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Record 1 of 50
By: Jeanjean, A (Jeanjean, Anais); Olives, R (Olives, Regis); Py, X (Py, Xavier)
Title: Selection criteria of thermal mass materials for low-energy building construction applied to conventional and alternative materials
Source: ENERGY AND BUILDINGS
Volume: 63
Pages: 36-48
DOI: 10.1016/j.enbuild.2013.03.047
Published: AUG 2013
Abstract: According to the recent worldwide environmental problems, there is a need to reduce the energy consumption and the green house gas emission of the building
sector. Therefore, the properties and performances of the building envelops have to be enhanced before considering any energetic equipments. A particular attention should
then be made in the selection of the materials used in buildings. The scope of the present paper is to propose tools for selection and comparison of construction materials and
especially thermal mass materials. The CES selector software has been used to compare conventional materials to new recycled ceramics in terms of thermal properties,
mechanical properties, cost and embodied energy. The recycled ceramic, made of inert vitrified asbestos containing wastes, is a good alternative material presenting one of
the best thermal and mechanical properties for a very low price. Its use as thermal mass material offers a new life cycle with a pay-back of its embodied energy needed for the
waste treatment. Nevertheless, the high temperature waste treatment process leads to a too high embodied energy before conventional materials. This aspect highlights the
need in new hybrid vitrification processes taking advantage of renewable energies such as concentrated solar technologies. Finally, the dynamic thermal behavior of a
wooden house prototype was simulated using the thermal mass materials previously studied. The influence of the selected materials on the inside comfort of the house was
analyzed using the French software "Pleiades + Comfie" under dynamic outside temperature variation. The combination of thermal inertia, incoming solar flux control and
nocturnal over ventilation leads to a whole indoors temperatures range closed to the comfort standard level. (C) 2013 Elsevier B.V. All rights reserved.
Times Cited in Web of Science: 0
Times Cited in BIOSIS Citation Index: 0
Times Cited in Chinese Science Citation Database: 0
Times Cited in SciELO Citation Index: 0
Total Times Cited: 0
ISSN: 0378-7788
Accession Number: WOS:000320909500004
Record 2 of 50
By: Tapbergenov, SO (Tapbergenov, S. O.); Zhetpisbaev, BA (Zhetpisbaev, B. A.); Ilderbayev, OZ (Ilderbayev, O. Z.); Zhetpisbaeva, HS (Zhetpisbaeva, H. S.); Olzhayeva,
RR (Olzhayeva, R. R.); Prozor, II (Prozor, I. I.); Usenova, OA (Usenova, O. A.); Ilderbayeva, GO (Ilderbayeva, G. O.)
Title: Free Radical Oxidation in Rats in the Delayed Period after Combined Exposure to Dust and Radiation
Source: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume: 154
Issue: 6
Pages: 747-749
DOI: 10.1007/s10517-013-2046-z
Published: APR 2013
Abstract: We studied the intensity of free radical processes in organs (liver, spleen, thymus, lymph nodes of the small intestine, and adrenal glands) and cells (lymphocytes)
in the delayed period after combined exposure to a sublethal dose of gamma-radiation (6 Gy) and asbestos dust particles. Combined exposure was followed by accumulation
of LPO metabolites (diene conjugates and malonic dialdehyde) in homogenates of the studied organs and resulted in antioxidant defense failure in experimental animals.
Ionizing radiation have a pivotal role in these processes.
ISSN: 0007-4888
Record 3 of 50
Inventor(s): CHEN D
Title: Method for processing C-shaped central hole by cutter, involves forming central locating hole, drilling hole with specific dimension by utilizing drill bit, and drilling
conical surface of hole with another specific dimension
Patent Number: CN102699654-B; CN102699654-A
Patent Assignee: NANJING JINXIN TRANSMISSION EQUIP CO LTD
Accession Number: DIIDW:2013A80781
Record 4 of 50
Inventor(s): CHENG J
Title: Dual cylinder water film desulfurizing dust remover, has smoke pipe whose two ends are connected with main cylinder and secondary cylinder, where bottom side wall
of secondary cylinder is provided with discharging smoke main pipe
Patent Number: CN202876602-U
Patent Assignee: CHENG J
Abstract: NOVELTY - This utility model claims a kind of double-cylinder water film desulfurizing dust remover, it is mainly composed of a main cylinder, a secondary
cylinder, a ring cavity-shaped water channel of the main body the upper part of the annular water injection pipe and a smoke pipe, one end of the flange is connected to the
main body of the smoke pipe, the smoke pipe the other end of tube is assembled in the secondary cylinder connecting seat of sliding sleeve according to the mode and the
asbestos or rubber mud. It is the reserved current) of dirt catcher base structure and working principle, and are provided with secondary cylinder composed of the main
cylinder body side is double-cylinder structure can effectively prolong the cleaning stroke of flue gas and the processing ability of the smoke, making the tail gas after
treatment can reach the first area of the national standard without pollution, the utility model is provided with simple structure, low production cost, convenient installation
and construction, flue gas processing capacity, desulfurizing and dust-removing effect, low operation cost, and it has good application prospect.
Accession Number: DIIDW:2013P43763
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Record 5 of 50
Inventor(s): ABE Y; UCHIDA T
Title: Melting detoxifying apparatus for melting and detoxifying asbestos containing waste material has throwing-in unit, crushing unit and conveying unit connected in
series to enable negative-pressure management in building
Patent Number: JP2013176713-A
Patent Assignee: TOBISHIMA KENSETSU KK; MOGAMI CLEAN CENT KK
Abstract: NOVELTY - The melting detoxifying apparatus has a melting unit (6) that melts and detoxifies the asbestos containing waste material (10) conveyed by a
conveying unit. An exhausting unit purifies the waste gas emitted by melting and it discharges waste gas outside. A throwing-in unit (7), a crushing unit (3) and the
conveying unit are connected in series inside a building to enable negative-pressure management inside of the building. The throwing-in unit throws in the packed asbestos
containing waste material in an apparatus. The crushing unit crushes the thrown-in packed asbestos.
USE - Melting detoxifying apparatus for melting and detoxifying asbestos containing waste material.
ADVANTAGE - Prevents scattering of asbestos during melting detoxifying process of asbestos containing waste material. Attains negative-pressure management of both
throwing-in chamber and throwing-in unit. Ensures stable dregs discharge. Reduces running cost and fuel consumption of melting furnace.
DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for an asbestos processing method.
DESCRIPTION Of DRAWING(S) - The drawing shows the schematic diagram of an asbestos melting treatment apparatus.Crushing unit (3)Melting unit (6)Throwing-in unit
(7)Asbestos containing waste material (10)Slag outlet (11)
Accession Number: DIIDW:2013N14662
Record 6 of 50
By: 3|; ; j; ||
By: Peng Tongjiang; Ding Wenjin; Sun Hongjuan; Chen Jiming
Title: Effects of Heat Treatment on Crystallization Behaviors of Glass-Ceramics from Chrysotile Asbestos Tailing
Title: J][,{|[(|\(||,[
Source: Acta Mineralogica Sinica
Source: (||
Volume: 33
Issue: 2
Pages: 129-134
Article Number: 1000-4734(2013)33:2<129:RCLZDD>2.0.TX;2-N
Published: 2013
Abstract: Based on the significant effects of heat treatment on crystallization behaviors of glass-ceramics, influences of nucleation temperature and crystallization
temperature on crystallization behavior of CaO-MgO-SiO2 glass-ceramics were studied. Heating temperatures for nucleation and crystallization were both determined by
using DTA curve of the parent glass. Crystalline phase and microstructure of the glass-ceramics were investigated by means of X-ray diffraction (XRD) and scanning
electron microscope (SEM). The results indicate that the main crystalline akermanite of the glass-ceramics converted into melilitite and the crystallization ability was
improved with increasing nucleation and crystallization temperature, meanwhile, the minor crystalline phase diopside and forsterite were disappeared gradually. The toxic
asbestos fibers converted into silicate materials and became harmless for environment after the heat treatment process.
Abstract: ]_J][,|\(||,}[,[;||[|[,CaO-MgO-SiO2{|[(|\(||,[,DTA;|
|[)]\(U||[[;[X@;]@|jj;||\(||U|j],;9,|:||||[)(,|\(|p
||]j{},j[{,||p||7J];,|j]j{f{J9,|J|{|;n|,,fj;[@(|,
ISSN: 1000-4734
Accession Number: CSCD:4843701
Record 7 of 50
By: Kim, Myung-Chul; Cui, Feng-Ji; Kim, Yongbaek
Title: Hydrogen peroxide promotes epithelial to mesenchymal transition and stemness in human malignant mesothelioma cells.
Source: Asian Pacific journal of cancer prevention : APJCP
Volume: 14
Issue: 6
Pages: 3625-30
Published: 2013
Abstract: Reactive oxygen species (ROS) are known to promote mesothelial carcinogenesis that is closely associated with asbestos fibers and inflammation. Epithelial to
mesenchymal cell transition (EMT) is an important process involved in the progression of tumors, providing cancer cells with aggressiveness. The present study was
performed to determine if EMT is induced by H2O2 in human malignant mesothelioma (HMM) cells. Cultured HMM cells were treated with H2O2, followed by measuring
expression levels of EMT-related genes and proteins. Immunohistochemically, TWIST1 expression was confined to sarcomatous cells in HMM tissues, but not in epithelioid
cells. Treatment of HMM cells with H2O2 promoted EMT, as indicated by increased expression levels of vimentin, SLUG and TWIST1, and decreased E-cadherin
expression. Expression of stemness genes such as OCT4, SOX2 and NANOG was also significantly increased by treatment of HMM cells with H2O2. Alteration of these
genes was mediated via activation of hypoxia inducible factor 1 alpha (HIF-1alpha) and transforming growth factor beta 1 (TGF-beta1). Considering that treatment with
H2O2 results in excess ROS, the present study suggests that oxidative stress may play a critical role in HMM carcinogenesis by promoting EMT processes and enhancing the
expression of stemness genes.
ISSN: 1513-7368
Accession Number: MEDLINE:23886156
Record 8 of 50
2 di 17 24/02/14 22.28
By: Osada, M (Osada, Morihiro); Takamiya, K (Takamiya, Ken); Manako, K (Manako, Kazutaka); Noguchi, M (Noguchi, Masato); Sakai, S (Sakai, Shin-ichi)
Title: Demonstration study of high temperature melting for asbestos-containing waste (ACW)
Source: JOURNAL OF MATERIAL CYCLES AND WASTE MANAGEMENT
Volume: 15
Issue: 1
Pages: 25-36
DOI: 10.1007/s10163-012-0088-3
Published: JAN 2013
Abstract: The service life of many buildings and houses built using asbestos-containing materials is coming to an end and their demolition will lead to a great deal of
asbestos-containing waste (ACW). Conventionally, the disposal of such waste is conducted by isolation under controlled landfill procedures; however problems with this
method exist, such as the risk at the time of re-utilization of landfill sites and the depletion of lands to be reclaimed. Melting treatment is a promising technology that could be
used to solve these problems; a thermal process involving temperatures exceeding the melting points of asbestos, it transforms them into non-hazardous minerals. This
technology may be applicable not only for friable ACW but also for nonfriable ACW. We performed a demonstration test of melting treatment of nonfriable ACW using a
gasification and melting furnace of the shaft furnace type, which is a typical method for high temperature melting. Detailed observation using transmission electron
microscopy as well as general analyses verified that the same level of asbestos remained in the slag obtained by high temperature melting as that of the background soil. In
addition, the asbestos concentration in the exhaust gas and the dust from the facility were at sufficiently low levels, and it was thus verified that the asbestos concentration in
the atmosphere in the vicinity of the facility during the melting treatment was comparable to that of Japan's background level reported by the Ministry of the Environment in
2007.
