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List of publications: GRDINARU DANIELA

Publications relevant for professional achievements obtained after
conferring the title of doctor in sciences

IF = Impact factor (2012); IS = Influence score of journals indexed in ISI Thomson Reuters
(2012); Number of citations in Web of Science 159. HIRSCH INDEX 7.
PhD Thesis
Grdinaru Daniela, 1998.Research regarding the expression and regulation of
glucuronidation enzymes in the cerebral ageing. University of Bucharest. Scientific
coordinator: Prof. Dr. Dana Iordchescu.

Books chapters printed by international publishing houses
1. Dinischiotu A, Stanca L, Grdinaru D, Petrache SN, Radu M, erban AI - Lipid
peroxidation due to in vitro and in vivo exposure of biological samples to nanoparticles
Oxidative Stress and Nanotechnology - Methods and Protocols, Series: Methods in Molecular
Biology, Vol. 1028, Armstrong Donald; Bharali Dhruba J (Eds.) Springer Protocols, Humana
Press, 2013;1028:155-64. (www.springer.com/chemistry/biotechnology/book/978-1-62703-
474-6).
2. Bora C., Ionescu C., Grdinaru D* - Oxidized LDL and NO synthesis as biomarkers of
atherogenesis. Correlations with metabolic profile in elderly. In: Parthasarathy S, editor.
Atherogenesis. InTech Open Access Publisher; 2012, 473-494. Available at:
http://www.intechopen.com/books/atherogenesis/oxidized-ldl-and-no-synthesis-as-
biomarkers-of-atherogenesis-correlations-with-metabolic-profile-in-
* Corresponding author

3. Minn A., El-Bacha R.S., Bayol- Denizot C., Lagrange P., Suleman F.G., Grdinaru D. -
Drug metabolism in the brain: benefits and risks, Blood- Brain and Drug Delivery on the CNS
Begley D., Bradbury M.W. and Kreuter J., Eds., Marcel Dekker, New York, 2000, 145-170.

4. Minn A., Grdinaru D., Chat M., Bayol-Denizot C., Lagrange P. - Drug metabolizing
enzyme activities in an in vitro model of rat blood-brain barrier, Drug Transport Across the
Blood-Brain Barrier: In Vitro and In Vivo Techniques, A.G. de Boer & W. Sutanto, Eds.,
Harwood Academic Publishers, Amsterdam, 1997, 37-47.





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I N EXTENSO ARTICLES PUBLISHED IN INTERNATIONAL SCIENTIFIC FLUX
ISI, Scopus and PubMed indexed Articles
1. Grdinaru D*, Bora C, Ionescu C, Margin D - Advanced oxidative and glycoxidative
protein damage markers in elderly with type 2 diabetes. Journal of Proteomics, 2013, [Epub
ahead of print], Elsevier. IF = 4,088; IS = 1,66389
* Corresponding author

2. Margin D, Grdinaru D, Manda G, Neagoe I, Ilie M Membranar effects exerted in vitro
by polyphenols quercetin, epigallocatechin gallate and curcumin on HUVEC and Jurkat
cells, relevant for diabetes mellitus. Food and Chemical Toxicology, 2013, [Epub ahead of
print], Elsevier. IF = 3,010; IS = 1,95098
3. Grdinaru D*, Bora C, Ionescu C, Margin D, Prada GI, Jansen E - Vitamin D status and
oxidative stress markers in elderly with impaired fasting glucose and type 2 diabetes mellitus,
Aging Clinical and Experimental Research. 2012, 24, 596 602. IF = 1,006; IS = 0,69621;
1 citation
* Corresponding author

4. Grdinaru D*, Minn AL, Artur Y, Minn A, Heydel JM - Effect of oxidative stress on UDP-
glucuronosyltransferases in rat astrocytes, Toxicology Letters. 2012, 213(3):316-24.
IF = 3,145; IS = 1,42903
* Corresponding author

