Syndrome classSyndromeMain causal cancersCausal mechanismEndocrine

[6]
Cushing syndrome
small-cell lung cancer
[7]

Pancreatic carcinoma
[7]

Neural tumors
[7]

Thymoma
Ectopic ACTH and ACTH-like substanceSIADH
small-cell lung cancer
[7]

CNS malignancies
[7]

antidiuretic hormone
[7]
Hypercalcemia
Lung cancer (typically squamous cell)
[7]

Breast carcinoma
[7]

Renal carcinoma
[7]

Multiple myeloma (may occur independent of osteolytic lesions)
Adult T cell leukemia/lymphoma
[7]

Ovarian carcinoma
[7]

PTHrP (Parathyroid hormone-related protein),TGF-, TNF, IL-1
[7]
Hypoglycemia
Fibrosarcoma
[7]

Other mesenchymal sarcomas
[7]

Insulinoma
Hepatocellular carcinoma
[7]

Insulin or insulin-like substance
[7]
or "big" IGF-IICarcinoid syndrome
Bronchial adenoma (carcinoid type)
[7]

Pancreatic carcinoma
[7]

Gastric carcinoma
[7]

Serotonin, bradykinin
[7]
PolycythemiaSee hematological paraneoplastic
syndromesHyperaldosteronism
Adrenal adenoma / Conn's syndrome
Non-Hodgkin's lymphoma
ovarian carcinoma
pulmonary
Aldosterone
[8]
Neurological
[9]
Lambert-Eaton myasthenic syndrome (LEMS)
Small-cell lung cancer
ImmunologicParaneoplastic cerebellar degeneration
lung
ovarian cancer
breast carcinoma
Hodgkin's lymphoma
Encephalomyelitisinflammation of the brain and spinal cordLimbic encephalitis
small-cell lung carcinoma
Brainstem encephalitisParaneoplastic Opsoclonus (involving eye movement)-Myoclonus
breast carcinoma
ovarian carcinoma
small-cell lung carcinoma
neuroblastoma (in children)
Autoimmune reaction against the RNA-binding protein Nova-1
[10]
Anti-NMDA receptor
encephalitis
Teratoma
[11]

Autoimmune reaction against NMDA-receptorsubunitsPolymyositis
Non-Hodgkin lymphoma
lung cancers
bladder cancers
Mucocutaneous
[12]
Acanthosis nigricans
Gastric carcinoma
[7]

Lung carcinoma
[7]

Uterine carcinoma
[7]

Immunologic
[7]

Secretion of EGF
Dermatomyositis
Bronchogenic carcinoma
[7]

Breast carcinoma
[7]

ovarian cancer
pancreatic cancer
stomach cancer
colorectal cancer
Non-hodgkin's lymphoma
[13]

Immunologic
[7]
Leser-Trlat signNecrolytic migratory erythemaGlucagonomaSweet's
syndromeFlorid cutaneous papillomatosisPyoderma gangrenosumAcquired generalized
hypertrichosisHematological
[14]
GranulocytosisG-CSFPolycythemia
Renal carcinoma
[7]

Cerebellar hemangioma
[7]

Hepatocellular carcinoma
[7]

Erythropoietin
[7]
Trousseau sign
Pancreatic carcinoma
[7]

Bronchogenic carcinoma
[7]

Mucins that activate clotting,
[7]
othersNonbacterial thrombotic endocarditis
Advanced cancers
[7]

Hypercoagulability
[7]
Anemia
Thymic neoplasms
[7]

Unknown
[7]
OthersMembranous glomerulonephritis
Various
[7]

Tumor antigens
[7]

Immune complexes
[7]

Tumor-induced osteomalacia
Hemangiopericytoma
Phosphaturic mesenchymal tumor
[15]

FGF-23 (Fibroblast growth factor-23)
Stauffer syndrome
renal cell carcinoma
Neoplastic fever
[16]