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APAKAH HASIL PENELITIAN TERSEBUT VALID? A. Petunjuk Primer 1.

Apakah terdapat sampel yang representatif, terdefinisi jelas, dan berada pada kondisi yang sama dalam perjalanan penyakitnya? The criteria for surgical resection of HCC patients in this study were (1) patients with tumor invasion in single lobe or tumors in both lobes involving no more than 3 Healeys segments, (2) Child-Turcotte-Pugh (CTP) class A or B with \25% retention of indocyanine green 15 min after injection, and (3) no main portal vein trunk involvement or distant metastasis.
Variables associated with therapeutic strategy and longterm prognosis were comprehensively selected into the propensity score model involving 146 matched pairs of patients from each treatment arm (Table 3). There were no significant baseline differences in age, sex, etiology of liver disease, tumor-related parameters, severity of cirrhosis, performance status, vascular invasion, and cancer staging systems between the 2 patient groups. A matched study population was constructed to compare the long-term prognosis between these 2 groups.

2. Apakah follow-up cukup lama dan lengkap? Comparison of long-term survival between the 2 groups in the propensity model is shown in Fig. 3. Patients undergoing SR had significantly better long-term survival than patients receiving TACE (P\.001). During a mean follow-up period of 20 17 months, 44 (30%) and 68 (47%) patients undergoing SR and TACE, respectively, died. The 1-, 3-, and 5-year survival rates of HCC patients receiving SR and TACE were 82% vs 65%, 68% vs 29%, and 46% vs 22%, respectively. In the univariate survival analysis, patients receiving TACE had significantly poorer prognosis than patients receiving SR (HR: 2.44, 95% CI: 1.653.59; P\.001). In the multivariate Cox model, age C65 years (HR: 2.13, 95% CI: 1.443.17; P\.001), TACE (HR: 2.56, 95% CI: 1.733.78; P\.001), tumor size C7 cm (HR: 1.62, 95% CI: 1.082.42; P = .019) and vascular invasion (HR: 2.13, 95% CI: 1.443.17; P\.001) were identified as independent predictors of poor prognosis

APA HASILNYA? 1. Bagaimana gambaran outcome menurut waktu? APAKAH HASIL PENELITIAN INI DAPAT DIAPLIKASIKAN? 1. Apakah pasien dalam penelitian tersebut serupa dengan pasien saya? YA

2. Apakah hasil tersebut membantu memilih atau menghindari terapi tertentu? YA Dalam jurnal penelitian ini surgical resection merupakan terapi yang dipilih untuk pasien karsinoma hepatoseluler stadium intermediate

3. Apakah hasilnya membantu dalam memberikan konseling kepada pasien saya? YA Dalam jurnal penelitian ini disebutkan bahwa hasil prognosis dilakukan surgical resection bagi pasien karsinoma hepatoseluler stadium intermediate lebih baik dibanding dengan TACE.