ISSN: 1438-4957
Record 9 of 50
By: Balucan, RD (Balucan, Reydick D.); Dlugogorski, BZ (Dlugogorski, Bogdan Z.)
Title: Thermal Activation of Antigorite for Mineralization of CO2
Source: ENVIRONMENTAL SCIENCE & TECHNOLOGY
Volume: 47
Issue: 1
Pages: 182-190
DOI: 10.1021/es303566z
Published: JAN 1 2013
Abstract: This contribution demonstrates the sensitivity of antigorite dehydroxylation to treatment conditions and discusses the implications of the observations for scientific
(i.e., dehydroxylation kinetics) and technological (i.e., energy efficient conditions and design of practical activation reactors) applications. At present, the energy cost of
dehydroxylation of serpentinite ores represent the most important impediment for a large scale implementation of sequestering CO2 by mineralization. We have analyzed
changes in antigorite's derivative thermogravimetric curves (DTG) and deduced factors affecting the mass loss profiles. The imposed heating rate, type of purge gas, type of
comminution and sample mass all influence the dehydroxylation curve. However, the results show no influence of material of construction of the heating vessel and flow rate
of the purge gas. We report an important effect of oxidation of Fe2+ under air purge gas that occurs prior to dehydroxylation and leads to formation of hematite serpentinite
particles, slowing down subsequent mass transfer and increasing the treatment temperature. From the skins on process perspective, 75 mu m particles afford optimal
conditions of temperature and rate of dehydroxylation. Overall, the practical considerations, in thermally activating serpentinite ores for storing CO2 by carbonation,
comprise rapid heating, proper size reduction, prior demagnetisation, and fluidization of the powder bed.
ISSN: 0013-936X
Record 10 of 50
By: Hatfield, LA (Hatfield, Laura A.); Boye, ME (Boye, Mark E.); Hackshaw, MD (Hackshaw, Michelle D.); Carlin, BP (Carlin, Bradley P.)
Title: Multilevel Bayesian Models for Survival Times and Longitudinal Patient-Reported Outcomes With Many Zeros
Source: JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
Volume: 107
Issue: 499
Pages: 875-885
DOI: 10.1080/01621459.2012.664517
Published: SEP 2012
Abstract: Regulatory approval of new therapies often depends on demonstrating prolonged survival. Particularly when these survival benefits are modest, consideration of
therapeutic benefits to patient-reported outcomes (PROs) may add value to the traditional biomedical clinical trial endpoints. We extend a popular class of joint models for
longitudinal and survival data to accommodate the excessive zeros common in PROs, building hierarchical Bayesian models that combine information from longitudinal
PRO measurements and survival outcomes. The model development is motivated by a clinical trial for malignant pleural mesothelioma, a rapidly fatal form of pulmonary
cancer usually associated with asbestos exposure. By separately modeling the presence and severity of PROs, using our zero-augmented beta (ZAB) likelihood, we are able
to model PROs on their original scale and learn about individual-level parameters from both presence and severity of symptoms. Correlations among an individual's PROs
and survival are modeled using latent random variables, adjusting the fitted trajectories to better accommodate the observed data for each individual. This work contributes to
understanding the impact of treatment on two aspects of mesothelioma: patients' subjective experience of the disease process and their progression-free survival times. We
uncover important differences between outcome types that are associated with therapy (periodic, worse in both treatment groups after therapy initiation) and those that are
responsive to treatment (aperiodic, gradually widening gap between treatment groups). Finally, our work raises questions for future investigation into multivariate modeling,
choice of link functions, and the relative contributions of multiple data sources in joint modeling contexts.
3 di 17 24/02/14 22.28
ISSN: 0162-1459
Record 11 of 50
By: Teixeira, APC (Teixeira, Ana Paula C.); Purceno, AD (Purceno, Aluir D.); Barros, AS (Barros, Aline S.); Lemos, BRS (Lemos, Bruno R. S.); Ardisson, JD (Ardisson,
Jose D.); Macedo, WAA (Macedo, Waldemar A. A.); Nassor, ECO (Nassor, Evelisy C. O.); Amorim, CC (Amorim, Camila C.); Moura, FCC (Moura, Flavia C. C.);
Hernandez-Terrones, MG (Hernandez-Terrones, Manuel G.); Portela, FM (Portela, Flaysner M.); Lago, RM (Lago, Rochel M.)
Author Identifiers:
Author ResearcherID Number ORCID Number
Teixeira, AnaPaula N-9482-2013
Catalise, Inct K-2293-2013
Title: Amphiphilic magnetic composites based on layered vermiculite and fibrous chrysotile with carbon nanostructures: Application in catalysis
Source: CATALYSIS TODAY
Volume: 190
Issue: 1
Pages: 133-143
DOI: 10.1016/j.cattod.2012.01.042
Published: AUG 1 2012
Abstract: This work describes the synthesis and catalytic applications of magnetic composites based on carbon nanotubes and nanofibers prepared by CVD (chemical vapor
deposition) using two natural materials with special morphology, i.e. layered vermiculite clay and fibrous chrysotile. Extensive characterization by XRD, Mossbauer, Raman,
SEM, TEM, TG/DTA, contact angle showed that the composites are made mainly of carbon nanotubes and nanofibers fixed on the surface of the layered or fibrous matrix
containing also carbon coated iron or cobalt cores responsible for the magnetic properties of the composites. The combination of hydrophilic Si and Al oxides surface with
the hydrophobic carbon nanostructure produced amphiphilic materials with remarkable effect on the interaction and separation of two phases system, e. g. oil and water. For
example, immiscible oil/water mixtures can be easily emulsified in the presence of the amphiphilic composites producing a much more efficient interface. It is demonstrated
that this emulsification is very important for the biodiesel synthesis and hydrolysis of soybean oil. After reaction, the emulsion can be easily broken by a simple magnetic
separation process. This emulsion-demulsification process can be also used for biodiesel purification and wastewater treatment. The composites are also used to prepare a
magnetically recoverable supported Pd catalyst for the hydrogenation of the model molecule 1,5-COD. (C) 2012 Elsevier B.V. All rights reserved.
ISSN: 0920-5861
Record 12 of 50
By: Yu Li-feng; Wei Wen-xia; Tian Ya-jing; Wu Guang-long; Li Pei-zhong; Zhao Dan
Title: Analysis of Characteristics of Dioxin Contamination in the Chlor-alkali Site that Uses Graphite Anode for Production
Source: Huanjing Kexue
Volume: 33
Issue: 6
Pages: 2000-2005
Published: JUN 15 2012
Abstract: In order to find out the characteristics of dioxin contamination, we sampled and analyzed the soil and groundwater on a chlor-lkali factory site that uses graphite
anode for production. The results show that the toxic equivalent quantity (TEQ) of dioxins in soil samples exceeds the U. S. EPA region screening value (RSL), with the
chlorine hydrogen processing workshop, the electric tank workshop, the asbestos stack area, the sewage treatment plant and the oil depot were affected. The dioxin
concentration limit of the groundwater sample doesn't exceed the drinking water standard of China. Considering the fingerprints characteristics of dioxin-ontaminated
concentration, dioxin isomers content and TEQ, the priority pollutants for control on this site are 2, 3, 7, 8-TCDF, 2,3,4,7,8-PeCDF, 1,2,3,4,7,8-HxCDF, OCDD and
2,3,7,8-TCDD. The results show that dioxin pollution is very serious in the chlor-alkali plant that uses graphite anode for production, and the environmental supervision is
imperative.
ISSN: 0250-3301
Accession Number: BCI:BCI201200603539
Record 13 of 50
By: Yu, Li-Feng; Wei, Wen-Xia; Tian, Ya-Jing; Wu, Guang-Long; Li, Pei-Zhong; Zhao, Dan
Title: [Analysis of characteristics of dioxin contamination in the chlor-alkali site that uses graphite anode for production].
Source: Huan jing ke xue= Huanjing kexue / [bian ji, Zhongguo ke xue yuan huan jing ke xue wei yuan hui "Huan jing ke xue" bian ji wei yuan hui.]
Volume: 33
Issue: 6
Pages: 2000-5
Published: 2012-Jun
Abstract: In order to find out the characteristics of dioxin contamination, we sampled and analyzed the soil and groundwater on a chlor-alkali factory site that uses graphite
anode for production. The results show that the toxic equivalent quantity (TEQ) of dioxins in soil samples exceeds the U. S. EPA region screening value (RSL), with the
chlorine hydrogen processing workshop, the electric tank workshop, the asbestos stack area, the sewage treatment plant and the oil depot were affected. The dioxin
concentration limit of the groundwater sample doesn't exceed the drinking water standard of China. Considering the fingerprints characteristics of dioxin-contaminated
concentration, dioxin isomers content and TEQ, the priority pollutants for control on this site are 2,3,7,8-TCDF, 2,3,4,7,8-PeCDF, 1,2,3,4,7,8-HxCDF, OCDD and
2,3,7,8-TCDD. The results show that dioxin pollution is very serious in the chlor-alkali plant that uses graphite anode for production, and the environmental supervision is
imperative.
4 di 17 24/02/14 22.28
ISSN: 0250-3301
Record 14 of 50
By: Seo, YN (Seo, Yoo-Na); Lee, YJ (Lee, Yong-Jin); Lee, MY (Lee, Mi-Young)
Title: Differential gene expression by chrysotile in human bronchial epithelial cells
Source: ANIMAL CELLS AND SYSTEMS
Volume: 16
Issue: 2
Pages: 95-103
DOI: 10.1080/19768354.2011.628696
Published: APR 2012
Abstract: Asbestos exposure has been known to contribute to several lung diseases named asbestosis, malignant mesothelioma and lung cancer, but the disease-related
molecular and cellular mechanisms are still largely unknown. To examine the effects of asbestos exposure in human bronchial epithelial cells at gene level, the global gene
expression profile was analyzed following chrysotile treatment. The microarray results revealed differential gene expression in response to chrysotile treatment. The genes
up-and down-regulated by chrysotile were mainly involved in processes including metabolism, signal transduction, transport, development, transcription, immune response,
and other functions. The differential gene expression profiles could provide clues that might be used to understand the pathological mechanisms and therapeutic targets
involved in chrysotile-related diseases.
ISSN: 1976-8354
Record 15 of 50
By: Lustrato, G (Lustrato, Giuseppe); Alfano, G (Alfano, Gabriele); Andreotti, A (Andreotti, Alessia); Colombini, MP (Colombini, Maria Perla); Ranalli, G (Ranalli,
Giancarlo)
Author Identifiers:
Alfano, Gabriele H-3479-2012
lustrato, giuseppe H-3480-2012
ranalli, giancarlo H-3498-2012
Title: Fast biocleaning of mediaeval frescoes using viable bacterial cells
Source: INTERNATIONAL BIODETERIORATION & BIODEGRADATION
Volume: 69
Pages: 51-61
DOI: 10.1016/j.ibiod.2011.12.010
Published: APR 2012
Abstract: The 14th-century fresco Stories of the Holy Fathers (size 6.10 x 15.65 m), at Camposanto Monumentale in Pisa, Italy, was painted by Buonamico Buffalmacco.