5. Margin D, Ilie M, Grdinaru D - Quercetin and epigallocatechin gallate induce in vitro a
dose-dependent stiffening and hyperpolarizing effect on the cell membrane of human
mononuclear blood cells, International Journal of Molecular Sciences. 2012;13(4):4839-59.
IF = 2,464; IS = 1,60778; 1 citation
6. Margin D, Ilie M, Manda G, Neagoe I, Mocanu M, Ionescu D, Grdinaru D, Ganea C -
Quercetin and epigallocatechin gallate effects on the cell membranes biophysical properties
correlate with their antioxidant potential, General Physiology and Biophysics. 2012, (1):47-55.
IF = 0,852; IS = 0,41990; 4 citations
7. Margin D, Grdinaru D, Panaite C, Cimponeriu D, Vldic M, Dnciulescu R, Mitrea N -
The association of adipose tissue markers for redox imbalance and the cardio-vascular risk in
obese patients, HealthMED Journal. 2011, 5,1, 194-199. IF = 0,435
8. Breusing N, Grune T, Andrisic L, Atalay M, Bartosz G, Biasi F, Borovic S, Bravo L, Casals
I, Casillas R, Dinischiotu A, Drzewinska J, Faber H, Fauzi NM, Gajewska A, Gambini J,
Grdinaru D, Kokkola T, Lojek A, Luczaj W, Margin D, Mascia C, Mateos R, Meinitzer A,
Mitjavila MT, Mrakovcic L, Munteanu MC, Podborska M, Poli G, Sicinska P, Skrzydlewska
E, Vina J, Wiswedel I, Zarkovic N, Zelzer S, Spickett CM - An inter-laboratory validation of
methods of lipid peroxidation measurement in UVA-treated human plasma samples, Free
Radial Research. 2010, 44(10):1203-15. IF = 3,279; IS = 0,86844; 19 citations

9. Margin D, Ilie M, Negrei C, Grdinaru D, Blnescu A, Mitrea N - Quercetin and
epigallocatechin gallate in vitro induced changes in the membrane anisotropy of peripheral
blood mononuclear cells from patients with inflammatory diseases, Journal of Medicinal Plants
Research, 2010, 4(22), 2388-2392. IF = 0,590; 1 citation


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10. Grdinaru D*, Minn AL, Artur Y, Minn A, Heydel JM Drug metabolizing enzyme
expression in rat choroid plexus: effects of in vivo xenobiotics treatment, Archives of
Toxicology. 2009, 83, 581-586. IF = 5,215; IS = 1,0500; 6 citations
* Corresponding author

11. Grdinaru D*, Margin D, Bora C - In vitro studies regarding the antioxidant effects of
procaine, Gerovital H3 and Aslavital, Revue Roumaine de Chimie, 2009, 54(9), 761-766.
IF = 0,331
* Corresponding author

12. Grdinaru D*, Mitrea N, Margin D, Arsene A, Gruia V, Drgoi C, Nicolae A, Bora C,
Gherasim P Evaluation of serum osteocalcin in elderly patients with type-2 diabetes mellitus,
Farmacia. 2009, 57, 3, 331-339. IF = 0,578; 5 citations
* Corresponding author

13. Margin D, Vldic M, Dnciulescu R, Grdinaru D, Mitrea N - Comparison of different
assessment models of insulin resistance in Romanian obese patients, Farmacia. 2009, 57, 6,
711-720. IF = 0,578

14. Ilie M, Margin D, Katona E, Ganea C, Pencea C, Vldic M, Grdinaru D, Mitrea N,
Bllu D - Quercetin and epigallocatechin gallate effect on the lipid order parameter of
peripheral blood mononuclear cells from diabetes patients, Romanian Biotechnological Letters.
2009, 14, 6, 4804-4811. IF = 0,363

15. Margin D, Grdinaru D*, Mitrea N - Development of a potentiometric method for the
evaluation of redox status in human serum, Revue Roumaine de Chimie. 2009, 54(1), 4548.
IF = 0,331; 2 citations
* Corresponding author

16. Gruia V, Aram C, Mitrea N, Arsene A, Grdinaru D, Drgoi C The HPLC plasmatic
profile of some fat-soluble antioxidant micronutrients (all-trans-retinol, -tocopherol,
coenzyme Q10) in diabetic and dyslipidemic patients, Farmacia. 2009, 57, 5, 630 638.
IF = 0,578; 2 citations

17. Margin D, Mitrea N, Grdinaru D, Vldic M, Dnciulescu R The influence of
thiazolidinediones on markers of the endothelial status at type II diabetes mellitus patients,
Farmacia. 2008, vol LVI, 1, 99-106. IF = 0,578; 1 citation

18. Gruia V, Arsene-Niulescu A, Mohora M, Mitrea N, Grdinaru D, Margin D, Begona
YM - Correlations between some plasmatic redox parameters in diabetic pacients, Farmacia.
2008, LVI, 6, 692-696. IF = 0,578; 2 citations

19. Margin D, Vldic M, Dnciulescu R, Grdinaru D, Mitrea N - Clinical study regarding
the influence of hygieno-dietetic regimen on hyperglicemic overweight patients, Archives of
the Balkanic Medical Union. 2005, 40, 3, 162-166.

