Delta-cadinene synthase

Delta-cadinene synthase
(+)-delta-cadinene synthase
Identifiers EC number CAS number 4.2.3.13 [1] [2]

166800-09-5

Databases IntEnz BRENDA ExPASy KEGG MetaCyc PRIAM PDB structures Gene Ontology IntEnz view [3] [4] [5]

BRENDA entry NiceZyme view KEGG entry [6]

metabolic pathway profile [8] [9]

[7]

RCSB PDB AmiGO

PDBe

[10]

PDBsum

[11]

[12]

/ EGO

[13]

Search PMC articles [14]

PubMed articles [15] NCBI proteins [16]

In enzymology, a (+)-delta-cadinene synthase (EC 4.2.3.13 [17]) is an enzyme that catalyzes the chemical reaction 2-trans,6-trans-farnesyl diphosphate (+)-delta-cadinene + diphosphate

Hence, this enzyme has one substrate, 2-trans,6-trans-farnesyl diphosphate, and two products, (+)-delta-cadinene and diphosphate. This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-delta-cadinene-forming). This enzyme participates in terpenoid biosynthesis. It employs one cofactor, magnesium. Delta-cadinene synthase, a sesquiterpene cyclase[18], is an enzyme expressed in plants that catalyzes a cyclization reaction in terpenoid biosynthesis. The enzyme cyclizes farnesyl diphosphate to delta-cadinene and releases pyrophosphate. Delta-cadinene synthase is one of the key steps in the synthesis of gossypol, a toxic terpenoid produced in cotton seeds. Recently, cotton plants that stably underexpress the enzyme in seeds have been developed using RNA interference techniques, producing a plant that had been proposed as a rich source of dietary protein for developing countries.[19]

Delta-cadinene synthase

External links
BRENDA entry [20] SwissProt entry [21]

References
[1] [2] [3] [4] [5] [6] [7] [8] [9] http:/ / www. chem. qmul. ac. uk/ iubmb/ enzyme/ EC4/ 2/ 3/ 13. html http:/ / tools. wmflabs. org/ magnustools/ cas. php?language=en& cas=166800-09-5& title= http:/ / www. ebi. ac. uk/ intenz/ query?cmd=SearchEC& ec=4. 2. 3. 13 http:/ / www. brenda-enzymes. org/ php/ result_flat. php4?ecno=4. 2. 3. 13 http:/ / www. expasy. org/ enzyme/ 4. 2. 3. 13 http:/ / www. genome. ad. jp/ dbget-bin/ www_bget?enzyme+ 4. 2. 3. 13 http:/ / biocyc. org/ META/ substring-search?type=NIL& object=4. 2. 3. 13 http:/ / priam. prabi. fr/ cgi-bin/ PRIAM_profiles_CurrentRelease. pl?EC=4. 2. 3. 13 http:/ / www. rcsb. org/ pdb/ search/ smartSubquery. do?smartSearchSubtype=EnzymeClassificationQuery& Enzyme_Classification=4. 2. 3. 13 [10] http:/ / www. ebi. ac. uk/ pdbe-srv/ PDBeXplore/ enzyme/ ?ec=4. 2. 3. 13 [11] http:/ / www. ebi. ac. uk/ thornton-srv/ databases/ cgi-bin/ enzymes/ GetPage. pl?ec_number=4. 2. 3. 13 [12] http:/ / amigo. geneontology. org/ cgi-bin/ amigo/ go. cgi?query=GO:0047461& view=details [13] http:/ / www. ebi. ac. uk/ ego/ DisplayGoTerm?id=GO:0047461& format=normal [14] http:/ / www. ncbi. nlm. nih. gov/ entrez/ query. fcgi?db=pubmed& term=4. 2. 3. 13%5BEC/ RN%20Number%5D%20AND%20pubmed%20pmc%20local%5Bsb%5D [15] http:/ / www. ncbi. nlm. nih. gov/ entrez/ query. fcgi?db=pubmed& term=4. 2. 3. 13%5BEC/ RN%20Number%5D [16] http:/ / www. ncbi. nlm. nih. gov/ protein?term=4. 2. 3. 13%5BEC/ RN%20Number%5D [17] http:/ / enzyme. expasy. org/ EC/ 4. 2. 3. 13 [18] http:/ / toolserver. org/ %7Edispenser/ cgi-bin/ dab_solver. py?page=Delta-cadinene_synthase& editintro=Template:Disambiguation_needed/ editintro& client=Template:Dn [19] Sunilkumar G, Campbell L, Puckhaber L, Stipanovic R, Rathore K (2006). "Engineering cottonseed for use in human nutrition by tissue-specific reduction of toxic gossypol". Proc Natl Acad Sci U S A 103 (48): 18054-9. PMID 17110445 [20] http:/ / www. brenda. uni-koeln. de/ php/ result_flat. php4?ecno=4. 2. 3. 13 [21] http:/ / expasy. org/ uniprot/ P93665

Chen XY, Chen Y, Heinstein P, Davisson VJ (1995). "Cloning, expression, and characterization of (+)-delta-cadinene synthase: a catalyst for cotton phytoalexin biosynthesis". Arch. Biochem. Biophys. 324 (2): 25566. doi: 10.1006/abbi.1995.0038 (http://dx.doi.org/10.1006/abbi.1995.0038). PMID 8554317 (http:// www.ncbi.nlm.nih.gov/pubmed/8554317). Davis EM, Tsuji J, Davis GD, Pierce ML, Essenberg M (1996). "Purification of (+)-delta-cadinene synthase, a sesquiterpene cyclase from bacteria-inoculated cotton foliar tissue". Phytochemistry. 41 (4): 104755. doi: 10.1016/0031-9422(95)00771-7 (http://dx.doi.org/10.1016/0031-9422(95)00771-7). PMID 8728715 (http:// www.ncbi.nlm.nih.gov/pubmed/8728715). Davis GD, Essenberg M (1995). "(+)-delta-Cadinene is a product of sesquiterpene cyclase activity in cotton". Phytochemistry 39 (3): 553567. doi: 10.1016/0031-9422(95)00067-H (http://dx.doi.org/10.1016/ 0031-9422(95)00067-H).

Article Sources and Contributors

Article Sources and Contributors

Delta-cadinene synthase Source: http://en.wikipedia.org/w/index.php?oldid=566821115 Contributors: Amkilpatrick, Cesium 133, Edgar181, Opabinia regalis, Rjwilmsi, Sophie means wisdom

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