Sulbutiamine. References are numbered.

Sulbutiamine (1) AKA (thiamine disulfide, Aneurin DBE ) and pretty much most of the thiamine analogues out there in my opinion are fairly
dangerous to the user if they do not know what they are doing to themselves. The reason this stuff has so much kick when taken in products is
because it manipulates the neurotransmitter dopamine in an identical pathway to cocaineingestion. Unlike amphetamines and other uppers,
such as ephedrine, the thiamine analogues REDUCE the bodys ability to produce dopamine, trap dopamine in the area of the brain called the
synapse, and almost stop the function of dopamine transporters called DATs just like cocaine. (1,2,3,4,6)

Heres why this is addictive in a nutshell and based off of my research and its similarities to cocaine. (8) Dopamine is the bodys feel good
neurotransmitter. When thiamine analogues are ingested dopamine transporters are disabled. Dopamine transporters take dopamine out of the
synapse (and area in the brain that processes neurotransmitters) so that the receptors in the synapse are not overloaded with too much dopamine
at once. If there is too much of an overload at once then a stimulatory affect occurs along with appetite suppression, euphoria, etc. The problem
here is that the dopamine transporters are literally shut down and the body keeps pumping the rest of its dopamine in the synapse making your
neurons go FREAKIN NUTS, with no way to get out. You can maintain a good effect for about 3 or 4 days blocking DAT. Then, the come down
occurs. Finally the body will bounce back in a couple of days and increase DAT and start pulling that dopamine out of the synapse all the while
desensitizing the body to dopamine for being trapped in the synapse for so long. Then you have reduced dopamine output, desensitized
dopamine receptors in the synapse, and lowered DAT levels. All those levels reduced are the equivalent to depression, lethargy, emotionless
state, etc. This is the addiction mechanism that people are experiencing, not to mention one interesting case of a guy coping well with his bipolar
disorder then completely disregarding this therapy after taking thiamine analogues. (7)

Heres where this product gets more dangerous. If taken with a very widely prescribed SSRI like Zoloft (sertaline HCL) a person could literally
render themselves clinically insane for a real good couple of hours. Mind you people do not just publically go out of their way to claim that they
take antidepressants. Zoloft and other SSRI antidepressants like it FORCE a HUGE dopamine release in the body to curb depression in individuals.
Now put two and two together here. You take one drug that forces a high release of dopamine, then the next product traps that forced release of
dopamine in the synapse where it cannot be removed because the DAT (dopamine transporters) are almost disabled. Two words for that
individual: temporary psychosis. I would not want to be on the business end of that kind of withdrawal.

The other aspect I do not like about this fat burner is that its ability to suppress appetite causes most to eat well below their caloric intake per day
and disrupts the mini meal process. Most traditional dieters are terrible when it comes to eating properly without getting too busy at work, life,
etc. To cut properly a person needs to eat within negative 500-1000 calories per day with high protein, glutamine, and efa intake. Any more
calories than that is just a prayer for a pro-catabolic environment to burn muscle for energy. Im personally bothered when I hear about the girl
who likes it because she only needs to eat one time a day or the guy who says the same thing for that matter as it contradicts core aspects of
dieting to reduce catabolism a.k.a. the body using muscle for energy.

The reality of the product in my opinion is along the lines of pro hormones. Some people feel the side effects while others suffer minimal
headaches if none at all. I think due to a high number of people on the net giving the same feedback of depression, lethargy, motivational issues, it
sounds exactly like a person riding high on cocaine for days then needing almost a week off to function like normal.

If you know a person who has ingested a product like this I would recommend taking L-Glutamine, L-Tyrosine, L-Phenylalanine, 5-HTP, L-DOPA,
and a multivitamin, to jump start the bodys ability to produce dopamine in adequate quantities once again.

1. http://www.ncbi.nlm.nih.gov/pubmed/10996447 (Sulbutiamine, Reduces Dopamine output, Increases D1 receptor from use, lower DAT)

2. http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_ResultsP anel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum (Reduction of DAT and
storing dopamine in synapse is stimulation of cocaine)

3. http://www.pnas.org/content/103/9/3399.full (Cocaine Use Increase in D1 Receptor)

4. http://www.ncbi.nlm.nih.gov/pubmed/8156390 (D1,D2 increase in cocaine use, Lower DAT)

5. http://www.ncbi.nlm.nih.gov/pubmed/1...?dopt=Abstract (Reduced dopamine levels creates early Parkinsons Type Syndrome)

6. http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_ResultsP anel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum (Rats good source for
testing of human dopamine neurotransmitter conditions )

7. http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_ResultsP anel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum (Bipolar patient had
developed high tolerance to sulbutimine and intake of compound lead to increase mental instability)

8. http://www.utexas.edu/research/asrec/dopamine.html (General Document to understand the addiction physiological process)

Read more: http://www.drugs-forum.com/forum/showthread.php?t=101487#ixzz31bmzKmo7