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Xharisz Yuka Mei S.

Dulin BS Phar II
Member No. ________ Date: _______________________
Group No. __________ Instructors Signature: ________
Exercise 5

GENTIAN VIOLET SOLUTION

SYNONYMS: Crystal Violet ; Basic Violet 3 ; Methylrosanilinium Chloride

FORMULA: MASTER FORMULA: WORKING FORMULA:1/40

Gentian Violet crystals 10g
Purified Water 1000mL

PROCEDURES:
1) Mix alcohol with purified water.
2) Dissolve the gentian violet by agitation.
3) In this mixture, add sufficient amount of purified water to make the volume.
4) Place in a suitable container.
5) Label accordingly.

USES: Gentian violet is an antiseptic dye used to treat fungal infections of the skin (e.g.,
ringworm, athlete's foot). It also has weak antibacterial effects and may be used on minor cuts
and scrapes to prevent infection.

QUESTIONS:
1) What is the purpose of alcohol in the preparation?
- Alcohol is used for better solubility of the gentian violet.


2) What is the chief solvent use?
- Water is the chief solvent used.


3) What is the chief important use of the preparation when use internally?
- This solution is used to control some intestinal parasitic worms, e.g. threadworm; In blood
banks to prevent blood transmission of Chagas disease; and as a dye to stain structures in the
eye, e.g. during eye surgery



Member No. ________ Date: _______________________
Group No. __________ Instructors Signature: ________
Exercise 6

STRONG IODINE SOLUTION

SYNONYMS: lugols solution

FORMULA: MASTER FORMULA: WORKING FORMULA:1/20
Iodine crystals 50 g
Potassium Iodide 100 g
Purified Water q.s 1000mL

PROCEDURE:
1) Dissolve the Iodine crystals in purified water containing the dissolved Potassium Iodide.
2) Stir well; add enough purified water to make 1000 mL of solution.
3) Place in the suitable container.
4) Label accordingly.

USES: Strong Iodine Solution is a germacide and fungicide, it is applied to directly to areas needing
antiseptic. It is alos used in preoperative administration of Lugol's solution decreases
intraoperative blood loss during thyroidectomy in patients with Grave's disease.

QUESTIONS:
1) What is the percentage strength of Iodine in the solution?
- 5%

2) What is the role of Sodium Iodide on the formula?
- It is used for the formation of triiodide ions.

3) What is the usual dose of Strong Iodine Solution?
For oral dosage form (solution):
To treat overactive thyroid (hyperthyroid):
- Adults and teenagersOne milliliter (mL) three times a day. The first dose is taken at least
one hour after the first dose of your antithyroid medicine.
- ChildrenUse and dose must be determined by your doctor.
To prepare for surgery to remove thyroid gland:
- Adults, teenagers, and children3 to 5 drops (approximately 0.1 to 0.3 mL) three times a
day for ten days before surgery. This medicine is usually given along with your antithyroid
medicine.
To protect the thyroid gland against radiation exposure:
- Adults and teenagers130 mg once a day for ten days.
- Children65 mg once a day for ten days.
To treat iodine deficiency:
- Adults and teenagers0.3 to 1 mL three to four times a day.
- ChildrenUse and dose must be determined by your doctor.



4) Which is more effective as an antibacterial agent between Povidome or Iodine Topical
solution?
- Both are equally effective since their action is microbicidal; oxidizes cell constituents;
iodinates proteins and inactivates them.



Member No. ________ Date: _______________________
Group No. __________ Instructors Signature: ________
Exercise 7

MAGNESIUM CITRATE SOLUTION

SYNONYMS: citrate, citrate of magnesia

FORMULA: MASTER FORMULA: WORKING FORMULA:1/5
Magnesium Carbonate 15g
Citric Acid (Anhydrous) 24.4g
Syrup 60mL
Talc 5g
Lemon Oil 0.1mL
Potassium Bicarbonate 2.5g
Purified Water q.s 350 mL


PROCEDURE:
1) Dissolve the anhydrous citric acid in 150mL of hot purified water in a suitable dish; add
slowly the magnesium carbonate, previously mixed with 100mL of purified water, and stir
until it is dissolved.
2) Then add the syrup, heat the mixed liquids to the boiling point.
3) Immediately add the lemon oil, previously triturated with the talc and filter the mixture, while
hot, into a strong bottle (previously rinsed with boiling purified water) of suitable capacity.
4) Add enough boiled purified water to make the product measure 350 mL.
5) Stopper the bottle with purified cotton, allow to cool.
6) Add the potassium bicarbonate and immediately stopper the bottle securely.
7) Lastly, shake the solution occasionally until the potassium bicarbonate is dissolved, cap the
bottle and sterilize the solution.
8) Label accordingly.

