; p110; ISBN: 978-3-8443-2223-1.

v AH Nwabo Kamdje. Experimental biology and Molecular Pathology. LAP LAMBERT

Academic Publishing GmbH & Co. KG. 2011, 15th April; p120; ISBN: 978-3-8443-3430-
2.

v AH Nwabo Kamdje and G Lando. Effet du VIH sur les enzymes anti-oxydantes. Editions
Universitaires Europeennes. 2010, 30th December; p88; ISBN-13:978-613-1-55597.
ISBN-10: 6131555974.

v AH Nwabo Kamdje and G Lando. Nouvelles approches therapeutiques dans le traitement

du cancer. Editions Universitaires Europeennes. 2011, 7th January; p76; ISBN: 978-613-
1-56006-4.

v AH Nwabo Kamdje and L Kaptue. Nouvelles armes contre le cancer. Editions

Universitaires Europeennes. 2011, 7th March; p88; ISBN: 978-613-1-52937-5.

v AH Nwabo Kamdje. Notch signaling and stromal microenvironment in acute leukemia:

Role of Notch in acute leukemia. LAP LAMBERT Academic Publishing GmbH & Co. KG.
2011, 12nd October; p120; ISBN: 978-3846530627.

v AH Nwabo Kamdje. NOTCH signaling as a novel target for cancer: NOTCH signaling as
a novel target for cancer therapy. LAP LAMBERT Academic Publishing GmbH & Co. KG.
2011, 13th May; p127; ISBN: 978-3844395709.

Conference abstracts publications

v G Bassi, P Takam Kamga, A Nwabo Kamdje, R Stradoni, G Malpeli, E Amati, I

Nichele, R Carusone, Z Jasmina, G Pizzolo, M Krampera. Role of stromal cell-
mediated notch signaling in hematological malignancies. Cytotherapy 2014. 4: S79.

v Giulio Bassi, Paul Takam Kamga, Armel Nwabo Kamdje, Roberta Stradoni, Giorgio
Malpeli, Eliana Amati, Ilaria Nichele, Roberta Carusone, Jasmina Zanoncello,
Giovanni Pizzolo, and Mauro Krampera Role Of Stromal Cell-Mediated Notch
Signaling In Hematological Malignancies. Blood 2013 122:4939.
 v Giulio Bassi, Paul Takam Kamga, Armel Nwabo Kamdje, Roberta Stradoni, Giorgio
Malpeli, Eliana Amati, Ilaria Nichele, Roberta Carusone, Jasmina Zanoncello,
Giovanni Pizzolo, and Mauro Krampera Role Of Stromal Cell-Mediated Notch
Signaling In B-Cell Acute and Chronic Lymphoproliferative Diseases. 44° Congress
of the Italian Society of Hematology Verona, Italy, October 20–23, 2013
Haematologica October 2013 98: 1-280.

v Nwabo Kamdje AH, Bassi G, Pacelli L, Malpeli G, Amati E, Nichele I, Pizzolo G,

Krampera M. Role of stromal cell-mediated Notch signaling in CLL resistance to
chemotherapy. Haematologica the hematology journal, Roma, 17th-19th october
2012. Italian Society of the Experimental Hematology (SIES).

v Nwabo Kamdje AH, Bassi G, Pacelli L, Malpeli G, Amati E, Nichele I, Pizzolo G,

Krampera M. ROLE OF STROMAL CELL-MEDIATED NOTCH SIGNALING IN
CHRONIC LYMPHOCYTIC LEUKEMIA SURVIVAL AND RESISTANCE TO
CHEMOTHERAPY. XII Congress of the Italian Society of Experimental
Hematology Haematologica October 2012 97: S1-S136.

v AH Nwabo Kamdje, F Mosna, F Bifari, V Lisi, M Mimiola, O Perbellini, G Pizzolo,

M Krampera. Notch-3 and Notch-4 signaling promotes the resistance to steroids of
Human B-ALL Cells in presence of Mesenchymal Stromal Cells. 43° Congress of the
Italian Society of Hematology, Napoli, Italy, October 16–19, 2011. Haematologica
October 2011 96: 1-287.