The building housing it was damaged by a bomb during World War II and the fresco was quickly removed from the original walls under extremely dangerous conditions. It
was detached using the "tear-off" technique with gauze and a layer of warm animal glue, and it was then stored by rolling it up, without adding any rigid support. In a 1960s
restoration, an asbestos-cement support (eternit) was applied to the back and the gauze and thick layer of animal glue were removed from the front of the fresco. Early
alteration phenomena such as swelling and detachment of the paint layer were noticed. In 2008, the fresco was again detached from the Camposanto wall for further
restoration, which would include removal of residual traces of casein and animal glue from previous restorations and the reattachment of the paintings to a more suitable
support. On this fresco, the combined removal in one step of casein and animal glue was based on the fast application of whole, viable bacterial cells of Pseudomonas
stutzeri, A29 strain, to the fresco surface for a period of 2 h. An assessment of the effectiveness of the biological cleaning test was carried out using analytical pyrolysis. The
results confirmed the success of this advanced biological approach for recovering valuable frescoes, and gave insight into selecting the optimum conditions for fast-treatment
efficiency. Data on short- and medium-term microbial monitoring confirm both that viable cells are not present in the fresco after biotreatment and the absence of any
potentially negative effects that could have been caused by metabolism. The conclusion was that the procedure was safe, non-invasive, and risk-free. The relatively low-cost
of this biological cleaning process means that this biotechnological application represents a highly competitive, cost-effective solution. (C) 2012 Elsevier Ltd. All rights
reserved.
ISSN: 0964-8305
Record 16 of 50
Inventor(s): Albers, Ronald J.; Ayala, Leticia; Clareen, Steven S.; Delgado Mederos, Maria Mercedes; Hilgraf, Robert; Hegde, Sayee G.; Hughes, Kevin; Kois, Adam;
Plantevin-Krenitsky, Veronique; McCarrick, Meg; Nadolny, Lisa; Palanki, Moorthy S. S.; Sahasrabudhe, Kiran; Sapienza, John; Satoh, Yoshitaka; Sloss, Marianne K.;
Sudbeck, Elise; Wright, Jonathan
Title: Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
Patent Number: US 08101588
Patent Assignee: Signal Pharmaceuticals LLC
Source: Official Gazette of the United States Patent and Trademark Office Patents
Published: JAN 24 2012
Abstract: Provided herein are Aminopurine Compounds having the following structure: wherein R-1, R(2 )and R(3 )are as defined herein, compositions comprising an
effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an
inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary
hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a
5 di 17 24/02/14 22.28
patient in need thereof.
ISSN: 0098-1133
Accession Number: BCI:BCI201200137216
Record 17 of 50
Inventor(s): CHEN G; TAN X; WANG S
Title: Welding process and apparatus for major diameter roller
Patent Assignee: SHANGHAI BAOSTEEL EQUIP MAINTENANCE CO L
Record 18 of 50
Inventor(s): NIE X; WANG X
Title: Asbestos-containing material utilizing method for neutralizing e.g. a concrete asbestos plate involves heating the material that is mixed with sodium hydroxide and
sodium silicate water
Patent Assignee: NIE X
Accession Number: DIIDW:2012C91663
Record 19 of 50
Inventor(s): VANDENBUSSCHE F
Title: Method for flash heat treatment of e.g. materials by microwave radiation, involves heating material by stirring material and pre-heated bed for predetermined time so
that heat is transferred to material by conduction and convection
Patent Number: FR2976062-A1; FR2976062-B1
Patent Assignee: IDCO
Abstract: NOVELTY - The method involves preheating, by microwave radiation, a material bed (L) permeable to microwave radiation in a rotating bowl (2), so as to bring
the bed to predetermined flash heating temperature. A material to be treated (P) is introduced through an opening (4a) into the material bed as soon as the bed reaches the
predetermined temperature. The material to be treated is heated by stirring the material and the bed for predetermined time so that heat is transferred to the material by
conduction and convection from the bed and by microwave radiation, and the treated material is removed.
USE - Method for flash heat treatment of materials by microwave radiation. Uses include but are not limited to grains, granules, powder, paste, liquid, clay, silica, asbestos,
glass, slag, and mud.
ADVANTAGE - The material to be treated is heated by stirring the material and the pre-heated bed for the predetermined time, so that heat is transferred to the material by
conduction and convection from the bed and by microwave radiation, thus enabling effective and quick heating of the material between 1 second to 30 minutes at temperature
between 200 and 800 degrees Celsius. The method allows mixing of the material with the material bed, so as to ensure perfect homogeneity of heating. The method allows
the temperature of the bed to be maintained uniform and adequate during heating the material. The method allows precise regulation of the temperature and heating time,
allows continuous processing of materials, allows effective heat treatment of materials of small particle size, and provides exceptional product quality.
DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for a device for flash heat treatment.
DESCRIPTION Of DRAWING(S) - The drawing shows a schematic longitudinal sectional view of a flash heat treatment device.Material bed (L)Material to be treated
(P)Enclosure (1)Rotating bowl (2)Opening (4a)
Accession Number: DIIDW:2012Q94941
Record 20 of 50
Inventor(s): BAI Y; TANG Y; WANG C; YANG Y; ZHANG W; ZHU R
Title: Anti-freeze processing method for cold area concrete structure base, involves providing concrete structure base with frost layer mixed material, and processing
concrete structure base according to normal concrete base backfilling process
Patent Number: CN102587422-A
Patent Assignee: CHINA RAILWAY FIRST ENG CO LTD
Abstract: NOVELTY - The method involves heating asphalt at temperature of about 100 to 150 degrees centigrade. An asphalt coating device is uniformly coated and
melted on an outside surface of a concrete structure base. The concrete structure base is coated with an asphalt cool film. Asphalt mixed material is filled with asbestos
powder. Frost layer mixed material is uniformly coated with a bonding layer by a coating tool. The concrete structure base is provided with the frost layer mixed material.
The concrete structure base is processed according to normal concrete base backfilling process.
USE - Anti-freeze processing method for a cold area concrete structure base.
ADVANTAGE - The method enables performing anti-freeze treatment with simplified steps, low maintenance cost, convenient construction effect and high maintenance
quality, thus effectively preventing the concrete structure base from frost heaving force damage and improving stability.
DESCRIPTION Of DRAWING(S) - The drawing shows a flow diagram illustrating an anti-freeze processing method.'(Drawing includes non-English language text)'
Accession Number: DIIDW:2012L81783
Record 21 of 50
Inventor(s): SHINOHARA T
Title: Asbestos containing suspended matter combustion melting treatment apparatus for motor vehicle comprises tank which can be sealed, and vacuum pump which makes
the inside of the tank a negative-pressure state with respect to external air
Patent Number: JP2012096155-A; JP5192025-B2
Patent Assignee: CHUTOKU KENKI KK
6 di 17 24/02/14 22.28
Abstract: NOVELTY - An asbestos containing suspended matter combustion melting treatment apparatus (1) comprises tank (2) which can be sealed, and vacuum pump (3)
which makes the inside of the tank a negative-pressure state with respect to external air and connects with the tank and an engine (4) which burns air-fuel mixture of air and
fuel. The air-fuel mixture of the air and fuel containing asbestos needle crystal which the engine produced from the asbestos-containing waste material loaded up in the tank
is burned.
USE - Asbestos containing suspended matter combustion melting treatment apparatus for motor vehicle.
ADVANTAGE - The apparatus can detoxify asbestos needle crystal without requiring special reagent and apparatus.
DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for an asbestos containing suspended matter combustion melting treatment process involving loading
asbestos containing waste material up in the tank (2), intaking air fuel mixture of air and fuel which are produced in the tank to engine (4) which burns the air fuel mixture of
air and fuel and burning air fuel mixture of air and fuel containing asbestos needle crystal which the engine produced from asbestos-containing waste material loaded up in
the tank.
DESCRIPTION Of DRAWING(S) - The drawing shows a schematic view of the asbestos containing suspended matter combustion melting treatment apparatus.Asbestos
containing suspended matter combustion melting treatment apparatus (1)Tank (2)Vacuum pump (3)Engine (4)Dust removal apparatus (5)
Accession Number: DIIDW:2012G02096
Record 22 of 50
Inventor(s): YU X
Title: Drying box, has temperature control box connected provided with operating panel that is connected with temperature display, and asbestos refractory part equipped
with heating tube that is placed at side by side of box body
Patent Assignee: FANCHANG JINKE CASTING CO LTD
Abstract: NOVELTY - The box has a box body provided with a bottom part whose three sides are connected with fire-proof asbestos. An asbestos refractory part is
equipped with a heating tube. The heating tube is placed at a side by side of the box body. The heating tube is connected with a temperature control box. The temperature
control box is connected with an operating panel and a safety lock. The operating panel is connected with a temperature display.
USE - Drying box.
ADVANTAGE - The box can adjust display temperature of the temperature control box that clearly displays and accurately monitors heat treatment of a product. The box can
effectively avoid waste generation during heat treatment process. The operating panel is provided with the safety lock so as to ensure safety. The box reduces labor intensity
and saves production cost so as to improve production efficiency.
DESCRIPTION Of DRAWING(S) - The drawing shows a perspective view of a drying box.
Accession Number: DIIDW:2012E15147
Record 23 of 50
Inventor(s): THOMAS D G; PEARGIN T
Title: Method for treating volume of porous contaminated material e.g. oily waste, in fuel material e.g. vegetable oil, within reaction vessel to remediate soil, involves
initiating smoldering combustion process in portions of mixture
Patent Number: US2012288332-A1; WO2012154402-A1
Patent Assignee: CHEVRON USA INC
Abstract: NOVELTY - The method involves combining a porous contaminated material e.g. furan, with a fuel material (26) e.g. food-grade oil, to provide a combustible
mixture (22). A smoldering combustion process is initiated in multiple portions of the combustible mixture to remediate contaminated volume. A reaction vessel having a
subterranean ignition system (16) is provided. The ignition system is activated to initiate the smoldering combustion process in the reaction vessel. An oxidizer is distributed
into the reaction vessel to sustain the smoldering combustion process.
USE - Method for treating volume of a porous contaminated material e.g. asbestos fiber, oily waste, chlorinated solvent, polychlorinated biphenyl, dioxin, furan and
polynuclear aromatic hydrocarbon, in a fuel material e.g. liquid such as oily waste or soil contaminating oil waste, non-waste oil, vegetable oil or food-grade oil (all claimed),
within a reaction vessel to remediate soil. Can also be used for solid, solid and liquid mixture, natural gas, propane, butane, nitrogen or carbon dioxide.
ADVANTAGE - The method enables initiating the smoldering combustion process in the portions of the combustible mixture to remediate the volume of the contaminated
material in a better manner. The method enables providing a potentially inexpensive and effective treatment of the contaminated material, where an end product of a
combustion process can be reused.
DETAILED DESCRIPTION - The fuel material has a contaminated material selected from one of chlorinated solvent and asbestos fiber. INDEPENDENT CLAIMS are also
included for the following:(1) a method for performing a thermal treatment of a land holding contaminated material(2) a system for treating volume of porous contaminated
material(3) an article of manufacture storing a program for performing thermal treatment of a volume of a porous contaminated material.