20. Margin D, Vldic M, Dnciulescu R, Grdinaru D, Mitrea N - Adiponectin level and
NO synthesis as atherogenic markers in overweight and obese patients,
(Pharmacia) Bulgaria. 2005, LII, 1-2, 68-70. IF = 0,840


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21. Heurtaux T, Benani A, Bianchi A, Moindrot, Grdinaru D, Magdalou J, Netter P, Minn A
Redox state alteration modulates astrocyte glucuronidation, Free Radical Biology &
Medicine. 2004, 37, 1051 1063. IF = 5,271; 9 citations

22. Margin D, Grdinaru D, Mitrea N Clinical study regarding the atherogenic properties
of the oxidatively modified low-density lipoproteins, Archives of the Balkanic Medical Union.
2004, 39, 2, 78-83.

23. Leclerc S, Heydel JM, Amosse V, Grdinaru D, Cattarelli M, Artur Y, Goudonnet H,
Magdalou J, Netter P, Pelczar H, Minn A Glucuronidation of odorant molecules in the rat
olfactory system. Activity, expression and age-linked modications of UDP-
glucuronosyltransferase isoforms, UGT1A6 and UGT2A1, and relation to mitral cell activity,
Molecular Brain Research. 2002, 107, 201-213. IF = 2,879; IS = 0,87003; 15 citations

24. Minn A, Leclerc S, Heydel JM, Minn AL, Denizot C, Cattarelli M, Netter P, Grdinaru D
Drug transport into the mammalian brain: the nasal pathway and its specific metabolic barrier,
Journal of Drug Targeting. 2002, 10, 4, 285-296. IF = 2.768; IS = 1,13922; 39 citations

25. Heydel JM, Leclerc S, Bernard P, Pelczar H, Grdinaru D, Magdalou J, Minn A, Artur Y,
Goudonnet H Rat olfactory bulb and epithelium UDP-glucuronosyltransferase 2A1
(UGT2A1) expression: in situ mRNA localization and quantitative analysis, Molecular Brain
Research. 2001, 90, 83-92. IF = 2,879; IS = 0,87003; 21 citations
26. Grdinaru D, Suleman FG, Leclerc S, Heydel JM, Grillasca JP, Magdalou J, Minn A
UDP-Glucuronosyltransferase in the rat olfactory bulb: identification of the UGT1A6 isoform
and age-related changes in 1-naphthol glucuronidation, Neurochemical Research. 1999, 24, 8,
995-1000. IF = 2,125; IS = 0,74283; 12 citations
27. Rusu C, Bora C, Grdinaru D, Ionescu C - Oxidative damage in vivo and possible
interactions between vitamin E and cellular electron transfer systems, Romanian Journal of
Gerontology and Geriatrics. 1999, 21, 7-17.

28. Suleman FG, Abid A, Grdinaru D, Daval JL, Magdalou J, Minn A - Identification of the
uridine diphosphate glucuronosyltransferase isoform UGT1A6 in the rat brain and in primary
cultures of neurons and astrocytes, Archives of Biochemistry and Biophysics. 1998, 358, 63-67.
IF = 3,370; IS = 1,01704; 38 citations

Conference papers presented at international scientific meetings,
published in special issues of ISI indexed journals

I n extenso published articles:

1. Revnic F, Revnic CR, Nica A, Ginghina C, Prada G, Grdinaru D, Prada S, Sonea C, Pena
C Evaluation of Matrix Metalloproteinase-9 (MMP-9) and its tissue inhibitor of
metalloproteinase-1 (Timp-1) in patients with coronary syndromes after percutaneous
intervention (PCI), Coronary Artery Disease: 2011 Update Proceedings of the 9th
International Congress on Coronary Artery Disease, Venice, Italy, October 23-26, 2011, 49-53.


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2. Revnic CR, Nica AS, Prada G, Grdinaru D, Sonea A, Pena C, Prada S, Revnic F Carotid
Doppler Ultrasound in elderly diabetes and non-diabetes patients, Coronary Artery Disease:
2011 Update Proceedings of the 9th International Congress on Coronary Artery Disease,
Venice, Italy, October 23-26, 2011, 193-197.