v AH Nwabo Kamdje, F Mosna, F Bifari, V Lisi, M Mimiola, O Perbellini, G Pizzolo,

M Krampera. Jagged-1, Jagged-2 and DLL-1 are the elements of Notch signaling
mainly responsabile for the antiapoptotic effect on B-lineage Acute Lymphoblastic
Leukemia exerted by Bone Marrow Mesenchymal Stem Cells. Haematologica the
hematology journal, Torino, 8th october 2010; 95(s3), abs. C079. Italian Society of
the Experimental Hematology (SIES).

v AH Nwabo Kamdje, F Mosna, F Bifari, V Lisi, M Mimiola, O Perbellini, G Pizzolo,

M Krampera. Notch-3 and Notch-4 signaling rescue from apoptosis human B-lineage
acute lymphoblastic leukemia cells in contact with human bone marrow-derived
mesenchymal stromal cells. abs. 20; MSC, Toulouse 20th November 2010 book p.
65; www.stemcellreslab-verona.it/.../1st-European-Conference-on-MSC-Toulouse-
2010.pdf.

v AH Nwabo Kamdje, F Mosna, F Bifari, V Lisi, M Mimiola, O Perbellini, G Pizzolo,

M Krampera. Human Bone Marrow Mesenchymal Stem Cells protect B-cell Acute
Lymphoblastic Leukemia cells from apoptosis in vitro by upregulating Notch-3 and
Notch-4 on both cell types. Haematologica the hematology journal, Barcelona 13th
June 2010; 95[suppl.2]:3, abs. 0006. European Hematology Association (EHA).

Selected oral presentations

Ø Nwabo Kamdje AH, Bassi G, Pacelli L, Malpeli G, Amati E, Nichele I, Pizzolo G,
Krampera M. Role of stromal cell-mediated Notch signaling in CLL resistance to
chemotherapy. Haematologica the hematology journal, Roma, 17th-19th october 2012. Italian
Society of the Experimental Hematology (SIES).

Ø AH Nwabo Kamdje, F Mosna, F Bifari, V Lisi, M Mimiola, O Perbellini, G Pizzolo, M

Krampera. Jagged-1, Jagged-2 and DLL-1 are the elements of Notch signaling mainly
responsabile for the antiapoptotic effect on B-lineage Acute Lymphoblastic Leukemia exerted by
Bone Marrow Mesenchymal Stem Cells. Haematologica the hematology journal, Torino, 8th
october 2010; 95(s3), abs. C079. Italian Society of the Experimental Hematology (SIES).
Ø AH Nwabo Kamdje, F Mosna, F Bifari, V Lisi, M Mimiola, O Perbellini, G Pizzolo, M
Krampera. Notch-3 and Notch-4 signaling rescue from apoptosis human B-lineage acute
lymphoblastic leukemia cells in contact with human bone marrow-derived mesenchymal stromal
cells. abs. 20; MSC, Toulouse 20th November 2010 book p. 65; www.stemcellreslab-
verona.it/.../1st-European-Conference-on-MSC-Toulouse-2010.pdf.
Ø AH Nwabo Kamdje, F Mosna, F Bifari, V Lisi, M Mimiola, O Perbellini, G Pizzolo, M
Krampera. Role of Notch and Wnt signaling pathway in the interaction between Leukemia Stem
Cells and Bone Marrow Mesenchymal Stromal Cells. Verona, 10th March 2010, Annual Report
concerning the Ph.D day, University of Verona.