DESCRIPTION Of DRAWING(S) - The drawing shows a schematic block diagram of a thermal treatment system with a reaction vessel in which a smoldering combustion
process is initiated to remediate a contaminated material.Thermal treatment system (10)Structure of reaction vessel (14)Subterranean ignition system (16)Actuators (18,
22)Air supply (20)Combustible mixture (22)Fuel material (26)
Record 24 of 50
Inventor(s): GRANT G; MAJOR D; GERHARD J; TORERO J; SCHOLES G; PIRONI P; SWITZER C
Title: Method for reducing volume of organic liquids i.e. sludge, by using self-sustained smoldering combustion, involves terminating source of heat applied to mixture to
initiate self-sustaining smoldering combustion of mixture
Patent Number: US2012272878-A1; WO2012149183-A1
Patent Assignee: GEOSYNTEC CONSULTANTS INC
Abstract: NOVELTY - The method involves admixing organic liquid with porous matrix material (103) to produce a mixture. A portion of the mixture is heated. An oxidant
(105) i.e. Oxygen, is forced through the mixture. A source of heat applied to the mixture is terminated to initiate self-sustaining smoldering combustion of the mixture and to
cause volumetric reduction of the organic liquid. A propagation of the combustion away from point of ignition of the combustion is caused. The organic liquid is aggregated
in a reaction vessel (101). The organic liquid is aggregated in a pile.
7 di 17 24/02/14 22.28
USE - Method for reducing volume of organic liquids e.g. sludge (claimed) such as hydrocarbon sludge, by using self-sustained smoldering combustion. Can also be used for
reducing volume of slurry and emulsion.
ADVANTAGE - The method enables designing the reaction vessel such that batch addition of fuel additive to the aggregate before to smoldering to ensures that smoldering
combustion is self-sustaining or the required temperature to reduce or remove contaminants in the matrix or organic liquid such as heavy metals or asbestos. The method
enables smoldering combustion to provide low energy requirements, more rapid treatment and effective treatment at low cost. The method enables providing combustion
products e.g. carbon dioxides, for self-sustaining smoldering combustion process, so that land filling of the organic liquid is not required, thus allowing the smoldering
combustion process to avoid need for the continuous addition of energy, heat or fuels as in an incineration process.
DETAILED DESCRIPTION - The porous matrix material is selected from a group comprising sand, soils, silt, loam, fill, cobbles, gravel, crushed stone, glass, ceramics,
zeolite, woodchips, charcoal, coal and drill cuttings.
DESCRIPTION Of DRAWING(S) - The drawing shows a cross-section view of a reaction vessel in which a conveyor or auger device is used to convey a continuous or
semi-continuous supply of an admixture of an organic liquid and porous matrix material to a smoldering combustion reaction front.Reaction vessel (101)Conveyor system
(102)Porous matrix material (103)Oxidant (105)Mixing or conveyor tool (106)Treated porous matrices (107, 109)
Record 25 of 50
Inventor(s): PU X
Title: Annealing fixture of cold-rolled thin deep-drawn steel belt, comprises a sizing block, asbestos arranged on a coil base, a convection plate, steel coils, bearing lantern
ring arranged on steel coil, bearing sleeves and a core winding sleeve
Patent Assignee: YONGXIN PRECISION MATERIAL WUXI CO LTD
Abstract: NOVELTY - Annealing fixture of cold-rolled thin deep-drawn steel belt, comprises a sizing block and asbestos arranged on a coil base. The fixture further
comprises a convection plate arranged between two adjacent steel coils. The convection plate is fixed on a bearing lantern ring. The bearing lantern ring is arranged on the
periphery of the steel coil. The entire central parts of the convention plates are equipped with bearing sleeves. The bearing sleeve is arranged in a core winding sleeve of the
steel coil.
USE - Used as an annealing fixture of cold-rolled thin deep-drawn steel belt.
ADVANTAGE - The fixture comprising the convention plate are sequentially stacked which prevents each layer from bearing weight from the upper steel coil layer, and
bonding of the steel belts whose thickness is not greater than 0.1 mm during the annealing process; ensures the product quality; prevents the product from scraping; carries
out processing of many steel coils in the same furnace; saves the cost of annealing treatment, and thus is economical; and reduces the energy loss.
Record 26 of 50
Inventor(s): LIU N; WANG J; SHI Z; YUE W
Title: Natural medicinal composition useful in preparing medicine e.g. for reducing vomiting resulted from cancer chemotherapy, comprises e.g. decoction concentrated
extract of Zingiber and Piper longum, gingerol, and piperine
Patent Number: CN102526666-A
Patent Assignee: UNIV QINGDAO
Abstract: NOVELTY - Natural medicinal composition comprises decoction concentrated extract of Zingiber and Piper longum, gingerol, ethanol extract of Piper longum,
and piperine. The preparation of the decoction concentrated extract of Zingiber and Piper longum comprises taking Zingiber and Piper longum, adding distilled water, heating
and decocting, filtering, adding distilled water, decocting and filtering the decoction residue, mixing filtrates, heating and concentrating, filtering, vacuum extracting and
drying to obtain brown yellow powder.
USE - The natural medicinal composition is useful in preparing medicine for reducing vomiting resulted from cancer chemotherapy, and enhancing efficacy of cancer
treatment (claimed).
ADVANTAGE - The composition has good treatment effect to vomiting and other side effects resulted from cancer chemotherapy and can inhibit the tumor at the same time.
DETAILED DESCRIPTION - Natural medicinal composition comprises decoction concentrated extract of Zingiber and Piper longum, gingerol, ethanol extract of Piper
longum, and piperine in a ratio of 2-8:1-4:2-4:3-9. The preparation of the decoction concentrated extract of Zingiber and Piper longum comprises taking Zingiber and Piper
longum according to a ratio of 1:1 or 1-4:1, adding 10 times of distilled water to soak the materials for 1 hour, heating and decocting the materials for 1 hour on an electric
furnace with a asbestos wire gauze, filtering the mixture using silk filter, keeping the filtrate, adding 6 times of distilled water to the decoction residue, soaking, decocting and
filtering the decoction residue by the same method, mixing twice filtrates, heating and concentrating the filtrate to have a small volume, filtering the filtrate by an ultra-
filtration membrane, vacuum extracting and drying the filtrate by a vacuum drying oven at 70 degrees C for 36 hours to obtain brown yellow powder as the final product. The
preparation of the gingerol comprises slicing the Zingiber, naturally drying the sliced Zingiber, crushing the sliced Zingiber into powders by a high-speed universal grinder,
screening the powder by a sieve of 30 meshes, placing the fine powder passing through the sieve in a large ground glass bottle (5000 ml), soaking the powder with 6 times of
acetone for 72 hours, carrying out ultrasonic extraction for 15 minutes at an ultrasonic frequency of 40 KHz, centrifuging the mixture to obtain the supernatant, discarding the
residues, vacuum extracting and filtering the supernatant, placing the filtrate in a rotary evaporator to be concentrated in vacuum to obtain Zingiber oil mixture,
concentrating, drying and purifying the mixture for multiple times to obtain the product. The preparation of the ethanol extract of Piper longum comprises drying and
crushing Piper longum, screening the powder, soaking the powder with 7-10 times of ethanol for 12 hours, filtering the solution to obtain the clarified solution, soaking
continuously the residues for 12 hours, mixing twice filtrates, centrifuging the filtrate for 15 minutes at 3000 revolutions/minute, separating the supernatant, evaporating and
concentrating the supernatant in a water bath, vacuum drying the supernatant into dry extract, crushing the extract, screening the powder by a sieve of 100 meshes to obtain
the product. The preparation of the piperine comprises crushing the Piper longum particles into 20 meshes, soaking the particles for 12 hours with 7-10 times of ethanol,
filtering the mixture to obtain the clarified solution, soaking continuously the residues for 12 hours, mixing twice filtrates, vacuum extracting and concentrating the filtrate to
be viscous, placing statically the concentrated solution for 1-2 days at a cool place, separating out the piperine, filtering the piperine to obtain a crude product, dissolving the
dry crude product in ether, cleaning the crude product 3 times with potassium hydroxide (10%), collecting the ether layer, evaporating and removing the ether to obtain light
yellow solid powder, dissolving the obtained powder in ethanol, decolorizing and re-crystallizing mixture by activated carbon to obtain monoclinic prismatic crystallized
piperine. An INDEPENDENT CLAIM is also included for preparing the natural medicinal composition, comprising (i) preparing decoction concentrated extract of Zingiber
and Piper longum according to the above mentioned process, (ii) preparing gingerol according to the above mentioned process, (iii) preparing ethanol extract of Piper longum
according to the above mentioned process, (iv) preparing piperine according to the above mentioned process, and (v) mixing uniformly the decoction concentrated extract of
Zingiber and Piper longum, gingerol, ethanol extract of Piper longum, and piperine according to a ratio to obtain the finished product.
8 di 17 24/02/14 22.28
Record 27 of 50
Inventor(s): TRUSOV V A
Title: Rotating melting furnace for processing of nonferrous wastes, has cylindrical housing, burner device, charging loading, tap hole for melted metal drainage and tap hole
for liquid slag
Patent Number: RU2458302-C1
Patent Assignee: TRUSOV V A
Abstract: NOVELTY - Furnace consists in cylindrical housing, burner device, charging loading, tap hole for melted metal drainage and tap hole for liquid slag. Furnace also
has heat-insulating layer that consists of four layers of asbestos-sheet millboard and layer of lightweight chamotte that is covered by refractory layer from mullite-corundum
mass. Burner device is presented by gas induction burner fixed in the cover that closes charging hole located in the front end wall of the furnace. Burner has thirteen agitators,
five of which are equipped with nozzles and located in the centre with provision of flame 2.6 m long, and eight agitators are located along the periphery with provision of
flame 1.5 m long in case of gas-air mixture combustion. Note that the furnace is done with the possibility of operation on natural and artificial draft with the system of gas
treatment for obtaining ecologically pure process that consists of mixing chamber, smoke exhauster, gas treatment machine, cyclone and framed bag-type filter.
USE - Metallurgy.
ADVANTAGE - Invention allows decreasing emission of hazardous substances into the atmosphere, decreasing heat loss and extension of furnace service life.3 cl, 8 dwg
Accession Number: DIIDW:2012K50758
Record 28 of 50
By: Gordon, Gavin
Title: E-GEOD-2549.processed.1.zip.