Abstracts:

OXIDATIVE STRESS AND XENOBIOTIC DETOXIFICATION ENZYMES IN RAT
ASTROCYTES: CORRELATIONS WITH BRAIN AGING
D. Grdinaru, A.L. Minn, Y. Artur, J.-M. Heydel
Experimental Gerontology, Volume 48, Issue 7, July 2013, Page 688.
Proceedings of the Eleventh International Symposium on the Neurobiology and
Neuroendocrinology of Aging, July 29 - August 3 2012, Bregenz, Austria

INHIBITION OF SERUM LIPID AND LDL OXIDATION BY GEROVITAL H3
C. Bora, G.I. Prada, C. Ionescu, D. Margina, D. Grdinaru
Experimental Gerontology, Volume 48, Issue 7, July 2013, Pages 684-685.
Proceedings of the Eleventh International Symposium on the Neurobiology and
Neuroendocrinology of Aging, July 29 - August 3 2012, Bregenz, Austria

PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY UPON MMP2, MMP9 AND NOX1
RELEASE IN PATIENTS WITH STABLE ANGINA
C. Revnic, C. Ginghin, A. Mereu, D. Grdinaru, F. Revnic
Atherosclerosis Suppl., 2011, 12 (1), page 88
9th International Congress on Coronary Artery Disease, 23-26 October 2011, Venice, Italy

THE IMPACT OF PERCUTANEOUS CORONARY INTERVENTION (PCI) WITH STENT
IMPLANTATION UPON MMP9 AND INFLAMATORY MARKERS IN PATIENTS WITH
ACUTE CORONARY SYNDROMES
F. Revnic, C.R. Revnic, C. Ginghin, A. Mereu, D. Grdinaru, G. Prada, S. Prada, C. Pena,
C. Bora, C. Ionescu
Atherosclerosis Suppl., 2011, 12 (1), page 101
9th International Congress on Coronary Artery Disease, 23-26 October 2011, Venice, Italy

IN VITRO EVALUATIONS REGARDING SERUM REDOX STRESS PARAMETERS IN
INVESTIGATING AGING AND OXIDOPATHIES
D. Grdinaru, D. Margin
Turkiye Klinikleri Journal of Medical Sciences, 2009, 29 (Suppl.): S6
II Congress Anti-Aging & Aesthetic Medicine Society, 22-25 October 2009, Izmir, Turkey

ASLAN THERAPY (INSTITUTE): THE FIRST ANTI-AGING TREATMENT AS A
MODEL IN THE WORLD
D. Grdinaru
Turkiye Klinikleri Journal of Medical Sciences, 2009, 29 (Suppl.): S116
II Congress Anti-Aging & Aesthetic Medicine Society, 22-25 October 2009, Izmir, Turkey

STUDIES REGARDING PARAQUAT EFFECT ON PHASE I AND II DRUG
METABOLIZING ENZYMES EXPRESSION IN RAT BRAIN
D. Grdinaru, D. Margin, A.L. Arsene, Mitrea N.
Toxicology Letters, 2008, 180 (Suppl. 1): S165

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45th Congress of the European-Societies-of-Toxicology, 5 8 October 2008, Rhodes, Greece

IMMUNE RESPONSE IN HEALTHY AGEING: IMMUNOSENESCENCE VERSUS
IMMUNODEFICIENCY
M. Neagu, C. Constantin, G. Manda G, D. Grdinaru, Ursaciuc C.
FEBS Journal, 2008, 275 (Suppl. 1), page 210
Joint Conference of the 33rd FEBS Congress/11th IUBMB Conference, 28 June 3 July 2008,
Athens, Greece

REDOX STRESS PARAMETERS IN TYPE 2 DIABETES MELLITUS
M. Vladic, D. Margin, D. Grdinaru
Diabetologia, 2007, 50(Suppl. 1): S298
43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes, 18-21
September 2007, Amsterdam, Netherlands

THE RESPIRATORY BURST EVALUATION BY FLOW CYTOMETRY IN NORMAL
ELDERLY SUBJECTS
C. Constantin, D. Grdinaru, G. Manda
Cytometry, Part B-Clinical Cytometry, 2007, 72B(2):143
6th Euroconference on Clinical Cell Analysis, 14-16 September 2006 Stresa, Italy

CORRELATION BETWEEN METABOLIC PROFILE, INSULIN RESISTANCE AND
OXIDATIVE METABOLIC STATUS IN ELDERLY WOMEN WITH AND WITHOUT
TYPE 2 DIABETES
C. Rusu, D. Grdinaru, C. Bora, D. State, M. Georgescu
Diabetes & Vascular Disease Research (indexed EMBASE), 2005, 2,163
3-th Annual World Congress on Insulin Resistance Syndrome, 17-19 November 2005, San
Francisco, USA.

01.10.2013 Prof. Daniela Grdinaru, PhD