and Procedures:
Central Venous Lines Peripheral Venous Lines Medication Management Pain Management: Adult and Pediatric Pyxis Medication System Controlled Medication Management Epidural and Intrathecal Infusion Analgesia Equipment Failure and Safety Hazard Reporting
Approved by:
Professional Practice Policy and Procedure Committee Effective: 6/99 Revised: 1/11
Description: This policy and procedure describes the process for patients to receive safe and
effective administration of parenteral opioid analgesics with a patient controlled analgesia (PCA) infusion device. The goals are: 1. To provide procedures for initiating, checking, and verifying PCA orders. 2. To provide procedures for PCA opioid use, dosage, and safe practice. 3. To standardize monitoring parameters. 4. To standardize documentation.
Accountability:
1. A physician or allied health provider must order PCA infusions. Initial orders must be written on a pre-printed order form that includes standard concentrations, dose settings and monitoring parameters. Subsequent PCA orders may be written on a standard physician order form. 2. Opioids or sedatives ordered in addition to a PCA should be authorized by the physician service that wrote the PCA orders before they are administered. This is required to prevent excessive sedation from other systemic controlled substances or sedatives. 3. New PCA orders will be written when a patient is transferred to another nursing unit (e.g., transfer in/out of ICU). PCA orders will be rewritten or renewed every 14 days. 4. All health care professionals (physicians, nurses, pharmacists) are accountable for verifying and checking PCA orders for accuracy. Physicians and nurses are accountable for checking the intravenous (IV) site for patency prior to starting an infusion and may initiate PCA pumps only if appropriately instructed. PACU nurses are accountable for initiating PCA infusions for postoperative patients prior to sending the patient to another nursing unit. 5. Pharmacists are accountable for supplying opioids for PCA in pre-mixed syringes/bags. Any drug wastage from the PCA pump must be witnessed and appropriately independently documented by two nurses, physicians and/or pharmacists as per the UCH Controlled Medication Management policy.
c158411
Page 1 of 8
Table of Contents:
1. 2. 3. 4. 5. 6. 7. Verification of Orders PCA Opioid Use, Dosage, and Safe Practice Initiation of PCA Therapy Monitoring Documentation Education References
E. PCA by Proxy is not allowed. Unauthorized administration of a PCA dose by anyone other than the patient, i.e., family members, caregivers, clinicians, can lead to over sedation, respiratory depression, and even death. If a patient is unable to self-administer their PCA dose, notify the physician service managing the PCA. Consideration should be given to discontinuing PCA therapy and utilizing alternate therapy such as IV push. Under no circumstances should anyone else push the PCA button for the patient. If the patient asks a health care provider to push their PCA button for them (e.g., patient cannot reach button), the provider should provide the button to the patient to administer their own dose. F. Initial PCA dosages for acute/postoperative pain in opioid nave adults: Opioid (Concentration) Morphine (1 mg/ml) Hydromorphone (0.2 mg/ml) Fentanyl (10 mcg/ml) Initial Loading 2 mg 0.4 mg 25 mcg Initial Basal Not Recommended Initial Incremental 1-2 mg 0.2-0.4 mg 10-25 mcg Initial Lockout 8 min. 8 min. 8 min.
c158411
Page 3 of 8
H. The ratio of continuous (basal) dose to incremental (PCA) dose should remain approximately 1:2. I. Optimal opioid analgesic dose varies widely even among opioid-nave patients: adjust dosing based on patient response. J. For pediatric patients, the decision to use PCA will be based on their individual needs and abilities. Pediatric dosage will be by weight until 12 years of age/or 50 kg. The physician service managing the PCA must obtain consent from parent/legal guardian for pediatric patients under eighteen (18) years. Any special assessment, monitoring, or dose titration parameters should be established by the physician service managing the PCA when the infusion is ordered. K. Usual range of PCA dosages for acute/postoperative pain in pediatric patients: Opioid (Concentration) Morphine (1 mg/ml) Hydromorphone (0.2 mg/ml) Fentanyl (10 mcg/ml) Usual Loading Range 30 mcg/kg 5 mcg/kg 1 mcg/kg Usual Basal Range 0-30 mcg/kg/hr 0-5 mcg/kg/hr 0-1 mcg/kg/hr Usual Incremental Range 10-30 mcg/kg 3-5 mcg/kg 0.2-1 mcg/kg Usual Lockout 8-10 min. 8-10 min. 6-10 min.
Note: No limitation in dosing is implied by the above tables. L. PCA dosage ranges in the opioid-tolerant patient can be much higher than those listed in the above tables. The Acute Pain Service (APS) 303-266-6493 may be consulted to determine appropriate PCA dosages in this population. M. Nurses may adjust pump settings within ranges and give bolus doses as ordered. N. Two RNs must independently verify drug, volume, concentration, and rate including all pump settings against the orders when: 1. Initiating the PCA infusion 2. Accepting patient from another floor 3. Changing shift (with off-going RN to oncoming RN) 4. Changing any settings or changing drug O. Meperidine (Demerol) is not available for PCA due to accumulation of an active metabolite, normeperidine, which can cause seizures and tremors. P. Morphine should be used with caution in patients with renal insufficiency due to its more potent active metabolite, morphine-6-glucuronide (M6G). M6G has decreased clearance
c158411 Page 4 of 8
Q.
R. S. T.
3. Initiation of PCA Therapy A. Infusion medication and labeling 1. Manufacturer pre-mixed morphine syringes (30 ml, 1 mg/ml) and UH pharmacy prepared hydromorphone bags (50 ml, 0.2 mg/ml) and fentanyl bags (100 ml, 10 mcg/ml) are stocked in the Pyxis machine. 2. Higher concentrations of all PCA opioids are available on an as ordered basis. 3. Verify compatibility of other drugs being administered before connecting the PCA line. 4. PCA tubing must be connected into a continuously running maintenance IV. B. PCA Initiation: 1. Verify physician order 2. Ensure patient meets criteria for use of PCA 3. Gather equipment: a. PCA pump with lock box and key b. Two replacement batteries c. PCA tubing with Y connector d. PCA extension tubing e. Syringe/bag with ordered medication 4. Wash hands.
c158411 Page 5 of 8
B. Increasing somnolence can be a key indicator of pending opioid induced respiratory depression. C. Assess the patients pain intensity at least every 4 hours and within 1 hour after bolus doses or rate/medication changes. D. Assess the patient for the following side effects and treat as needed: 1. Nausea and/or vomiting 2. Pruritus 3. Urinary retention 4. Constipation
c158411 Page 6 of 8
c158411
Page 8 of 8