Allan J. Collins, MD, Robert N. Foley, MB, Blanche Chavers, MD, David Gilbertson, PhD, Charles Herzog, MD, Kirsten Johansen, MD, Bertram Kasiske, MD, Nancy Kutner, PhD, Jiannong Liu, PhD, Wendy St. Peter, PharmD, Haifeng Guo, Sally Gustafson, MS, Brooke Heubner, MS, Kenneth Lamb, PhD, Shuling Li, MS, Suying Li, PhD, Yi Peng, MS, Yang Qiu, MS, Tricia Roberts, MS, Melissa Skeans, MS, Jon Snyder, PhD, Craig Solid, MS, Bryn Thompson, BA, Changchun Wang, MS, Eric Weinhandl, MS, David Zaun, MS, Cheryl Arko, BA, Shu-Cheng Chen, MS, Frank Daniels, BS, James Ebben, BS, Eric Frazier, BS, Christopher Hanzlik, BS, Roger Johnson, Daniel Sheets, BS, Xinyue Wang, BA/BS, Beth Forrest, BBA, Edward Constantini, MA, Susan Everson, PhD, Paul Eggers, PhD, and Lawrence Agodoa, MD T his 23rd US Renal Data System (USRDS) An- nual Data Report covers data through 2009, and again includes a section on chronic kidney disease (CKD) in the United States, dening its burden in the general population. Using NHANES (National Health and Nutrition Examination Survey), Medicare, and employer group health plan data, we look at cardiovas- cular and other comorbid conditions, adverse events, preventive care, Medicare Part D prescription drug use, and associated costs of CKD to Medicare and employer group health plans. New ndings show -blocker use is 65% among those with congestive heart failure and identied CKD. In those with a history of CKD and an acute myocardial infarction, use is 72%. Angiotensin-converting enzyme inhibitor and angiotensin receptor blockers in those with CKD and congestive heart failure is 47%-57% and 57.4% in the non-CKD population. As in recent years, the second section of the report focuses on end-stage renal disease (ESRD) and the historical data that were the basis of the rst USRDS reports. In 2009, 116,395 patients started therapy for ESRD, and the prevalent population reached 571,414 (including 398,861 dialysis patients); 17,736 trans- plants were performed, and 172,553 patients had a functioning graft at years end. Program expenditures reached $42.5 billion, with $29.0 billion from Medi- care (accounting for 5.9% of total Medicare expendi- tures, excluding Part D). The incident rate increased 1.1%, to 355.4 per million. At their rst outpatient hemodialysis treatment, 65% of patients used only a catheter and 14% began treatment with an arterio- venous stula. During 2009, 40% of prevalent dialy- sis patients had a mean monthly hemoglobin level within the previous NKF-KDOQI (National Kidney Foundations Kidney Disease Outcomes Quality Ini- tiative) target of 11-12 g/dL, and the mean erythropoi- etin dose per week averaged 18,206 units. First-year mortality declined by 3%, while morbidity among hemodialysis patients continued to be a major issue secondary to increasing rates of hospitalization due to infection. Rehospitalizations are high, with 38%return- ing within 30 days after a single hospitalization event. The public health effect of kidney disease is larger than previously appreciated, and early detection, edu- cation, intervention, and risk factor control need to address the heavy burden of cardiovascular disease and adverse events in this vulnerable population. ACKNOWLEDGEMENTS Suggested Citation: Collins AJ, Foley RN, Chavers B, et al: US Renal Data System 2011 Annual Data Report. Am J Kidney Dis. 2012;59(1)(suppl 1):e1-e420. Publications based upon USRDS data reported here or supplied upon request must include this citation and the following notice: The data reported here have been supplied by the US Renal Data System (USRDS). The interpretation and reporting of these data are the responsibility of the author(s) and in no way should be seen as an ofcial policy or interpretation of the US government. Support: Funding for the USRDS Coordinating Center is pro- vided under contract to the Minneapolis Medical Research Founda- tion (MMRF; NIH contract HHSN 267 2007 15002C/NO1-DK-7- 5002). Financial Disclosure: Relevant nancial interests for contribu- tors to the supplement are listed in the Funding and Chapter Contributors page of the supplement. 2011by the National Kidney Foundation, Inc. Publishedby Elsevier Inc. All rights reserved. 0272-6386/$36.00 doi:10.1053/j.ajkd.2011.11.015 Am J Kidney Dis. 2012;59(1)(suppl 1):evii evii