Source: ArrayExpress Archive
Source URL: http://www.ebi.ac.uk/arrayexpress/files/E-GEOD-2549/E-GEOD-2549.processed.1.zip
Published: 2012-06-10
Abstract: Malignant pleural mesothelioma (MPM) is a highly lethal, poorly understood neoplasm that is typically associated with asbestos exposure. We performed
transcriptional profiling using high-density oligonucleotide microarrays containing approximately 22,000 genes to elucidate potential molecular and pathobiological
pathways in MPM using discarded human MPM tumor specimens (n=40), normal lung specimens (n=4), normal pleura specimens (n=5), and MPM and SV40-immortalized
mesothelial cell lines (n=5). In global expression analysis using unsupervised clustering techniques, we found two potential subclasses of mesothelioma which correlate
loosely with tumor histology. We also identified sets of genes with expression levels that distinguish between multiple tumor subclasses, normal and tumor tissues, and
tumors with different morphologies. Microarray gene expression data were confirmed using quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) and
protein analysis for three novel candidate oncogenes (NME2, CRI1, and PDGFC) and one candidate tumor suppressor (GSN). Finally, we used bioinformatics tools (i.e.
software) to create and explore complex physiological pathways that may be relevant in mesothelioma tumorigenesis, pathobiology, or both. Tissues and cell lines profiled
using microarrays. Discarded MPM surgical specimens (n=40), normal pleura specimens (n=5), and normal lung specimens (n=4) were freshly collected (and snap frozen)
from patients who underwent surgery at Bostons Brigham and Womens Hospital (BWH) between October 1998 and August 2000. All of these patients underwent
extrapleural pneumonectomy with heated intra-pleural cisplatin chemotherapy delivered after the specimens were removed. All normal specimens were obtained from
patients who were never diagnosed with MPM. Two human MPM cell lines (MS589 and MS428) were kindly provided by Jonathan A. Fletcher, M.D., Department of
Pathology, BWH. The JMN1B MPM cell line19,20 has been described previously. The SV40-immortalized, non-tumorigenic mesothelial cell line (Met-5A)21 and the MPM
cell line MSTO-211H22 were purchased from the American Type Culture Collection. Normal tissues were obtained from additional consented patients undergoing treatment
for diseases other than MPM. All MPM samples used in these studies contained relatively pure tumor (greater than 50% tumor cells per high power field examined in a
section adjacent to the tissue used). The microscopic slides from the patients resection specimens were reviewed by one of the authors (J.G.), and the diagnosis and histologic
subclassification of MPM confirmed in all cases. Linked clinical and pathological data were obtained for all patients who contributed tumor specimens. Specimens and data
were rendered anonymous to protect patient confidentiality. Studies utilizing human tissues were approved by and conducted in accordance with the policies of the
Institutional Review Board at BWH. SUBMITTER_CITATION: Gordon, G. J., Rockwell, G. N., Jensen, R. V., Rheinwald, J. G., Glickman, J.N., Aronson, J. P., Pottorf, B.
J., Nitz, M. D., Richards, W. G., Sugarbaker, D. J., and Bueno, R. Identification of novel candidate oncogenes and tumor suppressors in malignant pleural mesothelioma
using large-scale transcriptional profiling. American Journal of Pathology, 166: 1827-1840, 2005.
Accession Number: DRCI:DATA2012149001332909
Record 29 of 50
By: Shukla, A; MacPherson, MB; Hillegass, J; Ramos-Nino, ME; Alexeeva, V; Vacek, PM; Bond, JP; Pass, HI; Steele, C; Mossman, BT
Abstract: Human mesothelial cells (LP9/TERT-1) were exposed to low and high (15 and 75 m2/cm2 dish) equal surface area concentrations of crocidolite asbestos,
nonfibrous talc, fine titanium dioxide (TiO2), or glass beads for 8 or 24 h. RNA was then isolated for Affymetrix microarrays, GeneSifter analysis and QRT-PCR. Gene
changes by asbestos were concentration- and time-dependent. At low nontoxic concentrations, asbestos caused significant changes in mRNA expression of 29 genes at 8 h
and 205 genes at 24 h, whereas changes in mRNA levels of 236 genes occurred in cells exposed to high concentrations of asbestos for 8 h. Human primary pleural
mesothelial cells also showed the same patterns of increased gene expression by asbestos. Nonfibrous talc at low concentrations in LP9/TERT-1 mesothelial cells caused
increased expression of 1 gene Activating Transcription Factor 3 (ATF3) at 8 h and no changes at 24 h, whereas expression levels of 30 genes were elevated at 8 h at high talc
concentrations. Fine TiO2 or glass beads caused no changes in gene expression. In human ovarian epithelial (IOSE) cells, asbestos at high concentrations elevated expression
of 2 genes (NR4A2, MIP2) at 8 h and 16 genes at 24 h that were distinct from those elevated in mesothelial cells. Since ATF3 was the most highly expressed gene by
asbestos, its functional importance in cytokine production by LP9/TERT-1 cells was assessed using siRNA approaches. Results reveal that ATF3 modulates production of
inflammatory cytokines (IL-1SS, IL-13, G-CSF) and growth factors (VEGF and PDGF-BB) in human mesothelial cells. Microarrays were performed on samples from 3
independent experiments. All cell types, time points, and mineral types and concentrations were included in all 3 experiments. For each experiment, n=3 dishes were pooled
into one sample per treatment group. Each of the pooled samples was analyzed on a separate array, i.e., n=3 arrays per condition (3 independent biological replicates). We
tested the hypothesis that alteration in gene expression in human cells correlate with mineral pathogenicity. We used GeneSifter program to analyze our data and pairwise
analysis showed that number of gene changes correlate with toxicity of pathogenic minerals. While non-pathogenic minerals glass beads and fine TiO2 treatment to cell
resulted in no gene change, crocidolite asbestos caused maximum number of gene changes followed by talc.
9 di 17 24/02/14 22.28
Record 30 of 50
By: Tang, Naimei; Zhang, Xinbo
Abstract: Malignant pleural mesothelioma (MPM), which is associated with occupational asbestos exposure, is a deadly disease with no effective treatments due mainly to
its high resistance to anti-cancer drugs. The molecular mechanisms responsible for its chemotherapeutic resistance are complicated and undefined. However, the presence of
side population cells (SP cells) in tumors is a well-accepted explanation for their anti-cancer drug resistance. To identify SP cell-specific gene expression signature,
microarray technique has been employed. Our data show differential gene expression profiles between SP and non-SP cells of H2714 mesothelioma cells. SP cells
over-expressed genes associated with cancer stem cell (CSC) and drug resistance: DUSP6, SPRY2 and IL6, as well as multi-pathways, including the cancer stem
cell-associated pathways Notch and c-Kit. Therefore, we believe that targeting CSC-specific genes and pathways in SP cells may hold the key to the discovery of effective
treatments for reversing chemotherapeutic resistance to MPM treatment. 4 samples.
Record 31 of 50
By: ; 3|; ||
By: Ding Wenjin; Peng Tongjiang; Chen Jiming
Title: Effects of nucleation and crystallization temperature on preparation of glass-ceramics with chrysotile asbestos tailing
Title: |||[,{|[(]|\([
Source: Transactions of Materials and Heat Treatment
Source: )J|
Volume: 33
Issue: 5
Pages: 28-33
Article Number: 1009-6264(2012)33:5<28:HHHJHW>2.0.TX;2-P
Published: 2012
Abstract: Glass-ceramics was prepared with chrysotile asbestos tailing,limestone and quartz sand as primary material by different processes.Effects of nucleation
temperature and crystallization temperature on crystallization behavior,microstructure and compressive strength of glass-ceramics samples were analyzed by means of
DTA,XRD,SEM and other analytical methods.The results show that with the increasing of heat treatment temperature,the species of the main crystalline is the same,but the
intensity of XRD peak increase first,and then decrease.The glass-ceramics samples with best properties are obtained by nucleating at 820 ! and crystallizing at 1050 !.The
glass-ceramics sample consisting of small columnar crystals has high compressive strength of 523 MPa.
Abstract: ){|[(.{[{{9[,}[),|J]|\(,][DTA.XRD]SEM;||[,[;|||[
,|\(||,.|j]]|][[,;9,|:|J[)(,|\(|,|q,j|]@|][|])
g,||[,820!,|[,1050!|,|\(|pjU||;|,|][]]7523 MPa,
ISSN: 1009-6264
Record 32 of 50
Inventor(s): VANDENBUSSCHE F
Title: Continuous heat treatment device for dividing e.g. grains, in industrial application, has conveying and stirring units provided with mixing blades that are provided over
portion in length direction
Patent Number: WO2012045923-A1; FR2965907-A1
Patent Assignee: IDCO INNOVATION&DEV CO
Abstract: NOVELTY - The device has a microwave-impermeable enclosure (1) comprising an inlet and an outlet. An introducing unit (2) introduces a product (P) to be
treated into the enclosure. A discharging unit discharges the product from the enclosure. A waveguide (5) is placed between a microwave generator (4) and the enclosure.
Conveying and stirring units (6, 12) conveys and stirs the product. The conveying and stirring units are provided with mixing blades (19) that are provided over a portion in a
length direction.
USE - Continuous heat treatment device for dividing materials using microwave radiation in an industrial application such as drying, cooking, expansion, decontamination
and chemical processes. Uses include but are not limited to grains, aggregates, powders, pastes, liquid, mineral or organic origin e.g. clay, silica and asbestos, glass, blast-
furnace slag, mud and homogenates.
ADVANTAGE - The conveying and stirring units convey and stir the product, and are provided with the mixing blades that are provided over the portion in the length
direction, so that the device can perform uninterrupted heat treatment and adjustable mixing of the product in an effective manner.
DESCRIPTION Of DRAWING(S) - The drawing shows a cross-sectional view of a continuous heat treatment device.Product (P)Microwave-impermeable enclosure
(1)Introducing unit (2)Microwave generator (4)Waveguide (5)Conveying and stirring units (6, 12)Mixing blades (19)
Accession Number: DIIDW:2012E24651
Record 33 of 50
10 di 17 24/02/14 22.28
By: Fiorelli, J (Fiorelli, Juliano); Schmidt, R (Schmidt, Rene); Kawabata, CY (Kawabata, Celso Yoji); de Oliveira, CEL (Lins de Oliveira, Celso Eduardo); Savastano, H
(Savastano Junior, Holmer); Rossignolo, JA (Rossignolo, Joao Adriano)
Author Identifiers:
Savastano Junior, Holmer B-8369-2012 0000-0003-1827-1047
Title: Thermal efficiency of fiber cement corrugated sheets applied to individual housing for calves exposed to sun and shade
Source: CIENCIA RURAL
Volume: 42
Issue: 1
Pages: 64-67
Published: JAN 2012
Abstract: This research presents a study of roof thermal efficiency in individual housing for calves exposed to sun and shade through infrared thermography, internal
temperature and thermal comfort indexes. Four different individual housing for calves covered with asbestos-free fiber-cement corrugated sheets were evaluated. Three of
them were directly exposed to the sun: (i) corrugated sheets painted white in the external surface, (ii) corrugated sheets without painting and (iii) with screen shade fabric
installed 0.10m under de internal surface of the corrugated sheet. The fourth individual housing was installed in the shade area and covered with unpainted corrugated fiber-
cement sheets. The analysis was taken for 21 days at 11h00min, 14h00min and 17h00min. The results indicate significant variations in the roofing surface temperature and
thermal comfort indexes among the treatments exposed to the sun and shade, for all the evaluations during the day. The infrared thermography images were effective for
better understanding the heat transfer processes from the roof to the internal environment of the housing.
ISSN: 0103-8478
Record 34 of 50
By: Holmes, EP (Holmes, Emma P.); Wilson, J (Wilson, Julie); Schreier, H (Schreier, Hans); Lavkulich, LM (Lavkulich, Les M.)