Selected poster presentation

v Nwabo Kamdje AH, Bassi G, Pacelli L, Malpeli G, Amati E, Nichele I, Pizzolo G,

Krampera M. Role of stromal cell-mediated Notch signaling in CLL resistance to
chemotherapy. Haematologica the hematology journal, Roma, 17th-19th october 2012.
Italian Society of the Experimental Hematology (SIES).

v AH Nwabo Kamdje, F Mosna, F Bifari, V Lisi, M Mimiola, O Perbellini, G Pizzolo, M

Krampera. Human Bone Marrow Mesenchymal Stem Cells protect B-cell Acute
Lymphoblastic Leukemia cells from apoptosis in vitro by upregulating Notch-3 and
Notch-4 on both cell types. Haematologica the hematology journal, Barcelona 13th June
2010; 95[suppl.2]:3, abs. 0006. European Hematology Association (EHA).

v AH Nwabo Kamdje, F Mosna, F Bifari, V Lisi, M Mimiola, O Perbellini, G Pizzolo, M

Krampera. Role of Notch and Wnt signaling pathway in the interaction between Leukemia
Stem Cells and Bone Marrow Mesenchymal Stromal Cells. Verona, 6th February 2009,
Annual Report concerning the Ph.D day, University of Verona.

Invited oral presentation and session chair/moderator

1- 1st Annual International Symposium of Hematology (AISH) -2012, China

2- XII National Congress. Italian Society of Experimental Hematology (SIES) Roma,
2012/10/17-19
3- 5th Annual Congress of Regenerative Medicine and Stem Cell 2012 (December 2-4,
2012, Guangzhou , China ).
4- Cell Therapy-2012 Oct 1-3 Chicago USA
Awards & achievements
Jul 2012
Award: Prize of the best selected abstract for the 12 nd National Congress. Italian Society of
Experimental Hematology (SIES) Roma, 2012/10/17-19
Nov 2010
Grant: European MSC Prize of the best selected abstract for the 1st European Conference on
Mesenchymal Stem Cells TOULOUSE, November 18-20 http://www.stemcellreslab-
verona.it/workspace/file-news/1st-European-Conference-on-MSC-Toulouse-2010.pd.
Jun 2010
Scholarship: Travel grant winners for the 15th Congress of the European Hematology
Association (EHA) Barcelona, June 11, 2010 http://eha.eurocongres.com/15th/travel-
grant.asp.

Scientific Memberships
1- European Hematology Association (EHA)
2- Italian Society of Experimental Hematology (SIES)
4-American Society of Hematology (ASH)

Journal Referees
1-Hematologica,
2-Tissue and Cell,
3- Recent Patents on Anti-Cancer Drug Discovery,
4-Molecular Biology Reports (MOLE)
5- BMC Microbiology Journal

Editorial Board
1-Editor of the journal of blood and lymph
2-International Blood Research and Reviews

Working languages
English, French and Italian

Referees

v Pr. Dr. Mauro Krampera, Department of Clinical and Experimental Medicine Section of
Haematology, University of Verona, Ospedale Policlinico “G.B. Rossi” Verona (Italy).
Tel:(+39)-045-8124173 e-mail: mauro.krampera@univr.it.
v Dr. Maria Teresa Scupoli, Department of Clinical and Experimental Medicine Section of
Haematology, University of Verona, Ospedale Policlinico “G.B.Rossi” Verona
(Italy).Tel:(+39)-0458128418 e-mail: mariateresa.scupoli@univr.it.
v Jacob Souopgui, Ph. D, Chair in Developmental Biology, Laboratory of Developmental
Genetics, DBM-IBMM, Université Libre de Bruxelles, Rue des Professeurs Jeener et
Brachet, 12, 6041 Gosselies, BELGIUM, Tel.: +32 2 650 9936/Fax: +32 2 650 9900
Email: Jacob.Souopgui@ulb.ac.be, website: http://www.souopguijacob.com

v Elias Nchiwan Nukenine, PhD, Associate Professor of Entomology, Vice-Dean i/c

Admissions, Records and Students' Affairs, Faculty of Science, University of Ngaoundere,
PO Box 454 Ngaoundere, Cameroon, E-mail: elinchiwan@yahoo.fr, E-mail:
ennukenine@fulbrightmail.org
Tel +237-77 25 14 28 / -79 59 86 55/ -22 25 40 60 / -22 65 55 66 / -90 15 78 98

Relevant computer experience

Practical experience with word, Excel, windows.

Update January 2014

Comments to kamdjewa@yahoo.fr