USES: It is a chemical agent used medicinally as a saline laxative and to completely empty the
bowel prior to a major surgery or colonoscopy.














QUESTIONS:
1) What is a Saline Cathartic drug?
- saline cathartic one that increases fluidity of intestinal contents by retention of water by
osmotic forces and indirectly increases motor activity.


2) What is the role of each ingredient in the formula, give it use?

Magnesium Carbonate hydrating agents or osmotics
Citric Acid (Anhydrous) - stabilizing agent
Syrup- sweetening agent
Talc- disperssing agent
Lemon Oil- flavorant
Potassium Bicarbonate - hydrating agents or osmotics

3) What is the purpose of adding potassium bicarbonate? What is a good substitute if not
available?
- Potassium bicarbonate is added as hydrating agent or osmotics.Sodium carbonate can be a
substitute foe potassium bicarbonate.


4) What can replace anhydrous citric acid in the formulation?
- Lemon juice or vinegar can be used as substitute.

5) What is the usual adult dose and child dose?
- For an adult the standard dose is 240 mL, which is approximately one cup. For children
between the ages of 6 and 12, the standard dose is 50 to 100 mL, which is approximately 1/4
to 1/2 of a cup. For children between the ages of 2 and 6, the recommended dose is 4 to 12
mL, which is approximately 1 to 3 tsp.

6) Show the chemical reaction involve to form Magnesium Citrate.
















Member No. ________ Date: _______________________
Group No. __________ Instructors Signature: ________
Exercise 8

RINGERS SOLUTION

SYNONYMS: Ringer lactate

FORMULA: MASTER FORMULA: WORKING FORMULA:1/40
Sodium Chloride 86g
Potassium Chloride 6.3g
Calcium Chloride 0.33g
Purified Water 1000mL

PROCEDURE:
1) Dissolve the three salts in sufficient quantity of recently boiled water.
2) Filter and complete the volume.
3) Place in a suitable container.
4) Label accordingly.

USES: Ringer's solution is frequently used in in vitro experiments on organs or tissues, such as in
vitro muscle testing. It may also be used for therapeutic purposes, such as arthroscopic lavage in
the case of septic arthritis.

QUESTIONS:
1) What are the three salts in the preparation?
Sodium Chloride
Potassium Chloride
Calcium Chloride

2) Compute for the amount of each ingredient needed to prepare 1 pint of the preparation.
1 US pint =473.176 ml

473.176/1000=0.473

Sodium Chloride 86g*0.473 =40.7g
Potassium Chloride 6.3g*0.473 =3.0g
Calcium Chloride 0.33g*0.473 =0.15g
Purified Water 1000mL*0.473=473ml


3) What is the solvent used in the formula?
- purified water














Member No. ________ Date: _______________________
Group No. __________ Instructors Signature: ________
Exercise 9

POTASSIUM IODIDE SOLUTION

SYNONYMS: : Potide, potassium salt; Iodic acid

FORMULA: MASTER FORMULA: WORKING FORMULA:1/40
Potassium Iodide 1000 g
Purified Water q.s 1000 mL

PROCEDURE:
1) Dissolved potassium iodide in sufficient amount of hot purified water.
2) Cool to about 25
0
C and add sufficient purified water to make 1000 mL.
3) Filter until clear.
4) Add enough water to make up to the volume.
5) Place in a suitable container
6) Label accordingly

USES: Potassium iodide is used to loosen and break up mucus in the airways. This helps
you cough up the mucus so you can breathe more easily if you have long-term lungproblems. It
is also used along with antithyroid medicines to prepare thethyroid gland for surgical removal,
to treat certain overactive thyroid conditions (hyperthyroidism), and to protect the thyroid in
a radiation exposure emergency.

QUESTIONS:
1) What is the preservative added to the formula if Potassium Iodide solution is not used within
a short period of time?
- Table salt


2) What is the common name of the preparation?
- SSKI


3) What is the percentage strength of the solution?
- 100%