Title: Processes affecting surface and chemical properties of chrysotile: Implications for reclamation of asbestos in the natural environment
Source: CANADIAN JOURNAL OF SOIL SCIENCE
Volume: 92
Issue: 1
Special Issue: 1
Pages: 229-242
DOI: 10.4141/CJSS2010-014
Published: JAN 2012
Abstract: Holmes, E.P., Wilson, J., Schreier, H. and Lavkulich, L.M. 2012. Processes affecting surface and chemical properties of chrysotile: Implications for reclamation of
asbestos in the natural environment. Can. J. Soil Sci. 92: 229-242. A landslide at the headwaters of the Sumas River in southwestern British Columbia, is a seasonal and
episodic source of chrysotile asbestos to the floodplain soil. Fresh alluvial deposits of fibres have potential for aeolian movement, posing a health risk to the Sumas watershed
population. To understand the effects aquatic and pedogenic processes have on the fibres, asbestos materials from the river and floodplain were subjected to organic acid
treatments in the laboratory. Changes were monitored by X-ray diffraction, scanning electron microscopy and elemental analysis. Fibre surfaces modified by organic acid
treatments were similar to those affected by natural processes in that they showed a high loss of elements from the brucite layer compared with the silica tetrahedral layer,
and the surfaces became smoother due to the loss of a rough amorphous coating. To initiate sustainable reclamation practices, changes in fibre surfaces by natural processes
need to be considered and enhanced by incorporation of organic amendments that produce complexing soil acids. Reclamation activities should focus on recently deposited
sediment along the floodplain. Non-polluting organic material, such as peat, compost and sawdust could be applied to increase reaction potential and kinetics of the reaction
of chrysotile with naturally occurring acids.
ISSN: 0008-4271
Record 35 of 50
By: Colangelo, F (Colangelo, F.); Cioffi, R (Cioffi, R.); Lavorgna, M (Lavorgna, M.); Verdolotti, L (Verdolotti, L.); De Stefano, L (De Stefano, L.)
Author Identifiers:
Colangelo, Francesco I-2147-2013
Title: Treatment and recycling of asbestos-cement containing waste
Source: JOURNAL OF HAZARDOUS MATERIALS
Volume: 195
Pages: 391-397
DOI: 10.1016/j.jhazmat.2011.08.057
Published: NOV 15 2011
Abstract: The remediation of industrial buildings covered with asbestos-cement roofs is one of the most important issues in asbestos risk management. The relevant Italian
Directives call for the above waste to be treated prior to disposal on landfill. Processes able to eliminate the hazard of these wastes are very attractive because the treated
products can be recycled as mineral components in building materials. In this work, asbestos-cement waste is milled by means of a high energy ring mill for up to 4 h. The
very fine powders obtained at all milling times are characterized to check the mineralogical and morphological transformation of the asbestos phases. Specifically, after 120
min of milling, the disappearance of the chrysotile OH stretching modes at 3690 cm(-1), of the main crystalline chrysotile peaks and of the fibrous phase are detected by
means of infrared spectroscopy and X-ray diffraction and scanning electron microscopy analyses, respectively. The hydraulic behavior of the milled powders in presence of
lime is also tested at different times. The results of thermal analyses show that the endothermic effects associated to the neoformed binding phases significantly increase with
curing time. Furthermore, the technological efficacy of the recycling process is evaluated by preparing and testing hydraulic lime and milled powder-based mortars. The
complete test set gives good results in terms of the hydration kinetics and mechanical properties of the building materials studied. In fact, values of reacted lime around 40%
11 di 17 24/02/14 22.28
and values of compressive strength in the range of 2.17 and 2.29 MPa, are measured. (C) 2011 Elsevier B.V. All rights reserved.
ISSN: 0304-3894
Record 36 of 50
By: Prasauskas, T (Prasauskas, Tadas); Martuzevicius, D (Martuzevicius, Dainius); Krugly, E (Krugly, Edvinas); Kliucininkas, L (Kliucininkas, Linas); Kireitseu, M
(Kireitseu, Maksim); Zerrath, A (Zerrath, Axel)
Title: Comparative characterization of particle emissions from asbestos and non-asbestos cement roof slates
Source: BUILDING AND ENVIRONMENT
Volume: 46
Issue: 11
Pages: 2295-2302
DOI: 10.1016/j.buildenv2011.05.010
Published: NOV 2011
Abstract: The first aim of this study was to characterise total and size-fractionated particulate matter (PM) aerosol, including fibres, released from the processing operations
of cement roofing slates. The second aim was to compare particle emissions from asbestos-cement and non-asbestos cement sheets, with respect to total and size-fractionated
particulate matter as well as fibres emissions. Asbestos and cellulose-based cement sheets were compared during slate treatment processes, namely crushing, rubbing, rasping
and scrubbing. Generated PM and fibres were classified by a variety of methods (PM2.5 and PM10 cyclones, aerodynamic particle spectrometer and optical particle counter).
A substantial variation in the mass of generated particles has been noticed, both within each PM fraction and between different treatment processes. The PM10/PMtotal
concentration ratio ranged from 70 to 98% and PM2.5/PMtotal ratio equalled to similar to 20%. The new generation non-asbestos sheets produced three times higher PM
emissions than asbestos-cement sheets during crushing operation. Particle size distribution of number concentrations was mostly bimodal (two modes at 0.5 and 2.5 mu m).
With respect to fibres, the release of cellulose fibres from non-asbestos slates was from 1.8 to 13 times lower in comparison with asbestos fibres. At the same time, cellulose
fibre length was 1.4-1.6 times lower. Hence, new generation non-asbestos roofing slates were proved to be less hazardous from the point of view of fibre release, but more
hazardous with respect to total particle release. (C) 2011 Elsevier Ltd. All rights reserved.
ISSN: 0360-1323
Record 37 of 50
By: Davis, Cassandra; Vijaykumar, Jayaprabha; Lackovic, Michelle; Diaz, James H
Title: Asbestosis in Louisiana: a descriptive review and demographic analysis of hospitalizations for abestosis, 1999-2009.
Source: The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society
Volume: 163
Issue: 6
Pages: 336-41
Published: 2011 Nov-Dec
Abstract: Asbestosis is a debilitating, chronic, lung disease with no known treatment and most commonly occurs among workers in certain occupational settings. As a
condition highly associated with occupational exposure, its incidence has been affected by changes in industry standards. In particular, the bans on both production and new
uses of asbestos fibers put in place during the past 20 to 30 years have significantly reduced occupational exposures. Despite these restrictions, asbestos can still be found in
many products. Louisiana has more facilities that produce, process, or use asbestos than any other state in the US. Health outcomes associated with asbestos exposure include
asbestosis, mesothelioma, and lung cancer. To evaluate the impact of asbestos exposure on Louisiana residents, Louisiana Hospital Inpatient Discharge Data (LAHIDD) from
1999-2009 was analyzed. Results indicate that asbestosis hospitalizations have remained steady over the 11-year period with approximately 295 cases per year. White males
have the highest rates, and cases are clustered geographically. Overall, Louisiana's rate is significantly greater than the US rate (p < 0.0001).
ISSN: 0024-6921
Record 38 of 50
By: Zucali, PA (Zucali, P. A.); Ceresoli, GL (Ceresoli, G. L.); De Vincenzo, F (De Vincenzo, F.); Simonelli, M (Simonelli, M.); Lorenzi, E (Lorenzi, E.); Gianoncelli, L
(Gianoncelli, L.); Santoro, A (Santoro, A.)
Title: Advances in the biology of malignant pleural mesothelioma
Source: CANCER TREATMENT REVIEWS
Volume: 37
Issue: 7
Pages: 543-558
DOI: 10.1016/j.ctrv.2011.01.001
Published: NOV 2011
Abstract: Malignant pleural mesothelioma is a highly aggressive cancer with a very poor prognosis. Although the mechanism of carcinogenesis is not fully understood,
approximately 80% of malignant pleural mesothelioma can be attributed to asbestos fiber exposure. This disease is largely unresponsive to conventional chemotherapy or
radiotherapy, and most patients die within 10-17 months of their first symptoms. Currently, malignant pleural mesothelioma therapy is guided by clinical stage and patient
characteristics rather than by the histological or molecular features of the tumor. Several molecular pathways involved in malignant pleural mesothelioma have been
identified: these include cell cycle regulation, apoptosis, growth factor pathways, and angiogenesis. Unfortunately, several agents targeting these processes, including
erlotinib, gefitinib, and imatinib, have proven ineffective in clinical trials. A greater understanding of the molecular pathways involved in malignant pleural mesothelioma is
needed to develop better diagnostics, therapeutics, and preventative measures. Moreover, understanding the biological basis of mesothelioma progression may facilitate
12 di 17 24/02/14 22.28
personalized treatment approaches, and early identification of poor prognostic indicators may help reduce the heterogeneity of the clinical response. This paper reviews
advances in the molecular biology of malignant pleural mesothelioma in terms of pathogenesis, the major molecular pathways and the associated therapeutic strategies, and
the roles of biomarkers. (C) 2011 Elsevier Ltd. All rights reserved.
ISSN: 0305-7372
Record 39 of 50
By: Gelain, DP (Gelain, Daniel Pens); Pasquali, MAD (de Bittencourt Pasquali, Matheus Augusto); Caregnato, FF (Caregnato, Fernanda Freitas); Moreira, JCF (Fonseca
Moreira, Jose Claudio)
Author Identifiers:
Gelain, Daniel I-5144-2013 0000-0001-5254-0509
Title: Vitamin A (retinol) up-regulates the receptor for advanced glycation endproducts (RAGE) through p38 and Akt oxidant-dependent activation
Source: TOXICOLOGY
Volume: 289
Issue: 1
Pages: 38-44
DOI: 10.1016/j.tox.2011.07.008
Published: OCT 28 2011
Abstract: Retinol (vitamin A) is believed to exert preventive/protective effects against malignant, neurodegenerative and cardiovascular diseases by acting as an antioxidant.
However, later clinical and experimental data show a pro-oxidant action of retinol and other retinoids at specific conditions. The receptor for advanced glycation endproducts
(RAGE) is a pattern recognition receptor, being activated by different ligands such as S100 proteins, HMGB1 (amphoterin), beta-amyloid peptide and advanced glycation
endproducts (AGE). RAGE activation influences a wide range of pathological conditions such as diabetes, pro-inflammatory states and neurodegenerative processes. Here,
we investigated the involvement of different mitogen-activated protein kinases (MAPK: ERK1/2, p38 and JNK), PKC, PKA and Akt in the up-regulation of RAGE by
retinol. As previously reported, we observed that the increase in RAGE immunocontent by retinol is reversed by antioxidant co-treatment, indicating the involvement of
oxidative stress in this process. Furthermore, the p38 inhibitor SB203580 and the Akt inhibitor LY294002 also decreased the effect of retinol on RAGE levels, suggesting the
involvement of these protein kinases in such effect. Both p38 and Akt phosphorylation were increased by treatment with pro-oxidant concentrations of retinol, and the
antioxidant co-treatment blocked this effect, indicating that activation of p38 and Akt during retinol treatment is dependent on reactive species production. The 2',7'-
dichlorohydrofluorescein diacetate (DCFH) assay also indicated that retinal treatment enhances cellular reactive species production. Altogether, these data indicate that
RAGE up-regulation by retinol is mediated by the free radical-dependent activation of p38 and Akt. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
ISSN: 0300-483X
Record 40 of 50
By: Bernardo, E (Bernardo, E.); Esposito, L (Esposito, L.); Rambaldi, E (Rambaldi, E.); Tucci, A (Tucci, A.)
Title: Sintered glass ceramic articles from plasma vitrified asbestos containing waste
Source: ADVANCES IN APPLIED CERAMICS
Volume: 110
Issue: 6
Pages: 346-352
DOI: 10.1179/1743676111Y.0000000020
Published: AUG 2011
Abstract: Plasma vitrification is a safe technique for eliminating the environmental impact of asbestos containing materials. Additional advantages may arise from the
obtainment of valuable ceramics from vitrified waste if low cost treatments, comparable to those applied to traditional ceramics, are feasible. In the present paper, the
application of a fast heating rate (40 degrees C min(-1)) to produce dense sinter crystallised materials from vitrified asbestos containing waste, having strength in excess of
100 MPa, is discussed. Sinter crystallisation, with fast heating processes, constituted also the basis of cellular glass ceramics and a new type of stoneware, with waste glass
replacing conventional feldspar fluxes.
ISSN: 1743-6753
Record 41 of 50
By: Py, X (Py, Xavier); Calvet, N (Calvet, Nicolas); Olives, R (Olives, Regis); Meffre, A (Meffre, Antoine); Echegut, P (Echegut, Patrick); Bessada, C (Bessada, Catherine);
Veron, E (Veron, Emmanuel); Ory, S (Ory, Sandra)
Author Identifiers:
VERON, Emmanuel C-1825-2008
Echegut, Patrick B-3990-2013
Title: Recycled Material for Sensible Heat Based Thermal Energy Storage to be Used in Concentrated Solar Thermal Power Plants
Source: JOURNAL OF SOLAR ENERGY ENGINEERING-TRANSACTIONS OF THE ASME
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Volume: 133
Issue: 3
Article Number: 031008
DOI: 10.1115/1.4004267
Published: AUG 2011
Abstract: Current technologies of concentrated solar power plants (CSP) are under extensive industrial development but still suffer from lack of adapted thermal energy
storage (TES) materials and systems. In the case of extended storage (some hours), thousands of tonnes of materials are concerned leading to high investment cost, high
energy and GHG contents and major conflicts of use. In this paper, recycled industrial ceramics made by vitrification of asbestos containing wastes (ACW) are studied as
candidates to be used as sensible TES material. The material presents no hazard, no environmental impact, good thermophysical properties (lambda= 1.4 W m(-1) K(-1); Cp
= 1025 J kg(-1) K(-1); rho= 3100 kg m(-3)) and at very low investment cost. Thanks to the vitrification process of the wastes, the obtained ceramics is very stable up to 1200
degrees C and can be directly manufactured with the desired shape. The vitrified ACW can be used as TES material for all kinds of the CSP processes (from medium up to
high concentration levels) with properties in the same range than other available materials but with lower cost and without conflict of use. The proposed approach leads also
to sustainable TES allowing a pay back of the energy needed for the initial waste treatment. Furthermore, this new use of the matter can enhance the waste treatment industry
instead of land fill disposal. [DOI: 10.1115/1.4004267]
ISSN: 0199-6231
Record 42 of 50
By: Kim, JS (Kim, Jin Sik); Lee, K (Lee, Kyu); Lee, YH (Lee, Young Hee); Cho, HS (Cho, Hyun Sun); Kim, KH (Kim, Ki Heon); Choi, KH (Choi, Kyung Hee); Lee, SH
(Lee, Sang Hee); Song, KS (Song, Kyung Seuk); Kang, CS (Kang, Chang Soo); Yu, IJ (Yu, Il Je)
Author Identifiers:
Lee, Young Hee A-5424-2013
Title: Aspect ratio has no effect on genotoxicity of multi-wall carbon nanotubes
Source: ARCHIVES OF TOXICOLOGY
Volume: 85
Issue: 7
Pages: 775-786
DOI: 10.1007/s00204-010-0574-0
Published: JUL 2011
Abstract: Carbon nanotubes (CNTs) have specific physico-chemical and electrical properties that are useful for telecommunications, medicine, materials, manufacturing
processes and the environmental and energy sectors. Yet, despite their many advantages, it is also important to determine whether CNTs may represent a hazard to the
environment and human health. Like asbestos, the aspect ratio (length:diameter) and metal components of CNTs are known to have an effect on the toxicity of carbon
nanotubes. Thus, to evaluate the toxic potential of CNTs in relation to their aspect ratio and metal contamination, in vivo and in vitro genotoxicity tests were conducted using
high-aspect-ratio (diameter: 10-15 nm, length: similar to 10 mu m) and low-aspect-ratio multi-wall carbon nanotubes (MWCNTs, diameter: 10-15 nm, length: similar to 150
nm) according to OECD test guidelines 471 (bacterial reverse mutation test), 473 (in vitro chromosome aberration test), and 474 (in vivo micronuclei test) with a good
laboratory practice system. To determine the treatment concentration for all the tests, a solubility and dispersive test was performed, and a 1,2-dipalmitoyl-sn-glycero-
3-phosphocholine (DPPC) solution found to be more suitable than distilled water. Neither the high- nor the low-aspect-ratio MWCNTs induced any genotoxicity in a bacterial
reverse mutation test (similar to 1,000 mu g/plate), in vitro chromosome aberration test (without S9: similar to 6.25 mu g/ml, with S9: similar to 50 mu g/ml), or in vivo
micronuclei test (similar to 50 mg/kg). However, the high-aspect-ratio MWCNTs were found to be more toxic than the low-aspect-ratio MWCNTs. Thus, while
high-aspect-ratio MWCNTs do not induce direct genotoxicity or metabolic activation-mediated genotoxicity, genotoxicity could still be induced indirectly through oxidative
stress or inflammation.
ISSN: 0340-5761
Record 43 of 50
By: Osmond-McLeod, MJ (Osmond-McLeod, Megan J.); Poland, CA (Poland, Craig A.); Murphy, F (Murphy, Fiona); Waddington, L (Waddington, Lynne); Morris, H
(Morris, Howard); Hawkins, SC (Hawkins, Stephen C.); Clark, S (Clark, Steve); Aitken, R (Aitken, Rob); McCall, MJ (McCall, Maxine J.); Donaldson, K (Donaldson, Ken)
Author Identifiers:
Poland, Craig B-3211-2009
Hawkins, Stephen H-2724-2013
Waddington, Lynne H-3500-2013
McCall, Maxine H-4707-2013 0000-0003-4000-8069
Title: Durability and inflammogenic impact of carbon nanotubes compared with asbestos fibres
Source: PARTICLE AND FIBRE TOXICOLOGY
Volume: 8
Article Number: 15
DOI: 10.1186/1743-8977-8-15
Published: MAY 13 2011
Abstract: Background: It has been suggested that carbon nanotubes might conform to the fibre pathogenicity paradigm that explains the toxicities of asbestos and other
fibres on a continuum based on length, aspect ratio and biopersistence. Some types of carbon nanotubes satisfy the first two aspects of the fibre paradigm but only recently
has their biopersistence begun to be investigated. Biopersistence is complex and requires in vivo testing and analysis. However durability, the chemical mimicking of the
process of fibre dissolution using in vitro treatment, is closely related to biopersistence and more readily determined. Here, we describe an experimental process to determine
14 di 17 24/02/14 22.28
the durability of four types of carbon nanotubes in simulated biological fluid (Gambles solution), and their subsequent pathogenicity in vivo using a mouse model sensitive to
inflammogenic effects of fibres. The in vitro and in vivo results were compared with well-characterised glass wool and asbestos fibre controls.
Results: After incubation for up to 24 weeks in Gambles solution, our control fibres were recovered at percentages consistent with their known in vitro durabilities and/or in
vivo persistence, and three out of the four types of carbon nanotubes tested (single-walled (CNTSW) and multi-walled (CNTTANG2, CNTSPIN)) showed no, or minimal,
loss of mass or change in fibre length or morphology when examined by electron microscopy. However, the fourth type [multi-walled (CNTLONG1)] lost 30% of its original
mass within the first three weeks of incubation, after which there was no further loss. Electron microscopy of CNTLONG1 samples incubated for 10 weeks confirmed that
the proportion of long fibres had decreased compared to samples briefly exposed to the Gambles solution. This loss of mass and fibre shortening was accompanied by a loss
of pathogenicity when injected into the peritoneal cavities of C57Bl/6 mice compared to fibres incubated briefly. CNTSW did not elicit an inflammogenic effect in the
peritoneal cavity assay used here.
Conclusions: These results support the view that carbon nanotubes are generally durable but may be subject to bio-modification in a sample-specific manner. They also
suggest that pristine carbon nanotubes, either individually or in rope-like aggregates of sufficient length and aspect ratio, can induce asbestos-like responses in mice, but that
the effect may be mitigated for certain types that are less durable in biological systems. Results indicate that durable carbon nanotubes that are either short or form tightly
bundled aggregates with no isolated long fibres are less inflammogenic in fibre-specific assays.
ISSN: 1743-8977
Record 44 of 50
By: Teeguarden, JG (Teeguarden, Justin G.); Webb-Robertson, BJ (Webb-Robertson, Bobbie-Jo); Waters, KM (Waters, Katrina M.); Murray, AR (Murray, Ashley R.); Kisin,
ER (Kisin, Elena R.); Varnum, SM (Varnum, Susan M.); Jacobs, JM (Jacobs, Jon M.); Pounds, JG (Pounds, Joel G.); Zanger, RC (Zanger, Richard C.); Shvedova, AA
(Shvedova, Anna A.)
Title: Comparative Proteomics and Pulmonary Toxicity of Instilled Single-Walled Carbon Nanotubes, Crocidolite Asbestos, and Ultrafine Carbon Black in Mice
Source: TOXICOLOGICAL SCIENCES
Volume: 120
Issue: 1
Pages: 123-135
DOI: 10.1093/toxsci/kfq363
Published: MAR 2011
Abstract: Reflecting their exceptional potential to advance a range of biomedical, aeronautic, and other industrial products, carbon nanotube (CNT) production and the
potential for human exposure to aerosolized CNTs are increasing. CNTs have toxicologically significant structural and chemical similarities to asbestos (AB) and have
repeatedly been shown to cause pulmonary inflammation, granuloma formation, and fibrosis after inhalation/instillation/aspiration exposure in rodents, a pattern of effects
similar to those observed following exposure to AB. To determine the degree to which responses to single-walled CNTs (SWCNT) and AB are similar or different, the
pulmonary response of C57BL/6 mice to repeated exposures to SWCNTs, crocidolite AB, and ultrafine carbon black (UFCB) were compared using high-throughput global
high performance liquid chromatography fourier transform ion cyclotron resonance mass spectrometry (HPLC-FTICR-MS) proteomics, histopathology, and bronchoalveolar
lavage cytokine analyses. Mice were exposed to material suspensions (40 micrograms per mouse) twice a week for 3 weeks by pharyngeal aspiration. Histologically, the
incidence and severity of inflammatory and fibrotic responses were greatest in mice treated with SWCNTs. SWCNT treatment affected the greatest changes in abundance of
identified lung tissue proteins. The trend in number of proteins affected (SWCNT [376] > AB [231] > UFCB [184]) followed the potency of these materials in three
biochemical assays of inflammation (cytokines). SWCNT treatment uniquely affected the abundance of 109 proteins, but these proteins largely represent cellular processes
affected by AB treatment as well, further evidence of broad similarity in the tissue-level response to AB and SWCNTs. Two high-sensitivity markers of inflammation, one
(S100a9) observed in humans exposed to AB, were found and may be promising biomarkers of human response to SWCNT exposure.
ISSN: 1096-6080
Record 45 of 50
Inventor(s): SEIDERS T J; HUTCHINSON J H
Title: Inhalable formulation useful for treating e.g. lung cancer, asthma, obstructive pulmonary disease, pulmonary fibrosis, silicosis, and acute lung injury comprises
lysophosphatidic acid receptor antagonist and excipient
Patent Number: WO2011159633-A1
Patent Assignee: AMIRA PHARM INC
Abstract: NOVELTY - An inhalable formulation comprises a lysophosphatidic acid (LPA) receptor antagonist and at least one excipient, where the formulation is in a form
suitable for administration to the lungs of a mammal.
USE - For the treatment of LPA-dependent or LPA-mediated disease or condition selected from lung cancer, asthma, chronic obstructive pulmonary disease, pulmonary
fibrosis, idiopathic pulmonary fibrosis, radiation induced fibrosis, silicosis, asbestos induced pulmonary or pleural fibrosis, acute lung injury, acute respiratory distress
syndrome (ARDS), usual interstitial pneumonia (UIP), cystic fibrosis, chronic lymphocytic leukemia (CLL)-associated fibrosis, Hamman-Rich syndrome, Caplan syndrome,
coal worker's pneumoconiosis, cryptogenic fibrosing alveolitis, obliterative bronchiolitis, chronic bronchitis, emphysema, Wegner's granulomatosis, lung scleroderma,
interstitial lung disease (claimed), allergic rhinitis, cardiovascular disease or pulmonary arterial hypertension; and also useful for preventing or treating eosinophil and/or
basophil and/or dendritic cell and/or neutrophil and/or monocyte and/or T-cell recruitment in mammal.
ADVANTAGE - The inhalable formulation allows rapid delivery of LPA receptor antagonist into the circulatory system and/or target organ (e.g. the lungs) of mammal in
need of it; and regulates functions of fibroblasts in wound healing, including proliferation, migration, differentiation and contraction. The LPA binding to its cognate G
protein-coupled receptors (GPCRs) (LPA LPA2, LPA3, LPA4, LPA5) activates intracellular signaling pathways that mediate a variety of biological responses, including e.g.
beneficial processes such as wound healing, angiogenesis, myelination, immunity and/or neurogenesis. The inhalable administration of LPA receptor antagonist to the lungs
of mammal minimizes systemic absorption of LPA receptor antagonist compound, and reduces possible side effects associated with systemic administration of LPA receptor
antagonist compound.
Accession Number: DIIDW:2011Q71163
Record 46 of 50
Inventor(s): WANG R; XIN H
15 di 17 24/02/14 22.28
Title: Photocatalyst self-cleaning finishing agent used for processing article including metal, non-metal or textile comprises sol containing nano microballoons prepared from
titanium alkoxide, silicon alkoxide and metal salt
Patent Number: CN102071568-A; CN102071568-B
Patent Assignee: HONG KONG RES&DEV CENT TEXTILE&CLOTH
Abstract: NOVELTY - A photocatalyst self-cleaning finishing agent comprises sol containing nano microballoons prepared from titanium alkoxide, silicon alkoxide and
metal salt at mol. ratio of 1-10x 103:1-10:1-10:1-10x 10-(1-10).
USE - Photocatalyst self-cleaning finishing agent used for processing article. The article is metal, non-metal or textile. The metal comprises steel, aluminum and copper. The
non-metal comprises ceramic, glass, mica, paper, sapphire and silicon. The textile is fiber, yarn, fabric or dress. The textile is textile made of vegetable textile, animal textile,
artificial textile or mineral textile. The vegetable textile is cotton, flax, jute, hemp or Modal. The animal textile comprises textile made of wool, silk or leather. The artificial
textile is textile made of Dacron, aramid fiber, acrylic fiber, nylon, spandex and olefin fiber. The mineral textile is textile made of asbestos, basalt fiber or glass fiber (all
claimed).
ADVANTAGE - The finishing agent has good dispersibility. The nano microballoons containing silicon and titanium which is mixed with metal have good hydrophilicity.
The use of article processed by the finishing agent can effectively carry out self-cleaning treatment for blot.
DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for:(1) preparation of the finishing agent which comprises (A) using titanium alkoxide, silicon
alkoxide and metal salt to prepare presolution; and (B) irradiating presolution under UV rays to prepare photocatalyst self-cleaning finishing agent; and(2) processing
photocatalyst self-cleaning article which comprises exposing photocatalyst self-cleaning article which is stained with blot in visible light under environment of steam or water
to make nano microballoons in photocatalyst self-cleaning finishing agent attached on photocatalyst self-cleaning article and promote rapid reaction of radical or molecule;
and starting blot degradation to realize self-cleaning treatment.
Accession Number: DIIDW:2011H60437
Record 47 of 50
Inventor(s): SEILER J; SEILER J M
Title: Biomass material e.g. coal, heat treatment method for producing e.g. electricity, involves choosing operating temperature of reactor in steady state in manner such that
operating temperature is greater than liquid temperature of ashes
Patent Number: WO2011003966-A2; FR2947834-A1; WO2011003966-A3; FR2947834-B1; US2012097516-A1; EP2451905-A2
Patent Assignee: COMMISSARIAT ENERGIE ATOMIQUE
Abstract: NOVELTY - The method involves determining liquid temperature of ashes resulting from a material (4) treated in a entrained flow reactor (1), where the reactor
includes a high-temperature chamber (8) and a self-crucible wall. Operating temperature of the reactor in a steady state is chosen in a manner such that operating temperature
of the reactor is greater than liquid temperature. Initial composition of the treated material is modified by adding inorganic compounds to the material.
USE - Method for heat treatment of a biomass material e.g. coal, sewage sludge, solid and/or liquid wastes, in a reactor i.e. entrained flow reactor, for realization of
gasification of the material in the reactor so as to produce electricity or biofuels. Can also be used for heat treatment of the material in a plasma reactor, an asbestos fusion
reactor or a reactor in which hydrogen or methane gases are added.
ADVANTAGE - The method enables heat treatment of all types of biomass materials in the reactor even if operating temperature of the reactor is not known, and without
deterioration of the reactor. The method enables realization of optimal thermochemical conversion of inorganic compounds present in the material to be treated, and
limitation of thermal losses at a level of a wall of the chamber of the reactor.
DESCRIPTION Of DRAWING(S) - The drawing shows a schematic view of an entrained flow reactor used in a heat treatment process.Entrained flow reactor (1)Material
(4)High-temperature chamber (8)Outlet orifice (12)Burner (22)
Record 48 of 50
By: ; 3|; ||
By: Ding Wenjin; Peng Tongjiang; Chen Jiming
Title: Crystallization of Glass-ceramics with Chrysotile Asbestos Tailing
Title: {|[(|\(|
Source: Non-metallic Mines
Source: ]Q(
Volume: 34
Issue: 5
Pages: 8-10,14
Article Number: 1000-8098(2011)34:5<8:WSMWKW>2.0.TX;2-8
Published: 2011
Abstract: The glass-ceramics was prepared with chrysotile asbestos tailing as primary material,supplemented by limestone and quartz sand.The crystallization process and
microstructure of the glass-ceramics were investigated by DTA,XRD,SEM and FT-IR.The results show that the glass-ceramics with fibroid structure is produced after definite
heat treatment.The main crystallization phase is diopside and forsteritr is the minor crystallization phase.The optimal crystallization temperature is 1050!.With increasing of
crystallization temperature,the FT-IR absorption bands of parent glass appear obvious split,which provides the position of heterogeneous nucleation for the growth of crystal.
Abstract: ){|[(,}[),j){[{{9[,[[;]|\(,}[DTA.XRD.SEM]FT-IR|Z,|\(|p|
|;|j|[;,;9,|:])JJ))]]|,f{,,|,j]j{||;||\(,j||[,1050!,||
[j(,]\(j/|]=|;],,J[j{])U|j
ISSN: 1000-8098
Record 49 of 50
By: Naumczyk, J (Naumczyk, Jeremi); Kucharska, M (Kucharska, Malgorzata)
Author Identifiers:
16 di 17 24/02/14 22.28
Kucharska, Malgorzata B-1081-2013
Naumczyk, Jeremi A-9106-2013
Title: TANNERY WASTEWATER TREATMENT BY ANODIC ELECTROOXIDATION COUPLED WITH ELECTRO-FENTON PROCESS
Source: ENVIRONMENT PROTECTION ENGINEERING
Volume: 37
Issue: 3
Pages: 47-54
Published: 2011
Abstract: Investigations were performed on tannery wastewater, previously coagulated with FeCl(3). An electrolyzer was equipped with two graphite cathodes and
Ti/SnO(2)/PdO(2)/RuO(2) anode, divided by the diaphragm made of asbestos fibre. The current density was: cathodic 2.0 A/dm(2) and anodic 2.1 A/dm(2). After 55 min of
the process the catholyte was transferred into the anodic space and the process was continued. After 55 min of electro-Fenton process, the COD was reduced by 52.0%
(current efficiency of COD removal was 10.6%). Electrooxidation continued by the anodic process resulted in elimination of ammonia in 55 min and a total reduction of
COD by 72.9%. The coupled process d could be considered a simulation of the combined process under flow conditions. The effect of this process was compared to that of a
two-steps process: Fenton process followed by indirect anodic oxidation.
ISSN: 0324-8828
Record 50 of 50
By: Prieto, MA (Prieto, M. A.); Suess, A (Suess, A.); March, JC (March, J. C.); Danet, A (Danet, A.); Corral, OP (Perez Corral, O.); Martin, A (Martin, A.)
Title: Opinions and expectations of patients with health problems associated to asbestos exposure
Source: ANALES DEL SISTEMA SANITARIO DE NAVARRA
Volume: 34
Issue: 1
Pages: 33-41
Published: JAN-APR 2011
Abstract: Background. The prevalence of diseases related to asbestos exposure requires the development of monitoring programs and specific health care protocols. The aim
of this study is to determine the opinions and expectations of former workers of an asbestos factory, in order to adapt the care process to the needs of the affected population,
and to learn about the activity of the association that represents them.
Methods. Qualitative study. Focus groups with former employees of a corrugated asbestos factory, members of the association AVIDA (Seville). Recording and transcription
of interviews. Discourse analysis with Nudist Vivo 1.0.
Results. All respondents have health problems, including asbestosis, lung cancer and mesothelioma. Through the association, they are involved in an ongoing process of
negotiation with the public administration, to improve healthcare, achieve recognition as having an occupational disease and the payment of compensation. The lack of
monitoring and continuity in care is designated as the major problem in the current care process. They welcome the creation of special care units, the good treatment received
and the quality of technical instruments in the public health system. On the contrary, they criticize the difficulties in finding an accurate diagnosis, the lack of continuity of
care, and the bureaucratic difficulties and lack of specific care directed to affected relatives. The participants expectations highlight their intention to participate in the
development of future programs and protocols.
Conclusions. This study confirms the multifactor nature of diseases related to asbestos exposure and the importance of determining the needs and demands of the affected
population in order to improve health care.
ISSN: 1137-6627
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